SSRIs antidepressant activity is influenced by Gβ3 variants

European Neuropsychopharmacology

Volumn 13, Issue 2, 2003, Pages 117-122

  Serretti, Alessandro ^a   Lorenzi, Cristina ^a   Cusin, Cristina ^a   Zanardi, Raffaella ^a   Lattuada, Enrico ^a   Rossini, David ^a   Lilli, Roberta ^b   Pirovano, Adele ^a   Catalano, Marco ^a   Smeraldi, Enrico ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Antidepressant treatment; Fluvoxamine; Mood disorders; Paroxetine; Pharmacogenetics

Indexed keywords

FLUVOXAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PAROXETINE; PINDOLOL; PROTEIN SUBUNIT; SEROTONIN UPTAKE INHIBITOR;

ADULT; ALLELE; ARTICLE; BIPOLAR DEPRESSION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; GENETIC VARIABILITY; GENOTYPE; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PHARMACOGENETICS; PRIORITY JOURNAL;

EID: 0037337013     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(02)00154-2     Document Type: Article

References (66)

1. Diagnostic and Statistical Manual of Mental Disorders. 4th Edition: 1994;American Psychiatric Association, Washington, DC.
2. Avissar S., Barki-Harrington L., Nechamkin Y., Roitman G., Schreiber G. Elevated dopamine receptor-coupled G(s) protein measures in mononuclear leukocytes of patients with schizophrenia. Schizophr. Res. 47:2001;37-47.
3. Avissar S., Nechamkin Y., Barki-Harrington L., Roitman G., Schreiber G. Differential G protein measures in mononuclear leukocytes of patients with bipolar mood disorder are state dependent. J. Affect. Disord. 43:1997;85-93.
4. Avissar S., Nechamkin Y., Roitman G., Schreiber G. Reduced G protein functions and immunoreactive levels in mononuclear leukocytes of patients with depression. Am. J. Psychiatry. 154:1997;211-217.
5. Bech P., Malt U., Dencker S., Ahlfors U., Elgen K., Lewander T., Lundell A., Simpson G., Lingjaerde O. Scales for assessment of diagnosis and severity of mental disorders. Acta Psychiatr. Scand. 87:(Suppl. 372):1993;37-40.
6. Beige J., Hohenbleicher H., Distler A., Sharma A.M. G-Protein beta3 subunit C825T variant and ambulatory blood pressure in essential hypertension. Hypertension. 33:1999;1049-1051.
7. Bellini L., Gatti F., Gasperini M., Smeraldi E. A comparison between delusional and non-delusional depressives. J. Affect. Disord. 25:1992;129-138.
8. Benjafield A.V., Jeyasingam C.L., Nyholt D.R., Griffiths L.R., Morris B.J. G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension. 32:1998;1094-1097.
9. Berrettini W. Progress and pitfalls: bipolar molecular linkage studies. J. Affect. Disord. 50:1998;287-297.
10. Birnbaumer L., Abramowitz J., Brown A.M. Receptor-effector coupling by G proteins. Biochim. Biophys. Acta. 1031:1990;163-224.
11. Brand E., Herrmann S.M., Nicaud V., Ruidavets J.B., Evans A., Arveiler D., Luc G., Plouin P.F., Tiret L., Cambien F. The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertension. Hypertension. 33:1999;1175-1178.
12. Camps M., Carozzi A., Schnabel P., Scheer A., Parker P.J., Gierschik P. Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits. Nature. 360:1992;684-686.
13. Cohen J. Statistical Power Analysis For the Behavioral Sciences. 1988;8-14 Lawrence Erlbaum Associates, Hillsdale, NJ.
14. Corson T.W., Li P.P., Kennedy J.L., Macciardi F., Cooke R.G., Parikh S.V., Warsh J.J. Association analysis of G-protein beta 3 subunit gene with altered Ca(2+) homeostasis in bipolar disorder. Mol. Psychiatry. 6:2001;125-126.
15. Dong Y., Zhu H., Sagnella G.A., Carter N.D., Cook D.G., Cappuccio F.P. Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks. Hypertension. 34:1999;1193-1196.
16. Franchini L., Serretti A., Gasperini M., Smeraldi E. Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees. J. Psychiatr. Res. 32:1998;255-259.
17. Frankel W., Schork N. Who's afraid of epistasis? Nat. Genet. 14:1996;371-373.
18. Gasparini P., Estivill X., Volpini V., Totaro A., Castellvi-Bel S., Govea N., Mila M., Della Monica M., Ventruto V., De Benedetto M., Stanziale P., Zelante L., Mansfield E.S., Sandkuijl L., Surrey S., Fortina P. Linkage of DFNB1 to non-syndromic neurosensory autosomal-recessive deafness in Mediterranean families. Eur. J. Hum. Genet. 5:1997;83-88.
