1H-Nuclear magnetic resonance pattern recognition studies with N-phenylanthranilic acid in the rat: Time-and dose-related metabolic effects

Biomarkers

Volumn 8, Issue 6, 2003, Pages 472-490

  Williams, Rebecca E ^a,c   Cottrell, Lisa ^a   Jacobsen, Matthew ^a   Bandara, Lasantha R ^b   Kelly, Mike D ^b   Kennedy, Sandy ^b   Lock, Edward A ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^b Oxford GlycoSciences   (United Kingdom)

^c AstaZeneca ^*  (United Kingdom)

Author keywords

Ketonuria; N phenylanthranilic acid; Renal papillary necrosis

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ACETONE; ASCORBIC ACID; BIOLOGICAL MARKER; EFENAMIC ACID; KETONE BODY; ANTHRANILIC ACID DERIVATIVE; FENAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL CHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; FATTY ACID METABOLISM; GLUCURONIDATION; HISTOPATHOLOGY; KETONURIA; KIDNEY PAPILLA NECROSIS; LIVER METABOLISM; MALE; METABOLIC DISORDER; MULTIVARIATE ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATTERN RECOGNITION; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINALYSIS; URINARY EXCRETION; ANIMAL; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; RAT STRAIN; TIME; URINE;

ANIMALS; ANTHRANILIC ACIDS; ASCORBIC ACID; BIOLOGICAL MARKERS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; KETONE BODIES; KIDNEY PAPILLARY NECROSIS; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RATS; RATS, INBRED STRAINS; TIME FACTORS; URINALYSIS;

EID: 1842484217     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/13547500310001647030     Document Type: Article

References (48)

