Anticancer activities of some new synthesized thiazolo[3,2-a]pyrido[4,3-d]pyrimidine derivatives

American Journal of Biochemistry and Biotechnology

Volumn 7, Issue 2, 2011, Pages 43-54

  Mohamed, Ashraf M ^a,b   Amr, Abdel Galil E ^c   Alsharari, Musaed A ^a   Al Qalawi, Husam R M ^a   Germoush, Mosa O ^a   Al Salahi, Rashad A ^b  

^a JOUF UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Anticancer activity; Biological activity; Nitrogen heterocyclic; Pyrimidines derivatives; Pyrimidinethione; Reactions; Starting materials; Synthesis; Thiazolopyrimidine

Indexed keywords

ANTICANCER ACTIVITIES; PYRIMIDINES DERIVATIVES; PYRIMIDINETHIONE; REACTIONS; THIAZOLOPYRIMIDINE;

AROMATIC COMPOUNDS; CELL CULTURE; SULFUR; TUMORS;

BRAIN;

2 (4 CHLOROBENZYLIDENE) 9 BEZYLIDENE 5 PHENYL 6,7,8,9 TETRAHYDRO 7 METHYLTHIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDIN 3(5H) ONE; 2 (4 CHLORODIBEZYLIDENE) 9 (4 FLOUROBENZYLIDENE) 5 (4 FLOURROPHENYL) 6,7,8,9 TETRAHYDRO 7 METHYLTHIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDIN 3(5H) ONE; 2 (4 FLOURODIBEZYLIDENE) 9 (4 CHLOROBENZYLIDENE) 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 7 METHYLTHIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDIN 3(5H) ONE; 2 (4 METHOXYDIBEZYLIDENE) 9 (4 CHLOROBENZYLIDENE) 5 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 7 METHYLTHIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDIN 3(5H) ONE; 2,9 DIBEZYLIDENE 5 PHENYL 6,7,8,9 TETRAHYDRO 7 METHYLTHIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDIN 3(5H) ONE; 8 (2 CHLOROBENZYLIDENE) 3,4,5,6,7,8 HEXAHYDRO 6 METHYL 4 (2 CHLOROPHENYL)PYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (3 BROMOBENZYLIDENE) 3,4,5,6,7,8 HEXAHYDRO 6 METHYL 4 (3 BROMOPHENYL)PYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (4 CHLOROBENZYLIDENE) 3,4,5,6,7,8 HEXAHYDRO 6 METHYL 4 (4 CHLOROPHENYL) PYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 (4 FLOUROBENZYLIDENE) 3,4,5,6,7,8 HEXAHYDRO 6 METHYL 4 (4 FLOUROPHENYL)PYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 8 BENZYLIDENE 3,4,5,6,7,8 HEXAHYDRO 6 METHYL 4 PHENYLPYRIDO[4,3 D]PYRIMIDINE 2(1H) THIONE; 9 (2 CHLOROBENZYLIDENE) 2,3,6,7,8,9 HEXAHYDRO 7 METHYL 5H 5 (2 CHLOROPHENYL)THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE; 9 (2 CHLOROBENZYLIDENE) 6,7,8,9 TETRAHYDRO 2,7 DIMETHYL 5 (2 CHLOROPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (2 CHLOROBENZYLIDENE) 6,7,8,9 TETRAHYDRO 7 METHYL 5 (2 CHLOROPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (3 BROMOBENZYLIDENE) 2,3,6,7,8,9 HEXAHYDRO 7 METHYL 5H 5 (3 BROMOPHENYL)THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE; 9 (4 BROMOBENZYLIDENE) 6,7,8,9 TETRAHYDRO 2,7 DIMETHYL 5 (4 BROMOPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (4 BROMOBENZYLIDENE) 6,7,8,9 TETRAHYDRO 7 METHYL 5 (4 BROMOPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (4 CHLOROBENZYLIDENE) 2,3,6,7,8,9 HEXAHYDRO 7 METHYL 5H 5 (4 CHLOROPHENYL)THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE; 9 (4 CHLOROBENZYLIDENE) 6,7,8,9 TETRAHYDRO 2,7 DIMETHYL 5 (4 CHLOROPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (4 CHLOROBENZYLIDENE) 6,7,8,9 TETRAHYDRO 5 (4 CHLOROPHENYL) 7 METHYL 2(2 PHENYLDIAZENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDIN 3(5H) ONE; 9 (4 CHLOROBENZYLIDENE) 6,7,8,9 TETRAHYDRO 7 METHYL 5 (4 CHLOROPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (4 FLOUROBENZYLIDENE) 2,7 DIMETHYL 6,7,8,9 TETRAHYDRO 5 (4 FLOUROPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (4 FLOUROBENZYLIDENE) 6,7,8,9 TETRAHYDRO 7 METHYL 5 (4 FLOUROPHENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; 9 (4 FLUOROBENZYLIDENE) 2,3,6,7,8,9 HEXAHYDRO 7 METHYL 5H 5 (4 FLOUROPHENYL)THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE; 9 BENZYLIDENE 2,3,6,7,8,9 HEXAHYDRO 7 METHYL 5H 5 PHENYL THIAZOLO[3,2 A]PYRIDO[4,3 D] PYRIMIDINE; 9 BENZYLIDENE 6,7,8,9 TETRAHYDRO 2,7 DIMETHYL 5 PHENYL 2H THIAZOLO[3,2 A]PYRIDO[4,3 D] PYRIMIDINE 3(5H) ONE; 9 BENZYLIDENE 6,7,8,9 TETRAHYDRO 5 PHENYL 7 METHYL 2 (4 TOLYLDIAZENYL) 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDIN 3(5H) ONE; 9 BENZYLIDENE 6,7,8,9 TETRAHYDRO 7 METHYL 5 PHENYL 2H THIAZOLO[3,2 A]PYRIDO[4,3 D]PYRIMIDINE 3(5H) ONE; ANTINEOPLASTIC AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CENTRAL NERVOUS SYSTEM TUMOR; COLON CANCER; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; LEUKEMIA CELL LINE; LUNG NON SMALL CELL CANCER; MALE; MELANOMA CELL; OVARY CANCER; PROSTATE CANCER;

EID: 80051718874     PISSN: 15533468     EISSN: None     Source Type: Journal    
DOI: 10.3844/ajbbsp.2011.43.54     Document Type: Article

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