Startle reflex abnormalities in women with sexual assault-related posttraumatic stress disorder

American Journal of Psychiatry

Volumn 154, Issue 8, 1997, Pages 1076-1080

  Morgan III, Charles A ^a   Grillon, Christian ^b   Lubin, Hadar ^b   Southwick, Steven M ^b  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUDITORY STIMULATION; CLINICAL ARTICLE; EYELID REFLEX; FEMALE; HEMISPHERIC DOMINANCE; HUMAN; POSTTRAUMATIC STRESS DISORDER; PREVALENCE; PRIORITY JOURNAL; RAPE; SEXUAL ABUSE; STARTLE REFLEX; STIMULUS RESPONSE;

EID: 0030853909     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.154.8.1076     Document Type: Article

References (45)

1. Beebe DK, Gulledge KM, Cristy M, Replegle W: Prevalence of sexual assault among women patients seen in family practice clinics. Fam Pract Res J 1994; 14:223-228
2. Davis GC, Breslau N: PTSD in victims of civilian trauma and criminal violence. Psychiatr Clin North Am 1994; 17:289-299
3. Kilpatrick DG, Saunders BE, Amicle-McMullan A, Best CL: Victim and crime factors associated with the development of crime-related PTSD. Behavior Therapy 1989; 20:199-214
4. Koss MP, Koss P, Woodruff WJ: Deleterious effects of criminal victimization on women's health and medical utilization. Arch Intern Med 1991; 151:342-357
5. Schwartz IL: Sexual violence against women: prevalence, consequences, social factors and prevention. Am J Prev Med 1991; 7:363-373
6. Norris FN: The epidemiology of trauma: frequency and impact of different potentially traumatic events on different demographic groups. J Consult Clin Psychol 1992; 60:409-418
7. Rothbaum BO, Foa EB, Riggs DS, Murdock T: A prospective examination of post-traumatic stress disorder in rape victims. J Trauma Stress 1992; 5:455-475
8. Davis M: The mammalian startle response, in Neural Mechanisms of Startle Behavior. Edited by Eaton RC. New York, Plenum, 1984, pp 287-351
9. Davis M: Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm. Behav Neurosci 1986; 100:814-824
10. Davis M: Animal models of anxiety based on classical conditioning: the conditioned emotional response (CER) and the fear-potentiated startle effect. Pharmacol Ther 1990; 47:147-165
11. Shalev AY, Orr SP, Peri T, Schreiber S, Pitman RK: Physiologic response to loud tones in Israeli patients with posttraumatic stress disorder. Arch Gen Psychiatry 1992; 49:870-875
12. Butler RW, Braff DL, Rausch JL, Jenkins MA, Sprock J, Geyer MA: Physiological evidence of exaggerated startle response in a subgroup of Vietnam veterans with combat-related PTSD. Am J Psychiatry 1990; 147:1308-1312
13. Grillon C, Morgan CA III, Davis M, Charney DS: Baseline startle amplitude and prepulse inhibition in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res 1996; 64:169-178
14. Orr SP, Pitman RK, Shalev AY: Physiologic responses to loud tones in Vietnam veterans with posttraumatic stress disorder. J Abnorm Psychol 1995; 104:75-82
15. Ornitz EM, Pynoos RS: Startle modulation in children with posttraumatic stress disorder. Am J Psychiatry 1989; 146:866-870
16. Morgan CA III, Grillon C, Southwick SM, Davis M, Charney DS: Exaggerated acoustic startle reflex in Gulf War veterans with posttraumatic stress disorder. Am J Psychiatry 1996; 153:64-68
17. Bremner JD, Randall P, Scott TM, Bronen RA, Seibyl JP, Southwick SM, Delaney RC, McCarthy G, Charney DS, Innis RB: MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 1995; 152:973-981
18. Bremner JD, Randall P, Vermetten E, Staib L, Bronen RA, Capelli S, McCarthy G, Innis RB, Charney DS: Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse - a preliminary report. Biol Psychiatry 1997; 41: 23-32
19. Davis M: Sensitization of the acoustic startle reflex by footshock. Behav Neurosci 1989; 103:495-503
