Posttraumatic stress disorder from Vietnam to today: The evolution of understanding during eugene brody's tenure at the journal of nervous and mental disease

Journal of Nervous and Mental Disease

Volumn 199, Issue 8, 2011, Pages 544-552

  Benedek, David M ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

cognitive therapy; exposure based psychotherapy; fear response; Posttraumatic stress disorder (PTSD); practice guidelines; SSRIs

Indexed keywords

4 AMINOBUTYRIC ACID; ADRENALIN; AMFEBUTAMONE; CORTICOTROPIN RELEASING FACTOR; FLUOXETINE; GABAPENTIN; GLUCOCORTICOID; MIRTAZAPINE; N METHYL DEXTRO ASPARTIC ACID; NEFAZODONE; NORADRENALIN; OLANZAPINE; PRAZOSIN; PROPRANOLOL; RISPERIDONE; SERTRALINE; TIAGABINE; TOPIRAMATE; VALPROATE SEMISODIUM; VENLAFAXINE;

BEHAVIOR THERAPY; CENTRAL NERVOUS SYSTEM FUNCTION; COGNITIVE THERAPY; DISEASE SEVERITY; DRUG DOSE TITRATION; FEAR; GENETIC PREDISPOSITION; GROUP THERAPY; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; METABOLIC PARAMETERS; POSTTRAUMATIC STRESS DISORDER; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RAPE; REM SLEEP; REVIEW; RISK FACTOR; SEROTONINERGIC SYSTEM; SEX DIFFERENCE; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM; STRESS; TREATMENT OUTCOME; TREATMENT RESPONSE; VIET NAM; VIOLENCE; WEIGHT GAIN;

COGNITIVE THERAPY; EYE MOVEMENT DESENSITIZATION REPROCESSING; HUMANS; PREVALENCE; PSYCHOTHERAPY, GROUP; SEROTONIN UPTAKE INHIBITORS; STRESS DISORDERS, POST-TRAUMATIC; WAR;

EID: 80051757578     PISSN: 00223018     EISSN: 1539736X     Source Type: Journal    
DOI: 10.1097/NMD.0b013e318225f0e9     Document Type: Review

References (89)

