Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults

Psychiatry Research - Neuroimaging

Volumn 193, Issue 3, 2011, Pages 161-167

  Gillihan, Seth J ^a   Rao, Hengyi ^b,c   Brennan, Lauretta ^b   Wang, Danny J J ^b   Detre, John A ^b   Sankoorikal, Geena Mary V ^b   Brodkin, Edward S ^b   Farah, Martha J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c SOUTH CHINA NORMAL UNIVERSITY   (China)

Author keywords

5 HTTLPR; Amygdala; Depression; Mood; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; AMYGDALOID NUCLEUS; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; BRAIN REGION; CLINICAL ARTICLE; DEPRESSION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MALE; NEUROBIOLOGY; NEUROIMAGING; PRIORITY JOURNAL; RISK FACTOR; SYMPTOM;

ADOLESCENT; ADULT; AMYGDALA; BRAIN MAPPING; DEPRESSION; FEMALE; FUNCTIONAL LATERALITY; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN; PERSONALITY ASSESSMENT; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 80051684095     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2011.03.003     Document Type: Article

References (45)

1. Beck A.T., Steer R.A., Brown G.K. Beck Depression Inventory Manual 1996, Psychological Corporation, San Antonio, TX. 2nd ed.
2. Brett M., Anton J.L., Valabregue R., Poline J.B. Region of interest analysis using an SPM toolbox. Neuroimage 2002, 16:497A.
3. Brockmann H., Zobel A., Schuhmacher A., Daamen M., Joe A., Biermann K., Schwab S.G., Biersack H.-J., Maier W., Boecker H. Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression. Journal of Psychiatric Research 2011, 45:442-451.
4. Canli T., Omura K., Haas B.W., Fallgatter A., Constable R.T., Lesch K.P. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences 2005, 102:12224-12229.
5. Canli T., Qui M., Omura K., Congdon E., Haas B.W., Amin Z., Hermann M.J., Constable R.T., Lesch K.P. Neural correlates of epigenesis. Proceedings of the National Academy of Sciences 2006, 103:16033-16038.
6. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., Herrmann M.J., Constable R.T., Lesch K.P. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
7. Chen M.C., Joormann J., Hallmayer J., Gotlib I.H. Serotonin transporter polymorphism predicts waking cortisol in young girls. Psychoneuroendocrinology 2009, 34:681-686.
8. Cohen J. A power primer. Psychological Bulletin 1992, 112:155-159.
9. Costa P.T., McCrae R.R. Revised NEO Personality Inventory (NEO-PI-R) and NEO-Five-Factor Inventory (NEO-FFI) Professional Manual 1992, Psychological Assessment Resources, Odessa, FL.
10. Dannlowski U., Ohrmann P., Bauer J., Deckert J., Hohoff C., Kugel H., Arolt V., Heindel W., Kersting A., Baune B.T., Suslow T. 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology 2008, 33:418-424.
11. Detre J.A., Leigh J.S., Williams D.S., Koretsky A.P. Perfusion imaging. Magnetic Resonance in Medicine 1992, 23:37-45.
12. Drevets W.C., Price J.L., Bardgett M.E., Reich T., Todd R.D., Raichle M.E. Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacology, Biochemistry and Behavior 2002, 71:431-447.
13. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) 1996, American Psychiatric Press, Inc., Washington, D.C.
14. Fortier E., Noreau A., Lepore F., Boivin M., Pérusse D., Rouleau G.A., Beauregard M. Early impact of 5-HTTLPR polymorphism on the neural correlates of sadness. Neuroscience Letters 2010, 485:261-265.
15. Friedel E., Schlagenhauf F., Sterzer P., Park S.Q., Bermpohl F., Ströhle A., Stoy M., Puls I., Hägele C., Wrase J., Büchel C., Heinz A. 5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls. Psychopharmacology 2009, 205:261-271.
16. Furman, D.J., Hamilton, P., Joormann, J., Gotlib, I.H., in press. Altered timing of amygdala activation during sad mood elaboration as a function of 5-HTTLPR. Social Cognitive and Affective Neuroscience.
17. Furmark T., Tillfors M., Garpenstrand H., Marteinsdottir I., Långström B., Oreland L., Fredrickson M. Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neuroscience Letters 2004, 362:189-192.
18. Gelernter J., Cubells J.F., Kidd J.R., Pakstis A.J., Kidd K.K. Population studies of polymorphisms of the serotonin transporter protein gene. Human Genetics 1997, 101:243-246.
19. Gillihan S.J., Rao H., Wang J., Detre J.A., Breland J., Sankoorikal G.M.V., Brodkin E.S., Farah M.J. Serotonin transporter genotype modulates amygdala activity during mood regulation. Social Cognitive and Affective Neuroscience 2010, 5:1-10.
20. Gotlib I.H., Joormann J., Minor K.L., Hallmayer J. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry 2008, 63:847-851.
