Mechanical improvements to reinforced porous silk scaffolds

Journal of Biomedical Materials Research - Part A

Volumn 99 A, Issue 1, 2011, Pages 16-28

  Gil, Eun Seok ^a   Kluge, Jonathan A ^a   Rockwood, Danielle N ^a   Rajkhowa, Rangam ^b   Wang, Lijing ^c   Wang, Xungai ^b   Kaplan, David L ^a  

^a Tufts University   (United States)

^b DEAKIN UNIVERSITY   (Australia)

^c RMIT UNIVERSITY   (Australia)

Author keywords

composite; particles; reinforcement; scaffolds; silk; tissue engineering

Indexed keywords

BIODEGRADABLE SCAFFOLD; CANCELLOUS BONE; COMPOSITE; FUNCTIONAL TISSUE; HEXAFLUOROISOPROPANOL; HOMOGENEOUS DISTRIBUTION; INTERFACIAL COMPATIBILITY; LOAD-BEARING; MATERIAL DENSITY; MATRIX; PARTICLE CONTENT; PORE WALL; POROGENS; POWER LAW RELATIONSHIP; SILK PROTEINS; SILK SCAFFOLD; SOLUTION CONCENTRATION; TWO-COMPONENT;

BEARINGS (MACHINE PARTS); BIOMECHANICS; BONE; DENSITY (SPECIFIC GRAVITY); LEACHING; SCAFFOLDS (BIOLOGY); TISSUE;

SILK;

HEXAFLUORO 2 PROPANOL; SCAFFOLD PROTEIN; SOLVENT;

ARTICLE; BIODEGRADABILITY; BIOMECHANICS; CANCELLOUS BONE; COMPOSITE MATERIAL; DENSITY; HYDROLYSIS; NONHUMAN; POROSITY; PROTEIN DEGRADATION; SILK; TISSUE ENGINEERING;

MATERIALS TESTING; POROSITY; PROTEOLYSIS; SILK; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 80051862644     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33158     Document Type: Article

References (63)