1. American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (3rd ed). Washington, DC: American Psychiatric Association.
2. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (4th ed). Washington, DC: American Psychiatric Association.
3. American Psychiatric Association (2004a) Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry. 161:1-56.
4. American Psychiatric Association (2004b) Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder. Arlington, VA: American Psychiatric Association.
5. American Psychiatric Association (2008) Practice guidelines for the treatment of patients with panic disorders (2nd ed). Arlington, VA: American Psychiatric Association.
6. Baker DG,West SA, Niholson WE, Ekhator NN, Kasckow JW, Hill KK, Bruce AB, Orth DN, Geracioti TD Jr (1999) Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 156:585-588.
7. Bartzokis G, Lu PH, Turner J, Mintz J, Saunders CS (2005) Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder. Biol Psychiatry. 57:474-479.
8. Basoglu M, Salcioglu E, Livanou M (2007) A randomized controlled study of single-session behavioural treatment of earthquake-related post-traumatic stress disorder using an earthquake simulator. Psychol Med. 37:203-213.
9. Basoglu M, Salcioglu E, Livanou M, Kalender D, Acar G (2005) Single-session behavioral treatment of earthquake-related posttraumatic stress disorder: A randomized waiting list controlled trial. J Trauma Stress. 18:1-11.
10. Becker ME, Hertzberg MA, Moore SD, Dennis MF, Bukenya DS, Beckham JC (2007) A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder. J Clin Psychopharmacol. 27:193-197.
11. Benedek DM, Friedman MJ, Zarzick D, Ursano RJ, Guideline Watch (2009) Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorder. Focus. 7(2):204-213.
12. Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, Tang Y, Gillespie CF, Heim CM, Nemeroff CB, Schwartz AC, Cubells JF, Ressler KJ (2008) Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA. 299: 1291-1305.
13. Bremner JD, Elzinga B, Schmahl C, Vermetten E (2008) Structural and functional
14. Bremner JD, Innis RB, Southwick SM, Staib L, Zoghbi S, Charney DS (2000) Decreased benzodiazepine receptor binding in prefrontal cortex in combat related posttraumatic stress disorder. Am J Psychiatry. 157:1120-1126.
15. Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS (1997) Elevated CSF corticotropin-releasing factors concentrations in posttraumatic stress disorder. Am J Psychiatry. 154:624-629.
16. Breslau N, Davis GC, Andreski P, Peterson E (1991) Traumatic events and posttraumatic stress disorder in an urban population of young adults. Arch Gen Psychiatry. 48:216-222.
17. Breslau N, Kessler RC, Chilcoat HD, Schultz LR, Davis GC, Andreski P (1998) Trauma and posttraumatic stress disorder in the community: The 1996 Detroit Area Survey of Trauma. Arch Gen Psychiatry. 55:626-632.
18. Chard KM (2005) An evaluation of cognitive processing therapy for the treatment of posttraumatic stress disorder related to childhood sexual abuse. J Consult Clin Psychol. 73:965-971.
19. Comings DE, Muhleman D, Glysin R (1996) Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication. Biol Psychiatry. 40:368-372.
20. Connor KM, Davidson JR,Weisler RH, ZhangW, Abraham K (2006) Tiagabine for posttraumatic stress disorder: Effects of open-label and double-blind discontinuation treatment. Psychopharmacology (Berl). 184:21-25.
21. Creamer M, Burgess P, McFarlane AC (2001) Post-traumatic stress disorder: Findings from the Australian National Survey of Mental Health and Well- Being. Psychol Med. 31:1237-1247.
22. Davidson J, Baldwin D, Stein DJ, Kuper E, Benattia I, Ahmed S, Pedersen R, Musgnung J (2006a) Treatment of posttraumatic stress disorder with venlafaxine extended release: A 6-month randomized controlled trial. Arch Gen Psychiatry. 63:1158-1165.
23. Davidson J, Rothbaum BO, Tucker P, Asnis G, Benattia I, Musgnung JJ (2006b) Venlafaxine extended release in posttraumatic stress disorder: A sertraline- and placebo-controlled study. J Clin Psychopharmacol. 26:259-267.
24. Davidson JR, Brady K, Mellman TA, Stein MB, Pollack MH (2007) The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder. J Clin Psychopharmacol. 27:85-88.
