Haplotypes of the adrenergic system predict the blood pressure response to-blockers in women with essential hypertension

Pharmacogenomics

Volumn 11, Issue 3, 2010, Pages 319-325

  Filigheddu, Fabiana ^a   Argiolas, Giuseppe ^b   Degortes, Simona ^b   Zaninello, Roberta ^b   Frau, Francesca ^b   Pitzoi, Silvia ^b   Bulla, Emanuela ^b   Bulla, Patrizia ^b   Troffa, Chiara ^b   Glorioso, Nicola ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b NONE

Author keywords

Adrenergic antagonist; Genetics; GNB3; High blood pressure; Pharmacogenomics; SNP

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT;

ADRENERGIC SYSTEM; ADULT; ARTICLE; BLOOD PRESSURE MONITORING; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFICACY; DRUG SAFETY; ESSENTIAL HYPERTENSION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHARMACOGENETICS; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TREATMENT RESPONSE;

ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; ATENOLOL; BASE SEQUENCE; BLOOD PRESSURE; CASE-CONTROL STUDIES; DNA PRIMERS; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; HYPERTENSION; MIDDLE AGED; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2;

EID: 77949602777     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.09.158     Document Type: Article

References (47)

1. Filigheddu F, Argiolas G, Troffa C, Glorioso N: Essential hypertension: translating pathophysiology into pharmacogenomics. Current Pharmacogenomics 4, 219-229 (2006).
2. Filigheddu F, Reid JE, Troffa C et al.: Genetic polymorphisms of the b-adrenergic system: association with essential hypertension and response to b-blockade. Pharmacogenomics J. 4(3), 154-160 (2004).
3. Johnson J A, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: b 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin. Pharmacol. Ther. 74(1), 44-52 (2003).
4. Jia H, Hingorani AD, Sharma P et al.: Association of the G(s)a gene with essential hypertension and response to b-blockade. Hypertension 34(1), 8-14 (1999).
5. Jia H, Sharma P, Hopper R, Dickerson C, Lloyd DD, Brown MJ: b2-adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians. J. Hypertens. 18, 687-693 (2000).
6. Kotanko P, Binder A, Tasker J et al.: Essential hypertension in African Caribbeans associates with a variant of the b2-adrenoceptor. Hypertension 30, 773-776 (1997).
7. Xie HG, Stein CM, Kim RB et al.: Human b2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin. Pharmacol. Ther. 67, 670-675 (2000).
8. Clark AG: The role of haplotypes in candidate gene studies. Genet. Epidemiol. 27, 321-333 (2004).
9. Shastry BS: SNPs and haplotypes: genetic markers for disease and drug response. Int. J. Mol. Med. 11(3), 379-382 (2003).
10. Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES: High-resolution haplotype structure in the human genome. Nat. Genet. 29(2), 229-232 (2001).
11. Wagoner LE, Craft LL, Zengel P et al.: Polymorphisms of the b 1-adrenergic receptor predict exercise capacity in heart failure. Am. Heart J. 144(5), 840-846 (2002).
12. Herrmann SM, Nicaud V, Tiret L et al.: Polymorphisms of the b2-adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies. J. Hypertens. 20(2), 229-235 (2002).
13. Rosskopf D, Busch S, Manthey I, Siffert W: G protein b 3 gene: structure, promoter, and additional polymorphisms. Hypertension 36(1), 33-41 (2000).
14. Binder A, Garcia E, Wallace C et al.: Haplotypes of the b-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. J. Hypertens. 24(3), 471-477 (2006).
15. Bao X, Mills PJ, Rana BK et al.: Interactive effects of common b2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function. Hypertension 46(2), 301-307 (2005).
16. Wallerstedt SM, Eriksson AL, Ohlsson C, Hedner T: Haplotype association analysis of the polymorphisms Arg16Gly and Gln27Glu of the adrenergic b2 receptor in a Swedish hypertensive population. J. Hum. Hypertens. 19(9), 705-708 (2005).
17. Lee YW, Oh VM, Garcia E et al.: Haplotypes of the b2-adrenergic receptor gene are associated with essential hypertension in a Singaporean Chinese population. J. Hypertens. 22(11), 2111-2116 (2004).
18. Cappello N, Rendine S, Griffo R et al.: Genetic analysis of Sardinia: I. data on 12 polymorphisms in 21 linguistic domains. Ann. Hum. Genet. 60(Pt 2), 125-141 (1996).
19. Chobanian AV, Bakris GL, Black HR et al.: National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289(19), 2560-2572 (2003).
20. Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R: Association between genetic polymorphisms of the b2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J. Clin. Invest. 100(12), 3184-3188 (1997).
