Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave-on products

Contact Dermatitis

Volumn 65, Issue 3, 2011, Pages 167-174

  Schnuch, Axel ^a   Mildau, Gerd ^b   Kratz, Eva Maria ^b   Uter, Wolfgang ^c  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Chemical and Veterinary Investigation Office (CVUA Karlsruhe)   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

allergic contact dermatitis; cosmetics; exposure; leave on products; preservatives; risk; sensitizer

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE; 2 PHENOXYETHANOL; 4 HYDROXYBENZOIC ACID ESTER; 5 CHLORO 2 METHYL 4 ISOTHIAZOLIN 3 ONE; BENZOIC ACID; BENZYL ALCOHOL; CARBAMIC ACID DERIVATIVE; CONTACT ALLERGEN; COSMETIC; LEAVE ON PRODUCT; POLYSORBATE; PRESERVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATOPIC DERMATITIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXPOSURE VARIABLE; FEMALE; HUMAN; MALE; PATCH TEST; RISK ASSESSMENT; RISK FACTOR; SKIN ALLERGY; SKIN SENSITIZATION;

ADULT; ALLERGENS; COSMETICS; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, ATOPIC; ENVIRONMENTAL EXPOSURE; FACIAL DERMATOSES; FEMALE; HAND DERMATOSES; HUMANS; MALE; MIDDLE AGED; PATCH TESTS; PRESERVATIVES, PHARMACEUTICAL;

EID: 80051676692     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2011.01939.x     Document Type: Article

References (32)

