Epithelial inducible nitric oxide synthase causes bacterial translocation by impairment of enterocytic tight junctions via intracellular signals of Rho-associated kinase and protein kinase C zeta

Critical Care Medicine

Volumn 39, Issue 9, 2011, Pages 2087-2098

  Wu, Li Ling ^a   Chiu, Hsin Da ^a   Peng, Wei Hao ^a   Lin, Bor Ru ^b   Lu, Kuo Shyan ^a   Lu, Yen Zhen ^a   Yu, Linda Chia Hui ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

bacterial translocation; bowel obstruction; epithelial permeability; myosin light chain; nitric oxide; signal transduction; tight junctions

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; EPITHELIAL INDUCIBLE NITRIC OXIDE SYNTHASE; MYOSIN LIGHT CHAIN; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN KINASE C ZETA; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; DIGESTIVE TRACT PARAMETERS; ENTEROCYTIC TIGHT JUNCTION; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; INTESTINE OBSTRUCTION; INTRACELLULAR SIGNALING; LIGATION; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SMALL INTESTINE; SPLEEN; TIGHT JUNCTION; TRANSEPITHELIAL RESISTANCE;

EID: 80051926938     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31821cb40e     Document Type: Article

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