Intersections between pulmonary development and disease

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 4, 2011, Pages 401-406

  Whitsett, Jeffrey A ^a   Haitchi, Hans Michael ^a,b,c   Maeda, Yutaka ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Lung; Morphogenesis; Respiratory; Transcription

Indexed keywords

FIBROBLAST GROWTH FACTOR; HEPATOCYTE NUCLEAR FACTOR 3BETA; NOTCH RECEPTOR; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR SOX2;

ASTHMA; CELL DIFFERENTIATION; CELL GROWTH; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; EMBRYONIC STEM CELL; FIBROSING ALVEOLITIS; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; LUNG DISEASE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CHRONIC DISEASE; DNA-BINDING PROTEINS; EMBRYONIC DEVELOPMENT; EMBRYONIC STEM CELLS; FETAL DEVELOPMENT; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HUMANS; INFLAMMATION; LUNG; LUNG DISEASES; METAPLASIA; MORPHOGENESIS; PLURIPOTENT STEM CELLS; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTORS, NOTCH; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; TISSUE CULTURE TECHNIQUES; TRANSCRIPTION, GENETIC; WOUND HEALING;

EID: 80051817023     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201103-0495PP     Document Type: Review

References (47)

1. Warburton D., Tefft D., Mailleux A., Bellusci S., Thiery J.P., Zhao J., Buckley S., Shi W., Driscoll B. Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny? Am J Respir Crit Care Med 2001;164:S59-S62.
2. Shi W., Bellusci S., Warburton D. Lung development and adult lung diseases. Chest 2007;132:651-666.
3. Evans M.J., Van Winkle L.S., Fanucchi M.V., Plopper C.G. The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit. Am J Respir Cell Mol Biol 1999;21:655-657. (Pubitemid 129502283)
4. Holgate S.T., Davies D.E., Lackie P.M., Wilson S.J., Puddicombe S.M., Lordan J.L. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000;105:193-204. (Pubitemid 30109029)
5. Sorokin SP The Cells of the Lungs In: Nettesheim P, Hanna MG Jr, Deatherage JW Jr, editors. Morphology of Experimental Respiratory Carcinogenesis. Pages 3 through 43 with 30 electron micrographs. Proceedings of a Biology Division, Oak Ridge National Laboratory conference May 13-16, 1970, Gatlinburg, TN. pp. 3-43.
6. Zorn A.M., Wells J.M. Vertebrate endoderm development and organ formation. Annu Rev Cell Dev Biol 2009;25:221-251.
7. Serls A.E., Doherty S., Parvatiyar P., Wells J.M., Deutsch G.H. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 2005;132:35-47. (Pubitemid 40207965)
8. Cardoso W.V., Lü J. Regulation of early lung morphogenesis: Questions, facts and controversies. Development 2006;133:1611-1624. (Pubitemid 43810969)
9. Perl A.K., Wert S.E., Nagy A., Lobe C.G., Whitsett J.A. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci USA 2002;99:10482-10487.
10. Maeda Y., Davé V., Whitsett J.A. Transcriptional control of lung morphogenesis. Physiol Rev 2007;87:219-244. (Pubitemid 46207714)
11. Morrisey E.E., Hogan B.L. Preparing for the first breath: Genetic and cellular mechanisms in lung development. Dev Cell 2010;18:8-23.
12. Warburton D., El-Hashash A., Carraro G., Tiozzo C., Sala F., Rogers O., De Langhe S., Kemp P.J., Riccardi D., Torday J., et al. Lung organogenesis. Curr Top Dev Biol 2010;90:73-158.
13. Bohinski R.J., Di Lauro R., Whitsett J.A. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organspecific gene expression along the foregut axis. Mol Cell Biol 1994;14: 5671-5681.
14. DeFelice M., Silberschmidt D., DiLauro R., Xu Y., Wert S.E., Weaver T.E., Bachurski C.J., Clark J.C., Whitsett J.A. TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem 2003;278:35574-35583. (Pubitemid 37102330)
15. Minoo P., Su G., Drum H., Bringas P., Kimura S. Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol 1999;209:60-71. (Pubitemid 29194313)
16. Kimura S., Hara Y., Pineau T., Fernandez-Salguero P., Fox C.H., Ward J.M., Gonzalez F.J. The T/ebp null mouse: Thyroid-specific enhancerbinding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 1996;10:60-69. (Pubitemid 26025299)
17. Galambos C., Levy H., Cannon C.L., Vargas S.O., Reid L.M., Cleveland R., Lindeman R., DeMello D.E., Wert S.E., Whitsett J.A., et al. Pulmonary pathology in thyroid transcription factor-1 deficiency syndrome. Am J Respir Crit Care Med 2010;182:549-554.
18. Carré A., Szinnai G., Castanet M., Sura-Trueba S., Tron E, Broutin- L'Hermite I, Barat P, Goizet C, Lacombe D, Moutard ML, et al Five new TTF1/NKX2.1 mutations in brain-lung-thyroid syndrome: Rescue by PAX8 synergism in one case. Hum Mol Genet 2009;18:2266-2276.
19. Shi W., Chen F., Cardoso W.V. Mechanisms of lung development: Contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009;6:558-563.
20. Que J., Luo X., Schwartz R.J., Hogan B.L. Multiple roles for Sox2 in the developing and adult mouse trachea. Development 2009;136:1899-1907.