21. Siffert W, Rosskopf D, Siffert G et al.: Association of a human G-protein b3 subunit variant with hypertension. Nat. Genet. 18(1), 45-48 (1998).
22. Mander AP: Analysis of quantitative traits using regression and log-linear modeling when phase is unknown. Stata J. 2(1), 65-70 (2002).
23. Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2), 263-265 (2005).
24. Cagliani R, Fumagalli M, Pozzoli U et al.: Diverse evolutionary histories for b-adrenoreceptor genes in humans. Am. J. Hum. Genet. 85(1), 64-75 (2009).
25. Camussi A, Bianchi G: Genetics of essential hypertension. From the unimodal-bimodal controversy to molecular technology. Hypertension 12(6), 620-628 (1988).
26. Bhatnagar V, O'Connor DT, Brophy VH et al.: G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specifcity and interactions. Am. J. Hypertens. 22(3), 332-338 (2009).
27. Bianchi G, Staessen JA, Ferrari P: Pharmacogenomics of primary hypertension-the lessons from the past to look toward the future. Pharmacogenomics 4(3), 279-296 (2003).
28. Drysdale CM, McGraw DW, Stack CB et al.: Complex promoter and coding region b 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl Acad. Sci. USA 97(19), 10483-10488 (2000).
29. Hoehe MR, Köpke K, Wendel B et al.: Sequence variability and candidate gene analysis in complex disease: association of μ opioid receptor gene variation with substance dependence. Hum. Mol. Genet. 9(19), 2895-2908 (2000).
30. Martin ER, Lai EH, Gilbert JR et al.: SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am. J. Hum. Genet. 67(2), 383-394 (2000).
31. Shin J, Lobmeyer MT, Gong Y et al.: Relation of b2-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure. Am. J. Cardiol. 99, 250-255 (2007).
32. Zee RYL, Cook NR, Reynolds R, Cheng S, Ridker PM: Haplotype analysis of the b2 adrenergic receptor gene and risk of myocardial infarction in humans. Genetics 169, 1583-1587 (2005).
33. Li B, Ge D, Wang Y et al.: G protein b 3 subunit gene variants and essential hypertension in the northern Chinese Han population. Ann. Hum. Genet. 69(Pt 4), 468-473 (2005).
34. Pacanowski MA, Gong Y, Cooper-Dehoff RM et al.: b-adrenergic receptor gene polymorphisms and b-blocker treatment outcomes in hypertension. Clin. Pharmacol. Ther. 84(6), 715-721 (2008).
35. Bhatnagar V, O'Connor DT, Brophy VH et al.: G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specifcity and interactions. Am. J. Hypertens. 22(3), 332-338 (2009).
36. Petrone A, Zavarella S, Iacobellis G et al.: Association of b2 adrenergic receptor polymorphisms and related haplotypes with triglyceride and LDL-cholesterol levels. Eur. J. Hum. Genet. 14(1), 94-100 (2006).
37. Vargas-Alarcón G, Fragoso JM, Cruz-Robles D et al.: Association of adrenergic receptor gene polymorphisms with different fbromyalgia syndrome domains. Arthritis Rheum. 60(7), 2169-2173 (2009).
38. Watkins WS, Hunt SC, Williams GH et al.: Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. J. Hypertens. 28(1), 65-75 (2009).
39. Niu W, Qi Y, Hou S, Zhai X, Zhou W, Qiu C: Haplotype-based association of the renin-angiotensin-aldosterone system genes polymorphisms with essential hypertension among Han Chinese: the Fangshan study. J. Hypertens. 27(7), 1384-1391 (2009)
40. Mansego ML, Redon J, Marin R et al.: Renin polymorphisms and haplotypes are associated with blood pressure levels and hypertension risk in postmenopausal women. J. Hypertens. 26(2), 230-237 (2008).
41. Liu H, Zhang S, Jiang S et al.: Renin-angiotensin-aldosterone system gene polymorphisms and antihypertensive response to irbesartan in Chinese hypertensives. Methods Find. Exp. Clin. Pharmacol. 30(4), 307-312 (2008).
42. Su X, Lee L, Li X et al.: Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor. Circulation 115(6), 725-732 (2007).
43. Medical Research Council Working Party on Mild Hypertension: Course of blood pressure in mild hypertensives after withdrawal of long term antihypertensive treatment. Br. Med. J. (Clin. Res. Ed.) 293, 988-992 (1986)
44. Bianchi G, Manunta P, Glorioso N: Clinical impact of adducin polymorphism. J. Hypertens. 27(6), 1325-1327 (2009).
45. Forleo C, Sorrentino S, Guida P et al.: b1-and b2-adrenergic receptor polymorphisms affect susceptibility to idiopathic dilated cardiomyopathy J. Cardiovasc. Med. (Hagerstown) 8(8), 589-595 (2007).
46. Iacoviello M, Forleo C, Sorrentino S et al.: a-and b-adrenergic receptor polymorphisms in hypertensive and normotensive offspring. J. Cardiovasc. Med. (Hagerstown) 7(5), 316-321 (2006).
47. Pinelli M, Giacchetti M, Acquaviva F et al.: b2-adrenergic receptor and UCP3 variants modulate the relationship between age and Type 2 diabetes mellitus. BMC Med. Genet. 7, 85 (2006).