메뉴 건너뛰기




Volumn 11, Issue 7, 2011, Pages 638-642

Development of focal adhesion kinase inhibitors in cancer therapy

Author keywords

Cancer therapy; Drug development; FAK; Focal adhesion kinase

Indexed keywords

1,2,4,5 BENZENETETRAAMINE; 2 [5 CHLORO 2 [2 METHOXY 4 (4 MORPHOLINYL)PHENYLAMINO] PYRIMIDIN 4 YLAMINO] N METHYLBENZAMIDE; ADENOSINE TRIPHOSPHATE; CFAK C4; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; PF 04554878; PF 562271; TIVANTINIB; UNCLASSIFIED DRUG;

EID: 80051760309     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/187152011796817628     Document Type: Article
Times cited : (32)

References (50)
  • 2
    • 38949089708 scopus 로고    scopus 로고
    • Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic intervention
    • Parsons, J. T.; Slack-Davis, J.; Tilghman, R.; Roberts, W. G., Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention. Clin Cancer Res 2008, 14 (3), 627-32.
    • (2008) Clin Cancer Res , vol.14 , Issue.3 , pp. 627-632
    • Parsons, J.T.1    Slack-Davis, J.2    Tilghman, R.3    Roberts, W.G.4
  • 3
    • 80051724950 scopus 로고    scopus 로고
    • Focal Adhesion Kinase as a Therapeutic Target in Cancer
    • Gan, H. K.; Siu, L. L., Focal Adhesion Kinase as a Therapeutic Target in Cancer. ASCO 2009 Educational Book 2009, 130-136.
    • (2009) ASCO 2009 Educational Book , pp. 130-136
    • Gan, H.K.1    Siu, L.L.2
  • 6
    • 48849112195 scopus 로고    scopus 로고
    • Focal adhesion kinase versus p53: Apoptosis or survival
    • Cance, W. G.; Golubovskaya, V. M., Focal adhesion kinase versus p53: apoptosis or survival? Sci Signal 2008, 1 (20), pe22.
    • (2008) Sci Signal , vol.1 , Issue.20 , pp. 22
    • Cance, W.G.1    Golubovskaya, V.M.2
  • 8
    • 0029666251 scopus 로고    scopus 로고
    • P130cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
    • Harte, M. T.; Hildebrand, J. D.; Burnham, M. R.; Bouton, A. H.; Parsons, J. T., p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J Biol Chem 1996, 271 (23), 13649-55.
    • (1996) J Biol Chem , vol.271 , Issue.23 , pp. 13649-13655
    • Harte, M.T.1    Hildebrand, J.D.2    Burnham, M.R.3    Bouton, A.H.4    Parsons, J.T.5
  • 9
    • 0035985220 scopus 로고    scopus 로고
    • The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly
    • Liu, Y.; Loijens, J. C.; Martin, K. H.; Karginov, A. V.; Parsons, J. T., The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell 2002, 13 (6), 2147-56.
    • (2002) Mol Biol Cell , vol.13 , Issue.6 , pp. 2147-2156
    • Liu, Y.1    Loijens, J.C.2    Martin, K.H.3    Karginov, A.V.4    Parsons, J.T.5
  • 10
    • 0032478821 scopus 로고    scopus 로고
    • Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase
    • Taylor, J. M.; Hildebrand, J. D.; Mack, C. P.; Cox, M. E.; Parsons, J. T., Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase. J Biol Chem 1998, 273 (14), 8063-70.
    • (1998) J Biol Chem , vol.273 , Issue.14 , pp. 8063-8070
    • Taylor, J.M.1    Hildebrand, J.D.2    Mack, C.P.3    Cox, M.E.4    Parsons, J.T.5
  • 11
    • 0027448821 scopus 로고
    • Expression of focal adhesion kinase gene and invasive cancer
    • Weiner, T. M.; Liu, E. T.; Craven, R. J.; Cance, W. G., Expression of focal adhesion kinase gene and invasive cancer. Lancet 1993, 342 (8878), 1024-5.
    • (1993) Lancet , vol.342 , Issue.8878 , pp. 1024-1025
    • Weiner, T.M.1    Liu, E.T.2    Craven, R.J.3    Cance, W.G.4
  • 12
    • 0037359549 scopus 로고    scopus 로고
    • Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation
    • Lipinski, C. A.; Tran, N. L.; Bay, C.; Kloss, J.; McDonough, W. S.; Beaudry, C.; Berens, M. E.; Loftus, J. C., Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation. Mol Cancer Res 2003, 1 (5), 323-32.
