Screening of medicinal plants from Iranian traditional medicine for acetylcholinesterase inhibition

Phytotherapy Research

Volumn 25, Issue 8, 2011, Pages 1148-1152

  Adhami, Hamid Reza ^a   Farsam, Hassan ^b   Krenn, Liselotte ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

acetylcholinesterase inhibition; harmaline; harmine; Iranian traditional medicine; Peganum harmala; TLC bioautography

Indexed keywords

ACETYLCHOLINESTERASE; ACORUS CALAMUS EXTRACT; ALOE LITTORALIS EXTRACT; ANETHUM GRAVEOLENS EXTRACT; ASARUM EUROPAEUM EXTRACT; ASTRAGALUS ARBUSCULINUS EXTRACT; BOSWELLIA CARTERII EXTRACT; BUNIUM PERSICUM EXTRACT; CANNABIS; CHOLINESTERASE INHIBITOR; CINNAMOMUM ZEYLANICUM EXTRACT; COMMIPHORA MUKUL EXTRACT; CORIANDRUM SATIVUM EXTRACT; CUMINUM CYMINUM EXTRACT; CYPERUS LONGUS EXTRACT; DOREMA AMMONIACUM EXTRACT; ECHINOPS CEPHALOTES EXTRACT; EMBLICA OFFICINALIS EXTRACT; EUGENIA CARYOPHYLLATA EXTRACT; FERULA ASSA FOETIDA EXTRACT; FERULA GUMMOSA EXTRACT; HARMALINE; HARMINE; HERBACEOUS AGENT; IRIS GERMANICA EXTRACT; NARDOSTACHYS JATAMANSI EXTRACT; NEPETA MENTHOIDES EXTRACT; NIGELLA SATIVA EXTRACT; PEGANUM HARMALA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALOE LITTORALIS; AMMONIAC PLANT; AMNESIA; ANALYTIC METHOD; ARTICLE; ASARUM EUROPAEUM; ASTRAGALUS ARBUSCULINUS; BOSWELLIA CARTERII; BUNIUM PERSICUM; CINNAMOMUM ZEYLANICUM; CLOVE; COGNITIVE DEFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CUMIN; CYPERUS LONGUS; DILL; DRUG ACTIVITY; DRUG SCREENING; ECHINOPS CEPHALOTES; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACTION; FERULA ASSA FOETIDA; FERULA GUMMOSA; IC 50; IRANIAN TRADITIONAL MEDICINE; IRIS GERMANICA; MEDICINAL PLANT; MENTAL PERFORMANCE; NARDOSTACHYS JATAMANSII; NEPETA MENTHOIDES; TRADITIONAL MEDICINE;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HARMALINE; HARMINE; IRAN; MEDICINE, TRADITIONAL; PEGANUM; PLANT EXTRACTS; PLANTS, MEDICINAL; SEEDS;

PEGANUM HARMALA;

EID: 80051677680     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3409     Document Type: Article

References (28)

