메뉴 건너뛰기




Volumn 49, Issue 8, 2011, Pages 1247-1256

Translating pharmacogenetics into clinical practice: Interleukin (IL)28B and inosine triphosphatase (ITPA) polymophisms in hepatitis C virus (HCV) infection

Author keywords

hepatitis C virus (HCV); inosine triphosphatase (ITPA); interferon (IFN); interleukin 28B (IL28B); polymorphism (SNP); ribavirin (RBV)

Indexed keywords

DRUG METABOLITE; INOSINE TRIPHOSPHATASE; INTERFERON; INTERLEUKIN 28B; PEGINTERFERON ALPHA; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PHOSPHATASE; RIBAVIRIN; RIBAVIRIN TRIPHOSPHATE; UNCLASSIFIED DRUG;

EID: 80051766104     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.618     Document Type: Review
Times cited : (17)

References (102)
  • 1
    • 10744225097 scopus 로고    scopus 로고
    • Global burden of disease (GBD) for hepatitis C
    • Global Burden of Hepatitis C Working Group
    • Global Burden of Hepatitis C Working Group. Global burden of disease (GBD) for hepatitis C. J Clin Pharmacol 2004;44: 20-9.
    • (2004) J Clin Pharmacol , vol.44 , pp. 20-9
  • 2
    • 0037213958 scopus 로고    scopus 로고
    • The epidemiology of hepatitis C virus infection
    • Yen T, Keeffe EB, Ahmed A. The epidemiology of hepatitis C virus infection. J Clin Gastroenterol 2003;36:47-53.
    • (2003) J Clin Gastroenterol , vol.36 , pp. 47-53
    • Yen, T.1    Keeffe, E.B.2    Ahmed, A.3
  • 5
    • 0036166343 scopus 로고    scopus 로고
    • Seroprevalence, viremia and genotype distribution of hepatitis C virus: A community-based population study in northern Italy
    • DOI 10.1007/s15010-001-1197-4
    • Campello C, Poli A, Dal MG, Besozzi-Valentini F. Seroprevalence, viremia and genotype distribution of hepatitis C virus: A community-based population study in northern Italy. Infection 2002;30:7-12. (Pubitemid 34146405)
    • (2002) Infection , vol.30 , Issue.1 , pp. 7-12
    • Campello, C.1    Poli, A.2    Dal Molin, G.3    Besozzi-Valentini, F.4
  • 7
    • 33748694270 scopus 로고    scopus 로고
    • Chronic hepatitis C virus infection: Genotyping and its clinical role
    • Bowden DS, Berzsenyi MD. Chronic hepatitis C virus infection: Genotyping and its clinical role. Future Microbiol 2006;1: 103-12.
    • (2006) Future Microbiol , vol.1 , pp. 103-12
    • Bowden, D.S.1    Berzsenyi, M.D.2
  • 8
    • 0032748876 scopus 로고    scopus 로고
    • Hepatitis C virus genotypes in France: Relationship with epidemiology, pathogenicity and response to interferon therapy. The GEMHEP
    • Martinot-Peignoux M, Roudot-Thoraval F, Mendel I, Coste J, Izopet J, Duverlie G, et al. Hepatitis C virus genotypes in France: Relationship with epidemiology, pathogenicity and response to interferon therapy. The GEMHEP. J Viral Hepat 1999;6:435-43.
    • (1999) J Viral Hepat , vol.6 , pp. 435-43
    • Martinot-Peignoux, M.1    Roudot-Thoraval, F.2    Mendel, I.3    Coste, J.4    Izopet, J.5    Duverlie, G.6
  • 10
    • 55749109703 scopus 로고    scopus 로고
    • Interferon-based therapy for chronic hepatitis C: Current and future perspectives
    • Zeuzem S. Interferon-based therapy for chronic hepatitis C: Current and future perspectives. Nat Clin Pract Gastroenterol Hepatol 2008;5:610-22.
    • (2008) Nat Clin Pract Gastroenterol Hepatol , vol.5 , pp. 610-22
    • Zeuzem, S.1
  • 11
    • 0033965331 scopus 로고    scopus 로고
    • Is an 'a la carte' combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C?
