Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin ApxI induced expression of IL-1β, IL-8 and TNF- α in porcine alveolar macrophages

Veterinary Research

Volumn 42, Issue 1, 2011, Pages

  Chen, Zeng Weng ^a   Chien, Maw Sheng ^a   Chang, Nai Yun ^a   Chen, Ter Hsin ^a   Wu, Chi Ming ^a   Huang, Chienjin ^a   Lee, Wei Cheng ^a   Hsuan, Shih Ling ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOBACILLUS PLEUROPNEUMONIAE; BACTERIA (MICROORGANISMS); MYCOPLASMA; SUIDAE; SUS;

APXI TOXIN, BACTERIA; BACTERIAL PROTEIN; BETA INTEGRIN; HEMOLYSIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; TRYPAN BLUE; TUMOR NECROSIS FACTOR ALPHA;

ACTINOBACILLUS INFECTION; ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMAL; ANIMAL DISEASE; ARTICLE; GENETICS; IMMUNOLOGY; LUNG ALVEOLUS MACROPHAGE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SWINE; SWINE DISEASE; WESTERN BLOTTING;

ACTINOBACILLUS INFECTIONS; ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMALS; BACTERIAL PROTEINS; BLOTTING, WESTERN; HEMOLYSIN PROTEINS; INTEGRIN BETA CHAINS; INTERLEUKIN-1BETA; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUS SCROFA; SWINE; SWINE DISEASES; TRYPAN BLUE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051959446     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1186/1297-9716-42-25     Document Type: Article

References (43)