19. Gerfen C.R., Choi W.C., Suh P.G., Rhee S.G. Phospholipase C I and II brain isozymes: immunohistochemical localization in neuronal systems in rat brain. Proc. Natl. Acad. Sci. USA. 85:1988;3208-3212.
20. Gilman A.G. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56:1987;615-649.
21. Hamilton M. Development of a rating scale for primary depressive illness. Br. J. Soc. Clin. Psychol. 6:1967;278-296.
22. Hegele R.A., Harris S.B., Hanley A.J., Cao H., Zinman B. G protein beta3 subunit gene variant and blood pressure variation in Canadian Oji-Cree. Hypertension. 32:1998;688-692.
23. Jacobi J., Hilgers K.F., Schlaich M.P., Siffert W., Schmieder R.E. 825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. J. Hypertens. 17:1999;1457-1462.
24. Jia H., Hingorani A.D., Sharma P., Hopper R., Dickerson C., Trutwein D., Lloyd D.D., Brown M.J. Association of the G(s)alpha gene with essential hypertension and response to beta-blockade. Hypertension. 34:1999;8-14.
25. Kario K., Fujiwara M., Sone Y., Saiki K., Hoshide S., Shimada K., Schwartz J.E., Matsuo M. G protein beta3 subunit gene variant, twenty-four-hour blood pressure, and hypertensive cerebrovascular disease in a Japanese population. Am. J. Hypertens. 12:1999;1159-1160.
26. Kato N., Sugiyama T., Morita H., Kurihara H., Yamori Y., Yazaki Y. G protein beta3 subunit variant and essential hypertension in Japanese. Hypertension. 32:1998;935-938.
27. Kim D.K., Lim S.W., Lee S., Sohn S.E., Kim S., Hahn C.G., Carroll B.J. Serotonin transporter gene polymorphism and antidepressant response. Neuroreport. 11:2000;215-219.
28. Lahiri D.K., Nurnberger J.I.J. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19:1991;5444.
29. Leckman J.F., Sholomskas D., Thompson W.D., Belanger A., Weissman M.M. Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch. Gen. Psychiatry. 39:1982;879-883.
30. Levine M.A., Modi W.S., O'Brien S.J. Chromosomal localization of the genes encoding two forms of the G-protein beta polypeptide, beta-1 and beta-3, in man. Genomics. 8:1990;380-386.
31. Levine M.A., Smallwood P.M., Moen P.T.J., Helman L.J., Ahn T.G. Molecular cloning of beta-3 subunit, a third form of the G protein beta-subunit polypeptide. Proc. Natl. Acad. Sci. USA. 87:1990;2329-2333.
32. Lin C.N., Tsai S.J., Hong C.J. Association analysis of a functional G protein beta3 subunit gene polymorphism (C825T) in mood disorders. Neuropsychobiology. 44:2001;118-121.
33. Lucca A., Lucini V., Catalano M., Alfano M., Smeraldi E. Plasma tryptophan to large neutral amino acids ratio and therapeutic response to a selective serotonin uptake inhibitor. Neuropsychobiology. 29:1994;108-111.
34. Manji H.K., Potter W.Z., Lenox R.H. Signal transduction pathways. Arch. Gen. Psychiatry. 52:1995;531-543.
35. Nestler E.J., Duman R.S. G-proteins and cyclic nucleotides in the nervous system. Siegel G., Agranoff B., Albers R.W., Molinoff P. Basic Neurochemistry. Vol. 1:1994;449-474 Raven Press, New York.
36. O'Reilly R.L., Bogue L., Singh S.M. Pharmacogenetic response to antidepressants in a multicase family with affective disorder. Biol. Psychiatry. 36:1994;467-471.
37. Orsini A. Antidepressant responses and segregation analyses in affective families. Racagni G., Smeraldi E. Anxious Depression: Assessment and Treatment. 1987;Raven Press, New York.
38. Pare C.M., Mack J.W. Differentiation of two genetically specific types of depression by the response to antidepressant drugs. J. Med. Genet. 8:1971;306-309.
39. Pickar D., Rubinow K. Pharmacogenomics of psychiatric disorders. Trends Pharmacol. Sci. 22:2001;75-83.
40. Pietruck F., Moritz A., Montemurro M., Sell A., Busch S., Rosskopf D., Virchow S., Esche H., Brockmeyer N., Jakobs K.H., Siffert W. Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated. Circ. Res. 79:1996;974-983.
41. Pollock B.G., Ferrell R.E., Mulsant B.H., Mazumdar S., Miller M., Sweet R.A., Davis S., Kirshner M.A., Houck P.R., Stack J.A., Reynolds C.F., Kupfer D.J. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology. 23:2000;587-590.
42. Quitkin F.M., Rabkin J.G., Ross D., Stewart J.W. Identification of true drug response to antidepressants. Use of pattern analysis. Arch. Gen. Psychiatry. 41:1984;782-786.
43. Ram A., Guedj F., Cravchik A., Weinstein L., Cao Q., Badner J.A., Goldin L.R., Grisaru N., Manji H.K., Belmaker R.H., Gershon E.S., Gejman P.V. No abnormality in the gene for the G protein stimulatory alpha subunit in patients with bipolar disorder. Arch. Gen. Psychiatry. 54:1997;44-48.