    • Poynard T, McHutchison J, Goodman Z, Ling MH, Albrecht J. Is an ''a la carte'' combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C? The ALGOVIRC Project Group. Hepatology 2000;31:211-8. (Pubitemid 30033709)
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 211-218
    • Poynard, T.1    Mchutchison, J.2    Goodman, Z.3    Ling, M.-H.4    Albrecht, J.5
  • 12
    • 33745560465 scopus 로고    scopus 로고
    • Impact of obesity on treatment of chronic hepatitis C
    • DOI 10.1002/hep.21239
    • Charlton M, Pockros PJ, Harrison SA. Impact of obesity on treatment of chronic hepatitis C. Hepatology 2006;43:1177-86. (Pubitemid 43980094)
    • (2006) Hepatology , vol.43 , Issue.6 , pp. 1177-1186
    • Charlton, M.R.1    Pockros, P.J.2    Harrison, S.A.3
  • 13
    • 33751372117 scopus 로고    scopus 로고
    • Mechanisms and significance of liver steatosis in hepatitis C virus infection
    • Negro F. Mechanisms and significance of liver steatosis in hepatitis C virus infection. World J Gastroenterol 2006;12:6756-65. (Pubitemid 44811395)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.42 , pp. 6756-6765
    • Negro, F.1
  • 14
    • 49949115600 scopus 로고    scopus 로고
    • Pegylated interferon-alpha2b plus ribavirin: An efficacious and well-tolerated treatment regimen for patients with hepatitis C virus related histologically proven cirrhosis
    • Roffi L, Colloredo G, Pioltelli P, Bellati G, Pozzpi M, Parravicini P, et al. Pegylated interferon-alpha2b plus ribavirin: An efficacious and well-tolerated treatment regimen for patients with hepatitis C virus related histologically proven cirrhosis. Antivir Ther 2008;13:663-73.
    • (2008) Antivir Ther , vol.13 , pp. 663-73
    • Roffi, L.1    Colloredo, G.2    Pioltelli, P.3    Bellati, G.4    Pozzpi, M.5    Parravicini, P.6
  • 15
    • 79952308232 scopus 로고    scopus 로고
    • Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C
    • Villa E, Karampatou A, Cammá C, Di Leo A, Luongo M, Ferrari A, et al. Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C. Gastroenterology 2011;140:818-29.
    • (2011) Gastroenterology , vol.140 , pp. 818-29
    • Villa, E.1    Karampatou, A.2    Cammá, C.3    Di Leo, A.4    Luongo, M.5    Ferrari, A.6
  • 16
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009;461:399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3    Simon, J.S.4    Shianna, K.V.5    Urban, T.J.6
  • 17
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to PEGylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, et al. Genome-wide association of IL28B with response to PEGylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009;41:1105-9.
    • (2009) Nat Genet , vol.41 , pp. 1105-9
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3    Kurosaki, M.4    Matsuura, K.5    Sakamoto, N.6
  • 18
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009;41:1100-4.
    • (2009) Nat Genet , vol.41 , pp. 1100-4
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3    Berg, T.4    Weltman, M.5    Abate, M.L.6
  • 19
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009;461:798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3    Qi, Y.4    Ge, D.5    O'Huigin, C.6
  • 20
    • 77949831342 scopus 로고    scopus 로고
    • Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study
    • Rauch A, Kutalik Z, Descombes P, Cai T, Di IJ, Mueller T, et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study. Gastroenterology 2010;138:1338-45.
    • (2010) Gastroenterology , vol.138 , pp. 1338-45
    • Rauch, A.1    Kutalik, Z.2    Descombes, P.3    Cai, T.4    Di, I.J.5    Mueller, T.6
  • 21
    • 77952693487 scopus 로고    scopus 로고
    • Replicated association between an IL28B gene variant and a sustained response to PEGylated interferon and ribavirin
    • McCarthy JJ, Li JH, Thompson A, Suchindran S, Lao XQ, Patel K, et al. Replicated association between an IL28B gene variant and a sustained response to PEGylated interferon and ribavirin. Gastroenterology 2010;138:2307-14.
    • (2010) Gastroenterology , vol.138 , pp. 2307-14
    • McCarthy, J.J.1    Li, J.H.2    Thompson, A.3    Suchindran, S.4    Lao, X.Q.5    Patel, K.6
  • 22
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus
    • Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010;139:120-9.
    • (2010) Gastroenterology , vol.139 , pp. 120-9
    • Thompson, A.J.1    Muir, A.J.2    Sulkowski, M.S.3    Ge, D.4    Fellay, J.5    Shianna, K.V.6
  • 23
    • 77949773445 scopus 로고    scopus 로고
    • ITPA gene variants protect against anemia in patients treated for chronic hepatitis C
    • Fellay J, Thompson AJ, Ge D, Gumbs CE, Urban TJ, Shianna KV, et al. ITPA gene variants protect against anemia in patients treated for chronic hepatitis C. Nature 2010;464:405-8.
