Targeted delivery in breast cancer cells via iodine: Nuclear localization sequence conjugate

Bioconjugate Chemistry

Volumn 22, Issue 8, 2011, Pages 1567-1575

  Wang, Hui Yuan ^a   Li, Cao ^a   Yi, Wen Jie ^a   Sun, Yun Xia ^a   Cheng, Si Xue ^a   Zhuo, Ren Xi ^a   Zhang, Xian Zheng ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DISEASES; EFFICIENCY; GENE EXPRESSION; GENE TRANSFER; LANTHANUM COMPOUNDS; MOLECULAR BIOLOGY; SODIUM COMPOUNDS;

BREAST CANCER CELLS; CELLULAR INTERNALIZATION; HELA CELL; MCF-7 CELLS; NONVIRAL VECTORS; NUCLEAR ACCUMULATION; NUCLEAR LOCALIZATION SEQUENCES; SYMPORTERS; TARGETED DELIVERY; TRANSFECTION EFFICIENCY;

IODINE;

DNA; IODIDE; IODINE;

ARTICLE; BREAST CANCER; CANCER CELL; CELL NUCLEUS; CELL STRAIN MCF 7; COMPLEX FORMATION; CONJUGATE; CYTOPLASM; CYTOTOXICITY; GENE EXPRESSION; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; LYSOSOME; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR LOCALIZATION SIGNAL; PARTICLE SIZE; PEPTIDE SYNTHESIS; REPORTER GENE; SODIUM TRANSPORT;

EID: 80051731815     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc2001177     Document Type: Article

References (25)

