Lipopolysaccharide challenge of the mammary gland in bovine induced a transient glandular shift to anaerobic metabolism

Journal of Dairy Science

Volumn 94, Issue 9, 2011, Pages 4468-4475

  Silanikove, N ^a   Rauch Cohen, A ^a   Shapiro, F ^a   Blum, S ^b   Arieli, A ^c   Leitner, G ^b  

^a VOLCANI CENTER   (Israel)

^b KIMRON VETERINARY INSTITUTE   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Glycolysis; Lipopolysaccharide (LPS); Mammary gland; Stress response

Indexed keywords

CITRIC ACID; LACTIC ACID; LACTOSE; LIPOPOLYSACCHARIDE; MALIC ACID; MALIC ACID DERIVATIVE; UREA;

ANAEROBIC GROWTH; ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; CHEMISTRY; DRUG EFFECT; ESCHERICHIA COLI; FEMALE; GLYCOLYSIS; GROWTH, DEVELOPMENT AND AGING; LACTATION; METABOLISM; MICROBIOLOGICAL EXAMINATION; MILK; SECRETION; UDDER;

ANAEROBIOSIS; ANIMALS; BACTERIOLOGICAL TECHNIQUES; CATTLE; CITRIC ACID; ESCHERICHIA COLI; FEMALE; GLYCOLYSIS; LACTATION; LACTIC ACID; LACTOSE; LIPOPOLYSACCHARIDES; MALATES; MAMMARY GLANDS, ANIMAL; MILK; UREA;

ANIMALIA; BACTERIA (MICROORGANISMS); BOVINAE; ESCHERICHIA COLI;

EID: 80051708167     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2010-4092     Document Type: Article

References (39)