    • (2010) Nature , vol.464 , pp. 405-8
    • Fellay, J.1    Thompson, A.J.2    Ge, D.3    Gumbs, C.E.4    Urban, T.J.5    Shianna, K.V.6
  • 24
    • 78049469161 scopus 로고    scopus 로고
    • A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    • Tillmann HL, Thompson AJ, Patel K, Wiese M, Tenckhoff H, Nischalke HD, et al. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology 2010;139:1586-92.
    • (2010) Gastroenterology , vol.139 , pp. 1586-92
    • Tillmann, H.L.1    Thompson, A.J.2    Patel, K.3    Wiese, M.4    Tenckhoff, H.5    Nischalke, H.D.6
  • 26
    • 78851469540 scopus 로고    scopus 로고
    • Pre-treatment prediction of response to PEGylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors
    • Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, et al. Pre-treatment prediction of response to PEGylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J Hepatol 2011;54:439-48.
    • (2011) J Hepatol , vol.54 , pp. 439-48
    • Kurosaki, M.1    Tanaka, Y.2    Nishida, N.3    Sakamoto, N.4    Enomoto, N.5    Honda, M.6
  • 27
    • 79951679619 scopus 로고    scopus 로고
    • Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients
    • Sarrazin C, Susser S, Doehring A, Lange CM, Müller T, Schlecker C, et al. Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients. J Hepatol 2011;54:415-21.
    • (2011) J Hepatol , vol.54 , pp. 415-21
    • Sarrazin, C.1    Susser, S.2    Doehring, A.3    Lange, C.M.4    Müller, T.5    Schlecker, C.6
  • 28
    • 84925580987 scopus 로고    scopus 로고
    • An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    • Mangia A, Thompson AJ, Santoro R, Piazzolla V, Tillmann HL, Patel K, et al. An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response. Gastroenterology 2010;139:821-7.
    • (2010) Gastroenterology , vol.139 , pp. 821-7
    • Mangia, A.1    Thompson, A.J.2    Santoro, R.3    Piazzolla, V.4    Tillmann, H.L.5    Patel, K.6
  • 29
    • 79952899824 scopus 로고    scopus 로고
    • Impact of IL28B genotype on the early and sustained virologic response in treatment-naïve patients with chronic hepatitis C
    • Stättermayer AF, Stauber R, Hofer H, Rutter K, Beinhardt S, Scherzer TM, et al. Impact of IL28B genotype on the early and sustained virologic response in treatment-naïve patients with chronic hepatitis C. Clin Gastroenterol Hepatol 2011;9:344-50.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 344-50
    • Stättermayer, A.F.1    Stauber, R.2    Hofer, H.3    Rutter, K.4    Beinhardt, S.5    Scherzer, T.M.6
  • 30
    • 79951675730 scopus 로고    scopus 로고
    • Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b
    • Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, et al. Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b. J Hepatol 2011;54:408-14.
    • (2011) J Hepatol , vol.54 , pp. 408-14
    • Kawaoka, T.1    Hayes, C.N.2    Ohishi, W.3    Ochi, H.4    Maekawa, T.5    Abe, H.6
  • 31
    • 0028924826 scopus 로고
    • Persistent hepatitis C viremia after acute self-limiting posttransfusion hepatitis C
    • Barrera JM, Bruguera M, Ercilla MG, Gil C, Celis R, Gil MP, et al. Persistent hepatitis C viremia after acute self-limiting posttransfusion hepatitis C. Hepatology 1995;21:639-44.
    • (1995) Hepatology , vol.21 , pp. 639-44
    • Barrera, J.M.1    Bruguera, M.2    Ercilla, M.G.3    Gil, C.4    Celis, R.5    Gil, M.P.6
  • 32
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
    • Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence. J Clin Invest 2009;119:1745-54.
    • (2009) J Clin Invest , vol.119 , pp. 1745-54
    • Rehermann, B.1
  • 33
    • 63049130453 scopus 로고    scopus 로고
    • Immunological determinants of the outcomes from primary hepatitis C infection
    • Post J, Ratnarajah S, Lloyd AR. Immunological determinants of the outcomes from primary hepatitis C infection. Cell Mol Life Sci 2009;66:733-56.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 733-56
    • Post, J.1    Ratnarajah, S.2    Lloyd, A.R.3
  • 34
    • 78649708165 scopus 로고    scopus 로고
    • IL28B and the control of hepatitis C virus infection
    • Balagopal A, Thomas DL, Thio CL. IL28B and the control of hepatitis C virus infection. Gastroenterology 2010;139:1865-76.