20. Servatius RJ, Ottenweller JE, Bergen MT, Soldan S, Natelson BH: Persistent stress-induced sensitization of adrenocortical and startle responses. Physiol Behav 1994; 56:945-954
21. Spitzer RL, Williams JBW: Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1985
22. Keane TM, Caddell JM, Taylor KL: Mississippi Scale for Combat-Related Posttraumatic Stress Disorder: three studies in reliability and validity. J Consult Clin Psychol 1988; 56:85-90
23. Spielberger CD: State-Trait Anxiety Inventory. Palo Alto, Calif, Consulting Psychologists Press, 1983
24. Bradley MM, Cuthbert BN, Lang PJ: Startle and emotion: lateral acoustic probes and the bilateral blink. Psychophysiology 1991; 28:285-295
25. Bradley MM, Cuthbert BN, Lang PJ: Lateralized startle probes in the study of emotion. Psychophysiology 1996; 33:156-161
26. Grillon C, Davis M: Acoustic startle and anticipatory anxiety in humans: effects of monaural right and left ear stimulation. Psychophysiology 1995; 32:155-161
27. Hawk LW, Cook EW: Affective modulation of tactile startle. Psychophysiology 1997; 34:23-31
28. Ross RJ, Ball WA, Cohen ME, Silver SM, Morrison AR, Dinges DF: Habituation of the startle reflex in posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci 1989; 1:305-307
29. Inglis J, Lawson JS: Sex differences in the effects of unilateral brain damage on intelligence. Science 1981; 212:693-695
30. Kelly DD: Sexual differentiation of the nervous system, in Principles of Neural Science, 2nd ed. Edited by Kandel E, Schwartz JH. New York, Elsevier, 1985, pp 771-783
31. Coover GD, Levine S: Auditory startle response of hippocampectomized rats. Physiol Behav 1972; 9:75-78
32. Southwick SM, Morgan CA III, Darnell A, Bremner D, Nicholaou AL, Nagy LM, Charney DS: Trauma-related symptoms in veterans of Operation Desert Storm: a 2-year follow-up. Am J Psychiatry 1995; 152:1150-1155
33. Grinker RR, Spiegel JP: Men Under Stress. Philadelphia, Blakiston, 1945
34. Kardiner A: The Traumatic Neurosis of War. New York, Paul Hoeber, 1941
35. Blanchard EB, Kolb LC, Gerardi RJ, Ryan P, Pallmeyer TP: Cardiac response to relevant stimuli as an adjunctive tool for diagnosis of posttraumatic stress disorder in Vietnam veterans. Behavior Therapy 1986; 17:592-606
36. Pitman RK, Orr SP, Forgue DF, dejong JB, Claiborn JM: Psychophysiologic assessment of posttraumatic stress disorder in Vietnam combat veterans. Arch Gen Psychiatry 1987; 44:940-975
37. Pitman RK, Orr SP, Forgue DF, Altman B, dejong JB: Psychophysiological responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders. J Abnorm Psychol 1990; 99:49-54
38. Kolb LC: A neuropsychological hypothesis explaining posttraumatic stress disorders. Am J Psychiatry 1987; 144:989-995
39. Hitchcock JM, Sananes CB, Davis M: Sensitization of the startle reflex by footshock: blockade by lesions of the central nucleus of the amygdala or its efferent pathway to the brainstem. Behav Neurosci 1989; 103:509-518
40. Sananes CB, Davis M: N-Methyl-D-aspartate lesions of the lateral and basolateral nuclei of the amygdala block fear-potentiated startle and shock sensitization of startle. Behav Neurosci 1992; 106:72-80
41. Fanselow MS: Associative vs topographical accounts of the immediate shock-freezing deficit in rats: implications for the response selection rules governing species-specific defensive reactions. Learning and Motivation 1986; 17:16-39
42. Kiernan M, Cranney J: Immediate-startle stimulus presentation fails to condition freezing responses to contextual cues. Behav Neurol 1992; 106:121-124
43. Kim JJ, Fanselow MS: Modality-specific retrograde amnesia of fear. Science 1992; 256:675-677
44. Phillips RG, LeDoux JE: Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 1992; 106:274-285
45. Goelet P, Kandel ER: Tracking the flow of learned information from membrane receptors to genome. Trends Neurosci 1986; 9:492-499