    • (2003) Mol Cancer Res , vol.1 , Issue.5 , pp. 323-332
    • Lipinski, C.A.1    Tran, N.L.2    Bay, C.3    Kloss, J.4    McDonough, W.S.5    Beaudry, C.6    Berens, M.E.7    Loftus, J.C.8
  • 13
    • 33747837804 scopus 로고    scopus 로고
    • Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells
    • Wu, Z. M.; Yuan, X. H.; Jiang, P. C.; Li, Z. Q.; Wu, T., Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells. J Neurooncol 2006, 77 (2), 117-23.
    • (2006) J Neurooncol , vol.77 , Issue.2 , pp. 117-123
    • Wu, Z.M.1    Yuan, X.H.2    Jiang, P.C.3    Li, Z.Q.4    Wu, T.5
  • 14
    • 0032443850 scopus 로고    scopus 로고
    • The COOHterminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells
    • Xu, L. H.; Yang, X.; Craven, R. J.; Cance, W. G., The COOHterminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells. Cell Growth Differ 1998, 9 (12), 999-1005.
    • (1998) Cell Growth Differ , vol.9 , Issue.12 , pp. 999-1005
    • Xu, L.H.1    Yang, X.2    Craven, R.J.3    Cance, W.G.4
  • 15
    • 0034730632 scopus 로고    scopus 로고
    • The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways
    • Xu, L. H.; Yang, X.; Bradham, C. A.; Brenner, D. A.; Baldwin, A. S., Jr.; Craven, R. J.; Cance, W. G., The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem 2000, 275 (39), 30597-604.
    • (2000) J Biol Chem , vol.275 , Issue.39 , pp. 30597-33604
    • Xu, L.H.1    Yang, X.2    Bradham, C.A.3    Brenner, D.A.4    Baldwin Jr., A.S.5    Craven, R.J.6    Cance, W.G.7
  • 16
    • 0037064030 scopus 로고    scopus 로고
    • Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells
    • Golubovskaya, V.; Beviglia, L.; Xu, L. H.; Earp, H. S., 3rd; Craven, R.; Cance, W., Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem 2002, 277 (41), 38978-87.
    • (2002) J Biol Chem , vol.277 , Issue.41 , pp. 38978-38987
    • Golubovskaya, V.1    Beviglia, L.2    Xu, L.H.3    Earp, H.S.4    Craven, R.5    Cance, W.6
  • 17
    • 0030777767 scopus 로고    scopus 로고
    • Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase
    • Xiong, W.; Parsons, J. T., Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. J Cell Biol 1997, 139 (2), 529-39.
    • (1997) J Cell Biol , vol.139 , Issue.2 , pp. 529-539
    • Xiong, W.1    Parsons, J.T.2
  • 18
    • 27644545721 scopus 로고    scopus 로고
    • Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5- fluorouracil on the viability of melanoma cell lines
    • Smith, C. S.; Golubovskaya, V. M.; Peck, E.; Xu, L. H.; Monia, B. P.; Yang, X.; Cance, W. G., Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5- fluorouracil on the viability of melanoma cell lines. Melanoma Res 2005, 15 (5), 357-62.
    • (2005) Melanoma Res , vol.15 , Issue.5 , pp. 357-362
    • Smith, C.S.1    Golubovskaya, V.M.2    Peck, E.3    Xu, L.H.4    Monia, B.P.5    Yang, X.6    Cance, W.G.7
  • 22
    • 72549093102 scopus 로고    scopus 로고
    • Targeting Pyk2 for therapeutic intervention
    • Lipinski, C. A.; Loftus, J. C., Targeting Pyk2 for therapeutic intervention. Expert Opin Ther Targets 14 (1), 95-108.
    • Expert Opin Ther Targets , vol.14 , Issue.1 , pp. 95-108
    • Lipinski, C.A.1    Loftus, J.C.2
  • 25
    • 79952774782 scopus 로고    scopus 로고
    • Focal Adhesion Kinase as a Cancer Therapy Target
    • Golubovskaya, V. M., Focal Adhesion Kinase as a Cancer Therapy Target. Anticancer Agents Med Chem 10 (10), 735-741.
    • Anticancer Agents Med Chem , vol.10 , Issue.10 , pp. 735-741
    • Golubovskaya, V.M.1
  • 26
    • 34248136479 scopus 로고    scopus 로고
    • Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
