High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses

Journal of Applied Physiology

Volumn 111, Issue 2, 2011, Pages 537-542

  Frings Meuthen, Petra ^a   Buehlmeier, Judith ^a   Baecker, Natalie ^a   Stehle, Peter ^b   Fimmers, Rolf ^b   May, Francisca ^a   Kluge, Goetz ^a   Heer, Martina ^a  

^a GERMAN AEROSPACE CENTER DLR   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Bed rest; Bone and protein metabolism; Salt

Indexed keywords

BIOLOGICAL MARKER; CALCIUM; NITROGEN; PARATHYROID HORMONE; PROTEIN; SODIUM;

ACID BASE BALANCE; ADULT; ARTICLE; BLOOD; BLOOD GAS ANALYSIS; BODY POSTURE; BONE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DRUG EFFECT; HUMAN; MALE; METABOLISM; OSTEOLYSIS; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SALT INTAKE; URINE;

ACID-BASE EQUILIBRIUM; ADULT; BIOLOGICAL MARKERS; BLOOD GAS ANALYSIS; BONE AND BONES; BONE RESORPTION; CALCIUM; DIET; HEAD-DOWN TILT; HUMANS; MALE; NITROGEN; PARATHYROID HORMONE; PROTEINS; SODIUM; SODIUM CHLORIDE, DIETARY;

EID: 80051710041     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00454.2011     Document Type: Article

References (71)

