Pancreatic neuronal melanocortin-4 receptor modulates serum insulin levels independent of leptin receptor

Endocrine

Volumn 37, Issue 1, 2010, Pages 220-230

  Mansour, Mahmoud ^a   White, Doug ^b   Wernette, Catherine ^b   Dennis, John ^a   Tao, Ya Xiong ^a   Collins, Robert ^a   Parker, Lauren ^a   Morrison, Edward ^a  

^a AUBURN UNIVERSITY   (United States)

^b AUBURN UNIVERSITY   (United States)

Author keywords

Mc4r; NDP MSH; Pancreas; Proopiomelanocortin; Zucker diabetic fatty (ZDF) rats; MSH

Indexed keywords

ALPHA INTERMEDIN; ALPHA INTERMEDIN DERIVATIVE; BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; INSULIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; PROTEIN C FOS;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; ZUCKER DIABETIC FATTY RAT;

EID: 75949102364     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-009-9289-5     Document Type: Article

References (35)

1. RD Cone 2006 Studies on the physiological functions of the melanocortin system Endocr. Rev. 27 736 749 1:CAS:528:DC%2BD2sXns1WrtQ%3D%3D 17077189
2. GJ Morton DE Cummings DG Baskin GS Barsh MW Schwartz 2006 Central nervous system control of food intake and body weight Nature 443 289 295 10.1038/nature05026 1:CAS:528:DC%2BD28Xpslalu7c%3D 16988703 (Pubitemid 44435142)
3. S Stanley K Wynne B McGowan S Bloom 2005 Hormonal regulation of food intake Physiol. Rev. 85 1131 1158 10.1152/physrev.00015.2004 1:CAS:528:DC%2BD2MXhtFeqsr3O 16183909 (Pubitemid 41363743)
4. YX Tao 2006 Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications Pharmacol. Ther. 111 949 973 10.1016/j.pharmthera.2006.02.008 1:CAS:528: DC%2BD28Xns1SksLg%3D 16616374 (Pubitemid 44137384)
5. W Fan A Voss-Andreae WH Cao SF Morrison 2005 Regulation of thermogenesis by the central melanocortin system Peptides 26 1800 1813 10.1016/j.peptides. 2004.11.033 1:CAS:528:DC%2BD2MXhtVarsL3O 15979759 (Pubitemid 41354538)
6. JM Friedman 2004 Modern science versus the stigma of obesity Nat. Med. 10 563 569 10.1038/nm0604-563 1:CAS:528:DC%2BD2cXksVaju78%3D 15170194 (Pubitemid 38796839)
7. BA Boston KM Blaydon J Varnerin RD Cone 1997 Independent and additive effects of central POMC and leptin pathways on murine obesity Science 278 1641 1644 10.1126/science.278.5343.1641 1:CAS:528:DyaK2sXnslCgt7w%3D 9374468 (Pubitemid 27516287)
8. H Shimizu K Inoue M Mori 2007 The leptin-dependent and independent melanocortin signaling system: regulation of feeding and energy expenditure J. Endocrinol. 193 1 9 10.1677/JOE-06-0144 1:CAS:528:DC%2BD2sXlsFSju7Y%3D 17400797 (Pubitemid 46638526)
9. K Wynne S Stanley B McGowan S Bloom 2005 Appetite control J. Endocrinol. 184 291 318 10.1677/joe.1.05866 1:CAS:528:DC%2BD2MXhvVeitbk%3D 15684339 (Pubitemid 40347231)
10. W Fan DM Dinulescu AA Butler J Zhou DL Marks RD Cone 2000 The central melanocortin system can directly regulate serum insulin levels Endocrinology 141 3072 3079 10.1210/en.141.9.3072 1:CAS:528:DC%2BD3cXmtVers78%3D 10965876 (Pubitemid 32268993)
