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Helvetica Chimica Acta

Volumn 94, Issue 8, 2011, Pages 1496-1505

An efficient synthesis of a (-)-physostigmine's library for identifying potential anti-Alzheimer's agents

(4) Wu, Yi a Wang, Fusheng a Song, Hao a Qin, Yong a

a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS (China)

Author keywords

( ) Physostigmine; 1,2,3 Triazole derivatives; Alzheimer's disease

Indexed keywords

(-)-PHYSOSTIGMINE; 1,2,3-TRIAZOLE DERIVATIVES; ALZHEIMER'S DISEASE; COPPER-CATALYZED CYCLOADDITION; EFFICIENT SYNTHESIS; FACILE PREPARATION; HUISGEN CYCLOADDITION; ORGANOCATALYSIS; PROPARGYL; THREE-COMPONENT;

ACETYLENE; BROMINE; BROMINE COMPOUNDS; CATALYSIS; REACTION KINETICS;

NEURODEGENERATIVE DISEASES;

1 [1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL] N,N DIMETHYLMETHANAMINE; 2 [1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]ETHANOL; 2 [1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]METHANOL; 2 [1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]PROPAN 2 OL; 3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYL 5 (1H 1,2,3 TRIAZOL 1 YL)PYRROLO[2,3 B]INDOLE; 3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYL 5 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)PYRROLO[2,3 B]INDOLE; 3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYL 5 [4 (PIPERIDIN 1 YLMETHYL) 1H 1,2,3 TRIAZOL 1 YL]PYRROLO[2,3 B]INDOLE; 3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYL 5 [4 (PYRROLIDIN 1 YLMETHYL) 1H 1,2,3 TRIAZOL 1 YL]PYRROLO[2,3 B]INDOLE; 3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYL 5 [4 [(4 METHYLPIPERAZIN 1 YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL]PYRROLO[2,3 B]INDOLE; 3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYL 5 [4 [[4 (2 PHENYLETHYL)PIPERAZIN 1 YL] METHYL] 1H 1,2,3 TRIAZOL 1 YL]PYRROLO[2,3 B]INDOLE; 3A ETHYL 1,8 DIMETHYL 5 [4 (MORPHOLIN 4 YLMETHYL) 1H 1,2,3 TRIAZOL 1 YL] 1,2,3,3A,8,8A HEXAHYDROPYRROLO[2,3 B]INDOLE; 4 [1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]BUTAN 1 OL; 5 [4 [(4 BENZYLPIPERAZIN 1 YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO[2,3 B]INDOLE; [4 [[1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERAZIN 1 YL](PHENYL)METHANONE; ALKYNE; AMINE; AZIDE; BROMIDE; COPPER ION; ETHYL 1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOLE 4 CARBOXYLATE; N [[1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] N METHYLANILINE; N BUTYL N [[1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]METHYL]BUTAN 1 AMINE; N CYCLOHEXYL N [[1 [3A ETHYL 1,2,3,3A,8,8A HEXAHYDRO 1,8 DIMETHYLPYRROLO(2,3 B)INDOL 5 YL] 1H 1,2,3 TRIAZOL 4 YL]METHYL]CYCLOHEXANAMINE; NOOTROPIC AGENT; PHYSOSTIGMINE DERIVATIVE; PROPARGYLGLYCINE; UNCLASSIFIED DRUG; WATER;

ALZHEIMER DISEASE; ARTICLE; BIODIVERSITY; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CRYSTALLIZATION; CYCLOADDITION; DRUG ACTIVITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; INFRARED SPECTROMETRY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

EID: 80051889227 PISSN: 0018019X EISSN: 15222675 Source Type: Journal
DOI: 10.1002/hlca.201100020 Document Type: Article

Times cited : (6)

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