    • (2010) Gastroenterology , vol.139 , pp. 1865-1876
    • Balagopal, A.1    Thomas, D.L.2    Thio, C.L.3
  • 35
    • 78049470128 scopus 로고    scopus 로고
    • Variants in IL28B in liver recipients and donors correlate with response to PEG-interferon and ribavirin therapy for recurrent hepatitis C
    • Fukuhara T, Taketomi A, Motomura T, Okano S, Ninomiya A, Abe T, et al. Variants in IL28B in liver recipients and donors correlate with response to PEG-interferon and ribavirin therapy for recurrent hepatitis C. Gastroenterology 2010;139:1577-85.
    • (2010) Gastroenterology , vol.139 , pp. 1577-85
    • Fukuhara, T.1    Taketomi, A.2    Motomura, T.3    Okano, S.4    Ninomiya, A.5    Abe, T.6
  • 36
    • 77955691994 scopus 로고    scopus 로고
    • Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with PEGinterferon and ribavirin
    • Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, et al. Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with PEGinterferon and ribavirin. Hepatology 2010;52:421-9.
    • (2010) Hepatology , vol.52 , pp. 421-9
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3    Kawamura, Y.4    Yatsuji, H.5    Sezaki, H.6
  • 37
    • 77951880384 scopus 로고    scopus 로고
    • Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients
    • Rallón NI, Naggie S, Benito JM, Medrano J, Restrepo C, Goldstein D, et al. Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. AIDS 2010;24:F23-9.
    • (2010) AIDS , vol.24
    • Rallón, N.I.1    Naggie, S.2    Benito, J.M.3    Medrano, J.4    Restrepo, C.5    Goldstein, D.6
  • 38
    • 78149427491 scopus 로고    scopus 로고
    • IL28B SNP rs8099917 is strongly associated with PEGylated interferon-a and ribavirin therapy treatment failure in HCV/HIV-1 coinfected patients
    • Aparicio E, Parera M, Franco S, Pérez-Alvarez N, Tural C, Clotet B, et al. IL28B SNP rs8099917 is strongly associated with PEGylated interferon-a and ribavirin therapy treatment failure in HCV/HIV-1 coinfected patients. PLoS One 2010; 5:e13771.
    • (2010) PLoS One , vol.5
    • Aparicio, E.1    Parera, M.2    Franco, S.3    Pérez-Alvarez, N.4    Tural, C.5    Clotet, B.6
  • 39
    • 77957825574 scopus 로고    scopus 로고
    • Prediction of response to PEGylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus
    • Pineda JA, Caruz A, Rivero A, Neukam K, Salas I, Camacho A, et al. Prediction of response to PEGylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus. Clin Infect Dis 2010;51:788-95.
    • (2010) Clin Infect Dis , vol.51 , pp. 788-95
    • Pineda, J.A.1    Caruz, A.2    Rivero, A.3    Neukam, K.4    Salas, I.5    Camacho, A.6
  • 40
    • 78349296832 scopus 로고    scopus 로고
    • Modeling the probability of sustained virological response to therapy with PEGylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV
    • Medrano J, Neukam K, Rallón N, Rivero A, Resino S, Naggie S, et al. Modeling the probability of sustained virological response to therapy with PEGylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV. Clin Infect Dis 2010;51:1209-16.
    • (2010) Clin Infect Dis , vol.51 , pp. 1209-16
    • Medrano, J.1    Neukam, K.2    Rallón, N.3    Rivero, A.4    Resino, S.5    Naggie, S.6
  • 41
    • 79961211126 scopus 로고    scopus 로고
    • Genetic variation in IL28B polymorphism may predict HBsAg clearance in genotype D, HBeAg negative patients treated with interferon alfa wabstractx
    • Lampertico P, Viganó M, Cheroni C, Facchetti F, Valveri V, Soffredini R, et al. Genetic variation in IL28B polymorphism may predict HBsAg clearance in genotype D, HBeAg negative patients treated with interferon alfa wabstractx. Hepatology 2010;52:442A.
    • (2010) Hepatology , vol.52
    • Lampertico, P.1    Viganó, M.2    Cheroni, C.3    Facchetti, F.4    Valveri, V.5    Soffredini, R.6
  • 42
    • 78649619461 scopus 로고    scopus 로고
    • IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection
    • Martin MP, Qi Y, Goedert JJ, Hussain SK, Kirk GD, Hoots WK, et al. IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection. J Infect Dis 2010;202: 1749-53.
    • (2010) J Infect Dis , vol.202 , pp. 1749-53
    • Martin, M.P.1    Qi, Y.2    Goedert, J.J.3    Hussain, S.K.4    Kirk, G.D.5    Hoots, W.K.6
  • 43
    • 67349160018 scopus 로고    scopus 로고
    • A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
    • Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, et al. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 2009;41:591-5.
