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1
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77955267578
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Dorsal vagal preganglionic neurons: Differential responses to CCK1 and 5-HT3 receptor stimulation
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This study demonstrates that CCK-8 has differential effects on preganglionic neurons in the DMV, based on spatial location
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Mussa BM, Sartor DM, Verberne AJM. Dorsal vagal preganglionic neurons: Differential responses to CCK1 and 5-HT3 receptor stimulation. Auton Neurosci 2010; 156:36-43. This study demonstrates that CCK-8 has differential effects on preganglionic neurons in the DMV, based on spatial location.
-
(2011)
Auton Neurosci
, vol.156
, pp. 36-43
-
-
Mussa, B.M.1
Sartor, D.M.2
Verberne, A.J.M.3
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2
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78049300013
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Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion
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This study shows that pancreatic stellate cells can be stimulated by CCK to secrete acetylcholine, which then acts on acinar cells to release enzymes
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Phillips PA, Yang L, Shulkes A, et al. Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion. Proc Natl Acad Sci USA 2010; 107:17397-17402. This study shows that pancreatic stellate cells can be stimulated by CCK to secrete acetylcholine, which then acts on acinar cells to release enzymes.
-
(2011)
Proc Natl Acad Sci USA
, vol.107
, pp. 17397-17402
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Phillips, P.A.1
Yang, L.2
Shulkes, A.3
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3
-
-
4444354589
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New insights into neurohormonal regulation of pancreatic secretion
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Owyang C, Logsdon CD. New insights into neurohormonal regulation of pancreatic secretion. Gastroenterology 2004; 127:957-969.
-
(2004)
Gastroenterology
, vol.127
, pp. 957-969
-
-
Owyang, C.1
Logsdon, C.D.2
-
4
-
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48549100809
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Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
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Murphy JA, Criddle DN, Sherwood M, et al. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 2008; 135:632-641.
-
(2008)
Gastroenterology
, vol.135
, pp. 632-641
-
-
Murphy, J.A.1
Criddle, D.N.2
Sherwood, M.3
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5
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72749090107
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Cholecystokinin-58 and cholecystokinin- 8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells
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Criddle DN, Booth DM, Mukherjee R, et al. Cholecystokinin-58 and cholecystokinin- 8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 2009; 297:G1085-G1092.
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.297
-
-
Criddle, D.N.1
Booth, D.M.2
Mukherjee, R.3
-
6
-
-
0032944874
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Calcium signaling in rat pancreatic acinar cells: A role for Gaq, Ga11, and Ga14
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Yule DI, Baker CW, Williams JA. Calcium signaling in rat pancreatic acinar cells: A role for Gaq, Ga11, and Ga14. Am J Physiol Gastrointest Liver Physiol 1999; 276:G271-G279.
-
(1999)
Am J Physiol Gastrointest Liver Physiol
, vol.276
-
-
Yule, D.I.1
Baker, C.W.2
Williams, J.A.3
-
7
-
-
60149088035
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Functions and regulatory mechanisms of Gq-signaling pathways
-
Mizuno N, Itoh H. Functions and regulatory mechanisms of Gq-signaling pathways. Neurosignals 2009; 17:42-54.
-
(2009)
Neurosignals
, vol.17
, pp. 42-54
-
-
Mizuno, N.1
Itoh, H.2
-
9
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77749279684
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CCK activates RhoA and Rac1 differentially through Ga13 and Gaq in mouse pancreatic acini
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This study identifies the G proteins that are involved in CCK-mediated pancreatic secretion
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Sabbatini ME, Bi Y, Ji B, et al. CCK activates RhoA and Rac1 differentially through Ga13 and Gaq in mouse pancreatic acini. Am J Physiol Cell Physiol 2010; 298:C592-C601. This study identifies the G proteins that are involved in CCK-mediated pancreatic secretion.
-
(2011)
Am J Physiol Cell Physiol
, vol.298
-
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Sabbatini, M.E.1
Bi, Y.2
Ji, B.3
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10
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1842611506
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Ethanol modifies the actin cytoskeleton in rat pancreatic acinar cells - comparison with effects of CCK
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Siegmund E, Luthen F, Kunert J, et al. Ethanol modifies the actin cytoskeleton in rat pancreatic acinar cells - comparison with effects of CCK. Pancreatology 2004; 4:12-21.
