1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex

Toxicological Sciences

Volumn 122, Issue 2, 2011, Pages 502-511

  Miller, James A ^a   Runkle, Stephanie A ^b   Tjalkens, Ronald B ^a   Philbert, Martin A ^b  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

1,3 DNB; Astrocytes; PDHc

Indexed keywords

1,3 DINITROBENZENE; 2 OXOACID DEHYDROGENASE; ACETOACETIC ACID; ANTIOXIDANT; CARNITINE; DIHYDROLIPOAMIDE DEHYDROGENASE; LACTATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE COMPLEX; THIAMINE; THIOCTIC ACID; THIOL DERIVATIVE;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; GLIOMA CELL; IMMUNOREACTIVITY; MACROGLIA; METABOLIC DISORDER; NEUROTOXICITY; NONHUMAN; RAT; THIAMINE DEFICIENCY;

ANIMALS; ANTIOXIDANTS; ASTROCYTES; BLOTTING, WESTERN; CELL LINE; DINITROBENZENES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENERGY METABOLISM; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; PYRUVATE DEHYDROGENASE COMPLEX; RATS; THIAMINE DEFICIENCY; THIOCTIC ACID;

RATTUS; RODENTIA;

EID: 80051690825     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr102     Document Type: Article

References (47)

1. Bâ , A. (2008). Metabolic and structural role of thiamine in nervous tissues. Cell. Mol. Neurobiol. 28, 923-931.
2. Bailey, E., Peal, J. A., and Philbert, M. (1988). Determination of 1,3-dinitrobenzene and its metabolites in rat blood by capillary gas chromatography with electron-capture detection. J. Chromatogr. 425, 187-192.
3. Bogaert, Y. E., Rosenthal, R. E., and Fiskum, G. (1994). Postischemic inhibition of cerebral cortex pyruvate dehydrogenase. Free Radic. Biol. Med. 16, 811-820.
4. Brown, R. M., Head, R. A., Morris, A. A. M., Raiman, J. A. J., Walter, J. H., Whitehouse, W. P., and Brown, G. K. (2006). Pyruvate dehydrogenase E3 binding protein (protein X) deficiency. Dev. Med. Child Neurol. 48, 756-760.
5. Butterworth, R. F., and Besnard, A. M. (1990). Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metab. Brain Dis. 5, 179-184.
6. Cavanagh, J. B. (1988). Lesion localisation: implications for the study of functional effects and mechanisms of action. Toxicology 49, 131-136.
7. Cody, T. E., Witherup, S., Hastings, L., Stemmer, K., and Christian, R. T. (1981). 1,3-Dinitrobenzene: toxic effects in vivo and in vitro. J. Toxicol. Environ. Health 7, 829-847.
8. Cossum, P. A., and Rickert, D. E. (1985). Metabolism of dinitrobenzenes by rat isolated hepatocytes. Drug Metab. Dispos. 13, 664-668.
9. Edmond, J. (1992). Energy metabolism in developing brain cells. Can. J. Physiol. Pharmacol. 70(Suppl.), S118-S129.
10. Ellis, M. K., Hill, S., and Foster, P. M. (1992). Reactions of nitrosonitrobenzenes with biological thiols: identification and reactivity of glutathion-S-yl conjugates. Chem. Biol. Interact. 82, 151-163.
11. Finsterer, J. (2008). Leigh and Leigh-like syndrome in children and adults. Pediatr. Neurol. 39, 223-235.
12. Fukuchi, T., Katayama, Y., Kamiya, T., McKee, A., Kashiwagi, F., and Terashi, A. (1998). The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain. Brain Res. 792, 59-65.
13. Hard, M. L., Raha, S., Spino, M., Robinson, B. H., and Koren, G. (2001). Impairment of pyruvate dehydrogenase activity by acetaldehyde. Alcohol 25, 1-8.
14. Harter, D. R. (1985). The use and importance of nitroaromatic chemicals in the chemical industry. In Toxicity of Nitroaromatic Chemicals (D. E. Ricket, Ed.), pp. 1-14. Chemical Industry Institute of Toxicology Series, New York, NY.
15. Hu, H. L., Bennett, N., Holton, J. L., Nolan, C. C., Lister, T., Cavanagh, J. B., and Ray, D. E. (1999). Glutathione depletion increases brain susceptibility to m-dinitrobenzene neurotoxicity. Neurotoxicology 20, 83-90.
16. Humphries, K. M., and Szweda, L. I. (1998). Selective inactivation of alphaketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry 37, 15835-15841.
17. Kazanis, S., and McClelland, R. (1992). Electrophilic intermediate in the reaction of glutathione and nitroso arenes. J. Am. Chem. Soc. 114, 3052-3059.
18. Korotchkina, L. G., Yang, H., Tirosh, O., Packer, L., and Patel, M. S. (2001). Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. Free Radic. Biol. Med. 30, 992-999.
19. Lesnefsky, E. J., He, D., Moghaddas, S., and Hoppel, C. L. (2006). Reversal of mitochondrial defects before ischemia protects the aged heart. FASEB J. 20, 1543-1545.
