Two solutions for the same problem: Multiple binding modes of pyrrolidine-based HIV-1 protease inhibitors

Journal of Molecular Biology

Volumn 410, Issue 4, 2011, Pages 745-755

  Blum, Andreas ^a   Böttcher, Jark ^a   Dörr, Stefanie ^a   Heine, Andreas ^a   Klebe, Gerhard ^a   Diederich, Wibke E ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Crystallography; Deviating binding modes; HIV 1 protease inhibitors; Pyrrolidine based inhibitors; Structure based drug design

Indexed keywords

3 [(4 CARBAMOYL BENZENESULFONYL)(3 METHYLBUT 2 ENYL)AMINO] 4 [(4 CARBOXY BENZENESULFONYL)(3 METHYL BUT 2 ENYL)AMINO]PYRROLIDINIUM TRIFLUOROACETATE; 3,4 BIS [(4 BROMO BENZENESULFONYL)(3 METHYL BUT 2 ENYL)AMINO]PYRROLIDINIUM TRIFLUOROACETATE; 3,4 BIS [(4 CARBAMOYL BENZENESULFONYL)(3-METHYL-BUT-2-ENYL)AMINO]PYRROLIDINIUM TRIFLUOROACETATE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ASPARTIC ACID; NITROGEN; PROTEINASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTALLIZATION; DRUG BINDING; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80051767297     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.04.052     Document Type: Article

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