    • (2009) Nat Genet , vol.41 , pp. 591-5
    • Kamatani, Y.1    Wattanapokayakit, S.2    Ochi, H.3    Kawaguchi, T.4    Takahashi, A.5    Hosono, N.6
  • 45
    • 79959524146 scopus 로고    scopus 로고
    • The international hapmap consortium: A haplotype map of the human genome
    • The International HapMap Consortium
    • The International HapMap Consortium. The international hapmap consortium: A haplotype map of the human genome. Nature 2005;437:1299-320.
    • (2005) Nature , vol.437 , pp. 1299-320
  • 46
    • 77955852095 scopus 로고    scopus 로고
    • Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients
    • Abe H, Ochi H, Maekawa T, Hayes N, Tsuge M, Miki D, et al. Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. J Hepatol 2010;53:439-43.
    • (2010) J Hepatol , vol.53 , pp. 439-43
    • Abe, H.1    Ochi, H.2    Maekawa, T.3    Hayes, N.4    Tsuge, M.5    Miki, D.6
  • 47
    • 77952730427 scopus 로고    scopus 로고
    • Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection
    • Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, et al. Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. Hepatology 2010;51:1904-11.
    • (2010) Hepatology , vol.51 , pp. 1904-11
    • Li, J.H.1    Lao, X.Q.2    Tillmann, H.L.3    Rowell, J.4    Patel, K.5    Thompson, A.6
  • 48
    • 78049465963 scopus 로고    scopus 로고
    • A model explaining the correlations between IL28B-related genotypes, hepatitis C virus genotypes, and viral RNA levels
    • Lindh M, Lagging M, Norkrans G, Hellstrand K. A model explaining the correlations between IL28B-related genotypes, hepatitis C virus genotypes, and viral RNA levels. Gastroenterology 2010;139:1794-6.
    • (2010) Gastroenterology , vol.139 , pp. 1794-6
    • Lindh, M.1    Lagging, M.2    Norkrans, G.3    Hellstrand, K.4
  • 49
    • 78650973933 scopus 로고    scopus 로고
    • IL28B genomicbased treatment paradigms for patients with chronic hepatitis C infection: The future of personalized HCV therapies
    • Clark PJ, Thompson AJ, McHutchison JG. IL28B genomicbased treatment paradigms for patients with chronic hepatitis C infection: The future of personalized HCV therapies. Am J Gastroenterol 2011;106:38-45.
    • (2011) Am J Gastroenterol , vol.106 , pp. 38-45
    • Clark, P.J.1    Thompson, A.J.2    McHutchison, J.G.3
  • 50
    • 34447298368 scopus 로고    scopus 로고
    • Clearance of low-levels of HCV viremia in the absence of a strong adaptive immune response
    • Meyer MF, Lehmann M, Cornberg M, Wiegand J, Manns MP, Klade C, et al. Clearance of low-levels of HCV viremia in the absence of a strong adaptive immune response. Virol J 2007; 4:58.
    • (2007) Virol J , vol.4 , pp. 58
    • Meyer, M.F.1    Lehmann, M.2    Cornberg, M.3    Wiegand, J.4    Manns, M.P.5    Klade, C.6
  • 51
    • 68849124573 scopus 로고    scopus 로고
    • Interferon-lambdas: The modulators of antivirus, antitumor, and immune responses
    • Li M, Liu X, Zhou Y, Su SB. Interferon-lambdas: The modulators of antivirus, antitumor, and immune responses. J Leukoc Biol 2009;86:23-32.
    • (2009) J Leukoc Biol , vol.86 , pp. 23-32
    • Li, M.1    Liu, X.2    Zhou, Y.3    Su, S.B.4
  • 52
    • 77955860021 scopus 로고    scopus 로고
    • IL-28A, IL-28B, and IL-29: Promising cytokines with type I interferon-like properties
    • Witte K, Witte E, Sabat R, Wolk K. IL-28A, IL-28B, and IL-29: Promising cytokines with type I interferon-like properties. Cytokine Growth Factor Rev 2010;21:237-51.
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 237-51
    • Witte, K.1    Witte, E.2    Sabat, R.3    Wolk, K.4
  • 53
    • 63749132070 scopus 로고    scopus 로고
    • The role of genomic data in the discovery, annotation and evolutionary interpretation of the interferon-lambda family
    • Fox BA, Sheppard PO, O'Hara PJ. The role of genomic data in the discovery, annotation and evolutionary interpretation of the interferon-lambda family. PLoS One 2009;4:e4933.