21. Hariri A.R., Holmes A. Genetics of emotion regulation: the role of the serotonin transporter in neural function. Trends in Cognitive Sciences 2006, 10:182-191.
22. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., Egan M.F., Weinberger D.R. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-403.
23. Heinz A., Braus D.F., Smolka M.N., Wrase J., Puls I., Hermann D., Klein S., Grüsser S.M., Flor H., Schumann G., Mann K., Büchel C. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience 2005, 8:20-21.
24. Hermes M., Hagemann D., Britz P., Lieser S., Bertsch K., Naumann E., Walter C. Latent state-trait structure of cerebral blood flow in a resting state. Biological Psychology 2009, 80:196-202.
25. Hu X., Oroszi G., Chun J., Smith T.L., Goldman D., Schuckit M.A. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism, Clinical and Experimental Research 2005, 29:8-16.
26. Huettel S.A., Song A.W., McCarthy G. Functional Magnetic Resonance Imaging 2004, Sinauer Associates, Inc., Sunderland, MA.
27. Kaufman J., Yang B.-Z., Douglas-Palumberi H., Houshyar S., Lipschitz L., Krystal J.H., Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences 2004, 101:17316-17321.
28. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Archives of General Psychiatry 2005, 62:529-535.
29. Lesch K.-P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Müller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531.
30. Lotrich F.E., Pollock B.G. Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatric Genetics 2004, 14:121-129.
31. Malhotra A.K., Goldman D. Benefits and pitfalls encountered in psychiatric genetic association studies. Biological Psychiatry 1999, 45:544-550.
32. Morris J.S., Frith C.D., Perrett D.I., Rowland D., Young A.W., Calder A.J., Dolan R.J. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 1996, 383:812-815.
33. Munafò M.R., Brown S.M., Hariri A.R. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biological Psychiatry 2008, 63:852-857.
34. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., Egan M.F., Mattay V.S., Hariri A.R., Weinberger D.R. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience 2005, 8:828-834.
35. Posse S., Fitzgerald D., Gao K., Habel U., Rosenberg D., Moore G.J., Schneider F. Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness. Neuroimage 2003, 18:760-768.
36. Raichle M.E. Imaging the mind. Seminars in Nuclear Medicine 1998, 28:278-289.
37. Rao H., Gillihan S.J., Wang J., Korczykowski M., Sankoorikal G.M.V., Kaercher K.A., Brodkin E.S., Detre J.A., Farah M.J. Genetic variation in serotonin transporter alters resting brain function in healthy individuals. Biological Psychiatry 2007, 62:600-606.
38. Reimold M., Knobel A., Rapp M.A., Batra A., Wiedemann K., Ströhle A., Zimmer A., Schönknecht P., Smolka M.N., Weinberger D.R., Goldman D., Machulla H.-J., Bares R., Heinz A. Central serotonin transporter levels are associated with stress hormone response and anxiety. Psychopharmacology 2011, 213:563-572.
39. Risch N., Herrell R., Lehner T., Liang K.-Y., Eaves L., Hoh J., Griem A., Kovacs M., Ott J., Merikangas K.R. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. Journal of the American Medical Association 2009, 301:2462-2471.
40. Schardt D.M., Erk S., Nüsser C., Nöthen M.M., Cichon S., Rietschel M., Treutlein J., Goschke T., Walter H. Volition diminishes genetically mediated amygdala hyperreactivity. Neuroimage 2010, 53:943-951.
41. Seminowicz D.A., Mayberg H.S., McIntosh A.R., Goldapple K., Kennedy S., Segal Z., Rafi-Tari S. Limbic-frontal circuitry in major depression: a path modeling meta-analysis. Neuroimage 2004, 22:409-418.
42. Siegle G.J., Carter C.S., Thase M.E. Use of fMRI to predict recovery from unipolar depression with cognitive behavior therapy. The American Journal of Psychiatry 2006, 163:735-738.
43. Tzourio-Mazoyer N., Landeau B., Papathanassiou D., Crivello F., Etard O., Delcroix N., Mazoyer B., Joliot M. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002, 15:273-289.
44. Viviani R., Sim E.-J., Lo H., Beschoner P., Osterfeld N., Maier C., Seeringer A., Godoy A.L., Rosa A., Comas D., Kirchheiner J. Baseline perfusion and the serotonin transporter promoter polymorphism. Biological Psychiatry 2010, 67:317-322.
45. Wang J., Zhang Y., Wolf R.L., Roc A.C., Alsop D.C., Detre J.A. Amplitude modulated continuous arterial spin labeling perfusion MR with single coil at 3T-feasibility. Radiology 2005, 235:218-228.