-
(2004)
Pancreatology
, vol.4
, pp. 12-21
-
-
Siegmund, E.1
Luthen, F.2
Kunert, J.3
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11
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79951951300
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Ethanol impairs the assembly and disassembly of actin cytoskeleton and cell adhesion via the RhoA signaling pathway, catenin p120 and E-cadherin in CCK-stimulated pancreatic acini
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This article demonstrates that ethanol can impair the structural protein machinery involved in CCK-induced pancreatic secretion
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Iwata T, Nozu F, Imawari M. Ethanol impairs the assembly and disassembly of actin cytoskeleton and cell adhesion via the RhoA signaling pathway, catenin p120 and E-cadherin in CCK-stimulated pancreatic acini. Biochem Biophys Res Commun 2011; 405:558-563. This article demonstrates that ethanol can impair the structural protein machinery involved in CCK-induced pancreatic secretion.
-
(2011)
Biochem Biophys Res Commun
, vol.405
, pp. 558-563
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Iwata, T.1
Nozu, F.2
Imawari, M.3
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12
-
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0034618050
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P120 Catenin regulates the actin cytoskeleton via rho family GTPases
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Noren NK, Liu BP, Burridge K, et al. p120 Catenin regulates the actin cytoskeleton via rho family GTPases. J Cell Biol 2000; 150:567-579.
-
(2000)
J Cell Biol
, vol.150
, pp. 567-579
-
-
Noren, N.K.1
Liu, B.P.2
Burridge, K.3
-
13
-
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4644292587
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Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells
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Li C, Chen X, Williams JA. Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 2004; 287:G764-G771.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
-
-
Li, C.1
Chen, X.2
Williams, J.A.3
-
14
-
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70350630307
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Protein kinase C delta (Pkcd)- mediated processes in cholecystokinin-8- stimulated pancreatic acini
-
Thrower EC, Wang J, Cheriyan S, et al. Protein kinase C delta (Pkcd)- mediated processes in cholecystokinin-8-stimulated pancreatic acini. Pancreas 2009; 38:930-935.
-
(2009)
Pancreas
, vol.38
, pp. 930-935
-
-
Thrower, E.C.1
Wang, J.2
Cheriyan, S.3
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15
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77954896463
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Cholecystokinin is up-regulated in obese mouse islets and expands b-cell mass by increasing b-cell survival
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The authors provide evidence that in addition to inducing pancreatic secretions, CCK can also play a protective role in pancreatic islets under conditions of stress
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Lavine JA, Raess PW, Stapleton DS, et al. Cholecystokinin is up-regulated in obese mouse islets and expands b-cell mass by increasing b-cell survival. Endocrinology 2010; 151:3577-3588. The authors provide evidence that in addition to inducing pancreatic secretions, CCK can also play a protective role in pancreatic islets under conditions of stress.
-
(2011)
Endocrinology
, vol.151
, pp. 3577-3588
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Lavine, J.A.1
Raess, P.W.2
Stapleton, D.S.3
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16
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77957374080
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Unraveling the role of the ghrelin gene peptides in the endocrine pancreas
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This review provides detailed information on the action of ghrelin peptides on the pancreas
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Granata R, Baragli A, Settanni F, et al. Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 2010; 45:107-118. This review provides detailed information on the action of ghrelin peptides on the pancreas.
-
(2011)
J Mol Endocrinol
, vol.45
, pp. 107-118
-
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Granata, R.1
Baragli, A.2
Settanni, F.3
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17
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77956357163
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Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
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This article provides evidence in support of the inhibitory effect of ghrelin on pancreatic secretion in humans
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Tong J, Prigeon RL, Davis HW, et al. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 2010; 59:2145-2151. This article provides evidence in support of the inhibitory effect of ghrelin on pancreatic secretion in humans.
-
(2011)
Diabetes
, vol.59
, pp. 2145-2151
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Tong, J.1
Prigeon, R.L.2
Davis, H.W.3
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18
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77951298589
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Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in b cells
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This article shows that the AMPK-UCP2 pathway is important in the reduction of insulin secretion in murine cultured cells (MIN6). This pathway also plays a role in ghrelin action on NPY/AgRP neurons
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Wang Y, Nishi M, Doi A, et al. Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in b cells. FEBS Lett 2010; 584:1503-1508. This article shows that the AMPK-UCP2 pathway is important in the reduction of insulin secretion in murine cultured cells (MIN6). This pathway also plays a role in ghrelin action on NPY/AgRP neurons.