1. Langer R, Vacanti JP,. Tissue Eng Sci 1993; 260: 920-926.
2. LeGeros RZ,. Properties of osteoconductive biomaterials: Calcium phosphates. Clin Orthop Relat R 2002: 81-98.
3. Salgado AJ, Coutinho OP, Reis RL,. Bone tissue engineering: State of the art and future trends. Macromol Biosci 2004; 4: 743-765. (Pubitemid 39257140)
4. Zhou YF, Chen FL, Ho ST, Woodruff MA, Lim TM, Hutmacher DW,. Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts. Biomaterials 2007; 28: 814-824. (Pubitemid 44667017)
5. Leong KF, Cheah CM, Chua CK,. Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs. Biomaterials 2003; 24: 2363-2378. (Pubitemid 36434056)
6. Vitale-Brovarone C, Baino F, Verne E,. High strength bioactive glass-ceramic scaffolds for bone regeneration. J Mater Sci-Mater M 2009; 20: 643-653.
7. Dawson JI, Wahl DA, Lanham SA, Kanczler JM, Czernuszka JT, Oreffo ROC,. Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells. Biomaterials 2008; 29: 3105-3116.
8. Pek YS, Gao SJ, Arshad MSM, Leck KJ, Ying JY,. Porous collagen-apatite nanocomposite foams as bone regeneration scaffolds. Biomaterials 2008; 29: 4300-4305.
9. Oliveira JM, Rodrigues MT, Silva SS, Malafaya PB, Gomes ME, Viegas CA, Dias IR, Azevedo JT, Mano JF, Reis RL,. Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: Scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials 2006; 27: 6123-6137. (Pubitemid 44429972)
10. Le Nihouannen D, Le Guehennec L, Rouillon T, Pilet P, Bilban M, Layrolle P, Daculsi G,. Micro-architecture of calcium phosphate granules and fibrin glue composites for bone tissue engineering. Biomaterials 2006; 27: 2716-2722. (Pubitemid 43122075)
11. Sikavitsas VI, Bancroft GN, Mikos AG,. Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor. J Biomed Mater Res 2002; 62: 136-148. (Pubitemid 34831402)
12. Ochi K, Chen GP, Ushida T, Gojo S, Segawa K, Tai H, Ueno K, Ohkawa H, Mori T, Yamaguchi A, Toyama Y, Hata J, Umezawa A,. Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly- DL -lactic-co-glycolic acid (PLGA)-collagen sponge. J Cell Physiol 2003; 194: 45-53. (Pubitemid 35424226)
13. Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH, Tan KC,. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 2001; 55: 203-216. (Pubitemid 32198503)
14. Behravesh E, Timmer MD, Lemoine JJ, Liebschner MAK, Mikos AG,. Evaluation of the in vitro degradation of macroporous hydrogels using gravimetry, confined compression testing, and microcomputed tomography. Biomacromolecules 2002; 3: 1263-1270. (Pubitemid 35423024)
15. Yunoki S, Marukawa E, Ikoma T, Sotome S, Fan HS, Zhang XD, Shinomiya K, Tanaka J,. Effect of collagen fibril formation on bioresorbability of hydroxyapatite/collagen composites. J Mater Sci-Mater M 2007; 18: 2179-2183. (Pubitemid 350167372)
16. Yang XBB, Bhatnagar RS, Li S, Oreffo ROC,. Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Eng 2004; 10: 1148-1159. (Pubitemid 39223793)
17. Xiao Y, Qian H, Young WG, Bartold PM,. Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Eng 2003; 9: 1167-1177. (Pubitemid 37467664)
18. Hodgskinson R, Currey JD,. Young modulus. Density and material properties in cancellous bone over a large density range. J Mater Sci-Mater M 1992; 3: 377-381.
19. Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG,. Evolution of bone transplantation: Molecular, cellular and tissue strategies to engineer human bone. Biomaterials 1996; 17: 175-185. (Pubitemid 26031373)
20. Cullinane DM, Einhorn, T.A., Biomechanics of bone. In:, Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of Bone Biology, vol. 1, San Diego, CA: Academic Press; 2001. p. 17-32.
21. Del Gaudio C, Filippini P, Construsciere V, Di Federico E, Bianco A, Grigioni M,. Assessment of electrospun PCL scaffold for tissue engineering. Int J Artif Organs 2006; 29: 537-537.
22. Izquierdo R, Garcia-Giralt N, Rodriguez MT, Caceres E, Garcia SJ, Ribelles JLG, Monleon M, Monllau JC, Suay J,. Biodegradable PCL scaffolds with an interconnected spherical pore network for tissue engineering. J Biomed Mater Res A 2008; 85A: 25-35. (Pubitemid 351355352)
