Panton-Valentine Leukocidin associated Staphylococcus aureus infections in London, England: Clinical and socio-demographic characterisation, management, burden of disease and associated costs

Journal of Infection and Public Health

Volumn 4, Issue 3, 2011, Pages 145-153

  Edelstein, Michael ^a   Kearns, Angela ^a   Cordery, Rebecca ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

" Panton Valentine leukocidin"; " Staphyloccus aureus"; England; MRSA; PVL

Indexed keywords

CHLORHEXIDINE; PANTON VALENTINE LEUKOCIDIN; PSEUDOMONIC ACID; TRICLOSAN;

ADULT; ARTICLE; DEMOGRAPHY; DISINFECTION; FEMALE; HEALTH CARE COST; HUMAN; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; UNITED KINGDOM;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; BACTERIAL TOXINS; CARRIER STATE; CHILD; CHILD, PRESCHOOL; CONTACT TRACING; CROSS-SECTIONAL STUDIES; EXOTOXINS; FEMALE; GEOGRAPHY; HEALTH CARE COSTS; HUMANS; INFANT; INFANT, NEWBORN; LEUKOCIDINS; LONDON; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SOCIOECONOMIC FACTORS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS; YOUNG ADULT;

EID: 80051684976     PISSN: 18760341     EISSN: 1876035X     Source Type: Journal    
DOI: 10.1016/j.jiph.2011.04.001     Document Type: Article

References (27)

1. Kluytmans J., van Belkum A., Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 1997, 10(July (3)):505-520.
2. Lowy F.D. Staphylococcus aureus infections. N Engl J Med 1998, 339(8):520-532.
3. Morgan M. Staphylococcus aureus, Panton-Valentine leukocidin and necrotising pneumonia. BMJ 2005, 331:793-794.
4. Prévost G., Mourey L., Colin D.A., Menestrina G. Staphylococcal pore-forming toxins. Curr Top Microbiol Immunol 2001, 257:53-83.
5. Voyich J.M., Otto M., Mathema B., Braughton K.R., Whitney A.R., Welty D., et al. Is Panton-Valentine leukocidin the major virulence determinant in community associated methicillin-resistant Staphylococcus aureus disease?. J Infect Dis 2006, 194(December (12)):1761-1770.
6. Bae I.G., Tonthat G.T., Stryjewski M.E., Rude T.H., Reilly L.F., Barriere S.L., et al. Presence of genes encoding the panton-valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational trial. J Clin Microbiol 2009, 47(December (12)):3952-3957.
7. Lina G., Piemont Y., Godail-Gamot F., Bes M., Peter M.O., Gauduchon V., et al. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 1999, 29(November (5)):1128-1132.
8. Gillet Y., Issartel B., Vanhems P., Fournet J.C., Lina G., Bes M., et al. Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet 2002, 359(March (9308)):753-759.
9. Cunnington A., Brick T., Cooper M., Danin J., Hunt D., Jeanes A., et al. Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK. J Infect 2009, 59(July (1)):28-36. 10.1016/j.jinf.2009.05.003.
10. Shallcross L.J., Williams K., Hopkins S., Aldridge R.W., Johnson A.M., Hayward A.C. Panton Valentine Leukocidin associated Staphylococcal disease: a cross sectional study at a London Hospital, England. Clin Microbiol Infect 2009, December 23 [Epub ahead of print].
11. Holmes A., Ganner M., McGuane S., Pitt T.L., Cookson B.D., Kearns A.M. Staphylococcus aureus isolates carrying Panton Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol 2005, 43(May (5)):2384-2390.
12. Ellington M.J., Ganner M., Smith I.M., Perry C., Cookson B.D., Kearns A.M. Panton-Valentine Leucocidin-related disease in England and Wales. Clin Microbiol Infect 2010, 16(January (1)):86-88.
13. Hawkes M., Barton M., Conly J., Nicolle L., Barry C., Ford-Jones E.L. Community associated MRSA: superbug at our doorstep. CMAJ 2007, 176:54-56.
14. Wannet W.J., Spalburg E., Heck M.E., Pluister G.N., Tiemersma E., Willems R.J., et al. Emergence of virulent methicillin-resistant Staphylococcus aureus strains carrying Panton-Valentine leucocidin genes in The Netherlands. J Clin Microbiol 2005, 43(July (7)):3341-3345.
15. Denis O., Deplano A., De B.H., Hallin M., Huysmans G., Garrino M.G., et al. Polyclonal emergence and importation of community-acquired methicillin resistant Staphylococcus aureus strains harbouring Panton-Valentine leucocidin genes in Belgium. J Antimicrob Chemother 2005, 56(December (6)):1103-1106.
16. Health Protection Agency website. [accessed 16/09/2010]. http://www.hpa.org.uk/ProductsServices/LocalServices/LocalAndRegionalServices/.
17. Health Protection Agency Guidance on the diagnosis and management of PVL-associated Staphylococcus aureus infections (PVL-SA) in England 2008 November, [accessed 16/09/2010]. http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1218699411960, 2nd ed.
18. Office for National Statistics Socio Economic Classification. 2010, [accessed 01/10/2010]. http://www.ons.gov.uk/about-statistics/classifications/current/ns-sec/index.html.
19. Fridkin S.K., Hageman J.C., Morrison M., Sanza L.T., Como-Sabetti K., Jernigan J.A. Methicillin resistant Staphylococcus aureus disease in three communities. N Engl J Med 2005, 352(April (14)):1436-1444.
20. Mesrati I., Saïdani M., Ennigrou S., Zouari B., Ben Redjeb S. Clinical isolates of Pantone-Valentine leucocidin- and gamma-haemolysin-producing Staphylococcus aureus: prevalence and association with clinical infections. J Hosp Infect 2010, 75(August (4)):265-268.
21. Nimmo G.R., Schooneveldt J.M., Sutherland J.L., Power S., Olesen D., Selvey C., et al. Epidemiology of non-multiresistant methicillin-resistant Staphylococcus aureus infection in Queensland, Australia: associations with indigenous populations and Panton-Valentine leukocidin. Eur J Clin Microbiol Infect Dis 2010, June 18 [Epub ahead of print].
22. Yao D., Fang-You Y., Qin Z.Q., Chen C., He S.S., Chen Z.Q., et al. Molecular characterisation of Staphylococcus aureus isolates causing skin and soft tissue infections (SSTIs). BMC Infect Dis 2010, 10:133.
23. Wehrhahn M.C., Robinson J.O., Pearson J.C., O'Brien F.G., Tan H.L., Coombs G.W., et al. Clinical and laboratory features of invasive community-onset methicllin resistant Staphylococcus aureus infection: a prospective case-control study. Eur J Clin Microbiol Infect Dis 2010, June 12 [Epub ahead of print].
24. NHS Payment by Results 2010-11 National Tariff Information. [accessed 21/09/2010]. http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_112284.
25. Huijsdens X.W., van Santen-Verheuvel M.G., Spalburg E., Heck M.E., Pluister G.N., Eijkelkamp B.A., et al. Multiple cases of familial transmission of community-acquired methicillin-resistant Staphylococcus aureus. J Clin Microbiol 2006, 44:2994-2996.
26. Langhi S., Robinson J.O., Pearson J.C., Christiansen K.J., Coombs G.W., Murray R.J. Intrafamilial transmission of methicillin-resistant Staphylococcus aureus. Emerg Infect Dis 2009, 15(10):1688. http://www.cdc.gov/eid.
27. Screening and treatment of PVL-Staphylococcus aureus. Department of Health Steering Group on Healthcare-associated Infections/Association of Medical microbiologists/Health Protection Agency.