21. Tompkins D.H., Besnard V., Lange A.W., Wert S.E., Keiser A.R., Smith A.N., Lang R., Whitsett J.A. Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS ONE 2009;4:e8248.
22. Guseh J.S., Bores S.A., Stanger B.Z., Zhou Q., Anderson W.J., Melton D.A., Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 2009;136:1751-1759.
23. Tsao P.N., Vasconcelos M., Izvolsky K.I., Qian J., Lu J., Cardoso W.V. Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development 2009;136:2297-2307.
24. Morimoto M., Liu Z., Cheng H.T., Winters N., Bader D., Kopan R. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci 2010;123:213-224.
25. Rock J.R., Randell S.H., Hogan B.L. Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling. Dis Model Mech 2010;3:545-556.
26. Lu Y., Futtner C., Rock J.R., Xu X., Whitworth W., Hogan B.L., Onaitis M.W. Evidence that SOX2 overexpression is oncogenic in the lung. PLoS ONE 2010;5:e11022.
27. Tompkins D.H., Besnard V., Lange A.W., Keiser A.R., Wert S.E., Bruno M.D., Whitsett J.A. Sox2 activates cell proliferation and differentiation in the respiratory epithelium. Am J Respir Cell Mol Biol (In press)
28. Chen J., Knowles H.J., Hebert J.L., Hackett B.P. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest 1998; 102:1077-1082. (Pubitemid 28436267)
29. Brody S.L., Yan X.H., Wuerffel M.K., Song S.K., Shapiro S.D. Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am J Respir Cell Mol Biol 2000;23:45-51. (Pubitemid 30597094)
30. Nigg E.A., Raff J.W. Centrioles, centrosomes, and cilia in health and disease. Cell 2009;139:663-678.
31. Roy S. The motile cilium in development and disease: Emerging new insights. Bioessays 2009;31:694-699.
32. Park K.S., Korfhagen T.R., Bruno M.D., Kitzmiller J.A., Wan H., Wert S.E., Khurana Hershey G.K., Chen G., Whitsett J.A. SPDEF regulates goblet cell hyperplasia in the airway epithelium. J Clin Invest 2007; 117:978-988. (Pubitemid 46556754)
33. Chen G., Korfhagen T.R., Xu Y., Kitzmiller J., Wert S.E., Maeda Y., Gregorieff A., Clevers H., Whitsett J.A. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest 2009;119:2914-2924.
34. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676. (Pubitemid 44233629)
35. D'Amour K.A., Agulnick A.D., Eliazer S., Kelly O.G., Kroon E., Baetge E.E. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005;23:1534-1541. (Pubitemid 41752931)
36. Spence J.R., Mayhew C.N., Rankin S.A., Kuhar M.F., Vallance J.E., Tolle K., Hoskins E.E., Kalinichenko V.V., Wells S.I., Zorn A.M., et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 2011;470:105-109.
37. Green M.D., Chen A., Nostro M.C., d'Souza S.L., Schaniel C., Lemischka I.R., Gouon-Evans V., Keller G., Snoeck H.W. Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol 2011;29:267-272.
38. Bass A.J., Watanabe H., Mermel C.H., Yu S., Perner S., Verhaak R.G., Kim S.Y., Wardwell L., Tamayo P., Gat-Viks I., et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009;41:1238-1242.
39. Tanaka H., Yanagisawa K., Shinjo K., Taguchi A., Maeno K., Tomida S., Shimada Y., Osada H., Kosaka T., Matsubara H., et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res 2007;67:6007-6011. (Pubitemid 47037477)
40. Kendall J., Liu Q., Bakleh A., Krasnitz A., Nguyen K.C., Lakshmi B., Gerald W.L., Powers S., Mu D. Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer. Proc Natl Acad Sci USA 2007;104:16663-16668. (Pubitemid 350211073)
41. Weir B.A., Woo M.S., Getz G., Perner S., Ding L., Beroukhim R., Lin W.M., Province M.A., Kraja A., Johnson L.A., et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007;450:893-898. (Pubitemid 350231325)
42. Kwei K.A., Kim Y.H., Girard L., Kao J., Pacyna-Gengelbach M., Salari K., Lee J., Choi Y.L., Sato M., Wang P., et al. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene 2008;27:3635-3640. (Pubitemid 351793793)
43. Harris T., Pan Q., Sironi J., Lutz D., Tian J., Sapkar J., Perez-Soler R., Keller S., Locker J. Both gene amplification and allelic loss occur at 14q13.3 in lung cancer. Clin Cancer Res 2011;17:690-699.
44. Tang X., Kadara H., Behrens C., Liu D., Xiao Y., Rice D.C., Gazdar A.F., Fujimoto J., Moran C., Varella-Garcia M., et al. Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: Implications in lung cancer pathogenesis and prognosis. Clin Cancer Res 2011;17:2434-2443.
45. Plantier L., Crestani B., Wert S.E., Dehoux M., Zweytick B., Guenther A., Whitsett J.A. Ectopic respiratory epithelial cell differentiation in bronchiolized distal airspaces in idiopathic pulmonary fibrosis. Thorax (In press)
46. Chen G., Wan H., Luo F., Zhang L., Xu Y., Lewkowich I., Wills-Karp M., Whitsett J.A. Foxa2 programs Th2-cell mediated innate immunity in the developing lung. J Immunol 2010;184:6133-6141.
47. Park S.W., Verhaeghe C., Nguyenvu L.T., Barbeau R., Eisley C.J., Nakagami Y., Huang X., Woodruff P.G., Fahy J.V., Erle D.J. Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Am J Respir Crit Care Med 2009;180:603-610.