1. Virulence factors of Actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host. Chiers K, De Waele T, Pasmans F, Ducatelle R, Haesebrouck F, Vet Res 2010 41 65 10.1051/vetres/2010037 20546697
2. Virulence properties of Actinobacillus pleuropneumoniae. Inzana TJ, Microb Pathog 1991 11 305 316 10.1016/0882-4010(91)90016-4 1816486
3. Pathogenesis of porcine Actinobacillus pleuropneumoniae, part II: roles of proinflammatory cytokines. Huang H, Potter AA, Campos M, Leighton FA, Willson PJ, Haines DM, Yates WD, Can J Vet Res 1999 63 69 78 9918337
4. In-situ hybridization for the detection of inflammatory cytokines (IL-1, TNF- and IL-6) in pigs naturally infected with Actinobacillus pleuropneumoniae. Choi C, Kwon D, Min K, Chae C, J Comp Pathol 1999 121 349 356 10.1053/jcpa.1999.0332 10542124
5. Inflammatory cytokine expression in swine experimentally infected with Actinobacillus pleuropneumoniae. Baarsch MJ, Scamurra RW, Burger K, Foss DL, Maheswaran SK, Murtaugh MP, Infect Immun 1995 63 3587 3594 7642295
6. Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection. Bosse JT, Janson H, Sheehan BJ, Beddek AJ, Rycroft AN, Kroll JS, Langford PR, Microbes Infect 2002 4 225 235 10.1016/S1286-4579(01)01534-9 11880056 (Pubitemid 34183498)
7. Identification of hemolytic and cytotoxic proteins of Actinobacillus pleuropneumoniae by use of monoclonal antibodies. Kamp EM, Popma JK, Anakotta J, Smits MA, Infect Immun 1991 59 3079 3085 1879932
8. RTX toxins in Pasteurellaceae. Frey J, Kuhnert P, Int J Med Microbiol 2002 292 149 158 10.1078/1438-4221-00200 12398206
9. Pasteurella haemolytica leukotoxin and endotoxin induced cytokine gene expression in bovine alveolar macrophages requires NF-B activation and calcium elevation. Hsuan SL, Kannan MS, Jeyaseelan S, Prakash YS, Malazdrewich C, Abrahamsen MS, Sieck GC, Maheswaran SK, Microb Pathog 1999 26 263 273 10.1006/mpat.1998.0271 10222211 (Pubitemid 29224666)
10. Purified Pasteurella haemolytica leukotoxin induces expression of inflammatory cytokines from bovine alveolar macrophages. Yoo HS, Rajagopal BS, Maheswaran SK, Ames TR, Microb Pathog 1995 18 237 252 10.1016/S0882-4010(05) 80001-4 7476090
11. Pathophysiologic correlates of acute porcine pleuropneumonia. Baarsch MJ, Foss DL, Murtaugh MP, Am J Vet Res 2000 61 684 690 10.2460/ajvr.2000.61.684 10850846
12. RTX toxins recognize a 2 integrin on the surface of human target cells. Lally ET, Kieba IR, Sato A, Green CL, Rosenbloom J, Korostoff J, Wang JF, Shenker BJ, Ortlepp S, Robinson MK, Billings PC, J Biol Chem 1997 272 30463 30469 10.1074/jbc.272.48.30463 9374538 (Pubitemid 27512257)
13. The leukotoxin of Pasteurella haemolytica binds to 2 integrins on bovine leukocytes. Ambagala TC, Ambagala AP, Srikumaran S, FEMS Microbiol Lett 1999 179 161 167 10481101 (Pubitemid 29428219)
14. Lymphocyte function-associated antigen 1 is a receptor for Pasteurella haemolytica leukotoxin in bovine leukocytes. Jeyaseelan S, Hsuan SL, Kannan MS, Walcheck B, Wang JF, Kehrli ME, Lally ET, Sieck GC, Maheswaran SK, Infect Immun 2000 68 72 79 10.1128/IAI.68.1.72-79.2000 10603370 (Pubitemid 30016679)
15. Bovine CD18 identified as a species specific receptor for Pasteurella haemolytica leukotoxin. Li J, Clinkenbeard KD, Ritchey JW, Vet Microbiol 1999 67 91 97 10.1016/S0378-1135(99)00040-1 10414364 (Pubitemid 29257975)
16. Integrins in immunity. Evans R, Patzak I, Svensson L, De Filippo K, Jones K, McDowall A, Hogg N, J Cell Sci 2009 122 215 225 10.1242/jcs.019117 19118214
17. Bovine CD18 is necessary and sufficient to mediate Mannheimia (Pasteurella) haemolytica leukotoxin-induced cytolysis. Deshpande MS, Ambagala TC, Ambagala AP, Kehrli ME Jr, Srikumaran S, Infect Immun 2002 70 5058 5064 10.1128/IAI.70.9.5058-5068.2002 12183553
18. Pasteurella haemolytica A1-derived leukotoxin and endotoxin induce intracellular calcium elevation in bovine alveolar macrophages by different signaling pathways. Hsuan SL, Kannan MS, Jeyaseelan S, Prakash YS, Sieck GC, Maheswaran SK, Infect Immun 1998 66 2836 2844 9596757 (Pubitemid 28261793)
19. Porcine CD18 mediates Actinobacillus pleuropneumoniae ApxIII species-specific toxicity. Vanden Bergh PG, Zecchinon LL, Fett T, Desmecht D, Vet Res 2009 40 33 10.1051/vetres/2009016 19356397
20. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Kyriakis JM, Avruch J, Physiol Rev 2001 81 807 869 11274345 (Pubitemid 32267078)
