Circulating heat shock protein 70 (Hsp70) in elderly members of a rural population from Cameroon: Association with infection and nutrition

Archives of Gerontology and Geriatrics

Volumn 53, Issue 3, 2011, Pages 359-363

  Njemini, R ^a   Smitz, J ^b   Demanet, C ^b   Sosso, M ^c   Mets, T ^a,b  

^a FACULTY OF MEDICINE AND PHARMACY   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c UNIVERSITY OF YAOUNDÉ I   (Cameroon)

Author keywords

Elderly in Africa; Hsp70; Infection; Vitamin B12; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; CALCIUM; CYANOCOBALAMIN; FOLIC ACID; HEAT SHOCK PROTEIN 70; MALARIA ANTIBODY; PARASITE ANTIBODY; PARATHYROID HORMONE; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ANTIBODY TITER; ARTICLE; CALCIUM BLOOD LEVEL; CAMEROON; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FILARIASIS; FOLIC ACID BLOOD LEVEL; HUMAN; INFECTION; INFLAMMATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NUTRITION; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RURAL POPULATION; VITAMIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; AGING; C-REACTIVE PROTEIN; CAMEROON; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLIC ACID; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFECTION; INFLAMMATION; MALE; MIDDLE AGED; NUTRITIONAL STATUS; RURAL POPULATION; SOCIOECONOMIC FACTORS; VITAMIN B 12; VITAMIN D;

EID: 80051673124     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2011.01.005     Document Type: Article

References (73)