11. S Obici Z Feng J Tan L Liu G Karkanias L Rossetti 2001 Central melanocortin receptors regulate insulin action J. Clin. Invest. 108 1079 1085 1:CAS:528:DC%2BD3MXnt1Crs78%3D 11581309
12. DD Pierroz M Ziotopoulou L Ungsunan S Moschos JS Flier CS Mantzoros 2002 Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity Diabetes 51 1337 1345 10.2337/diabetes.51.5.1337 1:CAS:528:DC%2BD38XjtlGmtrY%3D 11978628
13. E Savontaus TL Breen A Kim LM Yang SC Chua Jr SL Wardlaw 2004 Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice Endocrinology 145 3881 3891 10.1210/en.2004-0263 1:CAS:528: DC%2BD2cXmtlCqsb0%3D 15117873 (Pubitemid 39037577)
14. K Tsou H Khachaturian H Akil SJ Watson 1986 Immunocytochemical localization of pro-opiomelanocortin-derived peptides in the adult rat spinal cord Brain Res. 378 28 35 10.1016/0006-8993(86)90283-0 1:CAS:528: DyaL28XltVyqtbw%3D 3017502 (Pubitemid 16055798)
15. T Kishi CJ Aschkenasi CE Lee KG Mountjoy CB Saper JK Elmquist 2003 Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat J. Comp. Neurol. 457 213 235 10.1002/cne.10454 1:CAS:528: DC%2BD3sXhs12jtro%3D 12541307 (Pubitemid 36158283)
16. LHT Van der Ploeg WJ Martin AD Howard RP Nargund CP Austin X Guan J Drisko D Cashen I Sebhat AA Patchett DJ Figueroa AG DiLella BM Connolly DH Weinberg CP Tan OC Palyha SS Pong T MacNeil C Rosenblum A Vongs R Tang H Yu AW Sailer TM Fong C Huang MR Tota RS Chang R Stearns C Tamvakopoulos G Christ DL Drazen BD Spar RJ Nelson DE MacIntyre 2002 A role for the melanocortin 4 receptor in sexual function PNAS 99 11381 11386 10.1073/pnas.172378699 (Pubitemid 34920934)
17. B Ahren 2000 Autonomic regulation of islet hormone secretion-implications for health and disease Diabetologia 43 393 410 10.1007/s001250051322 1:CAS:528:DC%2BD3cXit12hsLk%3D 10819232
18. AC Gyte LE Pritchard JC Brennand A White 2005 Hypothalamic expression of the glucose sensing KATP channel component Kir 6.2 is altered in animal models of obesity and diabetes Endocr. Abstr. 9 16
19. MM Ollmann BD Wilson YK Yang JA Kerns Y Chen I Gantz GS Barsh 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein Science 278 135 138 10.1126/science.278.5335.135 1:CAS:528:DyaK2sXmsV2ltrw%3D 9311920 (Pubitemid 27446294)
20. BD Wilson D Bagnol CB Kaelin MM Ollmann I Gantz SJ Watson GS Barsh 1999 Physiological and anatomical circuitry between agouti-related protein and leptin signaling Endocrinology 140 2387 2397 10.1210/en.140.5.2387 1:CAS:528:DyaK1MXislSntbw%3D 10218993
21. TM Fong 1997 ART (protein product of agouti-related transcript) as analogist of MC-3 and MC-4 receptors Biochem Bioph Res Commun 237 629 631 10.1006/bbrc.1997.7200 1:CAS:528:DyaK2sXmtV2gsbw%3D (Pubitemid 27434737)
22. JE McMinn CW Wilkinson PJ Havel SC Woods MW Schwartz 2000 Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 R695 R703 1:STN:280:DC%2BD3cvhtFCjug%3D%3D 10938261
23. T Adage AJ Scheurink SF de Boer K de Vries JP Konsman F Kuipers RH Adan DG Baskin MW Schwartz G van Dijk 2001 Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats J. Neurosci. 21 3639 3645 1:CAS:528:DC%2BD3MXjs1antbw%3D 11331393