23. Liao J, Guo X, Nelson DF, Kasper FK, Mikos AG,. Modulation of osteogenic properties of biodegradable polymer/extracellular matrix scaffolds generated with a flow perfusion bioreactor. Acta Biomater 2010; 6: 2386-2393.
24. Jin HJ, Kaplan DL,. Mechanism of silk processing in insects and spiders. Nature 2003; 424: 1057-1061. (Pubitemid 37064306)
25. Vepari C, Kaplan DL,. Silk as a biomaterial. Prog Polym Sci 2007; 32: 991-1007. (Pubitemid 47198292)
26. Kim UJ, Park J, Kim HJ, Wada M, Kaplan DL,. Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin. Biomaterials 2005; 26: 2775-2785. (Pubitemid 39600730)
27. Kim HJ, Kim UJ, Vunjak-Novakovic G, Min BH, Kaplan DL,. Influence of macroporous protein scaffolds on bone tissue engineering from bone marrow stem cells. Biomaterials 2005; 26: 4442-4452. (Pubitemid 40208605)
28. Nazarov R, Jin HJ, Kaplan DL,. Porous 3-D scaffolds from regenerated silk fibroin. Biomacromolecules 2004; 5: 718-726. (Pubitemid 38702237)
29. Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G,. Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors. Biomaterials 2006; 27: 6138-6149. (Pubitemid 44437575)
30. Kim HJ, Kim UJ, Leisk GG, Bayan C, Georgakoudi I, Kaplan DL,. Bone regeneration on macroporous aqueous-derived silk 3-D scaffolds. Macromol Biosci 2007; 7: 643-655. (Pubitemid 47264638)
31. Wang Y, Rudym DD, Walsh A, Abrahamsen L, Kim HJ, Kim HS, Kirker-Head C, Kaplan DL,. In vivo degradation of three-dimensional silk fibroin scaffolds. Biomaterials 2008; 29: 3415-3428.
32. Kim HJ, Kim UJ, Kim HS, Li CM, Wada M, Leisk GG, Kaplan DL,. Bone tissue engineering with premineralized silk scaffolds. Bone 2008; 42: 1226-1234.
33. Meinel L, Fajardo R, Hofmann S, Langer R, Chen J, Snyder B, Vunjak-Novakovic G, Kaplan D,. Silk implants for the healing of critical size bone defects. Bone 2005; 37: 688-698. (Pubitemid 41476392)
34. Meinel L, Karageorgiou V, Hofmann S, Fajardo R, Snyder B, Li CM, Zichner L, Langer R, Vunjak-Novakovic G, Kaplan DL,. Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds. J Biomed Mater Res 2004; 71: 25-34. (Pubitemid 39244392)
35. Altman GH, Horan RL, Lu HH, Moreau J, Martin I, Richmond JC, Kaplan DL,. Silk matrix for tissue engineered anterior cruciate ligaments. Biomaterials 2002; 23: 4131-4141. (Pubitemid 34765704)
36. Collins AM, Skaer NJV, Cheysens T, Knight D, Bertram C, Roach HI, Oreffo ROC, Von-Aulock S, Baris T, Skinner J, Mann S,. Bone-like resorbable silk-based scaffolds for load-bearing osteoregenerative applications. Adv Mater 2009; 21: 75-78.
37. Rajkhowa R, Gil ES, Kluge J, Numata K, Wang L, Wang X, Kaplan DL,. Reinforcing silk scaffolds with silk particles. Macromol Biosci 2010; 10: 599-611.
38. Rho KS, Jeong L, Lee G, Seo BM, Park YJ, Hong SD, Roh S, Cho JJ, Park WH, Min BM,. Electrospinning of collagen nanofibers: Effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials 2006; 27: 1452-1461. (Pubitemid 41739571)
39. Angele P, Muller R, Schumann D, Englert C, Zellner J, Johnstone B, Yoo J, Hammer J, Fierlbeck J, Angele MK, Nerlich N, Kujat R,. Characterization of esterified hyaluronan-gelatin polymer composites suitable for chondrogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A 2009; 91: 416-427.
40. Rockwood DN, Gil ES, Park SH, Kluge JA, Grayson W, Bhumiratana S, Rajkhowa R, Wang XG, Kim SJ, Vunjak-Novakovic G, Kaplan DL,. Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study. Acta Biomater 2011; 7: 144-151.
41. Jin HJ, Park J, Karageorgiou V, Kim UJ, Valluzzi R, Kaplan DL,. Water-stable silk films with reduced beta-sheet content. Adv Funct Mater 2005; 15: 1241-1247. (Pubitemid 41119966)
42. Rajkhowa R, Wang L, Kanwar J, Wang X,. Fabrication of ultrafine powder from eri silk through attritor and jet milling. Powder Technol 191: 155-163.