    • Liu, T. J.; LaFortune, T.; Honda, T.; Ohmori, O.; Hatakeyama, S.; Meyer, T.; Jackson, D.; de Groot, J.; Yung, W. K., Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther 2007, 6 (4), 1357-67.
    • (2007) Mol Cancer Ther , vol.6 , Issue.4 , pp. 1357-1367
    • Liu, T.J.1    Lafortune, T.2    Honda, T.3    Ohmori, O.4    Hatakeyama, S.5    Meyer, T.6    Jackson, D.7    de Groot, J.8    Yung, W.K.9
  • 27
    • 57049091187 scopus 로고    scopus 로고
    • Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation
    • Lietha, D.; Eck, M. J., Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One 2008, 3 (11), e3800.
    • (2008) PLoS One , vol.3 , Issue.11
    • Lietha, D.1    Eck, M.J.2
  • 31
    • 79952746902 scopus 로고    scopus 로고
    • Final report of phase I clinical, pharmacokinetic (PK), pharmacodynamic (PD) study of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with solid tumors
    • (suppl; abstr 3028)
    • Dhani, N. C.; Burris, H.; Siu, L. L.; Cambidge, D. R.; Mileshkin, L. R.; Xu, H.; Pierce, K. J.; Fahey, N. R.; Fingert, H. J.; Shreeve, S. M., Final report of phase I clinical, pharmacokinetic (PK), pharmacodynamic (PD) study of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with solid tumors. J Clin Oncol 28:15s, 2010 (suppl; abstr 3028).
    • (2010) J Clin Onco , vol.28 , Issue.15
    • Dhani, N.C.1    Burris, H.2    Siu, L.L.3    Cambidge, D.R.4    Mileshkin, L.R.5    Xu, H.6    Pierce, K.J.7    Fahey, N.R.8    Fingert, H.J.9    Shreeve, S.M.10
  • 32
    • 80051747204 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of PF-562271, a focal adhesion kinase (FAK) inhibitor, and its effect on CYP3A in patients with advanced nonhematologic malignancies
    • (suppl; abstr 2553)
    • Xu, H.; Yin, D.; Pierce, K. J.; Shreeve, S. M.; Duncan, B.; Bello, A., Pharmacokinetics (PK) of PF-562271, a focal adhesion kinase (FAK) inhibitor, and its effect on CYP3A in patients with advanced nonhematologic malignancies. J Clin Oncol 28:15s, 2010 (suppl; abstr 2553).
    • (2010) J Clin Oncol , vol.28 , Issue.15
    • Xu, H.1    Yin, D.2    Pierce, K.J.3    Shreeve, S.M.4    Duncan, B.5    Bello, A.6
  • 33
    • 77952474080 scopus 로고    scopus 로고
    • A phase I clinical, pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with advanced solid tumors
    • (May 20 suppl; abstr 3534)
    • Siu, L. L.; Burris, H.; Mileshkin, L. R.; Camidge, R.; Eckhardt, S.; Lamb, A.; Chen, E. X.; Jones, S. F.; Xu, H.; Fingert, H., A phase I clinical, pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of PF-00562271 targeting focal adhesion kinase (FAK) in patients (pts) with advanced solid tumors. J Clin Oncol 26: 2008 (May 20 suppl; abstr 3534).
    • (2008) J Clin Oncol , vol.26
    • Siu, L.L.1    Burris, H.2    Mileshkin, L.R.3    Camidge, R.4    Eckhardt, S.5    Lamb, A.6    Chen, E.X.7    Jones, S.F.8    Xu, H.9    Fingert, H.10
  • 35
    • 4444378842 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma
    • Nishida, N.; Yano, H.; Komai, K.; Nishida, T.; Kamura, T.; Kojiro, M., Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma. Cancer 2004, 101 (6), 1364-74.
    • (2004) Cancer , vol.101 , Issue.6 , pp. 1364-1374
    • Nishida, N.1    Yano, H.2    Komai, K.3    Nishida, T.4    Kamura, T.5    Kojiro, M.6
  • 36
    • 1142299737 scopus 로고    scopus 로고
    • Expression and significance of VEGF-C and FLT-4 in gastric cancer
    • Liu, X. E.; Sun, X. D.; Wu, J. M., Expression and significance of VEGF-C and FLT-4 in gastric cancer. World J Gastroenterol 2004, 10 (3), 352-5.
    • (2004) World J Gastroenterol , vol.10 , Issue.3 , pp. 352-355
    • Liu, X.E.1    Sun, X.D.2    Wu, J.M.3
