Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro

Biochemical and Biophysical Research Communications

Volumn 412, Issue 1, 2011, Pages 32-38

  Welander, Hedvig ^a   Bontha, Sai Vineela ^a   Näsström, Thomas ^a   Karlsson, Mikael ^b   Nikolajeff, Fredrik ^b   Danzer, Karin ^c,d   Kostka, Marcus ^c   Kalimo, Hannu ^e   Lannfelt, Lars ^a   Ingelsson, Martin ^a   Bergström, Joakim ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Synuclein; Aggregation; Dementia with Lewy bodies; Gelsolin; Lewy body; Parkinson's disease

Indexed keywords

ACTIN BINDING PROTEIN; ALPHA SYNUCLEIN; CALCIUM CHLORIDE; GELSOLIN;

AGED; ARTICLE; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LEWY BODY; MALE; NERVE FIBER; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION;

AGED; ALPHA-SYNUCLEIN; BRAIN; CALCIUM; CELL LINE; GELSOLIN; HUMANS; LEWY BODIES; MALE; PARKINSON DISEASE;

EID: 80051795457     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.07.027     Document Type: Article

References (24)

1. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997, 388:839-840.
2. Wakabayashi K., Yoshimoto M., Tsuji S., Takahashi H. Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neuroscience Letters 1998, 249:180-182.
3. Burré J., Sharma M., Tsetsenis T., Buchman V., Etherton M.R., Südhof T.C. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 2010, 329:1663-1667.
4. Clayton D.F., George J.M. Synucleins in synaptic plasticity and neurodegenerative disorders. Journal of Neuroscience Research 1999, 58:120-129.
5. Pham C.L., Leong S.L., Ali F.E., Kenche V.B., Hill A.F., Gras S.L., Barnham K.J., Cappai R. Dopamine and the dopamine oxidation product 5, 6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner. Journal of Molecular Biology 2009, 387:771-785.
6. Krüger R., Kuhn W., Müller T., Woitalla D., Graeber M., Kösel S., Przuntek H., Epplen J.T., Schöls L., Riess O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nature Genetics 1998, 18:106-108.
7. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di lorio G., Golbe L.I., Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
8. Zarranz J.J., Alegre J., Gómez-Esteban J.C., Lezcano E., Ros R., Ampuero I., Vidal L., Hoenicka J., Rodriguez O., Atarés B., Llorens V., Gomez Tortosa E., del Ser T., Muñoz D.G., de Yebenes J.G. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Annals of Neurology 2004, 55:164-173.
9. Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., Gwinn-Hardy K. Alpha-synuclein locus triplication causes Parkinson's disease. Science 2003, 302:841.
10. Leverenz J.B., Umar I., Wang Q., Montine T.J., McMillan P.J., Tsuang D.W., Jin J., Pan C., Shin J., Zhu D., Zhang J. Proteomic identification of novel proteins in cortical Lewy bodies. Brain Pathology 2007, 17:139-145.
11. Yin H.L. Gelsolin: calcium- and polyphosphoinositide-regulated actin-modulating protein. BioEssays 1987, 7:176-179.
12. Yin H.L., Kwiatkowski D.J., Mole J.E., Cole F.S. Structure and biosynthesis of cytoplasmic and secreted variants of gelsolin. Journal of Biological Chemistry 1984, 259:5271-5276.
13. Ghiso J., Haltia M., Prelli F., Novello J., Frangione B. Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type. Biochemical Journal 1990, 272:827-830.
14. Danzer K.M., Haasen D., Karow A.R., Moussaud S., Habeck M., Giese A., Kretzschmar H., Hengerer B., Kostka M. Different species of alpha-synuclein oligomers induce calcium influx and seeding. Journal of Neuroscience 2007, 27:9220-9232.
15. Encinas M., Iglesias M., Liu Y., Wang H., Muhaisen A., Cenã V., Gallego C., Comella J.X. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. Journal of Neurochemistry 2000, 75:991-1003.
16. Näsström T., Fagerqvist T., Barbu M., Karlsson M., Nikolajeff F., Kasrayan A., Ekberg M., Lannfelt L., Ingelsson M., Bergström J. The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radical Biology and Medicine 2011, 50:428-437.
17. Haltia M., Ghiso J., Wisniewski T., Kiuru S., Miller D., Frangione B. Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies. Neurobiology of Aging 1991, 12:313-316.
18. Hasegawa T., Matsuzaki M., Takeda A., Kikuchi A., Akita H., Perry G., Smith M.A., Itoyama Y. Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells. Brain Research 2004, 1013:51-59.
19. Zhou Y., Gu G., Goodlett D.R., Zhang T., Pan C., Montine T.J., Montine K.S., Aebersold R.H., Zhang J. Analysis of alpha-synuclein-associated proteins by quantitative proteomics. Journal of Biological Chemistry 2004, 279:39155-39164.
20. Alim M.A., Hossain M.S., Arima K., Takeda K., Izumiyama Y., Nakamura M., Kaji H., Shinoda T., Hisanaga S., Uéda K. Tubulin seeds alpha-synuclein formation. Journal of Biological Chemistry 2002, 277:2112-2117.
21. Bellani S., Sousa V.L., Ronzitti G., Valtorta F., Meldolesi J., Chieregatti E. The regulation of synaptic function by alpha-synuclein. Communicative and Integrated Biology 2010, 3:106-109.
22. Chauhan V.P., Ray I., Chauhan A., Wisniewski H.M. Binding of gelsolin, a secretory protein, to amyloid beta-protein. Biochemical and Biophysical Research Communications 1999, 258:241-246.
23. Matsuoka Y., Saito M., LaFrancois J., Saito M., Gaynor K., Olm V., Wang L., Casey E., Lu Y., Shiratori C., Lemere C., Duff K. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with affinity to beta-amyloid. Journal of Neuroscience 2003, 23:29-33.
24. K. Machaca, Ca(2+) signaling, genes and the cell cycle, Cell calcium 48 (2010) 243-250., 2011-05-23. http://blast.ncbi.nlm.nih.gov/BlastAlign.cgi.