    • (2009) PLoS One , vol.4
    • Fox, B.A.1    Sheppard, P.O.2    O'Hara, P.J.3
  • 54
    • 33845605155 scopus 로고    scopus 로고
    • Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
    • DOI 10.1053/j.gastro.2006.09.052, PII S0016508506022207
    • Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, MacDonald MR, et al. Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 2006;131: 1887-98. (Pubitemid 44958521)
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3    Machlin, E.S.4    Kotenko, S.V.5    Macdonald, M.R.6    Rice, C.M.7
  • 55
    • 77955873433 scopus 로고    scopus 로고
    • Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection
    • Muir AJ, Shiffman ML, Zaman A, Yoffe B, de la Torre A, Flamm S, et al. Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection. Hepatology 2010;52:822-32.
    • (2010) Hepatology , vol.52 , pp. 822-32
    • Muir, A.J.1    Shiffman, M.L.2    Zaman, A.3    Yoffe, B.4    De La Torre, A.5    Flamm, S.6
  • 56
    • 78649608515 scopus 로고    scopus 로고
    • IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    • Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, et al. IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology 2010;52: 1888-96.
    • (2010) Hepatology , vol.52 , pp. 1888-96
    • Urban, T.J.1    Thompson, A.J.2    Bradrick, S.S.3    Fellay, J.4    Schuppan, D.5    Cronin, K.D.6
  • 57
    • 77955475888 scopus 로고    scopus 로고
    • Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    • Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, et al. Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology 2010;139:499-509.
    • (2010) Gastroenterology , vol.139 , pp. 499-509
    • Honda, M.1    Sakai, A.2    Yamashita, T.3    Nakamoto, Y.4    Mizukoshi, E.5    Sakai, Y.6
  • 58
    • 79956147625 scopus 로고    scopus 로고
    • IL28B variation affects expression of interferon stimulated genes and effect of PEG-interferon and ribavirin therapy
    • Feb 4. wEpub ahead of printx
    • Abe H, Hayes N, Ochi H, Maekawa T, Tsuge M, Miki D, et al. IL28B variation affects expression of interferon stimulated genes and effect of PEG-interferon and ribavirin therapy. J Hepatol 2011 Feb 4. wEpub ahead of printx.
    • (2011) J Hepatol
    • Abe, H.1    Hayes, N.2    Ochi, H.3    Maekawa, T.4    Tsuge, M.5    Miki, D.6
  • 59
    • 19044361835 scopus 로고    scopus 로고
    • Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection
    • DOI 10.1053/j.gastro.2005.01.059, PII S0016508505003999
    • Chen L, Borozan I, Feld J, Sun J, Tannis LL, Coltescu C, et al. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology 2005;128:1437-44. (Pubitemid 40712193)
    • (2005) Gastroenterology , vol.128 , Issue.5 , pp. 1437-1444
    • Chen, L.1    Borozan, I.2    Feld, J.3    Sun, J.4    Tannis, L.-L.5    Coltescu, C.6    Heathcote, J.7    Edwards, A.M.8    McGilvray, I.D.9
  • 62
    • 79952305174 scopus 로고    scopus 로고
    • Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C
    • Dill MT, Duong FH, Vogt JE, Bibert S, Bochud PY, Terracciano L, et al. Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C. Gastroenterology 2011;140:1021-31.
    • (2011) Gastroenterology , vol.140 , pp. 1021-31
    • Dill, M.T.1    Duong, F.H.2    Vogt, J.E.3    Bibert, S.4    Bochud, P.Y.5    Terracciano, L.6
  • 63
    • 77956912415 scopus 로고    scopus 로고
    • IL28B in hepatitis C virus infection: Translating pharmacogenomics into clinical practice
    • Ahlenstiel G, Booth DR, George J. IL28B in hepatitis C virus infection: Translating pharmacogenomics into clinical practice. J Gastroenterol 2010;45:903-10.
    • (2010) J Gastroenterol , vol.45 , pp. 903-10
    • Ahlenstiel, G.1    Booth, D.R.2    George, J.3
  • 64
    • 77956547987 scopus 로고    scopus 로고
    • The recent breakthroughs in the understanding of host genomics in hepatitis C
    • Rauch A, Rohrbach J, Bochud PY. The recent breakthroughs in the understanding of host genomics in hepatitis C. Eur J Clin Invest 2010;40:950-9.
    • (2010) Eur J Clin Invest , vol.40 , pp. 950-9
    • Rauch, A.1    Rohrbach, J.2    Bochud, P.Y.3
  • 65
    • 77949853825 scopus 로고    scopus 로고
    • Interleukin-28b: A key piece of the hepatitis C virus recovery puzzle
    • Thio CL, Thomas DL. Interleukin-28b: A key piece of the hepatitis C virus recovery puzzle. Gastroenterology 2010;138: 1240-3.