44. Rhee S.G., Suh P.G., Ryu S.H., Lee S.Y. Studies of inositol phospholipid-specific phospholipase C. Science. 244:1989;546-550.
45. Rosskopf D., Busch S., Manthey I., Siffert W. G protein beta 3 gene: structure, promoter, and additional polymorphisms. Hypertension. 36:2000;33-41.
46. Saito T., Papolos D.F., Chernak D., Rapaport M.H., Kelsoe J.R., Lachman H.M. Analysis of GNAZ gene polymorphism in bipolar affective disorder. Am. J. Med. Genet. 88:1999;324-328.
47. Schorr U., Blaschke K., Beige J., Distler A., Sharma A.M. G-protein beta3 subunit 825T allele and response to dietary salt in normotensive men. J. Hypertens. 18:2000;855-859.
48. Sederer L.I. Depression. Sederer L.I. Inpatients Psychiatry Diagnosis and Treatment. 1986;20 William & Wilkins, Baltimore, MD.
49. Serretti A., Franchini L., Gasperini M., Rampoldi R., Smeraldi E. Mode of inheritance in mood disorders families according to fluvoxamine response. Acta Psychiatr. Scand. 98:1998;443-450.
50. Serretti A., Zanardi R., Cusin C., Rossini D., Lorenzi C., Smeraldi E. Tryptophan hydroxylase gene associated with paroxetine antidepressant activity. Eur. Neuropsychopharmacol. 11:2001;375-380.
51. Serretti A., Zanardi R., Rossini D., Cusin C., Lilli R., Smeraldi E. Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity. Mol. Psychiatry. 6:2001;586-592.
52. Siffert W., Rosskopf D., Erbel R. Genetic polymorphism of the G-protein beta3 subunit, obesity and essential hypertension. Herz. 25:2000;26-33.
53. Siffert W., Rosskopf D., Moritz A., Wieland T., Kaldenberg-Stasch S., Kettler N., Hartung K., Beckmann S., Jakobs K.H. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J. Clin. Invest. 96:1995;759-766.
54. Siffert W., Rosskopf D., Siffert G., Busch S., Moritz A., Erbel R., Sharma A.M., Ritz E., Wichmann H.E., Jakobs K.H., Horsthemke B. Association of a human G-protein beta3 subunit variant with hypertension. Nat. Genet. 18:1998;45-48.
55. Simon M.I., Strathmann M.P., Gautam N. Diversity of G proteins in signal transduction. Science. 252:1991;802-808.
56. Smeraldi E., Zanardi R., Benedetti F., Dibella D., Perez J., Catalano M. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiatry. 3:1998;508-511.
57. Sobin C.A., Sackeim H. Psychomotor symptoms of depression. Am. J. Psychiatry. 154:1997;4-17.
58. Tsai C.H., Yeh H.I., Chou Y., Liu H.F., Yang T.Y., Wang J.C., Wang N.M., Chang J.G. G protein beta3 subunit variant and essential hypertension in Taiwan-a case-control study. Int. J. Cardiol. 73:2000;191-195. discussion 197-198.
59. Tsiouris S.J., Breschel T.S., Xu J., McInnis M.G., McMahon F.J. Linkage disequilibrium analysis of G-olf alpha (GNAL) in bipolar affective disorder. Am. J. Med. Genet. 67:1996;491-494.
60. Wuthrich R.P., Cicvara S., Booy C., Widmer U., Binswanger U. The 825C/T polymorphism of the G-protein subunit beta3 does not influence blood pressure and renal function in kidney transplant recipients. Nephrol. Dial. Transplant. 15:2000;1663-1666.
61. Yoshid K., Ito K., Sato K., Takahashi H., Kamata M., Higuchi H., Shimizu T., Itoh K., Inoue K., Tezuka T., Suzuki T., Ohkubo T., Sugawara K., Otani K. Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients. Prog. Neuropsychopharmacol. Biol. Psychiatry. 26:2002;383-386.
62. Young L.T., Li P.P., Kamble A., Siu K.P., Warsh J.J. Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am. J. Psychiatry. 151:1994;594-596.
63. Zanardi R., Benedetti F., DiBella D., Catalano M., Smeraldi E. Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of serotonin transporter gene. J. Clin. Psychopharmacol. 20:2000;105-107.
64. Zanardi R., Serretti A., Rossini D., Franchini L., Cusin C., Lattuada E., Dotoli D., Smeraldi E. Factors affecting fluvoxamine antidepressant activity: influence of pindolol and 5-HTTLPR in delusional and nondelusional depression. Biol. Psychiatry. 50:2001;323-330.
65. Zeltner R., Delles C., Schneider M., Siffert W., Schmieder R.E. G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. Hypertension. 37:2001;882-886.
66. Zill P., Baghai T.C., Zwanzger P., Schule C., Minov C., Riedel M., Neumeier K., Rupprecht R., Bondy B. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. Neuroreport. 11:2000;1893-1897.