25. Davidson JR, Connor KM, Hertzberg MA, Weisler RH, Wilson WH, Payne VM (2005) Maintenance therapy with fluoxetine in posttraumatic stress disorder: A placebo-controlled discontinuation study. J Clin Psychopharmacol. 25:166-169.
26. Davidson JR, Weisler RH, Butterfield MI, Casat CD, Connor KM, Barnett S, van Meter S (2003) Mirtazapine vs. placebo in posttraumatic stress disorder: A pilot trial. Biol Psychiatry. 53:188-191.
27. Davis LL, Jewell ME, Ambrose S, Farley J, English B, Bartolucci A, Petty F (2004) A placebo-controlled study of nefazodone for the treatment of chronic posttraumatic stress disorder: A preliminary study. J Clin Psychopharmacol. 24:291-297.
28. Davis LL, Davidson JR, Ward LC, Bartolucci A, Bowden CL, Petty F (2008) Divalproex in the treatment of posttraumatic stress disorder: A randomized, double-blind, placebo-controlled trial in a veteran population. J Clin Psychopharmacol. 28:84-88.
29. Davis M, Ressler K, Rothbaum BO, Richardson R (2006) Effects of D-cycloserine on extinction: Translation from preclinical to clinical work. Biol Psychiatry. 60:369-375.
30. Difede J, Cukor J, Jayasinghe N, Patt I, Jedel S, Spielman L, Giosan C, Hoffman HG (2007) Virtual reality exposure therapy for the treatment of posttraumatic stress disorder following September 11, 2001. J Clin Psychiatry. 68:1639-1647.
31. Friedman MJ, Marmar CR, Baker DG, Sikes CR, Farfel GM (2007) Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting. J Clin Psychiatry. 68:711-720.
32. Gavish M, Laor N, Bidder M, Fisher D, Fonia O, Muller U, Reiss A, Wolmer L, Karp L, Weizman R (1996) Altered platelet peripheral-type benzodiazepine receptor in posttraumatic stress disorder. Neuropsychopharmacology. 14:181-186.
33. Gerardi M, Rothbaum BO, Ressler K, Heekin M, Rizzo A (2008) Virtual reality exposure therapy using a virtual Iraq: Case report. J Trauma Stress. 21:209-213.
34. Geuze E, van Berckel BN, Lammertsma AA, Boellaard R, de Kloet CS, Vermetten E, Westenberg HG (2008) Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder. Mol Psychiatry. 13:74-83.
35. Glover H (1993) A preliminary trial of nalmefene for the treatment of emotional numbing combat veterans posttraumatic stress disorder. Isr J Psychiatry Relat Sci. 30:255-263.
36. Guthrie RM, Bryant RA (2006) Extinction learning before trauma and subsequent posttraumatic stress. Psychosom Med. 68:307-311.
37. Hamner MB, Faldowski RA, Ulmer HG, Frueh BC, Huber MG, Arana GW (2003) Adjunctive risperidone treatment in post-traumatic stress disorder: A preliminary controlled trial of effects on comorbid psychotic symptoms. Int Clin Psychopharmacol. 18:1-8.
38. Hertzberg MA, Feldman ME, Beckham JC, Kudler HS, Davidson JR (2000) Lack of efficacy for fluoxetine in PTSD: A placebo controlled trial in combat veterans. Ann Clin Psychiatry. 12:101-105.
39. Högberg G, Pagani M, Sundin O, Soares J, Aberg-Wistedt A, Tärnell B, Hällström T (2007) On treatment with eye movement desensitization and reprocessing of chronic post-traumatic stress disorder in public transportation workersVA randomized controlled trial. Nord J Psychiatry. 61:54-61.
40. Hoge CW, Castro CA, Messer SC, McGurk D, Cotting DI, Koffman RL (2004) Combat duty in Iraq and Afghanistan, mental health problems and barriers to care. N Engl J Med. 351:13-22.
41. Institute of Medicine (2007) Treatment of PTSD: An assessment of the evidence. Washington, DC: National Academies Press. Retrieved from http://www.iom.edu/?id=47402. Accessed May 15, 2011.
42. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 62:617-627.
43. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995) Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 52:1048-1060.
44. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB, Breslau N (1999) Epidemiological risk factors for trauma and PTSD. In R Yehuda (Ed), Risk factors of posttraumatic stress disorder (pp. 23-60). Washington, DC: American Psychiatry Press.
45. Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, Gelernter J (2007) The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. Am J Psychiatry. 164:1693-1699.
46. LeDoux J (2003) The emotional brain, fear, and the amygdala. Cell Mol Neurobiol. 23:727-738.