1. Akhund, L., Quinet, R. J. and Ishaq, S. 2003, Celecoxib-related renal papillary necrosis. Archives of Internal Medicine, 163 (1), 114-115.
2. Anthony, M. L., Gartland, K. P., Beddell, C. R., Lindon, J. C. and Nicholson, J. K. 1992, Cephaloridine-induced nephrotoxicity in the Fischer 344 rat: proton NMR spectroscopic studies of urine and plasma in relation to conventional clinical chemical and histopathological assessments of nephronal damage. Archives of Toxicology, 66 (8), 525-537.
3. Anthony, M. L., Gartland, K. P., Beddell, C. R., Lindon, J. C. and Nicholson, J. K. 1994a, Studies of the biochemical toxicology of uranyl nitrate in the rat. Archives of Toxicology, 68 (1), 43-53.
4. Anthony, M. L., Sweatman, B. C., Beddell, C. R., Lindon,J. C. and Nicholson, J. K. 1994b, Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine. Molecular Pharmacology, 46 (1), 199-211.
5. Bach, P. H. and Bridges, J. W. 1985, Chemically induced renal papillary necrosis and upper urothelial carcinoma. Critical Reviews in Toxicology, 15 (3), 217-441.
6. Bach, P. H. and Hardy, T. L. 1985, Relevance of animal models to analgesic-associated renal papillary necrosis in humans. Kidney International, 28 (4), 605-613.
7. Bach, P. H. and Thanh, N. T. K. 1998, Renal papillary necrosis - 40 years on. Toxicologic Pathology, 26 (1), 73-91.
8. Bach, P. H., Scholey, D. J., Delacruz, L., Moret, M. and Nichol, S. 1991, Renal and urinary lipid changes associated with an acutely induced renal papillary necrosis in rats. Food and Chemical Toxicology, 29 (3), 211-219.
9. 1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine. Magnetic Resonance in Medicine, 3 (6 ), 849-856.
10. Beckwith-Hall, B. M., Nicholson, J. K., Nicholls, A. W., Foxall, P. J., Lindon, J. C., Connor, S. C., Abdi, M., Connelly, J. and Holmes, E. 1998, Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chemical Research in Toxicology, 11 (4), 260-272.
11. Beylot, M. 1996, Regulation of in vivo ketogenesis: role of free fatty acids and control by epinephrine, thyroid hormones, insulin and glucagons. Diabetes and Metabolism, 5, 299-304.
12. Brix, A. E. 2002, Renal papillary necrosis. Toxicologic Pathology, 30 (6), 672-674.
13. Burg, M. B. 1994, Molecular basis for osmoregulation of organic osmolytes in renal medullary cells. Journal of Experimental Zoology, 268 (2), 171-175.
14. Burns, J. J., Conney, A. H., Dayton, P. G., Evans, C., Martin, G. R. and Taller, D. 1960, Observations on the drug-induced synthesis of D-glucuronic, L-gulonic and L-ascorbic acids in rats. Journal of Pharmacology and Experimental Therapeutics, 129, 132-138.
15. Elhamri, M., Martin, M., Ferrier, B. and Baverel, G. 1993, Substrate uptake and utilization by the kidney of fed and starved rats in vivo. Renal Physiology and Biochemistry, 16 (6), 311-324.
16. 2 on renal papillary necrosis and gastrointestinal ulcerations (gastric, duodenal, intestinal) produced in rats by mefenamic acid. Life Sciences, 39 (5), 423-432.
17. Gartland, K. P., Bonner, F. W. and Nicholson, J. K. 1989, Investigations into the biochemical effects of region-specific nephrotoxins. Molecular Pharmacology, 35 (2), 242-250.
18. Gregg, N. J., Courtauld, E. A. and Bach, P. H. 1990, High resolution light microscopic morphological and microvascular changes in an acutely induced renal papillary necrosis. Toxicologic Pathology, 18(1), part 1, 47-55.
19. Hardy, T. L. 1970, N-Phenyl anthranilic acid: an agent for inducing and studying renal papillary necrosis in the rat. British Journal of Experimental Pathology, 51 (4), 348-355.
20. Hardy, T. L. and Bach, P. H. 1984, The effect of N-phenylanthranilic acid-induced renal papillary necrosis on urinary acidification and renal electrolyte handling. Toxicology and Applied Pharmacology, 75 (2), 265-277.
21. 1H NMR spectroscopy. Biochemical Pharmacology, 41(12), 2045-2049.
22. Holmes, E., Bonner, F. W., Sweatman, B. C., Landon J. C., Beddell, C. R., Rahr, E. and Nicholson, J. K. 1992, Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury (II) chloride and 2-bromoethanamine. Molecular Pharmacology, 42 (5), 922-930.
23. Holmes, E., Bonner, F. W. and Nicholson, J. K. 1995a, Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Archives of Toxicology, 70 (2), 89-95.
24. 2H NMR spectroscopic studies on the metabolism and biochemical effects of 2-bromoethanamine in the rat. Biochemical Pharmacology, 49 (10), 1349-1359.
25. 1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat and the multimammate desert mouse (Mastomys natalensis). Comparative Biochemistry and Physiology. Part C, Pharmacology. Toxicology and Endocrinology, 116 (2), 125-134.
