New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation

Bioconjugate Chemistry

Volumn 22, Issue 8, 2011, Pages 1479-1483

  Aweda, Tolulope A ^a   Eskandari, Vahid ^a   Kukis, David L ^a   Boucher, David L ^a   Marquez, Bernadette V ^a   Beck, Heather E ^a   Mitchell, Gregory S ^a   Cherry, Simon R ^a   Meares, Claude F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; COVALENT BONDS; LUMINESCENCE; MEDICAL APPLICATIONS; METAL COMPLEXES; SULFUR COMPOUNDS; SYNTHESIS (CHEMICAL); TUMORS;

BINDING AFFINITIES; BIOMEDICAL APPLICATIONS; CERENKOV; DISULFIDE BOND FORMATION; IN-VIVO; LUMINESCENCE IMAGING; PROPERTY; RADIOLABELED PROBES; TUMOR TARGETS; TUMOR UPTAKE;

PROBES;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ANTINEOPLASTIC METAL COMPLEX; FLUORODEOXYGLUCOSE F 18; YTTRIUM 90;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; COVALENT BOND; DISULFIDE BOND; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; ENTROPY; GENE EXPRESSION; GLIOMA CELL; IN VIVO STUDY; INTESTINE; ISOTOPE LABELING; KIDNEY; LUMINESCENCE; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE; REPORTER GENE; SPLEEN; TARGET CELL DESTRUCTION;

EID: 80051738685     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc2002049     Document Type: Article

References (17)

1. Liu, S. (2009) Radiolabeled cyclic RGD Peptides as integrin alphavbeta3-targeted radiotracers: maximizing binding affinity via bivalency Bioconjugate Chem. 20, 2199-2213
2. Maresca, K. P., Marquis, J. C., Hillier, S. M., Lu, G., Femia, F. J., Zimmerman, C. N., Eckelman, W. C., Joyal, J. L., and Babich, J. W. (2010) Novel polar single amino acid chelates for technetium-99m tricarbonyl-based radiopharmaceuticals with enhanced renal clearance: application to octreotide Bioconjugate Chem. 21, 1032-1042
3. Goodwin, D. A., Meares, C. F., Watanabe, N., McTigue, M., Chaovapong, W., Ransone, C. M., Renn, O., Greiner, D. P., Kukis, D. L., and Kronenberger, S. I. (1994) Pharmacokinetics of pretargeted monoclonal antibody 2D12.5 and Y-88-janus-2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecanetetraacetic acid (DOTA) in Balb/c mice with KHJJ mouse adenocarcinoma-a model for Y-90 radioimmunotherapy Cancer Res. 54, 5937-5946
4. Weiden, P., Breitz, H., Press, O., Appelbaum, J., Stone, D., Bryan, K., Su, F., Axworthy, D., Hylarides, M., Theodore, L., Beaumier, P., and Reno, J. (1998) Radioimmunotherapy (RIT) in the treatment of non-Hodgkins lymphoma (NHL): Advantage of pretargeted RIT (PRITR) Blood 92, 414A-414A
5. Lin, Y. K., Pagel, L. M., Axworthy, D., Pantelias, A., Hedin, N., and Press, O. W. (2006) A genetically engineered anti-CD45 single-chain antibody-streptavidin fusion protein for pretargeted radioimmunotherapy of hematologic malignancies Cancer Res. 66, 3884-3892
6. Chmura, A. J., Orton, M. S., and Meares, C. F. (2001) Antibodies with infinite affinity Proc. Natl. Acad. Sci. U. S. A. 98, 8480-8484 (Pubitemid 32678053)
7. Goldenberg, D. M., Rossi, E. A., Sharkey, R. M., McBride, W. J., and Chang, C.-H. (2008) Multifunctional antibodies by the dock-and-lock method for improved cancer imaging and therapy by pretargeting J. Nucl. Med. 49, 158-163
8. Devaraj, N., Upadhyay, R, Haun, J. B., Hilderbrand, S. A., and Weissleder, R. (2009) Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition Angew. Chem. Intl. Ed. 48, 7013-7016
9. Corneillie, T. M., Lee, K. C., Whetstone, P. A., Wong, J. P., and Meares, C. F. (2004) Irreversible engineering of the multielement-binding antibody 2D12.5 and its complementary ligands Bioconjugate Chem. 15, 1392-1402 (Pubitemid 39552030)
10. Corneillie, T. M., Whetstone, P. A., Lee, K. C., Wong, J. P., and Meares, C. F. (2004) Converting weak binders into infinite binders Bioconjugate Chem. 15, 1389-1391 (Pubitemid 39552029)
11. Wei, L. H., Olafsen, T., Radu, C., Hildebrandt, I. J., McCoy, M. R., Phelps, M. E., Meares, C., Wu, A. M., Czernin, J., and Weber, W. A. (2008) Engineered antibody fragments with infinite affinity as reporter genes for PET imaging J. Nucl. Med. 49, 1828-1835
12. Aweda, T. A., Beck, H. E., Wu, A. M., Wei, L. H., Weber, W. A., and Meares, C. F. (2010) Rates and equilibria for probe capture by an antibody with infinite affinity Bioconjugate Chem. 21, 784-791
13. Corneillie, T. M., Fisher, A. J., and Meares, C. F. (2003) Crystal structures of two complexes of the rare-earth-DOTA-binding antibody 2D12.5: Ligand generality from a chiral system J. Am. Chem. Soc. 125, 15039-15048 (Pubitemid 37509667)
14. Schottelius, M., Rau, F., Reubi, J. C., Schwaiger, M., and Wester, H.-J. (2005) Modulation of pharmacokinetics of radioiodinated sugar-conjugated somatostatin analogues by variation of peptide net charge and carbohydration chemistry Bioconjugate Chem. 16, 429-437 (Pubitemid 40388219)
15. Robertson, R., Germanos, M. S., Li, C., Mitchell, G. S., Cherry, S. R., and Silva, M. D. (2009) Optical imaging of cerenkov light generation from positron-emitting radiotracers Phys. Med. Biol. 54, N355-365
16. Page, M. I. and Jencks, W. P. (1971) Entropic contributions to rate accelerations in enzymic and intramolecular reactions and chelate effect Proc. Natl. Acad. Sci. U. S. A. 68, 1678-1683
17. Day, J. J., Marquez, B. V., Beck, H. E., Aweda, T. A., Gawande, P. D., and Meares, C. F. (2010) Chemically modified antibodies as diagnostic imaging agents Curr. Opin. Chem. Biol. 14, 803-809