1. Akima H, Kawakami Y, Kubo K, Sekiguchi C, Ohshima H, Miyamoto A, Fukunaga T. Effect of short-duration spaceflight on thigh and leg muscle volume. Med Sci Sports Exerc 32: 1743-1747, 2000.
2. Alkner BA, Tesch PA. Knee extensor and plantar flexor muscle size and function following 90 days of bed rest with or without resistance exercise. Eur J Appl Physiol 93: 294-305, 2004. (Pubitemid 39534632)
3. Alpern RJ, Cogan MG, Rector FC ,Jr. Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat. J Clin Invest 71: 736-746, 1983. (Pubitemid 13160822)
4. Andrews B. Bodily shame in relation to abuse in childhood and bulimia: a preliminary investigation. Br J Clin Psychol 36: 41-49, 1997. (Pubitemid 27092000)
5. Audran M, Legrand E. Hypercalciuria. Joint Bone Spine 67: 509-515, 2000. (Pubitemid 32014786)
6. Baecker N, Tomic A, Mika C, Gotzmann A, Platen P, Gerzer R, Heer M. Bone resorption is induced on the second day of bedrest: results of a controlled crossover trial. J Appl Physiol 95: 977-982, 2003. (Pubitemid 37033990)
7. Bailey JL, Price SR, England BK, Jurkovitz C, Wang X, Ding X, Mitch WE. Signals regulating accelerated muscle protein catabolism in uremia. Miner Electrolyte Metab 23: 198-200, 1997. (Pubitemid 27475344)
8. Bailey JL, Wang X, England BK, Price SR, Ding X, Mitch WE. The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway. J Clin Invest 97: 1447-1453, 1996. (Pubitemid 26097034)
9. Ballmer PE, Imoberdorf R. Influence of acidosis on protein metabolism. Nutrition 11: 462-468, 1995.
10. Ballmer PE, McNurlan MA, Hulter HN, Anderson SE, Garlick PJ, Krapf R. Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans. J Clin Invest 95: 39-45, 1995.
11. Biolo G, Ciocchi B, Lebenstedt M, Barazzoni R, Zanetti M, Platen P, Heer M, Guarnieri G. Short-term bed rest impairs amino acid-induced protein anabolism in humans. J Physiol 558: 381-388, 2004. (Pubitemid 39117589)
12. Caillot-Augusseau A, Lafage-Proust MH, Soler C, Dubois F, Alexandre C. Bone formation and resorption biological markers in cosmonauts during and after a 180-day spaceflight (Euromir 95). Clin Chem 44: 578-585, 1998. (Pubitemid 28141355)
13. Chambers MA, Moylan JS, Reid MB. Physical inactivity and muscle weakness in the critically ill. Crit Care Med 37: S337-S346, 2009.
14. Cooper C. Epidemiology of osteoporosis. Osteoporos Int 9, Suppl 2: S2-S8, 1999. (Pubitemid 29231749)
15. de Boer MD, Seynnes OR, di Prampero PE, Pisot R, Mekjavic IB, Biolo G, Narici MV. Effect of 5 weeks horizontal bed rest on human muscle thickness and architecture of weight bearing and non-weight bearing muscles. Eur J Appl Physiol 401-407, 2008.
16. DGE. Referenzwerte für die Nährstoffzufuhr. Frankfurt, Germany: Umschau Braus, 2000.
17. DGE. Ernaehrungsbericht 2004. Frankfurt, Germany: Deutsche Gesellschaft für Ernährung e. V.,2004.
18. + antiport and cytosolic alkalinization in healthy human subjects. Clin Investig 72: 817-821, 1994. (Pubitemid 24342961)
19. Farber SJ, Schubert M, Schuster N. The binding of cations by chondroitin sulfate. J Clin Invest 1715-1722, 1957.
20. Ferrando AA, Lane HW, Stuart CA, Davis-Street J, Wolfe RR. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol Endocrinol Metab 270: E627-E633, 1996.
21. Fiore CE, Pennisi P, Ciffo F, Scebba C, Amico A, Di Fazzio S. Immobilization-dependent bone collagen breakdown appears to increase with time: evidence for a lack of new bone equilibrium in response to reduced load during prolonged bed rest. Horm Metab Res 31: 31-36, 1999. (Pubitemid 29081250)
22. Franco V, Oparil S. Salt sensitivity, a determinant of blood pressure, cardiovascular disease and survival. J Am Coll Nutr 25: 247S-255S, 2006. (Pubitemid 46931004)
23. Frassetto L, Morris RC ,Jr, Sellmeyer DE, Todd K, Sebastian A. Diet, evolution and aging-the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr 40: 200-213, 2001. (Pubitemid 34093226)
24. Frassetto LA, Morris RC ,Jr, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolicacidosis in healthy humans consuming a net acid-producing diet. Am J Physiol Renal Physiol 293: F521-F525, 2007. (Pubitemid 47358122)
25. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride induced exaggerated bone resorption. J Bone Miner Res 23: 517-524, 2008. (Pubitemid 351501892)
26. Garibotto G, Russo R, Sofia A, Sala MR, Sabatino C, Moscatelli P, Deferrari G, Tizianello A. Muscle protein turnover in chronic renal failure patients with metabolic acidosis or normal acid-base balance. Miner Electrolyte Metab 22: 58-61, 1996. (Pubitemid 126448805)
27. Gougeon-Reyburn R, Marliss EB. Effects of sodium bicarbonate on nitrogen metabolism and ketone bodies during very low energy protein diets in obese subjects. Metabolism 38: 1222-1230, 1989. (Pubitemid 20015499)
28. Graham KA, Reaich D, Channon SM, Downie S, Gilmour E, Passlick-Deetjen J, Goodship TH. Correction of acidosis in CAPD decreases whole body protein degradation. Kidney Int 49: 1396-1400, 1996. (Pubitemid 26166413)
29. Graham KA, Reaich D, Channon SM, Downie S, Goodship TH. Correction of acidosis in hemodialysis decreases whole-body protein degradation. J Am Soc Nephrol 8: 632-637, 1997.
30. Grimble GK, West MF, Acuti AB, Rees RG, Hunjan MK, Webster JD, Frost PG, Silk DB. Assessment of an automated chemiluminescence nitrogen analyzer for routine use in clinical nutrition. JPEN 12: 100-106, 1988. (Pubitemid 18044807)
31. Guyton AC, Hall JE. Textbook of Medical Physiology. Philadelphia, PA: Saunders, 2000.
32. Hannaford MC, Leiter LA, Josse RG, Goldstein MB, Marliss EB, Halperin ML. Protein wasting due to acidosis of prolonged fasting. Am J Physiol Endocrinol Metab 243: E251-E256, 1982. (Pubitemid 12006831)
33. Hartig W, Biesalski HK, Druml W, Fuerst P, Weimann A. Ernährungs- und Infusionstherapie: Standards für Klinik, Infusionstherapie, und Ambulanz. Stuttgart, Germany: Georg Thieme Verlag, 2004.
34. Heaney RP. Role of dietary sodium in osteoporosis. J Am Coll Nutr 25: 271S-276S, 2006. (Pubitemid 46931006)
35. Heer M, Boerger A, Kamps N, Biener C, Korr C, Drummer C. Nutrient supply during recent European missions. Pflügers Arch 441, Suppl: R8-R14, 2000.
36. + exchanger in man. Eur J Clin Invest 27: 558-565, 1997.
37. Kim H, Iwasaki K, Miyake T, Shiozawa T, Nozaki S, Yajima K. Changes in bone turnover markers during 14-day 6 degrees head-down bed rest. J Bone Miner Metab 21: 311-315, 2003. (Pubitemid 38017709)
38. Kurtzman NA. Regulation of renal bicarbonate reabsorption by extracellular volume. J Clin Invest 49: 586-595, 1970.
39. LeBlanc A, Rowe R, Schneider V, Evans H, Hedrick T. Regional muscle loss after short duration spaceflight. Aviat Space Environ Med 66: 1151-1154, 1995. (Pubitemid 26004094)
40. LeBlanc A, Schneider V, Shackelford L, West S, Oganov V, Bakulin A, Voronin L. Bone mineral and lean tissue loss after long duration space flight. J Musculoskelet Neuronal Interact 1: 157-160, 2000.
41. LeBlanc A, Schneider V, Spector E, Evans H, Rowe R, Lane H, Demers L, Lipton A. Calcium absorption, endogenous excretion, and endocrine changes during and after long-term bed rest. Bone 16: 301S-304S, 1995.
42. LeBlanc A, Schneider VS, Evans HJ, Engelbretson DA, Krebs JM. Bone mineral loss and recovery after 17 weeks of bed rest. J Bone Miner Res 5: 843-850, 1990. (Pubitemid 20294768)
43. LeBlanc A, Shackelford L, Schneider V. Future human bone research in space. Bone 22: 113S-116S, 1998. (Pubitemid 28223267)
44. Leonard JI, Leach CS, Rambaut PC. Quantitation of tissue loss during prolonged space flight. Am J Clin Nutr 38: 667-679, 1983. (Pubitemid 14228297)
45. Lofberg E, Gutierrez A, Anderstam B, Wernerman J, Bergstrom J, Price SR, Mitch WE, Alvestrand A. Effect of bicarbonate on muscle protein in patients receiving hemodialysis. Am J Kidney Dis 48: 419-429, 2006. (Pubitemid 44262432)
46. Lüthy C, Moser C, Oetliker O. Acid-base determination of urine in 3 steps. Med Lab (Stuttg) 30: 174-181, 1977.
47. May RC, Hara Y, Kelly RA, Block KP, Buse MG, Mitch WE. Branched-chain amino acid metabolism in rat muscle: abnormal regulation in acidosis. Am J Physiol Endocrinol Metab 252: E712-E718, 1987.
