Impairment of pyruvate dehydrogenase activity by acetaldehyde

Alcohol

Volumn 25, Issue 1, 2001, Pages 1-8

  Hard, Marjie L ^a,b   Raha, Sandeep ^a,b   Spino, Michael ^a,c   Robinson, Brian H ^a,b   Koren, Gideon ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Apatex Inc   (Canada)

Author keywords

Acetaldehyde; Alcohol; Fetal alcohol syndrome; Fetotoxicity; Pyruvate dehydrogenase

Indexed keywords

ACETALDEHYDE; ADENOSINE TRIPHOSPHATE; DIHYDROLIPOAMIDE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHORUS 32; PYRUVATE DEHYDROGENASE;

ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME BINDING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FETAL ALCOHOL SYNDROME; GEL ELECTROPHORESIS; HEART; IN VITRO STUDY; NONHUMAN; SWINE; ULTRAVIOLET SPECTROPHOTOMETRY;

ACETALDEHYDE; ANIMALS; ENZYME INHIBITORS; KINETICS; MYOCARDIUM; PHOSPHORYLATION; PYRUVATE DEHYDROGENASE COMPLEX; SWINE;

EID: 0034780369     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0741-8329(01)00156-2     Document Type: Article

References (36)

1. An update on incidence of FAS: FAS is not an equal opportunity birth defect
2. Kinetic studies of the inhibitory effect of acetaldehyde and D(-)acetoin on the pyruvate dehydrogenase complex from pig heart
3. Inhibition by acetaldehyde of the pyruvate dehydrogenase complex from ox brain and ox kidney
4. Catalytic activity and quantitation of cytochrome P-450 2E1 in prenatal human brain
5. A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors
6. Acetaldehyde adducts with proteins: binding of [14C]acetaldehyde to serum albumin
7. Binding of metabolically derived acetaldehyde to hepatic proteins in vitro
8. Human blood acetaldehyde concentration during ethanol oxidation (update 1982)
9. Human blood acetaldehyde (update 1992)
10. Derangement of pyruvate dehydrogenase activity in circulating lymphocytes of a newborn with fetal alcohol syndrome [letter]
11. Ethanol, oxidative stress, reactive aldehydes, and the fetus
12. Pattern of malformation in offspring of chronic alcoholic mothers
13. Agenesis of the corpus callosum: a marker for inherited metabolic disease?
14. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
15. Comparison of the Akaike Information Criterion, the Schwarz criterion and the F test as guides to model selection
16. Covalent binding of acetaldehyde selectively inhibits the catalytic activity of lysine-dependent enzymes
17. Covalent binding of acetaldehyde to hepatic proteins during ethanol oxidation
18. Fitting curves to data using nonlinear regression: a practical and nonmathematical review
19. Maternal ethanol exposure induces transient impairment of umbilical circulation and fetal hypoxia in monkeys
20. Hemoglobin-acetaldehyde adducts are elevated in women carrying alcohol-damaged fetuses
21. Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and catalase/peroxidases
22. Abnormalities of the corpus callosum in children prenatally exposed to alcohol
23. Mitochondrial defects: an overview of inborn errors associated with lacticacidemia
24. Clinical presentation of mitochondrial respiratory chain defects in NADH-coenzyme Q reductase and cytochrome oxidase: clues to pathogenesis of Leigh disease
25. The development of pyruvate dehydrogenase in the subhuman primate Macaca mulatta
26. Reaction of acetaldehyde with hemoglobin
27. The role of maternal alcohol damage on ethanol teratogenicity in the rat
28. Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate dehydrogenase deficiency
29. Teratogenic effects of acetaldehyde in the rat
30. The chemistry of acetaldehyde-protein adducts
31. The interaction of acetaldehyde with tubulin
32. Functional consequences of acetaldehyde binding to proteins
33. Fetal abnormality and maternal ethanol metabolism [letter]
34. Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: implications for the study of the fetal alcohol syndrome
35. The interaction of ethanol and vitamin A as a potential mechanism for the pathogenesis of Fetal Alcohol syndrome