1. Abd el All H., Rey A., Duvillard P. Expression of heat shock protein 70 and c-myc in cervical carcinoma. Anticancer Res. 1998, 18:1533-1536.
2. Agrawal A., Cha-Molstad H., Samols D., Kushner I. Overexpressed nuclear factor-kappa-B can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBP-beta and signal transducer and activator of transcription-3. Immunology 2003, 108:539-547.
3. Arnadottir M., Gudnason V., Hultberg B. Treatment with different doses of folic acid in haemodialysis patients: effects on folate distribution and aminothiol concentrations. Nephrol. Dial. Transplant. 2000, 15:524-528.
4. Barreto A., Gonzalez J.M., Kabingu E., Asea A., Fiorentino S. Stress-induced release of HSC70 from human tumors. Cell Immunol. 2003, 222:97-104.
5. Biswas D.K., Johnson B.C. Glutathione reductase and dehydrogenase activity in vitamin B12 deficiency. Arch. Biochem. Biophys. 1964, 104:375-380.
6. Brewer L.D., Thibault V., Chen K.C., Langub M.C., Landfield P.W., Porter N.M. Vitamin D, hormone confers, neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J. Neurosci. 2001, 21:98-108.
7. Cheng T.C., Benton H.P. The intracellular Ca(2+)-pump inhibitors thapsi-gargin and cyclopiazonic acid induce stress proteins in mammalian chondrocytes. Biochem. J. 1994, 301:563-568.
8. Chirico W.J., Waters M.G., Blobel G. 70K heat shock related proteins stimulate protein translocation into microsomes. Nature 1988, 332:805-810.
9. De Maio A. The heat-shock response. New Horiz. 1995, 3:198-207.
10. De Maio A. Heat shock proteins: facts, thoughts, and dreams. Shock 1999, 11:1-12.
11. Deguchi Y., Kishimoto S. Enhanced expression of the heat shock protein gene in peripheral blood mononuclear cells of patients with active systemic lupus erythematosus. Ann. Rheum. Dis. 1990, 49:893-895.
12. Doong H., Rizzo K., Fang S., Kulpa V., Weissman A.M., Kohn E.C. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. J. Biol. Chem. 2003, 278:28490-28500.
13. Elo M.A., Sironen R.K., Kaarniranta K., Auriola S., Helminen H.J., Lammi M.J. Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytic cells. J. Cell Biochem. 2000, 79:610-619.
14. Evdonin A.L., Guzhova I.V., Margulis B.A., Medvedeva N.D. Phospholipse c inhibitor, u73122, stimulates release of hsp-70 stress protein from A431 human carcinoma cells. Cancer Cell Int. 2004, 4:2.
15. Fincato G., Polentarutti N., Sica A., Mantovani A., Colotta F. Expression of a heat-inducible gene of the HSP70 family in human myelomonocytic cells: regulation by bacterial products and cytokines. Blood 1991, 77:579-586.
16. Flohe S., Dominguez Fernandez E., Ackermann M., Hirsch T., Borgermann J., Schade F.U. Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10 VCAM-1 AND HSP 70 in lung and liver during endotoxin shock. Cytokine 1999, 11:796-804.
17. Ford L., Lobo C.A., Rodriguez M., Zalis M.G., Machado R.L., Rossit A.R., Cavasini C.E., Couto A.A., Enyong P.A., Lustigman S. Differential antibody responses to Plasmodium falciparum invasion ligand proteins in individuals living in malaria-endemic areas in Brazil and Cameroon. Am. J. Trop. Med. Hyg. 2007, 77:977-983.
18. Forsdyke D.R. Heat shock proteins defend against intracellular pathogens: a non-immunological basis for self/non-self discrimination?. J. Theor. Biol. 1985, 115:471-473.
19. Fukayama S., Lanske B., Guo J., Kronenberg H.M., Bringhurst F.R. Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels. Am. J. Physiol. 1996, 271:C121-C129.
20. Garcion E., Wion-Barbot N., Montero-Menei C.N., Berger F., Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol. Metab. 2002, 13:100-105.
21. Georgopoulos C., Welch W.J. Role of the major heat shock proteins as molecular chaperones. Annu. Rev. Cell Biol. 1993, 9:601-634.
22. Guzhova I., Kislyakova K., Moskaliova O., Fridlanskaya I., Tytell M., Cheetham M., Margulis B. In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res. 2001, 914:66-73.
23. Haranaga S., Yamaguchi H., Ikejima H., Friedman H., Yamamoto Y. Chlamydia pneumoniae infection of alveolar macrophages: a model. J. Infect. Dis. 2003, 187:1107-1115.
24. Heufelder A.E., Goellner J.R., Wenzel B.E., Bahn R.S. Immunohisto-chemical detection and localization of a 72-kilodalton heat shock protein in autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 1992, 74:724-731.
25. Hightower L.E., Guidon P.T. Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins. J. Cell Physiol. 1989, 138:257-266.
26. Hunter-Lavin C., Davies E.L., Bacelar M.M., Marshall M.J., Andrew S.M., Willi-ams J.H. Hsp70 release from peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 2004, 324:511-517.
27. Hunter-Lavin C., Hudson P.R., Mukherjee S., Davies G.K., Williams C.P., Harvey J.N., Child D.F., Williams J.H. Folate supplementation reduces serum hsp70 levels in patients with type 2 diabetes. Cell Stress Chaperones 2004, 9:344-349.
28. Isoda K., Kagaya N., Akamatsu S., Hayashi S., Tamesada M., Watanabe A., Kobayashi M., Tagawa Y., Kondoh M., Kawase M., Yagi K. Hepato-protective effect of vitamin B12 on dimethylnitrosamine-induced liver injury. Biol. Pharm. Bull. 2008, 31:309-311.
29. Kaufmann S.H. The cellular immune response to heat shock proteins. Experientia 1992, 48:640-643.
30. Kimura F., Itoh H., Ambiru S., Shimizu H., Togawa A., Yoshidome H., Ohtsuka M., Shimamura F., Kato A., Nukui Y., Miyazaki M. Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection. Am. J. Surg. 2004, 187:777-784.
31. Li J.J., Fang C.H. C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases. Med. Hypotheses 2004, 62:499-506.
