Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5568-5572

  Sime, Mairi ^a   Allan, Amanda C ^a   Chapman, Paul ^a   Fieldhouse, Charlotte ^a   Giblin, Gerard M P ^a   Healy, Mark P ^a   Lambert, Millard H ^b   Leesnitzer, Lisa M ^b   Lewis, Ann ^a   Merrihew, Raymond V ^b   Rutter, Richard A ^a   Sasse, Rosemary ^a   Shearer, Barry G ^b   Wilson, Timothy M ^b   Xu, Robert X ^b   Virley, David J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Alzheimer's disease; Benzimidazoles; Peroxisome proliferator activated receptor; PPAR

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; GSK 1997132B; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG ACTIVITY; DRUG BINDING; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

BENZIMIDAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; MOLECULAR STRUCTURE; PPAR GAMMA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051928116     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.088     Document Type: Article

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