20. MacDonald, M. J., Husain, R. D., Hoffmann-Benning, S., and Baker, T. R. (2004). Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0. J. Biol. Chem. 279, 27278-272-85.
21. Martin, E., Rosenthal, R. E., and Fiskum, G. (2005). Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress. J. Neurosci. Res. 79, 240-247.
22. Morris, A. A. M. (2005). Cerebral ketone body metabolism. J. Inherit. Metab. Dis. 28, 109-121.
23. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol.Methods. 65, 55-63.
24. Nabekura, T., Morishima, S., Cover, T. L., Mori, S.-I., Kannan, H., Komune, S., and Okada, Y. (2003). Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels. Glia 41, 247-259.
25. Park, L. C., Calingasan, N. Y., Sheu, K. F., and Gibson, G. E. (2000). Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells. Anal. Biochem. 277, 86-93.
26. Patel, M. S., and Roche, T. E. (1990). Molecular biology and biochemistry of pyruvate dehydrogenase complexes. FASEB J. 4, 3224-3233.
27. Phelka, A. D., Beck, M. J., and Philbert, M. A. (2003). 1,3-Dinitrobenzene inhibits mitochondrial complex II in rat and mouse brainstem and cortical astrocytes. Neurotoxicology 24, 403-415.
28. Philbert, M. A., Nolan, C. C., Cremer, J. E., Tucker, D., and Brown, A. W. (1987). 1,3-Dinitrobenzene-induced encephalopathy in rats. Neuropathol. Appl. Neurobiol. 13, 371-389.
29. Pocernich, C. B., and Butterfield, D. A. (2003). Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease. Neurotox. Res. 5, 515-520.
30. Ray, D. E., Abbott, N. J., Chan, M. W., and Romero, I. A. (1994). Increased oxidative metabolism and oxidative stress in m-dinitrobenzene neurotoxicity. Biochem. Soc. Trans. 22, 407S.
31. Reed, L. J. (1998). From lipoic acid to multi-enzyme complexes. Protein Sci. 7, 220-224.
32. Reed, L. J., and Hackert, M. L. (1990). Structure-function relationships in dihydrolipoamide acyltransferases. J. Biol. Chem. 265, 8971-8974.
33. Reeve, I. T., Voss, J. C., and Miller, M. G. (2002). 1,3-Dinitrobenzene metabolism and GSH depletion. Chem. Res. Toxicol. 15, 361-366.
34. Robinson, B. H. (2006). Lactic acidemia and mitochondrial disease. Mol. Genet. Metab. 89, 3-13.
35. Romero, I., Brown, A. W., Cavanagh, J. B., Nolan, C. C., Ray, D. E., and Seville, M. P. (1991). Vascular factors in the neurotoxic damage caused by 1,3-dinitrobenzene in the rat. Neuropathol. Appl. Neurobiol. 17, 495-508.
36. Romero, I. A., Lister, T., Richards, H. K., Seville, M. P., Wylie, S. P., and Ray, D. E. (1995). Early metabolic changes during m-dinitrobenzene neurotoxicity and the possible role of oxidative stress. Free Radic. Biol. Med. 18, 311-319.
37. Rook, G. A., Steele, J., Umar, S., and Dockrell, H. M. (1985). A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by gamma-interferon. J. Immunol. Methods. 82, 161-167.
38. Rosenthal, R. E., Williams, R., Bogaert, Y. E., Getson, P. R., and Fiskum, G. (1992). Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine. Stroke 23, 1312- 1317; discussion 1317-1318.
39. Samikkannu, T., Chen, C.-H., Yih, L.-H.,Wang, A. S. S., Lin, S.-Y., Chen, T.-C., and Jan, K.-Y. (2003). Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity. Chem. Res. Toxicol. 16, 409-414.
40. Sheu, K. F., Kim, Y. T., Blass, J. P., and Weksler, M. E. (1985). An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain. Ann. Neurol. 17, 444-449.
41. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985). Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
42. Smolle, M., Prior, A. E., Brown, A. E., Cooper, A., Byron, O., and Lindsay, J. G. (2006). A new level of architectural complexity in the human pyruvate dehydrogenase complex. J. Biol. Chem. 281, 19772-19780.
43. Tabatabaie, T., Potts, J. D., and Floyd, R. A. (1996). Reactive oxygen speciesmediated inactivation of pyruvate dehydrogenase. Arch. Biochem. Biophys. 336, 290- 296; 210.
44. Tsai, C. S. (1987). Nitroreductase activity of heart lipoamide dehydrogenase. Biochem. J. 242, 447-452.
45. Yang, M. S., Yu, L. C., and Gupta, R. C. (2004). Analysis of changes in energy and redox states in HepG2 hepatoma and C6 glioma cells upon exposure to cadmium. Toxicology 201, 105-113.
46. Yang, Y., and Balcarcel, R. R. (2004). 96-Well plate assay for sublethal metabolic activity. Assay Drug Dev. Technol. 2, 353-361.
47. Yeaman, S. J. (1989). The 2-oxo acid dehydrogenase complexes: recent advances. Biochem. J. 257, 625-632.