21. Multiple control of interleukin-8 gene expression. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M, J Leukoc Biol 2002 72 847 855 12429706 (Pubitemid 35365158)
22. MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Kaminska B, Biochim Biophys Acta 2005 1754 253 262 16198162 (Pubitemid 41797706)
23. The role of p38 mitogen-activated protein kinase in IL-1 transcription. Baldassare JJ, Bi Y, Bellone CJ, J Immunol 1999 162 5367 5373 10228013 (Pubitemid 29307144)
24. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Han J, Lee JD, Bibbs L, Ulevitch RJ, Science 1994 265 808 811 10.1126/science.7914033 7914033 (Pubitemid 24266145)
25. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young PR, Nature 1994 372 739 746 10.1038/372739a0 7997261
26. Lung inflammatory responses. Thacker EL, Vet Res 2006 37 469 486 10.1051/vetres:2006011 16611559 (Pubitemid 43725032)
27. Actinobacillus pleuropneumoniae serotype 10 derived ApxI induces apoptosis in porcine alveolar macrophages. Chien MS, Chan YY, Chen ZW, Wu CM, Liao JW, Chen TH, Lee WC, Yeh KS, Hsuan SL, Vet Microbiol 2009 135 327 333 10.1016/j.vetmic.2008.09.071 19013727
28. Virulence in Actinobacillus pleuropneumoniae and RTX toxins. Frey J, Trends Microbiol 1995 3 257 261 10.1016/S0966-842X(00)88939-8 7551637
29. The (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) colorimetric assay for the quantitation of Actinobacillus pleuropneumoniae cytotoxin. Chung WB, Backstrom LR, McDonald J, Collins MT, Can J Vet Res 1993 57 159 165 8358675
30. Expression of inflammatory cytokines (TNF-, IL-1, IL-6 and IL-8) in colon of pigs naturally infected with Salmonella typhimurium and Salmonella choleraesuis. Cho WS, Chae C, J Vet Med A Physiol Pathol Clin Med 2003 50 484 487 15157014 (Pubitemid 41742986)
31. -CT method. Livak KJ, Schmittgen TD, Methods 2001 25 402 408 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
32. The cytotoxin of Actinobacillus pleuropneumoniae (pleurotoxin) is distinct from the haemolysin and is associated with a 120 kDa polypeptide. Rycroft AN, Williams D, Cullen JM, Macdonald J, J Gen Microbiol 1991 137 561 568 2033378
33. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ, Cell 1994 76 1025 1037 10.1016/0092-8674(94) 90380-8 8137421 (Pubitemid 24106383)
34. Targeting bacterial endotoxin: two sides of a coin. Bosshart H, Heinzelmann M, Ann N Y Acad Sci 2007 1096 1 17 10.1196/annals.1397.064 17405910 (Pubitemid 47092492)
35. Cloning, sequencing and regulation of an mRNA encoding porcine interleukin-1 Huether MJ, Lin G, Smith DM, Murtaugh MP, Molitor TW, Gene 1993 129 285 289 10.1016/0378-1119(93)90281-7 8325511
36. Detection of tumor necrosis factor alpha from porcine alveolar macrophages using an L929 fibroblast bioassay. Baarsch MJ, Wannemuehler MJ, Molitor TW, Murtaugh MP, J Immunol Methods 1991 140 15 22 10.1016/0022-1759(91) 90121-U 1712031
37. Regulation of interleukin-8 expression in porcine alveolar macrophages by bacterial lipopolysaccharide. Lin G, Pearson AE, Scamurra RW, Zhou Y, Baarsch MJ, Weiss DJ, Murtaugh MP, J Biol Chem 1994 269 77 85 8276881 (Pubitemid 24026626)
38. Mutation in the LPS outer core biosynthesis gene, galU, affects LPS interaction with the RTX toxins ApxI and ApxII and cytolytic activity of Actinobacillus pleuropneumoniae serotype 1. Ramjeet M, Cox AD, Hancock MA, Mourez M, Labrie J, Gottschalk M, Jacques M, Mol Microbiol 2008 70 221 235 10.1111/j.1365-2958.2008.06409.x 18713318
39. TNF- gene expression in macrophages: regulation by NF-B is independent of c-Jun or C/EBP Liu H, Sidiropoulos P, Song G, Pagliari LJ, Birrer MJ, Stein B, Anrather J, Pope RM, J Immunol 2000 164 4277 4285 10754326 (Pubitemid 30215089)
40. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Gupta S, Campbell D, Derijard B, Davis RJ, Science 1995 267 389 393 10.1126/science.7824938 7824938
41. The stress-activated protein kinase subfamily of c-Jun kinases. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR, Nature 1994 369 156 160 10.1038/369156a0 8177321 (Pubitemid 24153440)
42. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW, Proc Natl Acad Sci USA 2001 98 13681 13686 10.1073/pnas.251194298 11717429 (Pubitemid 33115958)
43. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Thomas SM, DeMarco M, D'Arcangelo G, Halegoua S, Brugge JS, Cell 1992 68 1031 1040 10.1016/0092-8674(92)90075-N 1312392