48. May RC, Kelly RA, Mitch WE. Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. J Clin Invest 77: 614-621, 1986. (Pubitemid 16037664)
49. Mitch WE, Medina R, Grieber S, May RC, England BK, Price SR, Bailey JL, Goldberg AL. Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. J Clin Invest 93: 2127-2133, 1994. (Pubitemid 24143094)
50. Nordin BE, Need AG, Morris HA, Horowitz M. The nature and significance of the relationship between urinary sodium and urinary calcium in women. J Nutr 123: 1615-1622, 1993. (Pubitemid 23268018)
51. Pisot R, Narici MV, Simunic B, De Boer M, Seynnes O, Jurdana M, Biolo G, Mekjavic IB. Whole muscle contractile parameters and thickness loss during 35-day bed rest. Eur J Appl Physiol 409-414, 2008.
52. Purkerson ML, Lubowitz H, White RW, Bricker NS. On the influence of extracellular fluid volume expansion on bicarbonate reabsorption in the rat. J Clin Invest 48: 1754-1760, 1969.
53. Reaich D, Channon SM, Scrimgeour CM, Daley SE, Wilkinson R, Goodship TH. Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol Endocrinol Metab 265: E230-E235, 1993. (Pubitemid 23270361)
54. Reaich D, Channon SM, Scrimgeour CM, Goodship TH. Ammonium chloride-induced acidosis increases protein breakdown and amino acid oxidation in humans. Am J Physiol Endocrinol Metab 263: E735-E739, 1992.
55. Remer T, Manz F. Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. Am J Clin Nutr 59: 1356-1361, 1994. (Pubitemid 24165890)
56. Rittweger J. Ten years muscle-bone hypothesis: What have we learned so far? Almost a Festschrift. J Musculoskelet Neuronal Interact 8: 174-178, 2008.
57. Scheld K, Zittermann A, Heer M, Herzog B, Mika C, Drummer C, Stehle P. Nitrogen metabolism and bone metabolism markers in healthy adults during 16 weeks of bed rest. Clin Chem 47: 1688-1695, 2001. (Pubitemid 32781584)
58. Slatopolsky E, Hoffsten P, Purkerson M, Bricker NS. On the influence of extracellular fluid volume expansion and of uremia on bicarbonate reabsorption in man. J Clin Invest 49: 988-998, 1970.
59. Smith SM, Heer M. Calcium and bone metabolism during space flight. Nutrition 18: 849-852, 2002. (Pubitemid 35292256)
60. Smith SM, Nillen JL, LeBlanc A, Lipton A, Demers LM, Lane HW, Leach CS. Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab 83: 3584-3591, 1998. (Pubitemid 28500894)
61. Smith SM, Uchakin PN, Tobin BW. Space flight nutrition research: platforms and analogs. Nutrition 18: 926-929, 2002. (Pubitemid 35292267)
62. Smith SM, Wastney ME, O'Brien KO, Morukov BV, Larina IM, Abrams SA, Davis-Street JE, Oganov V, Shackelford LC. Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the mir space station. J Bone Miner Res 20: 208-218, 2005.
63. Stein TP, Gaprindashvili T. Spaceflight and protein metabolism, with special reference to humans. Am J Clin Nutr 60: 806S-819S, 1994. (Pubitemid 24327881)
64. Stewart PA. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 61: 1444-1461, 1983. (Pubitemid 14190843)
65. Strain JJ, Caballero B, Sadler MJ. Encyclopedia of Human Nutrition. 1998.
66. Tesch PA, Berg HE, Bring D, Evans HJ, Leblanc AD. Effects of 17-day spaceflight on knee extensor muscle function and size. Eur J Appl Physiol 93: 463-468, 2005. (Pubitemid 40074307)
67. Tesch PA, von WF, Gustafsson T, Linnehan RM, Trappe TA. Skeletal muscle proteolysis in response to short-term unloading in humans. J Appl Physiol 105: 902-906, 2008.
68. Vico L, Collet P, Guignandon A, Lafage-Proust MH, Thomas T, Rehaillia M, Alexandre C. Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts [see comments]. Lancet 355: 1607-1611, 2000. (Pubitemid 30240506)
69. Vormann J, Daniel H. The role of nutrition in human acid-base homeostasis. Eur J Nutr 40: 187-188, 2001.
70. Ward MW, Owens CW, Rennie MJ. Nitrogen estimation in biological samples by use of chemiluminescence. Clin Chem 26: 1336-1339, 1980. (Pubitemid 10035237)
71. Williams B, Layward E, Walls J. Skeletal muscle degradation and nitrogen wasting in rats with chronic metabolic acidosis. Clin Sci (Lond) 80: 457-462, 1991.