26. 1H NMR spectroscopy of urine combined with pattern recognition. NMR in Biomedicine, 11, 235-244.
27. Limas, C. and Limas, C. J. 1983, Phospholipid metabolism in the rat renal inner medulla. Biochimica Biophysica Acta, 753 (3), 314-323.
28. Marselos, M., Torronen, R. and Aitio, A. 1978, Responses of the d-glucuronic acid pathway in rat tissues to treatment with tetrachlorodibenzodioxin. Xenobiotica, 8 (7), 397-402.
29. Moolenaar, S. H., Poggi-Bach, J., Engelke, U. F., Corstiaensen, J. M., Heerschap, A., de Jong, J. G., Binzak, B. A., Vockley, J. and Wevers, R. A. 1999, Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study. Clinical Chemistry, 45 (4), 459-464.
30. Naito, J., Sasaki, E., Ohta, Y., Shinohara, R. and Ishiguro, I. 1984, Anthranilic acid metabolism in the isolated perfused rat liver: detection and determination of anthranilic acid and its related substances using high-performance liquid chromatography with electrochemical detection. Biochemical Pharmacology, 33 (20), 3195-3200.
31. Nakanishi, T., Uyama, O. and Sugita, M. 1991, Osmotically regulated taurine content in rat renal inner medulla. American Journal of Physiology, 261(6), part 2, F957-962.
32. Nakatani, T., Sakamoto, Y., Ando, H. and Kobayashi, K. 1996, Enhanced ketogenesis in the kidney during hepatic inflow occlusion with the administration of Ringer's acetate solution. Surgery, 119 (6), 684-689.
33. Nguyen, T. K., Obatomi, D. K. and Bach, P. H. 2001, Increased urinary uronic acid excretion in experimentally-induced renal papillary necrosis in rats. Renal Failure, 23 (1), 31-42.
34. Nicholls, A. W., Holmes, E., Landon, J. C., Shockcor, J. P., Farrant, R. D., Haselden, J. N., Damment, S. J., Waterfield, C. J. and Nicholson, J. K. 2001, Metabonomic investigations into hydrazine toxicity in the rat. Chemical Research in Toxicology, 14 (8), 975-987.
35. 1H NMR urinalysis studies on the biochemical effects of cadmium in the rat. Molecular Pharmacology, 36 (3), 398-404.
36. Oliw, E., Lunden, I. and Anggard, E. 1978, In vivo inhibition of prostaglandin synthesis in rabbit kidney by non-steroidal anti-inflammatory drugs. Acta Pharmacologica et Toxicologica, 42 (3), 179-184.
37. Poon, R., Chu, I., Lecavalier, P., Bergman, A. and Villeneuve, D. C. 1994, Urinary ascorbic acid - HPLC determination and application as a noninvasive biomarker of hepatic response. Journal of Biochemical Toxicology, 9 (6), 297-304.
38. Robertson, D. G., Reily, M. D., Albassam, M. and Dethloff, L. A. 2001, Metabonomic assessment of vasculitis in rats. Cardiovascular Toxicology, 1 (1), 7-19.
39. Sanins, S. M., Nicholson, J. K., Elcombe, C. and Timbrell, J. A. 1990, Hepatotoxin-induced hypertaurinuria: a proton NMR study. Archives of Toxicology, 64 (5), 407-411.
40. 1H NMR for the analysis of mixtures of isomeric ester glucuronide conjugates of trifluoromethylbenzoic acids. Journal of Chromatography A, 728, 377-385.
41. Sidelmann, U. G., Lenz, E. M., Spraul, M., Hofmann, M., Troke, J., Sanderson, P. N., Lindon, J. C., Wilson, I. D. and Nicholson, J. K. 1996b, 750 MHz HPLC-NMR spectroscopic studies on the separation and characterization of the positional isomers of the glucuronides of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid. Analytical Chemistry, 68 (1), 106-110.
42. Slim, R. M., Robertson, D. G., Albassam, M., Reily, M. D., Robosky, L. and Dethloff, L. A. 2002, Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats. Toxicology and Applied Pharmacology, 183 (2), 108-116.
43. Thanh, N. T. K., Stevenson, G., Obatomi, D. K., Aicher, B., Baumeister, M. and Bach, P. H. 2001a, Urinary lipid changes during the development of chemically-induced renal papillary necrosis: a study using mefenamic acid and N-phenylanthranilic acid. Biomarkers, 6 (6), 417-427.
44. Thanh, N. T. K., Obatomi, D. K. and Bach, P. H. 2001b, Phospholipiduria in 2-bromoethanamine-induced renal papillary necrosis. Biomarkers, 6, 326-334.
45. Waterfield, C. J., Asker,D. S., Patel, S. and Timbrell, J. A. 1998, Is there a correlation between taurine levels and xenobiotic-induced perturbations in protein synthesis? A study with tetracycline in rats. Amino Acids, 15 (1-2), 161-177.
46. 3H-N-phenylanthranilic acid in rats. Renal Physiology and Biochemistry, 12 (5-6), 406-412.
47. Williams, R. T. (editor), 1959, Detoxification Mechanisms: The Metabolism and Detoxicification of Drugs, Toxic Substances and other Organic Compounds, 2nd edition (London: Chapman and Hall), pp. 447-448.
48. Wolf, D. C., Carlton, W. W. and Turek, J. J. 1992, Experimental renal papillary necrosis in the Mongolian gerbil (Meriones unguiculatus). Toxicologic Pathology, 20(3), part 1, 341-349.