-
(2011)
FEBS Lett
, vol.584
, pp. 1503-1508
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Wang, Y.1
Nishi, M.2
Doi, A.3
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19
-
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49649122302
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UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
-
Andrews ZB, Liu Z-W, Walllingford N, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008; 454:846-851.
-
(2008)
Nature
, vol.454
, pp. 846-851
-
-
Andrews, Z.B.1
Liu, Z-.W.2
Walllingford, N.3
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20
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79952278066
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Ghrelin but not obestatin regulates insulin secretion from INS1 beta cell line via UCP2- dependent mechanism
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This article illustrates that in a rat pancreatic cell line, ghrelin stimulates insulin release via UCP2
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Chmielewska J, Szczepankiewicz D, Skrzypski M, et al. Ghrelin but not obestatin regulates insulin secretion from INS1 beta cell line via UCP2- dependent mechanism. J Biol Regul Homeost Agents 2010; 24:397-402. This article illustrates that in a rat pancreatic cell line, ghrelin stimulates insulin release via UCP2.
-
(2011)
J Biol Regul Homeost Agents
, vol.24
, pp. 397-402
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Chmielewska, J.1
Szczepankiewicz, D.2
Skrzypski, M.3
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21
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77955842961
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Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets
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This article shows that circulating desacyl ghrelin may inhibit acyl ghrelin activity, confounding the results obtained from in-vivo secretory analysis
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Kumar R, Salehi A, Rehfeld JF, et al. Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin. A study of pancreatic polypeptide secretion from mouse islets. Regul Pept 2010; 164:65-70. This article shows that circulating desacyl ghrelin may inhibit acyl ghrelin activity, confounding the results obtained from in-vivo secretory analysis.
-
(2011)
Regul Pept
, vol.164
, pp. 65-70
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Kumar, R.1
Salehi, A.2
Rehfeld, J.F.3
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22
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70350435713
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An osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion
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Hinoi E, Gao N, Jung DY, et al. An osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci 2009; 1173:E20-E30.
-
(2009)
Ann N Y Acad Sci
, vol.1173
-
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Hinoi, E.1
Gao, N.2
Jung, D.Y.3
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23
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77953028265
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Central infusion of leptin improves insulin resistance and suppresses b-cell function, but not b-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model
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This article supports previous studies that leptin modulates b cells through the sympathetic system
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Park S, Ahn IS, Kim DS. Central infusion of leptin improves insulin resistance and suppresses b-cell function, but not b-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model. Life Sci 2010; 86:854-862. This article supports previous studies that leptin modulates b cells through the sympathetic system.
-
(2011)
Life Sci
, vol.86
, pp. 854-862
-
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Park, S.1
Ahn, I.S.2
Kim, D.S.3
-
24
-
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72249092928
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Recent advances in understanding leptin signaling and leptin resistance
-
Morris DL, Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 2009; 297:E1247-E1259.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Morris, D.L.1
Rui, L.2
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25
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75949102364
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Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor
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This article illustrates the significance of melanocortin signaling pathway in insulin secretion
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Mansour M, White D, Wernette C, et al. Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor. Endocrine 2010; 37:220-230. This article illustrates the significance of melanocortin signaling pathway in insulin secretion.
-
(2011)
Endocrine
, vol.37
, pp. 220-230
-
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Mansour, M.1
White, D.2
Wernette, C.3
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26
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77954918646
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The atrial natriuretic peptide and guanylyl cyclase-A system modulates pancreatic b-cell function
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The role of guanylyl cyclase-A and cGMP signaling in ANF-mediated insulin secretion is demonstrated
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Ropero AB, Soriano S, Tuduri E, et al. The atrial natriuretic peptide and guanylyl cyclase-A system modulates pancreatic b-cell function. Endocrinology 2010; 151:3665-3674. The role of guanylyl cyclase-A and cGMP signaling in ANF-mediated insulin secretion is demonstrated.
-
(2011)
Endocrinology
, vol.151
, pp. 3665-3674
-
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Ropero, A.B.1
Soriano, S.2
Tuduri, E.3
-
27
-
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73249132245
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Natriuretic peptides: New players in energy homeostasis
-
Moro C, Smith SR. Natriuretic peptides: New players in energy homeostasis. Diabetes 2009; 58:2726-2728.
