Peptide-mediated lipofection is governed by lipoplex physical properties and the density of surface-displayed amines

Journal of Pharmaceutical Sciences

Volumn 97, Issue 11, 2008, Pages 4794-4806

  Rea, Jennifer C ^a   Barron, Annelise E ^b   Shea, Lonnie D ^a,c  

^a Northwestern University   (United States)

^b Stanford University   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cationic lipids; DNA delivery; Gene delivery; Gene vectors; Lipoplexes; Peptides

Indexed keywords

AMINE; LIPOFECTAMINE; LIPOFECTIN; LIPOPLEX; PEPTIDE;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GEL ELECTROPHORESIS; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; LIGHT SCATTERING; MOUSE; NONHUMAN; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; ZETA POTENTIAL;

EID: 55749094843     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21338     Document Type: Article

References (40)

1. Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, Northrop JP, Ringold GM, Danielsen M. 1987. Lipofection - A highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84:7413-7417.
2. Lasic DD, Templeton NS. 1996. Liposomes in gene therapy. Adv Drug Deliver Rev 20:221-266.
3. Woodle MC, Scaria P. 2001. Cationic liposomes and nucleic acids. Curr Opin Colloid In 6:78-84.
4. Templeton NS. 2002. Cationic liposome-mediated gene delivery in vivo. Biosci Rep 22:283-295.
5. Wasungu L, Hoekstra D. 2006. Cationic lipids, lipoplexes and intracellular delivery of genes. J Control Release 116:255-264.
6. Zabner J, Fasbender AJ, Moninger T, Poellinger KA, Welsh MJ. 1995. Cellular and molecular barriers to gene-transfer by a cationic lipid. J Biol Chem 270:18997-19007.
7. Carriere M, Tranchant I, Niore PA, Byk G, Mignet N, Escriou V, Scherman D, Herscovici J. 2002. Optimization of cationic lipid mediated gene transfer: Structure-function, physico-chemical, and cellular studies. J Liposome Res 12:95-106.
8. Tranchant I, Thompson B, Nicolazzi C, Mignet N, Scherman D. 2004. Physicochemical optimisation of plasmid delivery by cationic lipids. J Gene Med 6:S24-S35.
9. Felgner JH, Kumar R, Sridhar CN, Wheeler CJ, Tsai YJ, Border R, Ramsey P, Martin M, Felgner PL. 1994. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem 269:2550-2561.
10. Mack KD, Walzem RL, Lehmann-Bruinsma K, Powell JS, Zeldis JB. 1996. Polylysine enhances cationic liposome-mediated transfection of the hepatoblastoma cell line Hep G2. Biotechnol Appl Biochem 23:217-220.
11. Sorgi FL, Bhattacharya S, Huang L. 1997. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther 4:961-968.
12. Cheung CY, Murthy N, Stayton PS, Hoffman AS. 2001. A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer. Bioconjug Chem 12:906-910.
13. Wang L, MacDonald RC. 2004. New strategy for transfection: Mixtures of medium-chain and long-chain cationic lipids synergistically enhance transfection. Gene Ther 11:1358-1362.
14. Koynova R, Wang L, Tarahovsky Y, MacDonald RC. 2005. Lipid phase control of DNA delivery. Bioconjug Chem 16:1335-1339.
15. Narang AS, Thoma L, Miller DD, Mahato RL. 2005. Cationic lipids with increased DNA binding affinity for nonviral gene transfer in dividing and nondividing cells. Bioconjug Chem 16:156-168.
16. De Laporte L, Cruz Rea J, Shea LD. 2006. Design of modular non-viral gene therapy vectors. Biomaterials 27:947-954.
17. Ma H, Zhu J, Maronski M, Kotzbauer PT, Lee VMY, Dichter MA, Diamond SL. 2002. Non-classical nuclear localization signal peptides for high efficiency lipofection of primary neurons and neuronal cell lines. Neuroscience 112:1-5.
18. Simoes S, Slepushkin V, Gaspar R, de Lima MCP, Duzgunes N. 1998. Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides. Gene Ther 5:955-964.
19. Ou Z, Geiger T, Ou JS, Ackerman AW, Oldham KT, Pritchard KA. 2003. AP-4F, antennapedia peptide linked to an amphipathic alpha helical peptide, increases the efficiency of lipofectamine-mediated gene transfection in endothelial cells. Biochem Biophys Res Commun 305:605-610.