    • (2010) Gastroenterology , vol.138 , pp. 1240-3
    • Thio, C.L.1    Thomas, D.L.2
  • 71
    • 20644441571 scopus 로고    scopus 로고
    • Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: A multicenter trial
    • DOI 10.1002/hep.510260231
    • Bodenheimer HC, Lindsay KL, Davis GL, Lewis JH, Thung SN, Seeff LB. Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: A multicenter trial. Hepatology 1997; 26:473-7. (Pubitemid 27328328)
    • (1997) Hepatology , vol.26 , Issue.2 , pp. 473-477
    • Bodenheimer Jr., H.C.1    Lindsay, K.L.2    Davis, G.L.3    Lewis, J.H.4    Thung, S.N.5    Seeff, L.B.6
  • 76
    • 0031663638 scopus 로고    scopus 로고
    • The antiviral compound ribavirin modulates the T helper (Th)1/Th2 subset balance in hepatitis B and C virus-specific immune responses
    • Hultgren C, Milich DR, Weiland O, Sallberg M. The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses. J Gen Virol 1998;79:2381-91. (Pubitemid 28464295)
    • (1998) Journal of General Virology , vol.79 , Issue.10 , pp. 2381-2391
    • Hultgren, C.1    Milich, D.R.2    Weiland, O.3    Sallberg, M.4
  • 78
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • DOI 10.1016/S0140-6736(01)06102-5
    • Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al. PEGinterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial. Lancet 2001;358:958-65. (Pubitemid 32913521)
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.-H.9    Albrecht, J.K.10
  • 80
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and PEGinterferon with or without ribavirin for chronic HCV infection
    • Hézode C, Forestier N, Dusheiko G, Ferenci P, Pol S, Goeser T, et al. Telaprevir and PEGinterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009;360:1839-50.
    • (2009) N Engl J Med , vol.360 , pp. 1839-50
    • Hézode, C.1    Forestier, N.2    Dusheiko, G.3    Ferenci, P.4    Pol, S.5    Goeser, T.6
  • 81
    • 73649105503 scopus 로고    scopus 로고
    • Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment with telaprevir (MP-424), PEGylated interferon and ribavirin for 12 weeks
    • Suzuki F, Akuta N, Suzuki Y, Sezaki H, Yatsuji H, Kawamura Y, et al. Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment with telaprevir (MP-424), PEGylated interferon and ribavirin for 12 weeks. Hepatol Res 2009;39:1056-63.
    • (2009) Hepatol Res , vol.39 , pp. 1056-63
    • Suzuki, F.1    Akuta, N.2    Suzuki, Y.3    Sezaki, H.4    Yatsuji, H.5    Kawamura, Y.6
  • 85
    • 1242269919 scopus 로고    scopus 로고
    • Evidence that plasma concentration rather than dose per kilogram body weight predicts ribavirin-induced anaemia
    • DOI 10.1046/j.1365-2893.2003.00475.x
    • Lindahl K, Schvarcz R, Bruchfeld A, Ståhle L. Evidence that plasma concentration rather than dose per kilogram body weight predicts ribavirin-induced anemia. J Viral Hepat 2004;11:84-7. (Pubitemid 38221622)
    • (2004) Journal of Viral Hepatitis , vol.11 , Issue.1 , pp. 84-87
    • Lindahl, K.1    Schvarcz, R.2    Bruchfeld, A.3    Stahle, L.4
  • 88
    • 31844455940 scopus 로고    scopus 로고
    • Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population
    • DOI 10.1373/clinchem.2005.059501
    • Shipkova M, Lorenz K, Oellerich M, Wieland E, von Ahsen N. Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population. Clin Chem 2006;52:240-7. (Pubitemid 43185485)
    • (2006) Clinical Chemistry , vol.52 , Issue.2 , pp. 240-247
    • Shipkova, M.1    Lorenz, K.2    Oellerich, M.3    Wieland, E.4    Von Ansen, N.5
  • 91
    • 0036952564 scopus 로고    scopus 로고
    • DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency
    • Cao H, Hegele RA. DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency. J Hum Genet 2002;47:620-2. (Pubitemid 36083264)
    • (2002) Journal of Human Genetics , vol.47 , Issue.11 , pp. 620-622
    • Cao, H.1    Hegele, R.A.2
  • 94
    • 35348853228 scopus 로고    scopus 로고
    • Pharmacogenetic significance of inosine triphosphatase
    • DOI 10.2217/14622416.8.9.1221
    • Bierau J, Lindhout M, Bakker JA. Pharmacogenetic significance of inosine triphosphatase. Pharmacogenomics 2007;8: 1221-8. (Pubitemid 47578231)
    • (2007) Pharmacogenomics , vol.8 , Issue.9 , pp. 1221-1228
    • Bierau, J.1    Lindhout, M.2    Bakker, J.A.3
  • 95
    • 58449117037 scopus 로고    scopus 로고
    • Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia
    • Stocco G, Cheok MH, Crews KR, Dervieux T, French D, Pei D, et al. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin Pharmacol Ther 2009;85:164-72.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 164-72
    • Stocco, G.1    Cheok, M.H.2    Crews, K.R.3    Dervieux, T.4    French, D.5    Pei, D.6
  • 96
    • 49549145055 scopus 로고
    • Individual variation in inosine triphosphate accumulation in human erythrocytes
    • Fraser JH, Meyers H, Henderson JF, Brox LW, McCoy EE. Individual variation in inosine triphosphate accumulation in human erythrocytes. Clin Biochem 1975;8:353-64.