1. Adhami HR, Mesgarpour B, Farsam H,. 2007. Herbal medicine in Iran. HerbalGram 74: 34-43.
2. Amin GH,. 2005. Popular Medicinal Plants of Iran. Tehran University of Medical Sciences: Tehran.
3. Andrade C, Sudha S, Venkataraman BV,. 2000. Herbal treatments for ECS-induced memory deficits: A review of research and a discussion on animal models. J ECT 16: 144-156.
4. Arshad N, Zitterl-Eglseer K, Hasnain S, Hess M,. 2008. Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry. Phytother Res 22: 1533-1538. (Pubitemid 352789625)
5. Blaschek W, Ebel S, Hackenthal E, et al,. 2007. Hagers Enzyklopaedie der Arzneistoffe und Drogen, 6th edn. Wissenschaftliche Verlagsgeselschaft mbH Stuttgart: Stuttgart; 12: 113-115.
6. Brewer GJ,. 1998. Age-related toxicity to lactate, glutamate, and β-amyloid in cultured adult neurons. Neurobiol Aging 19: 561-568. (Pubitemid 29117123)
7. Carpinella MC, Andrione DG, Ruiz G, Palacios SM,. 2010. Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina. Phytother Res 24: 259-263.
8. El-Dwairi QA, Banihani SM,. 2007. Histo-functional effects of Peganum harmala on male rat's spermatogenesis and fertility. Neuro Endocrinol Lett 28: 305-310. (Pubitemid 47049459)
9. Francis PT, Palmer AM, Snape M, Wilcock GK,. 1999. The cholinergic hypothesis of Alzheimer's disease: a review of progress. J Neurol Neurosurg Psychiatry 66: 137-147. (Pubitemid 29103513)
10. Garcia-Alloza M, Zaldua N, Diez-Ariza M, et al,. 2006. Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. J Neuropathol Exp Neurol 65: 1074-1081. (Pubitemid 44684665)
11. Ghahreman A, Okhovvat AR,. 2004. Matching the Old Medicinal Plant Names with Scientific Terminology. University of Tehran Press: Tehran, Vol. 1.
12. Giacobini E,. 1990. The cholinergic system in Alzheimer disease. Prog Brain Res 84: 321-332. (Pubitemid 20373012)
13. Herraiz T, Gonzalez D, Ancin-Azpilicueta C, Aran VJ, Guillen H,. 2010. beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food Chem Toxicol 48: 839-845.
14. Hostettmann K, Borloz A, Urbain A, Marston A,. 2006. Natural product inhibitors of acetylcholinesterase. Curr Org Chem 10: 825-847.
15. Howes MJ, Houghton PJ,. 2003. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol Biochem Behav 75: 513-527. (Pubitemid 36939171)
16. Issa Bey A,. 1930. Dictionaire des Nomes des Plantes (premiere edition). Imprimerie National: Le Caire.
17. Li Y, Liang F, Jiang Wei, et al,. 2007. DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer Biol Ther 6: 1193-1199. (Pubitemid 351590371)
18. Marston A, Kissling J, Hostettmann K,. 2002. A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants. Phytochem Anal 13: 51-54. (Pubitemid 34126614)
19. Monsef HR, Ghobadi A, Iranshahi M, Abdollahi M,. 2004. Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. J Pharm Pharm Sci 7: 65-69. (Pubitemid 38628938)
20. Moura DJ, Richter MF, Boeira JM, Pêgas Henriques JA, Saffi J,. 2007. Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities. Mutagenesis 22: 293-302. (Pubitemid 47216620)
21. Mukherjee PK, Kumar V, Houghton PJ,. 2007. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 21: 1142-1145.
22. Nenaah G,. 2010. Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects. Fitoterapia April 14 (Epub ahead of print).
23. Rhee IK, van de Meent M, Ingkaninan K, Verpoorte R,. 2001. Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. J Chromatogr A 915: 217-223. (Pubitemid 32289341)
24. Shahverdi AR, Monsef-Esfahani HR, Nickavar B, Bitarafan L, Khodaee S, Khoshakhlagh N,. 2005. Antimicrobial activity and main chemical composition of two smoke condensates from Peganum harmala seeds. Z Naturforsch C 60: 707-710. (Pubitemid 41615698)
25. Wang X, Geng Y, Wang D, Shi X, Liu J,. 2008. Separation and purification of harmine and harmaline from Peganum harmala using pH-zone-refining counter-current chromatography. J Sep Sci 31: 3543-3547.
26. Zahedi E,. 1959. Botanical Dictionary: Scientific Names of Plants in English, French, German, Arabic and Persian Languages. Tehran University Publication: Tehran.
27. Zargari A,. 1989. Medicinal Plants. Tehran University Press: Tehran; Vol. 1: 637-639.
28. Zheng XY, Zhang ZJ, Chou GX, et al. 2009. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res 32: 1245-1251.