1. Blum S., Heller E.D., Krifucks O., Sela S., Hammer-Muntz O., Lietner G. Identification of a bovine mastitis Escherichia coli subset. Vet. Microbiol. 2008, 132:135-148.
2. Bramley A.J. Variations in the susceptibility of lactating and non-lactating bovine udders to infection when infused with Escherichia coli. J. Dairy Res. 1976, 43:205-211.
3. Burstein C., Cohn M., Kepes A., Monod J. Role du lactose et de ses produits metaboliques dans linduction de l'operon lactose chez Escherichia coli. Biochim. Biophys. Acta 1964, 95:634-639.
4. Cherepanov G.G., Danfaer A., Cant J.P. Simulation analysis of substrate utilization in the mammary gland of lactating cows. J. Dairy Res. 2000, 67:171-188.
5. Davis S.R., Farr V.C., Prosser C.G., Nichols G.D., Turner S.-A., Lee J., Hart A.L. Milk L-lactate concentration is increased during mastitis. J. Dairy Res. 2004, 71:175-181.
6. Haji-Michael P.G., Ladriere L., Sener A., Vincent J.L., Malaisse W.J. Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metab. Clin. Exp. 1999, 48:779-785.
7. Harmeyer J., Mertens H. Aspects of urea metabolism in ruminants with reference to the goat. J. Dairy Sci. 1980, 63:1707-1728.
8. Heumann D., Roger T. Initial responses to endotoxins and gram-negative bacteria. Clin. Chim. Acta 2002, 323:59-72.
9. Kadzere C.T., Murphy M.R., Silanikove N., Maltz E. Heat stress in lactating dairy cows: A review. Livest. Prod. Sci. 2002, 77:59-91.
10. Kominsky D.J., Campbell E.L., Colgan S.P. Metabolic shifts in immunity and inflammation. J. Immunol. 2010, 184:4062-4068.
11. Laury A.M., Alvarado M.V., Nace G., Alvarado C.Z., Brooks J.C., Echeverry A., Brashears M.M. Validation of a lactic acid- and citric acid-based antimicrobial product for the reduction of Escherichia coli O157:H7 and Salmonella on beef tips and whole chicken carcasses. J. Food Prot. 2009, 72:2208-2211.
12. Lavon Y., Leitner G., Goshen T., Braw-Tal R., Jacoby S., Wolfenson D. Exposure to endotoxin during estrus alters the timing of ovulation and hormonal concentrations in cows. Theriogenology 2008, 70:956-967.
13. Leitner G., Krifucks O., Merin U., Lavi Y., Silanikove N. Interactions between bacteria type, proteolysis of casein and physico-chemical properties of bovine milk. Int. Dairy J. 2006, 16:648-654.
14. Leitner G., Merin U., Silanikove N. Effects of glandular bacterial infection and stage of lactation on milk clotting parameters: comparison among cows, goats and sheep. Int. Dairy J. 2011, 21:279-285.
15. Lindmark-Mansson H., Branning C., Alden G., Paulsson M. Relationship between somatic cell count, individual leukocyte populations and milk components in bovine udder quarter milk. Int. Dairy J. 2006, 16:717-727.
16. Linzell J.L., Mepham T.B., Peaker M. Secretion of citrate to milk. J. Physiol. 1976, 260:739-750.
17. Lippolis J.D., Bayles B.O., Reinhardt T.A. Proteomic changes in Escherichia coli when grown in fresh milk versus laboratory media. J. Proteome Res. 2009, 8:149-158.
18. Nielsen S.S., Grofte T., Tygstrup N., Vilstrup H. Effect of lipopolysaccharide on in vivo and genetic regulation of rat urea synthesis. Liver Int. 2005, 25:177-183.
19. Nizet V., Johnson R.S. Interdependence of hypoxic and innate immune response. Nat. Rev. Immunol. 2009, 9:609-617.
20. Oltner R., Wiktorsson H. Urea concentration in milk and blood as influenced by feeding varying amount of protein and energy to dairy cows. Livest. Prod. Sci. 1983, 10:457-467.
21. Peyssonnaux C., Cejudo-Martin P., Doedens A., Zinkernagel A.S., Johnson R.S., Nizet V. Cutting edge: Essential role of hypoxia inducible factor-1 alpha in development of lipopolysaccharide-induced sepsis. J. Immunol. 2007, 178:7516-7519.
22. Qiao F., Trout D.R., Xiao C., Cant J.P. Kinetics of glucose transport and sequestration in lactating bovine mammary quarters measured in vivo with a paired indicator/nutrient dilution technique. J. Appl. Physiol. 2005, 99:799-806.
23. Rainard P., Riollet C. Innate immunity of the bovine mammary gland. Vet. Res. 2006, 37:369-400.
24. Raqib R., Cravioto A. Nutrition, immunology, and genetics: Future perspectives. Nutr. Rev. 2009, 67:S227-S236.
25. Raybaudi-Massilia R.M., Mosqueda-Melgar J., Martin-Belloso O. Antimicrobial activity of malic acid against Listeria monocytogenes Salmonella enteritidis and Escherichia coli O157:H7 in apple, pear and melon juices. Food Contr. 2009, 20:105-112.
26. JMP Statistics and Graphics Guide, Version 5 2002, SAS Institute, SAS Institute Inc., Cary, NC.
27. Shamay A., Shapiro F., Leitner G., Silanikove N. Infusions of casein hydrolyzates into the mammary gland disrupt tight junction integrity and induce involution in cows. J. Dairy Sci. 2003, 86:1250-1258.
28. Shamay A., Shapiro F., Mabjeesh S.J., Silanikove N. Casein-derived phosphopeptides disrupt tight junction integrity, and precipitously dry up milk secretion in goats. Life Sci. 2002, 70:2707-2719.
29. Shapiro F., Silanikove N. Rapid and accurate determination of D- and L-lactate, lactose and galactose by enzymatic reactions coupled to formation of a fluorochromophore: Applications in food quality control. Food Chem. 2010, 119:829-833.
30. Shapiro F., Silanikove N. Rapid and accurate determination of malate, citrate, pyruvate and oxaloacetate by enzymatic reactions coupled to formation of a fluorochromophore: Application in colorful juices and fermentable food (yogurt, wine) analysis. Food Chem. 2011, 129:608-613.
31. Silanikove N. The struggle to maintain hydration and osmoregulation in animals experiencing severe dehydration and rapid rehydration: The story of ruminants. Exp. Physiol. 1994, 79:281-300.
32. Silanikove N. Effects of heat stress on the welfare of extensively managed domestic ruminants. Livest. Prod. Sci. 2000, 67:1-18.
33. Silanikove N., Merin U., Leitner G. Physiological role of indigenous milk enzymes: An overview of an evolving picture. Int. Dairy J. 2006, 16:533-545.
34. Silanikove N., Shamay A., Shinder D., Moran A. Stress down regulates milk yield in cows by plasmin induced β-casein product that blocks K+ channels on the apical membranes. Life Sci. 2000, 67:2201-2212.
35. Silanikove N., Shapiro F. Distribution of xanthine oxidase and xanthine dehydrogenase activity in bovine milk: Physiological and technological implications. Int. Dairy J. 2007, 17:1188-1194.
36. Silanikove N., Shapiro F., Shinder D. Acute heat stress brings down milk secretion in dairy cows by up-regulating the activity of the milk-borne negative feedback regulatory system. BMC Physiol. 2009, 9:13.
37. Ullah M.S., Davies A.J., Halestrap A.P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1 alpha-dependent mechanism. J. Biol. Chem. 2006, 281:9030-9037.
38. Waldron M.R., Kulick A.E., Bell A.W., Overton T.R. Acute experimental mastitis is not causal toward the development of energy-related metabolic disorders in early postpartum dairy cows. J. Dairy Sci. 2006, 89:596-610.
39. Zulak I.M., Keenan T.W. Citrate accumulation by Golgi apparatus-rich fraction from lactating bovine mammary gland. Int. J. Biochem. 1983, 15:747-750.