  • 37
    • 1242269816 scopus 로고    scopus 로고
    • Role of lymphangiogenic factors in tumor metastasis
    • He, Y.; Karpanen, T.; Alitalo, K., Role of lymphangiogenic factors in tumor metastasis. Biochim Biophys Acta 2004, 1654 (1), 3-12.
    • (2004) Biochim Biophys Acta , vol.1654 , Issue.1 , pp. 3-12
    • He, Y.1    Karpanen, T.2    Alitalo, K.3
  • 40
    • 32944475609 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells
    • Garces, C. A.; Kurenova, E. V.; Golubovskaya, V. M.; Cance, W. G., Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res 2006, 66 (3), 1446-54.
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1446-1454
    • Garces, C.A.1    Kurenova, E.V.2    Golubovskaya, V.M.3    Cance, W.G.4
  • 41
    • 68549120961 scopus 로고    scopus 로고
    • Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo
    • Kurenova, E. V.; Hunt, D. L.; He, D.; Magis, A. T.; Ostrov, D. A.; Cance, W. G., Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem 2009, 52 (15), 4716-24.
    • (2009) J Med Chem , vol.52 , Issue.15 , pp. 4716-4724
    • Kurenova, E.V.1    Hunt, D.L.2    He, D.3    Magis, A.T.4    Ostrov, D.A.5    Cance, W.G.6
  • 43
    • 0028342938 scopus 로고
    • Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain
    • Xing, Z.; Chen, H. C.; Nowlen, J. K.; Taylor, S. J.; Shalloway, D.; Guan, J. L., Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell 1994, 5 (4), 413-21.
    • (1994) Mol Biol Cell , vol.5 , Issue.4 , pp. 413-421
    • Xing, Z.1    Chen, H.C.2    Nowlen, J.K.3    Taylor, S.J.4    Shalloway, D.5    Guan, J.L.6
  • 44
    • 0028173980 scopus 로고
    • Stable association of pp60src and pp59fyn with the focal adhesionassociated protein tyrosine kinase, pp125FAK
    • Cobb, B. S.; Schaller, M. D.; Leu, T. H.; Parsons, J. T., Stable association of pp60src and pp59fyn with the focal adhesionassociated protein tyrosine kinase, pp125FAK. Mol Cell Biol 1994, 14 (1), 147-55.
    • (1994) Mol Cell Biol , vol.14 , Issue.1 , pp. 147-155
    • Cobb, B.S.1    Schaller, M.D.2    Leu, T.H.3    Parsons, J.T.4
  • 45
    • 0028350859 scopus 로고
    • Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
    • Schaller, M. D.; Hildebrand, J. D.; Shannon, J. D.; Fox, J. W.; Vines, R. R.; Parsons, J. T., Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 1994, 14 (3), 1680-8.
    • (1994) Mol Cell Biol , vol.14 , Issue.3 , pp. 1680-1688
    • Schaller, M.D.1    Hildebrand, J.D.2    Shannon, J.D.3    Fox, J.W.4    Vines, R.R.5    Parsons, J.T.6
  • 46
    • 0031081425 scopus 로고    scopus 로고
    • Signaling through focal adhesion kinase
    • Hanks, S. K.; Polte, T. R., Signaling through focal adhesion kinase. Bioessays 1997, 19 (2), 137-45.
    • (1997) Bioessays , vol.19 , Issue.2 , pp. 137-145
    • Hanks, S.K.1    Polte, T.R.2
  • 47
    • 57349153946 scopus 로고    scopus 로고
    • Small molecule inhibitor A.1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth
    • Golubovskaya, V. M.; Nyberg, C.; Zheng, M.; Kweh, F.; Magis, A.; Ostrov, D.; Cance, W. G., A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem 2008, 51 (23), 7405-16.
    • (2008) J Med Chem , vol.51 , Issue.23 , pp. 7405-7416
    • Golubovskaya, V.M.1    Nyberg, C.2    Zheng, M.3    Kweh, F.4    Magis, A.5    Ostrov, D.6    Cance, W.G.7
  • 49
    • 64249135764 scopus 로고    scopus 로고
    • Novel agents on the horizon for cancer therapy
    • Ma, W. W.; Adjei, A. A., Novel agents on the horizon for cancer therapy. CA Cancer J Clin 2009, 59 (2), 111-37.
    • (2009) CA Cancer J Clin , vol.59 , Issue.2 , pp. 111-137
    • Ma, W.W.1    Adjei, A.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.