47. Marshall RD, Lewis-Fernandez R, Blanco C, Simpson HB, Lin SH, Vermes D, Garcia W, Schneier F, Neria Y, Sanchez-Lacay A, Liebowitz MR (2007) A controlled trial of paroxetine for chronic PTSD, dissociation, and interpersonal problems in mostly minority adults. Depress Anxiety. 24:77-84.
48. Martenyi F, Soldatenkova V (2006) Fluoxetine in the acute treatment and relapse prevention of combat-related post-traumatic stress disorder: Analysis of the veteran group of a placebo-controlled, randomized clinical trial. Eur Neuropsychopharmacol. 16:340-349.
49. McFarlane A (2004) The contribution of epidemiology to the study of traumatic stress. Soc Psychiatry Psychiatr Epidemiol. 39:874-882.
50. McRae AL, Brady KT, Mellman TA, Sonne SC, Killeen TK, Timmerman MA, Bayles-Dazet W (2004) Comparison of nefazodone and sertraline for the treatment of posttraumatic stress disorder. Depress Anxiety. 19:190-196.
51. Monson CM, Schnurr PP, Resick PA, Friedman MJ, Young-Xu Y, Stevens SP (2006) Cognitive processing therapy for veterans with military-related posttraumatic stress disorder. J Consult Clin Psychol. 74:898-907.
52. Myers KM, Davis M (2007) Mechanisms of fear extinction. Mol Psychiatry. 12: 120-150.
53. Neuner F, Schauer M, Klaschik C, Karunakara U, Elbert T (2004) A comparison of narrative exposure therapy, supportive counseling, and psychoeducation for treating posttraumatic stress disorder in an African refugee settlement. J Consult Clin Psychol. 72:579-587.
54. Newport DJ, Nemeroff CB (2000) Neurobiology of posttraumatic stress disorder. Curr Opin Neurobiology. 10:211-218.
55. Nugent NR, Amstadter AB, Koenen KC (2008) Genetics of posttraumatic stress disorder: Informing clinical conceptualization and promoting future research. Am J Med Genet C Semin Med Genet. 148:127-132.
56. Onder E, Tural U, Aker T (2006) A comparative study of fluoxetine, moclobemide, and tianeptine in the treatment of posttraumatic stress disorder following an earthquake. Eur Psychiatry. 21:174-179.
57. Padala PR, Madison J, Monnahan M, Marcil W, Price P, Ramaswamy S, Din AU, Wilson DR, Petty F (2006) Risperidone monotherapy for post-traumatic stress disorder related to sexual assault and domestic abuse in women. Int Clin Psychopharmacol. 21:275-280.
58. Pavcovich LA, Valentino RJ (1997) Regulation of a putative neurotransmitter effect of corticotropin-releasing factor: Effects of adrenalectomy. J Neurosci. 17:401-408.
59. Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP (2002) Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry. 51:189-192.
60. Pittman RK, Delahanty DL (2005) Conceptually driven pharmacologic approaches to acute trauma. CNS Spectr. 10:99-106.
61. Quirk GJ, Garcia R, Gonzalez-Lima F (2006) Prefrontal mechanisms in extinction of conditioned fear. Biol Psychiatry. 60:337-343.
62. Raskind MA, Peskind ER, Hoff DJ, Hart KL, Holmes HA, Warren D, Shofer J, O'Connell J, Taylor F, Gross C, Rohde K, McFall ME (2007) A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 61:928-934.
63. Raskind MA, Peskind ER, Kanter ED, Petrie EC, Radant A, Thompson CE, Dobie DJ, Hoff D, Rein RJ, Straits-Troster K, Thomas RG, McFall MM (2003) Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: A placebo-controlled study. Am J Psychiatry. 160:371-373.
64. Reich DB, Winternitz S, Hennen J, Watts T, Stanculescu C (2004) A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women. J Clin Psychiatry. 65:1601-1606.
65. Resick PA, Galovski TE, O'Brien UM, Scher CD, Clum GA, Young-Xu Y (2008) A randomized clinical trial to dismantle components of cognitive processing therapy for posttraumatic stress disorder in female victims of interpersonal violence. J Consult Clin Psychol. 76:243-258.
66. Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, Hodges L, Davis M (2004) Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 61:1136-1144.
67. Rothbaum BO, Astin MC, Marsteller F (2005) Prolonged exposure versus eye movement desensitization and reprocessing (EMDR) for PTSD rape victims. J Trauma Stress. 18:607-616.
68. Rothbaum BO, Killeen TK, Davidson JR, Brady KT, Connor KM, Heekin MH (2008) Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder. J Clin Psychiatry. 69:520-525.
