The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind-Srogl cross-coupling reaction

Tetrahedron

Volumn 67, Issue 38, 2011, Pages 7379-7385

  Břehová, Petra ^a   Česnek, Michal ^a   Dračínský, Martin ^a   Holý, Antonín ^a   Janeba, Zlatko ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Acyclic nucleoside phosphonates; Arylboronic acids; Liebeskind Srogl cross coupling; Microwave; Pyrimidines

Indexed keywords

2 (METHYLSULFANYL)PYRIMIDINE DERIVATIVE; 2 ARYLPYRIMIDINE; 4 HYDROXY 2 (4 FLUOROPHENYL) 6 (2) [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 4 HYDROXY 2 (4 FLUOROPHENYL) 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 4 HYDROXY 2 (4 HYDROXYPHENYL) 6 (2) [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 4 HYDROXY 2 (4 HYDROXYPHENYL) 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 4 HYDROXY 2 (4 METHOXYPHENYL) 6 (2) [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 4 HYDROXY 2 (4 METHOXYPHENYL) 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 4 HYDROXY 2 (4 NITROPHENYL) 6 (2) [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 4 HYDROXY 2 (4 NITROPHENYL) 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 4 HYDROXY 2 (4 TRIFLUOROPHENYL) 6 (2) [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 4 HYDROXY 2 (4 TRIFLUOROPHENYL) 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 4 HYDROXY 2 PHENYL 6 (2) [2 (PHOSPHONOMETHOXY) 3 HYDROXYPROPOXY]PYRIMIDINE; 4 HYDROXY 2 PHENYL 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; ACYCLIC NUCLEOSIDE; ACYCLIC NUCLEOSIDE PHOSPHONIC ACID DERIVATIVE; BENZENEBORONIC ACID; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ANTIVIRAL ACTIVITY; ARTICLE; CANCER INHIBITION; CHEMICAL ANALYSIS; CROSS COUPLING REACTION; CYTOSTASIS; CYTOTOXICITY; FRACTIONATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIEBESKIND SROGL CROSS COUPLING; PRIORITY JOURNAL; SYNTHESIS; UTERINE CERVIX CARCINOMA;

EID: 80051790004     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2011.07.040     Document Type: Article

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