20. White RE, Wade-Martins R, Hart SL, Frampton J, Huey B, Desai-Mehta A, Cerosaletti KM, Concannon P, James MR. 2003. Functional delivery of large genomic DNA to human cells with a peptide-lipid vector. J Gene Med 5:883-892.
21. Renigunta A, Krasteva G, Konig P, Rose F, Klepetko W, Grimminger F, Seeger W, Hanze J. 2006. DNA transfer into human lung cells is improved with Tat-RGD peptide by caveoli-mediated endocytosis. Bioconjug Chem 17:327-334.
22. Subramanian A, Ranganathan P, Diamond SL. 1999. Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells. Nat Biotechnol 17:873-877.
23. Aronsohn AI, Hughes JA. 1997. Nuclear localization signal peptides enhance cationic liposome-mediated gene therapy. J Drug Target 5:163-169.
24. Ritter W, Plank C, Lausier J, Rudolph C, Zink D, Reinhardt D, Rosenecker J. 2003. A novel transfecting peptide comprising a tetrameric nuclear localization sequence. J Mol Med 81:708-717.
25. Schwartz B, Ivanov MA, Pitard B, Escriou V, Rangara R, Byk G, Wils P, Crouzet J, Scherman D. 1999. Synthetic DNA-compacting peptides derived from human sequence enhance cationic lipid-mediated gene transfer in vitro and in vivo. Gene Ther 6:282-292.
26. Murray KD, Etheridge CJ, Shah SI, Matthews DA, Russell W, Gurling HMD, Miller AD. 2001. Enhanced cationic liposome-mediated transfection using the DNA-binding peptide mu (mu) from the adenovirus core. Gene Ther 8:453-460.
27. Bremner KH, Seymour LW, Logan A, Read ML. 2004. Factors influencing the ability of nuclear localization sequence peptides to enhance nonviral gene delivery. Bioconjug Chem 15:152-161.
28. Tagawa T, Manvell M, Brown N, Keller M, Perouzel E, Murray KD, Harbottle RP, Tecle M, Booy F, Brahimi-Horn MC, Coutelle C, Lemoine NR, Alton EWFW, Miller AD. 2002. Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu (mu) and plasmid DNA. Gene Ther 9:564-576.
29. Gao X, Huang L. 1996. Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry 35:1027-1036.
30. Plank C, Tang MX, Wolfe AR, Szoka FC. 1999. Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther 10:319-332.
31. Khalil IA, Kogure K, Futaki S, Hama S, Akita H, Ueno M, Kishida H, Kudoh M, Mishina Y, Kataoka K, Yamada M, Harashima H. 2007. Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Gene Ther 14:682-689.
32. Stewart JCM. 1980. Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal Biochem 104:10-14.
33. Read ML, Etrych T, Ulbrich K, Seymour LW. 1999. Characterisation of the binding interaction between poly(L-lysine) and DNA using the fluorescamine assay in the preparation of non-viral gene delivery vectors. FEBS Lett 461:96-100.
34. Bengali Z, Pannier AK, Segura T, Anderson BC, Jang JH, Mustoe TA, Shea LD. 2005. Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol Bioeng 90:290-302.
35. Vaysse L, Arveiler B. 2000. Transfection using synthetic peptides: Comparison of three DNA-compacting peptides and effect of centrifugation. Biochim Biophys Acta 1474:244-250.
36. Varga CM, Tedford NC, Thomas M, Klibanov AM, Griffith LG, Lauffenburger DA. 2005. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Ther 12:1023-1032.
37. Khalil IA, Kogure K, Futaki S, Harashima H. 2006. High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression. J Biol Chem 281:3544-3551.
38. Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA. 2000. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnol Bioeng 67:598-606.
39. Akita H, Tanimoto M, Masuda T, Kogure K, Hama S, Ninomiya K, Futaki S, Harashima H. 2006. Evaluation of the nuclear delivery and intranuclear transcription of plasmid DNA condensed with micro (mu) and NLS-micro by cytoplasmic and nuclear microinjection: A comparative study with poly-L-lysine. J Gene Med 8:198-206.
40. Dean DA, Strong DD, Zimmer WE. 2005. Nuclear entry of nonviral vectors. Gene Ther 12:881-890.