24. D Huszar CA Lynch V Fairchild-Huntress JH Dunmore Q Fang LR Berkemeier W Gu RA Kesterson BA Boston RD Cone FJ Smith LA Campfield P Burn F Lee 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 88 131 141 10.1016/S0092-8674(00)81865-6 1:CAS:528:DyaK2sXltF2nsg%3D%3D 9019399
25. KG Mountjoy MT Mortrud MJ Low RB Simerly RD Cone 1994 Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain Mol. Endocrinol. 8 1298 1308 10.1210/me.8.10.1298 1:CAS:528:DyaK2cXmvFeiurY%3D 7854347 (Pubitemid 24335073)
26. M van der Kraan RAH Adan ML Entwistle WH Gispen JPH Burbach JB Tatro 1998 Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands Endocrinology 139 2348 2355 10.1210/en.139.5.2348 9564844
27. M Ceol M Forino G Gambaro U Sauer ED Schleicher A D'Angelo F Anglani 2001 Quantitation of TGF-b1 mRNA in porcine mesangial cells by comparative kinetic RT/PCR: comparison with ribonuclease protection assay and in Situ hybridization J. Clin. Lab. Anal. 15 215 222 10.1002/jcla.1030 1:CAS:528:DC%2BD3MXlslaqtL0%3D 11436205 (Pubitemid 32642743)
28. JB Tatro S Reichlin 1987 Specific receptors for alpha-melanocyte- stimulating hormone are widely distributed in tissues of rodents Endocrinology 121 1900 1907 10.1210/endo-121-5-1900 1:CAS:528:DyaL2sXmt12lsL8%3D 2822378
29. MD Hirsch TL O'Donohue 1985 Characterization of alpha-melanocyte- stimulating hormone in rat pancreas Peptides 6 293 296 10.1016/0196-9781(85) 90054-3 1:CAS:528:DyaL2MXltFKmu74%3D 4034414 (Pubitemid 15051832)
30. ZA Abdel-Malek 2001 Melanocortin receptors: their functions and regulation by physiological agonists and antagonists Cell. Mol. Life Sci. 58 434 441 10.1007/PL00000868 1:CAS:528:DC%2BD3MXjtVahtL0%3D 11315190
31. EJ Jung DJ Han SH Chang DG Lim YM Wee JH Kim YH Kim SK Koo M Choi SC Kim 2007 Protective effect of alpha-melanocyte-stimulating hormone on pancreas islet cell against peripheral blood mononuclear cell-mediated cytotoxicity in vitro Transpl. Proc. 39 1604 1606 10.1016/j.transproceed.2006.11.011 1:CAS:528:DC%2BD2sXmsFygurg%3D (Pubitemid 46907872)
32. CY Lin DA Higginbotham RL Judd BD White 2002 Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats Am. J. Physiol. 282 E1084 E1091 1:CAS:528:DC%2BD38XjslWksr4%3D
33. MM Mansour HO Goyal TD Braden JC Dennis DD Schwartz RL Judd FF Bartol ES Coleman EE Morrison 2008 Activation of penile proadipogenic peroxisome proliferator-activated receptor γ with an estrogen: interaction with estrogen receptor alpha during postnatal development PPAR Res 2008 10
34. JS Yuan A Reed F Chen CN Stewart Jr 2006 Statistical analysis of real-time PCR data BMC Bioinformatics 7 1 12 10.1186/1471-2105-7-85 (Pubitemid 43362095)
35. WJ Fu J Hu T Spencer R Carroll G Wu 2006 Statistical models in assessing fold change of gene expression in real-time RT-PCR experiments Comp Biol Chem 30 21 26 10.1016/j.compbiolchem.2005.10.005 1:CAS:528:DC%2BD28XoslOjsA%3D%3D (Pubitemid 43144428)