Protective effects of Y-27632 on hypoxia/reoxygenation-induced intestinal injury in newborn rats

Journal of Pediatric Surgery

Volumn 46, Issue 8, 2011, Pages 1490-1494

  Balyemez, Gül ^a   Sivasli, Ercan ^a   Ceylan, Haluk ^a   Tutar, Ediz ^a   Ekiz, Sule ^b   Tarakcioglu, Mehmet ^a   Demiryurek, Abdullah T ^a   Coskun, M Yavuz ^a  

^a GAZIANTEP UNIVERSITY   (Turkey)

^b Gaziantep 25 Aralik Hospital   (Turkey)

Author keywords

Hypoxia reoxygenation; Necrotizing enterocolitis; Rho kinase inhibition; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; MALONALDEHYDE; NITRIC OXIDE;

AERATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; HISTOPATHOLOGY; HYPOXIA; INJURY SCALE; INTESTINE CRYPT; INTESTINE INJURY; INTESTINE VILLUS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; TISSUE LEVEL;

AMIDES; ANIMALS; ANOXIA; CARBON DIOXIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENTEROCOLITIS, NECROTIZING; ENZYME INHIBITORS; INTESTINAL MUCOSA; INTESTINES; MALONDIALDEHYDE; NITRIC OXIDE; NITROGEN; OXYGEN; PYRIDINES; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 80051896859     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2010.11.034     Document Type: Article

References (37)