    • (1975) Clin Biochem , vol.8 , pp. 353-64
    • Fraser, J.H.1    Meyers, H.2    Henderson, J.F.3    Brox, L.W.4    McCoy, E.E.5
  • 97
    • 79953208979 scopus 로고    scopus 로고
    • Inosine triphosphate protects against ribavirin-induced ATP loss by restoring adenylosuccinate synthase function
    • Hitomi Y, Cirulli ET, Fellay J, McHutchison JG, Thompson AJ, Gumbs CE, et al. Inosine triphosphate protects against ribavirin-induced ATP loss by restoring adenylosuccinate synthase function. Gastroenterology 2011;140:1314-21.
    • (2011) Gastroenterology , vol.140 , pp. 1314-21
    • Hitomi, Y.1    Cirulli, E.T.2    Fellay, J.3    McHutchison, J.G.4    Thompson, A.J.5    Gumbs, C.E.6
  • 98
    • 77957326039 scopus 로고    scopus 로고
    • Variants in the ITPA gene protect against ribavirininduced hemolytic anemia and decrease the need for ribavirin dose reduction
    • Thompson AJ, Fellay J, Patel K, Tillmann HL, Naggie S, Ge D, et al. Variants in the ITPA gene protect against ribavirininduced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology 2010;139:1181-9.
    • (2010) Gastroenterology , vol.139 , pp. 1181-9
    • Thompson, A.J.1    Fellay, J.2    Patel, K.3    Tillmann, H.L.4    Naggie, S.5    Ge, D.6
  • 99
    • 79251518906 scopus 로고    scopus 로고
    • Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/ 3 but do not decrease dose reductions of RBV or increase SVR
    • Thompson AJ, Santoro R, Piazzolla V, Clark PJ, Naggie S, Tillmann HL, et al. Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/ 3 but do not decrease dose reductions of RBV or increase SVR. Hepatology 2011;53:389-95.
    • (2011) Hepatology , vol.53 , pp. 389-95
    • Thompson, A.J.1    Santoro, R.2    Piazzolla, V.3    Clark, P.J.4    Naggie, S.5    Tillmann, H.L.6
  • 100
    • 77957346513 scopus 로고    scopus 로고
    • ITPA polymorphism affects ribavirin-induced anemia and outcome of therapy -a genome-wide study of Japanese HCV patients
    • Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, et al. ITPA polymorphism affects ribavirin-induced anemia and outcome of therapy -a genome-wide study of Japanese HCV patients. Gastroenterology 2010;139:1190-7.
    • (2010) Gastroenterology , vol.139 , pp. 1190-7
    • Ochi, H.1    Maekawa, T.2    Abe, H.3    Hayashida, Y.4    Nakano, R.5    Kubo, M.6
  • 101
    • 77958609097 scopus 로고    scopus 로고
    • ITPA gene variant protects against anemia induced by PEGylated interferon-a and ribavirin therapy for Japanese patients with chronic hepatitis C
    • Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, et al. ITPA gene variant protects against anemia induced by PEGylated interferon-a and ribavirin therapy for Japanese patients with chronic hepatitis C. Hepatol Res 2010;40:1063-71.
    • (2010) Hepatol Res , vol.40 , pp. 1063-71
    • Sakamoto, N.1    Tanaka, Y.2    Nakagawa, M.3    Yatsuhashi, H.4    Nishiguchi, S.5    Enomoto, N.6
  • 102
    • 79151483121 scopus 로고    scopus 로고
    • Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir
    • Suzuki F, Suzuki Y, Akuta N, Sezaki H, Hirakawa M, Kawamura Y, et al. Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir. Hepatology 2011;53:415-21.
    • (2011) Hepatology , vol.53 , pp. 415-21
    • Suzuki, F.1    Suzuki, Y.2    Akuta, N.3    Sezaki, H.4    Hirakawa, M.5    Kawamura, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.