69. Sack WH, Clarke GN, Seeley J (1995) Posttraumatic stress disorder across two generations of Cambodian refugees. J Am Acad Child Adolesc Psychiatry. 34: 1160-1166.
70. Schnurr PP, Friedman MJ, Engel CC, Foa EB, Shea MT, Chow BK, Resick PA, Thurston V, Orsillo SM, Haug R, Turner C, Bernardy N (2007) Cognitive behavioral therapy for posttraumatic stress disorder in women: A randomized controlled trial. JAMA. 297:820-830.
71. Sharot T, Delgado MR, Phelps EA (2004) How emotion enhances the feeling of remembering. Nat Neurosci. 7:1376-1380.
72. Southwick SM, Bremner JD, Rasmusson A, Morgan CA 3rd, Amsten A, Charney DS (1999) Role of norepinephrine in pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry. 46:1192-1204.
73. Spivak B, Strous RD, Shaked G, Shabash E, Kotler M, Weizman A (2006) Reboxetine versus fluvoxamine in the treatment of motor vehicle accidentrelated posttraumatic stress disorder: A double-blind, fixed-dosage, controlled trial. J Clin Psychopharmacol. 26:152-156.
74. Stein DJ, Ipser JC, Seedat S (2006a) Pharmacotherapy for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev. CD002795.
75. Stein DJ, van der Kolk BA, Austin C, Fayyad R, Clary C (2006b) Efficacy of sertraline in posttraumatic stress disorder secondary to interpersonal trauma or childhood abuse. Ann Clin Psychiatry. 18:243-249.
76. Stein MB, Kerridge C, Dimsdale JE, Hoyt DB (2007) Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress. 20:923-932.
77. Stein MB, Kline NA, Matloff JL (2002) Adjunctive olanzapine for SSRI-resistant combat-related PTSD: A double-blind, placebo-controlled study. Am J Psychiatry. 159:1777-1779.
78. Strawn JR, Geracioti TD (2008) Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress Anxiety. 25:260-271.
79. Su T, Zhang L, Chung M, Chen Y, Bi Y, Chou Y, Barker JL, Barrett JE, Maric D, Li X, Li H, Webster MJ, Benedek D, Carlton JR, Ursano R (2009) Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders. J Psych Research. 43:1078-1085.
80. Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, Peskind ER, Raskind MA (2008) Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: A placebo-controlled study. Biol Psychiatry. 63:629-632.
81. The Management of Post-traumatic Stress Working Group, (2011) The Management of Post-traumatic Stress Working Group (2011) VA/DoD clinical practice guideline for the management of post-traumatic stress. Retrieved April 15, 2011, from http://www.healthquality.va.gov/Post-Traumatic-Stress-Disorder- PTSD.asp.
82. Tucker P, Trautman RP, Wyatt DB, Thompson J, Wu SC, Capece JA, Rosenthal NR (2007) Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: A randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 68:201-206.
83. van der Kolk BA, Dreyfuss D, Michaels M, Shera D, Berkowitz R, Fisler R, Saxe G (1994) Fluoxetine in posttraumatic stress disorder. J Clin Psychiatry. 55: 517-522.
84. van der Kolk BA, Spinazzola J, Blaustein ME, Hopper JW, Hopper EK, Korn DL, Simpson WB (2007) A randomized clinical trial of eye movement desensitization and reprocessing (EMDR), fluoxetine, and pill placebo in the treatment of posttraumatic stress disorder: Treatment effects and long-term maintenance. J Clin Psychiatry. 68:37-46.
85. Wessa M, Flor H (2007) Failure of extinction of fear responses in posttraumatic stress disorder: Evidence from second-order conditioning. Am J Psychiatry. 164:1684-1692.
86. Wood DP, Murphy JA, Center KB, Russ C, McLay RN, Reeves D, Pyne J, Shilling R, Hagan J, Wiederhold BK (2008) Combat related posttraumatic stress disorder: A multiple case report using virtual reality graded exposure therapy with physiological monitoring. Stud Health Technol Inform. 132:556-561.
87. Yehuda R (2006) Advances in understanding neuroendocrine alternations in PTSD and their therapeutic implications. Ann N Y Acad Sci. 1071:137-166.
88. Yehuda R, Brand S, Yang RK (2006) Plasma neuropeptide Y concentrations in combat exposed veterans: Relationship to trauma exposure, recovery from PTSD, and coping. Biol Psychiatry. 59:660-663.
89. Zohar J, Amital D, Miodownik C, Kotler M, Bleich A, Lane RM, Austin C (2002) Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder. J Clin Psychopharmacol. 22:190-195.