1. Thompson A.M., and Bizzarro M.J. Necrotizing enterocolitis in newborns: pathogenesis, prevention and management Drugs 68 2008 1227 1238 (Pubitemid 351822112)
2. Petrosyan M., Guner Y.S., and Williams M. Current concepts regarding the pathogenesis of necrotizing enterocolitis Pediatr Surg Int 25 2009 309 318
3. Nowicki P.T. Ischemia and necrotizing enterocolitis: where, when, and how Semin Pediatr Surg 14 2005 152 158 (Pubitemid 41111601)
4. Riento K., and Ridley A.J. Rocks: multifunctional kinases in cell behaviour Nat Rev Mol Cell Biol 4 2003 446 456 (Pubitemid 36648590)
5. Rattan S, Phillips BR, Maxwell PJ III: RhoA/Rho-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation. Gastroenterology 2010;138:13-8. e1-3.
6. Amano M., Chihara K., and Kimura K. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase Science 275 1997 1308 1311 (Pubitemid 27114159)
7. Kureishi Y., Kobayashi S., and Amano M. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation J Biol Chem 272 1997 12257 12260 (Pubitemid 27203307)
8. Seasholtz T.M., Majumdar M., and Kaplan D.D. Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration Circ Res 84 1999 1186 1193 (Pubitemid 29244780)
9. Tamada M., Perez T.D., and Nelson W.J. Two distinct modes of myosin assembly and dynamics during epithelial wound closure J Cell Biol 176 2007 27 33 (Pubitemid 46041677)
10. Ishizaki T., Uehata M., and Tamechika I. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases Mol Pharmacol 57 2000 976 983 (Pubitemid 30253382)
11. Ceylan H., Yapici S., and Tutar E. Protective effects of dexpanthenol and Y-27632 on stricture formation in a rat model of caustic esophageal injury J Surg Res 2010 10.1016/j.jss.2010.05.005 (in press)
12. Darenfed H., Dayanandan B., and Zhang T. Molecular characterization of the effects of Y-27632 Cell Motil Cytoskeleton 64 2007 97 109 (Pubitemid 46106255)
13. Ceylan H., Yüncü M., and Gürel A. Effects of whole-body hypoxic preconditioning on hypoxia/reoxygenation-induced intestinal injury in newborn rats Eur J Pediatr Surg 15 2005 325 332
14. Clark D.A., Fornabaio D.M., and McNeill H. Contribution of oxygen-derived free radicals to experimental necrotizing enterocolitis Am J Pathol 130 1988 537 542 (Pubitemid 18091382)
15. Wasowicz W., Nève J., and Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage Clin Chem 39 1993 2522 2526 (Pubitemid 24008241)
16. Cortas N.K., and Wakid N.W. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method Clin Chem 36 1990 1440 1443
17. Caplan M.S., Sun X.M., and Hsueh W. Hypoxia causes ischemic bowel necrosis in rats: the role of platelet-activating factor (PAF-acether) Gastroenterology 99 1990 979 986 (Pubitemid 20338454)
18. Hsueh W., Caplan M.S., and Qu X.W. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts Pediatr Dev Pathol 6 2003 6 23 (Pubitemid 36323623)
19. Akisu M., Ozmen D., and Baka M. Protective effect of dietary supplementation with l-arginine and l-carnitine on hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice Biol Neonate 81 2002 260 265 (Pubitemid 34507594)
20. Caplan M.S., Hedlund E., and Adler L. Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis Pediatr Pathol 14 1994 1017 1028 (Pubitemid 24357149)
21. Okur H., Küçükaydin M., and Köse K. Hypoxia-induced necrotizing enterocolitis in the immature rat: the role of lipid peroxidation and management by vitamin E J Pediatr Surg 30 1995 1416 1419
22. Puiman P., and Stoll B. Animal models to study neonatal nutrition in humans Curr Opin Clin Nutr Metab Care 11 2008 601 606
23. Clark D.A., and Miller M.J. Intraluminal pathogenesis of necrotizing enterocolitis J Pediatr 117 1990 S64 S67
24. Kurose I., Wolf R., and Grisham M.B. Modulation of ischemia/reperfusion- induced microvascular dysfunction by nitric oxide Circ Res 74 1994 376 382 (Pubitemid 24064187)
25. Whittle B.J., Boughton-Smith N.K., and Moncada S. Biosynthesis and role of the endothelium-derived vasodilator, nitric oxide, in the gastric mucosa Ann N Y Acad Sci 664 1992 126 139 (Pubitemid 23022844)
26. Bergamini C.M., Gambetti S., and Dondi A. Oxygen, reactive oxygen species and tissue damage Curr Pharm Des 10 2004 1611 1626 (Pubitemid 38559774)
27. Chokshi N.K., Guner Y.S., and Hunter C.J. The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis Semin Perinatol 32 2008 92 99 (Pubitemid 351381164)
28. Whitehouse J.S., Xu H., and Shi Y. Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis J Surg Res 161 2010 1 8
29. Cetin S., Ford H.R., and Sysko L.R. Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions J Biol Chem 279 2004 24592 24600 (Pubitemid 38725326)
30. Cetin S., Leaphart C.L., and Li J. Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner Am J Physiol Gastrointest Liver Physiol 292 2007 G1347 G1358
31. Song J., Li J., and Lulla A. Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-delta pathway activation Am J Physiol Cell Physiol 290 2006 C1469 C1476
32. Markel T.A., Crisostomo P.R., and Wairiuko G.M. Cytokines in necrotizing enterocolitis Shock 25 2006 329 337
33. Bao W., Hu E., and Tao L. Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury Cardiovasc Res 61 2004 548 558 (Pubitemid 38210160)
34. Desai L.P., Aryal A.M., and Ceacareanu B. RhoA and Rac1 are both required for efficient wound closure of airway epithelial cells Am J Physiol Lung Cell Mol Physiol 287 2004 L1134 L1144
35. Rao J.N., Guo X., and Liu L. Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution Am J Physiol Cell Physiol 284 2003 C848 C859
36. Kawaguchi A., Ohmori M., and Harada K. The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes Eur J Pharmacol 403 2000 203 208
37. Mita S., Kobayashi N., and Yoshida K. Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats J Hypertens 23 2005 87 96 (Pubitemid 40128985)