43. Wang XQ, Wenk E, Matsumoto A, Meinel L, Li CM, Kaplan DL,. Silk microspheres for encapsulation and controlled release. J Control Release 2007; 117: 360-370. (Pubitemid 46216582)
44. Hu X, Kaplan D, Cebe P,. Determining beta-sheet crystallinity in fibrous proteins by thermal analysis and infrared spectroscopy. Macromolecules 2006; 39: 6161-6170. (Pubitemid 44412191)
45. Wu LB, Zhang H, Zhang JC, Ding JD,. Fabrication of three-dimensional porous scaffolds of complicated shape for tissue engineering. I. Compression molding based on flexible-rigid combined mold. Tissue Eng 2005; 11: 1105-1114. (Pubitemid 41321413)
46. Nazarov R, Jin H-J, Kaplan DL,. Porous 3-D scaffolds from regenerated silk fibroin. 2004; 5: 718-726.
47. Park SJ, Lee KY, Ha WS, Park SY,. Structural changes and their effect on mechanical properties of silk fibroin/chitosan blends. J Appl Polym Sci 1999; 74: 2571-2575. (Pubitemid 129305071)
48. Banse X, Devogelaer JP, Munting E, Delloye C, Cornu O, Grynpas M,. Inhomogeneity of human vertebral cancellous bone: Systematic density and structure patterns inside the vertebral body. Bone 2001; 28: 563-571. (Pubitemid 32410008)
49. Muller R, Van Campenhout H, Van Damme B, Van Der Perre G, Dequeker J, Hildebrand T, Ruegsegger P,. Morphometric analysis of human bone biopsies: A quantitative structural comparison of histological sections and micro-computed tomography. Bone 1998; 23: 59-66. (Pubitemid 28327502)
50. Itala AI, Ylanen HO, Ekholm C, Karlsson KH, Aro HT,. Pore diameter of more than 100 μm is not requisite for bone ingrowth in rabbits. J Biomed Mater Res 2001; 58: 679-683. (Pubitemid 33096568)
51. Burg KJL, Porter S, Kellam JF,. Biomaterial developments for bone tissue engineering. Biomaterials 2000; 21: 2347-2359.
52. Yang SF, Leong KF, Du ZH, Chua CK,. The design of scaffolds for use in tissue engineering. Part 1. Traditional factors. Tissue Eng 2001; 7: 679-689.
53. Albrektsson T, Johansson C, Osteoinduction, osteoconduction and osseointegration. Eur Spine J 2001; 10: S96-S101. (Pubitemid 32999812)
54. Lewandrowski KU, Bondre S, Hile DD, Thompson BMJ, Wise DL, Tomford WW, Trantolo DJ,. Porous poly(propylene fumarate) foam coating of orthotopic cortical bone grafts for improved osteoconduction. Tissue Eng 2002; 8: 1017-1027. (Pubitemid 35397247)
55. Lewandrowski KU, Bondre SP, Gresser JD, Wise DL, Tomford WW, Trantolo DJ,. Improved osteoconduction of cortical bone grafts by biodegradable foam coating. Bio-Med Mater Eng 1999; 9: 265-275. (Pubitemid 30194141)
56. Lin-Gibson S, Cooper JA, Landis FA, Cicerone MT,. Systematic investigation of porogen size and content on scaffold morphometric parameters and properties. Biomacromolecules 2007; 8: 1511-1518. (Pubitemid 46865123)
57. Borden M, El-Amin SF, Attawia M, Laurencin CT,. Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair. Biomaterials 2003; 24: 597-609. (Pubitemid 35346389)
58. Shutov FA,. Foamed Polymers-Cellular Structure and Properties. Adv Polym Sci 1983; 51: 155-225.
59. Lau KT, Gu C, Hui D,. A critical review on nanotube and nanotube/nanoclay related polymer composite materials. Compos Part B Eng 2006; 37: 425-436. (Pubitemid 43776119)
60. Ramakrishna S, Mayer J, Wintermantel E, Leong KW,. Biomedical applications of polymer-composite materials: a review. Compos Sci Technol 2001; 61: 1189-1224. (Pubitemid 32657276)
61. Shi F,. Miscibility and rheology of in-situ composite materials of thermoplastics with thermotropic liquid crystalline polymers II. Int J Polym Mater 1995; 28: 1-10.
62. Dellinger JG, Wojtowicz AM, Jamison RD,. Effects of degradation and porosity on the load bearing properties of model hydroxyapatite bone scaffolds. J Biomed Mater Res A 2006; 77: 563-571. (Pubitemid 47233581)
63. Alves CM, Yang Y, Carnes DL, Ong JL, Sylvia VL, Dean DD, Agrawal CM, Reis RL,. Modulating bone cells response onto starch-based biomaterials by surface plasma treatment and protein adsorption. Biomaterials 2007; 28: 307-315. (Pubitemid 44559690)