1. Schnuch A, Uter W, Geier J, Gefeller O., Epidemiology of contact allergy: an estimation of morbidity employing the clinical epidemiology and drug utilisation research (CE-DUR) approach. Contact Dermatitis 2002: 47: 32-39.
2. Menezes-de-Padua C A, Schnuch A, Nink K, Pfahlberg A, Uter W., Allergic contact dermatitis to topical drugs-epidemiological risk assessment. Pharmacoepidemiol Drug Saf 2008: 17: 813-821.
3. Menezes-de-Padua C A, Uter W, Schnuch A., Contact allergy to topical drugs: prevalence in a clinical setting and estimation of frequency at the population level. Pharmacoepidemiol Drug Saf 2007: 16: 377-384. (Pubitemid 46661425)
4. de Groot A C, Flyvholm M A, Lensen G, Menné T, Coenraads P J., Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers. Contact Dermatitis 2009: 61: 63-85.
5. Lundov M D, Johansen J D, Carlsen B C, Engkilde K, Menné T, Thyssen J P., Formaldehyde exposure and patterns of concomitant contact allergy to formaldehyde and formaldehyde-releasers. Contact Dermatitis 2010: 63: 31-36.
6. Statham B N, Smith E V, Bodger O G et al., Concomitant contact allergy to methylchloroisothiazolinone/methylisothiazolinone and formaldehyde-releasing preservatives. Contact Dermatitis 2010: 62: 56-57.
7. Lundov M D, Thyssen J P, Zachariae C, Johansen J D., Prevalence and cause of methylisothiazolinone contact allergy. Contact Dermatitis 2010: 63: 164-167.
8. Ackermann L, Aalto-Korte K, Alanko K et al., Contact sensitization to methylisothiazolinone in Finland-a multicentre study. Contact Dermatitis 2011: 64: 49-53.
9. Schnuch A, Lessmann H, Geier J, Uter W., Contact allergy to preservatives. Analysis of IVDK data 1996-2009. Br J Dermatol 2011: 164: 1316-1325.
10. Jong C T, Statham B N, Green C M et al., Contact sensitivity to preservatives in the UK, 2004-2005: results of multicentre study. Contact Dermatitis 2007: 57: 165-168. (Pubitemid 47228513)
11. Thyssen J P, Engkilde K, Lundov M D, Carlsen B C, Menné T, Johansen J D., Temporal trends of preservative allergy in Denmark (1985-2008). Contact Dermatitis 2010: 62: 102-108.
12. Zachariae C, Hall B, Cottin M, Cupferman S, Andersen K E, Menné T., Experimental elicitation of contact allergy from a diazolidinyl urea-preserved cream in relation to anatomical region, exposure time and concentration. Contact Dermatitis 2005: 53: 268-277. (Pubitemid 41719276)
13. The Scientific Committee on Cosmetic Products and Non Food Products Intended for the Consumer. Opinion concerning methylisothiazolinone. In: Adopted by the SCCNFP During the 23rd Plenary Meeting of March 2003. Available at: http://ec.europa.eu/health/ph-risk/committees/sccp/documents/out-201.pdf (last accessed 13 March 2011).
14. Schnuch A, Geier J, Gefeller O, Uter W., A common and insidious side-efect: allergic contact dermatitis caused by bufexamac used in the treatment of dermatitis (Eine heimtückische und häufige Nebenwirkung: Das Ekzemtherapeuticum Bufexamac verursacht selbst Kontaktallergien. Ergebnisse des IVDK). Dtsch Med Wochenschr 2005: 130: 2881-2886. (Pubitemid 43014752)
15. Zoli V, Tosti A, Silvani S, Vincenzi C., Moist toilet papers as possible sensitizers: review of the literature and evaluation of commercial products in Italy. Contact Dermatitis 2006: 55: 252-254. (Pubitemid 44350956)
16. Isaksson M, Gruvberger B, Bruze M., Occupational contact allergy and dermatitis from methylisothiazolinone after contact with wallcovering glue and after a chemical burn from a biocide. Dermatitis 2004: 15: 201-205. (Pubitemid 40250270)
17. Thyssen J P, Sederberg-Olsen N, Thomsen J F, Menné T., Contact dermatitis from methylisothiazolinone in a paint factory. Contact Dermatitis 2006: 54: 322-324. (Pubitemid 43886531)
18. García-Gavín J, Vansina S, Kerre S, Naert A, Goossens A., Methylisothiazolinone, an emerging allergen in cosmetics? Contact Dermatitis 2010: 63: 96-101.
19. SCCP. Opinion on dermal sensitisation quantitative risk assessment (citral, farnesol and phenylacetaldehyde). Available at: http://ec.europa.eu/ health/ph-risk/committees/04-sccp/docs/sccp-o-135.pdf (last accessed 13 march 2011).
20. Basketter D A, Clapp C J, Safford B J, Jowsey I R, McNamee P, Ryan C A, Gerberick G F., Preservatives and skin sensitization quantitative risk assessment. Dermatitis 2008: 19: 20-27. (Pubitemid 351428407)
21. Scientific Committee on Consumer Safety. Opinion on the mixture of 5-chloro-2-methylsiothiazolin-3(2H)-one and 2-methylisothiazolin-3(2H)-one. SCCS/1238/09. Available at: http://ec.europa.eu/health/scientific-committees/ consumer-safety/docs/sccs-o-009.pdf (last accessed 13 March 2011).
22. Frosch P J, Weickel R., Kontaktallergie auf das Konservierungsmittel Bronopol. Hautarzt 1987: 38: 267-270. (Pubitemid 17068046)
23. Frosch P J, White I R, Rycroft R J, Lahti A, Burrows D, Camarasa J G, Ducombs G, Wilkinson J D., Contact allergy to Bronopol. Contact Dermatitis 1990: 22: 24-26. (Pubitemid 20030026)
24. Natsch A, Gfeller H., LC-MS-based characterization of the peptide reactivity of chemicals to improve the in vitro prediction of the skin sensitization potential. Toxicol Sci 2008: 106: 464-478.
25. Roberts D W, Patlewicz G, Kern P S et al., Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem Res Toxicol 2007: 20: 1019-1030. (Pubitemid 47204815)
26. Basketter D A, Scholes E W, Kimber I., The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food Chem Toxicol 1994: 32: 543-547. (Pubitemid 24234386)
27. Gerberick G F, Ryan C A, Kern P S, Schlatter H, Dearman R J, Kimber I, Patlewicz G Y, Basketter D A., Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 2005: 16: 157-202. (Pubitemid 43053764)
28. Basketter D, Kimber I., Predictive tests for irritants and allergens and their use in quantitative risk assessment. In: Contact Dermatitis, 4th edition, Frosch P J, Menné T, Lepoittevin J-P, (eds): Berlin, Springer, 2006: pp. 179-187.
29. Yamano T, Shimizu M, Noda T., Quantitative comparison of the results obtained by the multiple-dose guinea pig maximization test and the non-radioactive murine local lymph-node assay for various biocides. Toxicology 2005: 211: 165-175. (Pubitemid 40603638)
30. Schnuch A, Geier J, Lessmann H, Uter W., Untersuchungen zur Verbreitung umweltbedingter Kontaktallergien mit Schwerpunkt im privaten Bereich. Im Auftrag des Umweltbundesamtes (FKZ 299 61 219). 2011: WaBoLu 2004; No. 01 (ISSN 0175-4211). Available at: http://www.umweltbundesamt.de/ubainfo-medien/dateien/ 2620.htm (last accessed 13 March 2011).
31. Yazar K, Johnsson S, Lind M L, Boman A, Lidén C., Preservatives and fragrances in selected consumer-available cosmetics and detergents. Contact Dermatitis 2011: 64: 265-272.
32. Flyvholm M A., Preservatives in registered chemical products. Contact Dermatitis 2005: 53: 27-32.