-
(2009)
Diabetes
, vol.58
, pp. 2726-2728
-
-
Moro, C.1
Smith, S.R.2
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28
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85027921683
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Mechanism of orexin B-stimulated insulin and glucagon release from the pancreas of normal and diabetic rats
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This article shows that b-adrenergic receptors play a role in orexin-B-mediated insulin secretion
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Adeghate E, Hameed R. Mechanism of orexin B-stimulated insulin and glucagon release from the pancreas of normal and diabetic rats. Pancreas 2011; 40:131-136. This article shows that b-adrenergic receptors play a role in orexin-B-mediated insulin secretion.
-
(2011)
Pancreas
, vol.40
, pp. 131-136
-
-
Adeghate, E.1
Hameed, R.2
-
29
-
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79953833843
-
Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion
-
MacDonald PE, Rorsman P. Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion. Diabetologia 2011; 54:719-721.
-
(2011)
Diabetologia
, vol.54
, pp. 719-721
-
-
MacDonald, P.E.1
Rorsman, P.2
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30
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79953823344
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Per-arnt-sim (PAS) domaincontaining protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion
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This article shows that PASK plays an important role in glucose-mediated insulin secretion
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Da Silva Xavier G, Farhan H, Kim H, et al. Per-arnt-sim (PAS) domaincontaining protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia 2011; 54:819-827. This article shows that PASK plays an important role in glucose-mediated insulin secretion.
-
(2011)
Diabetologia
, vol.54
, pp. 819-827
-
-
Da Silva Xavier, G.1
Farhan, H.2
Kim, H.3
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31
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77952003470
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Glucose suppression of glucagon secretion. Metabolic and calcium responses from a-cells in intact mouse pancreatic islets
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This work demonstrates that isolated a cells respond differently to glucose than intact islets, suggesting that cellular associations or paracrine effects may play a role in glucose-mediated glucagon secretion
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Le Marchand SJ, Piston DW. Glucose suppression of glucagon secretion. Metabolic and calcium responses from a-cells in intact mouse pancreatic islets. J Biol Chem 2010; 285:14389-14398. This work demonstrates that isolated a cells respond differently to glucose than intact islets, suggesting that cellular associations or paracrine effects may play a role in glucose-mediated glucagon secretion.
-
(2011)
J Biol Chem
, vol.285
, pp. 14389-14398
-
-
Le Marchand, S.J.1
Piston, D.W.2
-
32
-
-
77955557822
-
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice
-
Amisten S, Meidute-Abaraviciene S, Tan C, et al. ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice. Diabetologia 2010; 53:1927-1934.
-
(2010)
Diabetologia
, vol.53
, pp. 1927-1934
-
-
Amisten, S.1
Meidute-Abaraviciene, S.2
Tan, C.3
-
33
-
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77956184011
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Neurotensin is a regulator of insulin secretion in pancreatic beta-cells
-
Béraud-Dufour S, Abderrahmani A, Noel J, et al. Neurotensin is a regulator of insulin secretion in pancreatic beta-cells. Int J Biochem Cell Biol 2010; 42:1681-1688.
-
(2011)
Int J Biochem Cell Biol
, vol.42
, pp. 1681-1688
-
-
Béraud-Dufour, S.1
Abderrahmani, A.2
Noel, J.3
-
34
-
-
77954252193
-
G-Aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic b-cells
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Braun M, Ramracheya R, Bengtsson M, et al. g-Aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic b-cells. Diabetes 2010; 59:1694-1701.
-
(2011)
Diabetes
, vol.59
, pp. 1694-1701
-
-
Braun, M.1
Ramracheya, R.2
Bengtsson, M.3
-
35
-
-
78650983010
-
GPR39: A Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions
-
Popovics P, Stewart AJ. GPR39: A Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions. Cell Mol Life Sci 2011; 68:85-95.
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 85-95
-
-
Popovics, P.1
Stewart, A.J.2
-
36
-
-
78650414275
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Emerging roles for b-arrestin-1 in the control of the pancreatic b-cell function and mass: New therapeutic strategies and consequences for drug screening
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Dalle S, Ravier MA, Bertrand G. Emerging roles for b-arrestin-1 in the control of the pancreatic b-cell function and mass: New therapeutic strategies and consequences for drug screening. Cell Signal 2011; 23:522-528.
-
(2011)
Cell Signal
, vol.23
, pp. 522-528
-
-
Dalle, S.1
Ravier, M.A.2
Bertrand, G.3
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