1. Howlader, N., Altekruse, S. F., and Edwards, B. K. (2010) Monitoring the Burden of Cancer in the United States, in Bioactive Compounds and Cancer (Milner, J. A. and Romagnolo, J. A., Eds.) pp 3-23, Humana Press, New York.
2. Morris, G. J. and Mitchell, E. P. (2008) Higher incidence of aggressive breast cancers in African-American women: A review J. Natl. Med. Assoc. 100, 698-702 (Pubitemid 351874447)
3. Ferlay, J., Héry, C., Autier, P., and Sankaranarayanan, R. (2010) Global Burden of Breast Cancer, in Breast Cancer Epidemiology (Li, C. I., Ed.) pp 1-19, Springer Science + Business Media, New York.
4. Edelstein, M. L., Abedi, M. R., and Wixon, J. (2007) Gene therapy clinical trials worldwide to 2007: an update J. Gene Med. 9, 833-42 (Pubitemid 47543250)
5. Lungwitz, U., Breunig, M., Blunk, T., and Gopferich, A. (2005) Polyethylenimine-based non-viral gene delivery systems Eur. J. Pharm. Biopharm. 60, 247-66 (Pubitemid 40804565)
6. Neu, M., Fischer, D., and Kissel, T. (2005) Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives J. Gene Med. 7, 992-1009 (Pubitemid 41195062)
7. Kunath, K., Harpe, von A., Fischer, D., Petersen, H., Bickel, U., Voigt, K., and Kissel, T. (2003) Low-molecular-weight polyethyleneimine as a non-viral vector for DNA Delivery: comparison of physicochemical Properties, transfection efficiency and in vivo distribution with high-molecular- weight polyethyleneimine J. Controlled Release 89, 113-25 (Pubitemid 36412116)
8. Zeng, J., Wang, X., and Wang, S. (2007) Self-assembled ternary complexes of plasmid DNA, low molecular weight polyethylenimine and targeting peptide for nonviral gene delivery into neurons Biomaterials 28, 1443-51 (Pubitemid 46001462)
9. Pouton, C. W., Wagstaff, K. M., Roth, D. M., Moseley, G. W., and Jans, D. A. (2007) Targeted delivery to the nucleus Adv. Drug Delivery Rev. 59, 698-717 (Pubitemid 47320817)
10. Arenal, A., Pimentel, R., Garcia, C., Pimentel, E., and Alestrom, P. (2004) The SV40 T antigen nuclear localization sequence enhances Nuclear import of vector DNA in embryos of a crustacean (Litopenaeus schmitti) Gene 337, 71-7 (Pubitemid 38970106)
11. Nagasaki, T., Myohoji, T., Tachibana, T., Futaki, S., and Tamagaki, S. (2003) Can nuclear localization signals enhance nuclear localization of plasmid DNA? Bioconjugate Chem. 14, 282-6 (Pubitemid 36348650)
12. van der Aa., M, Koning, G. A., d'Oliveira, C., Oosting, R. S., Wilschut, K. J., Hennink, W. E., and Crommelin, D. J. (2005) An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems J. Gene Med. 7, 208-17 (Pubitemid 40348025)
13. Spitzweg, C., Joba, W., Eisenmenger, W., and Heufelder, A. E. (1998) Analysis of human sodium iodide symporter gene expression in extra-thyroidal tissues and cloning of its complementary deoxyribo-nucleic acids from salivary gland, mammary gland, and gastric mucosa J. Clin. Endocr. Metab. 83, 1746-51 (Pubitemid 28501052)
14. Kilbane, M. T., Ajjan, R. A., Weetman, A. P., Dwyer, R., Mcdermott, E. W. M., O' Higgins, N. J., and Smith, P. P. A. (2000) Tissue iodine content and serum-mediated 125I uptake-blocking activity in breast cancer J. Clin. Endocr. Metab. 85, 1245-50 (Pubitemid 32269380)
15. Tazebay, U. H., Wapnir, I. L., Levy, O., Dohan, O., Zuckier, L. S., Zhao, Q. H., Deng, H. F., Amenta, P. S., Fineberg, S., Pestell, R. G., and Carrasco, N. (2000) The mammary gland iodide transporter is expressed during lactation and in breast cancer Nat. Med. 6, 871-8 (Pubitemid 30644744)
16. Kogai, T., Schultz, J. J., Johnson, L. S., Huang, M., and Brent, G. A. (2000) Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line Proc. Natl. Acad. Sci. U.S.A. 97, 8519-24 (Pubitemid 30639705)
17. Perron, B., Rodriguez, A. M., Leblanc, G., and Pourcher, T. (2001) Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues J. Endocrinol. 170, 185-96 (Pubitemid 32677580)
18. Fields, G. B. and Noble, R. L. (1990) Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids Int. J. Pept. Protein Res. 35, 161-214 (Pubitemid 20126875)
19. Moore, N. M., Barbour, T. R., and Sakiyama-Elbert, S. E. (2008) Synthesis and characterization of four-arm poly(ethylene glycol)-based gene delivery vehicles coupled to integrin and DNA-binding peptides Mol. Pharmaceutics 5, 140-50 (Pubitemid 351300043)
20. Nakase, I., Niwa, M., Takeuchi, T., Sonomura, K., Kawabata, N., Koike, Y., Takehashi, M., Tanaka, S., Ueda, K., Simpson, J. C., Jones, A. T., Sugiura, Y., and Futaki, S. (2004) Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement Mol. Ther. 10, 1011-1022 (Pubitemid 39625245)
21. Xiong, M. P., Forrest, M. L., Ton, G., Zhao, A., Davies, N. M., and Kwon, G. S. (2007) Poly(aspartate-g-PEI800), a polyethylenimine analogue of low toxicity and high transfection efficiency for gene delivery Biomaterials 28, 4889-900 (Pubitemid 47285338)
22. Godbey, W. T., Wu, K. K., and Mikos, A. G. (1999) Poly(ethylenimine) and its role in gene delivery J. Controlled Release 60, 149-60 (Pubitemid 29335941)
23. Rea, J. C., BarronC, A. E., and Shea, L. D. (2008) Peptide-mediated lipofection is governed by lipoplex physical properties and the density of surface-displayed amines J. Pharm. Sci. 97, 4794-806
24. Fischer, D., Bieber, T., Lin, Y. X., Elsässer, H. P., and Kissel, T. (1999) A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity Pharm. Res. 16, 1273-9 (Pubitemid 29393618)
25. Ma, K., Hu, M. X., Xie, M., Shen, H. J., Qiu, L. Y., Fan, W. M., Sun, H. Y., Chen, S. Q., and Jin, Y. (2010) Investigation of polyethylenimine-grafted- triamcinolone acetonide as nucleus-targeting gene delivery systems J. Gene Med. 12, 669-80