32. Liao D.F., Jin Z.G., Baas A.S., Daum G., Gygi S.P., Aebersold R., Berk B.C. Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J. Biol. Chem. 2000, 275:189-196.
33. Liu H., Lightfoot R., Stevens J.L. Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols. J. Biol. Chem. 1996, 271:4805-4812.
34. Losem-Heinrichs E., Gorg B., Schleicher A., Redecker C., Witte O.W., Zilles K., Bidmon H.J. A combined treatment with 1alpha,25-dihydroxy-vitamin D3 and 17beta-estradiol reduces the expression of heat shock protein-32 (HSP-32) following cerebral cortical ischemia. J. Steroid Biochem. Mol. Biol. 2004, 89-90:371-374.
35. MacLaughlin J., Holick M.F. Aging decreases the capacity of human skin to produce vitamin D3. J. Clin. Invest. 1985, 76:1536-1538.
36. Maresca B., Kobayashi G.S. Hsp70 in parasites: as an inducible protective protein and as an antigen. Experientia 1994, 50:1067-1074.
37. Mets T.F. The disease pattern of elderly medical patients in Rwanda, central Africa. J. Trop. Med. Hyg. 1993, 96:291-300.
38. Mets T., Smitz J., Ngendahayo P., Sabbe L., Bigilimana I., Ngirabatware B. Hepatitis C virus infection in African patients with liver cirrhosis or primary hepatocellular carcinoma. Scand. J. Gastroenterol. 1993, 28:331-334.
39. Minota S., Cameron B., Welch W.J., Winfield J.B. Autoantibodies to the constitutive 73-kDa member of the hsp70 family of heat shock proteins in systemic lupus erythematosus. J. Exp. Med. 1988, 168:1475-1480.
40. Minowada G., Welch W.J. Clinical implications of the stress response. J. Clin. Invest. 1995, 95:3-12.
41. Moehler M.H., Zeidler M., Wilsberg V., Cornelis J.J., Woelfel T., Rommelaere J., Galle P.R., Heike M. Parvovirus H-1-induced tumor cell death enhances human immune response in vitro via increased phagocytosis, maturation, and cross-presentation by dendritic cells. Hum. Gene Ther. 2005, 16:996-1005.
42. Monahan I.M., Betts J., Banerjee D.K., Butcher P.D. Differential expression of mycobacterial proteins following phagocytosis by macrophages. Microbiology 2001, 147:459-471.
43. Moseley P.L. Heat shock proteins and the inflammatory response. Ann. N. Y. Acad. Sci. 1998, 856:206-213.
44. Nakano M., Knowlton A.A., Yokoyama T., Lesslauer W., Mann D.L. Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes. Am. J. Physiol. 1996, 270:H1231-H1239.
45. Nguyen N.Y., Suzuki A., Cheng S.M., Zon G., Liu T.Y. Isolation and characterization of Limulus C-reactive protein genes. J. Biol. Chem. 1986, 261:10450-11045.
46. Njemini R., Meyers I., Demanet C., Smitz J., Sosso M., Mets T. The prevalence of autoantibodies in an elderly sub-Saharan African population. Clin. Exp. Immunol. 2002, 127:99-106.
47. Njemini R., Lambert M., Demanet C., Mets T. Elevated serum heat-shock protein 70 levels in patients with acute infection: use of an optimized enzyme-linked immunosorbent assay. Scand. J. Immunol. 2003, 58:664-669.
48. Njemini R., Lambert M., Demanet C., Vanden Abeele M., Vandebosch S., Mets T. The induction of heat shock protein 70 in peripheral mononuclear blood cells in elderly patients: a role for inflammatory markers. Hum. Immunol. 2003, 64:575-585.
49. Njemini R., Demanet C., Mets T. Inflammatory status as an important determinant of heat shock protein 70 serum concentrations during aging. Biogerontology 2004, 5:31-38.
50. Njemini R., Demanet C., Mets T. Comparison of two ELISAs for the determination of Hsp70 in serum. J. Immunol. Methods 2005, 306:176-182.
51. Njemini R., Lambert M., Demanet C., Mets T. Heat shock protein 32 in human peripheral blood mononuclear cells: effect of aging and inflammation. J. Clin. Immunol. 2005, 25:405-417.
52. Njemini R., Bautmans I., Lambert M., Demanet C., Mets T. Heat shock proteins and chemokine/cytokine secretion profile in ageing and inflammation. Mech. Ageing Dev. 2007, 128:450-454.
53. Njemini R., Lambert M., Demanet C., Kooijman R., Mets T. Basal and infection-induced levels of heat shock proteins in human aging. Biogerontology 2007, 8:353-364.
54. Park J.W., Moon C., Yun S., Kim S.Y., Bae Y.C., Chun M.H., Moon J.I. Differential expression of heat shock protein mRNAs under in vivo glutathione depletion in the mouse retina. Neurosci. Lett. 2007, 413:260-264.
55. Pockley A.G. Heat shock proteins as regulators of the immune response. Lancet 2003, 362:469-476.
56. Polla B.S. Heat shock proteins in host-parasite interactions. Immunol. Today 1991, 12:A38-A41.
57. Polla B.S., Bachelet M., Elia G., Santoro M.G. Stress proteins in inflammation. Ann. N. Y. Acad. Sci. 1998, 851:75-85.
58. Ramage L., Proudfoot L., Guy K. Expression of C-reactive protein in human lung epithelial cells and upregulation by cytokines and carbon particles. Inhal. Toxicol. 2004, 16:607-613.
59. Salotra P., Chauhan D., Ralhan R., Bhatnagar R. Tumour necrosis factor-alpha induces preferential expression of stress proteins in virulent promas-tigotes of Leishmania donovani. Immunol. Lett. 1995, 44:1-5.
60. Sardar S., Chakraborty A., Chatterjee M. Comparative effectiveness of vitamin D3 and dietary vitamin E on peroxidation of lipids and enzymes of the hepatic antioxidant system in Sprague-Dawley rats. Int. J. Vitam. Nutr. Res. 1996, 66:39-45.
61. Sigal L.H., Williams S., Soltys B., Gupta R. H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme disease. Cell Mol. Neurobiol. 2001, 21:477-495.
62. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2002, 2:185-194.
63. Srivastava P.K., Udono H., Blachere N.E., Li Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 1994, 39:93-98.
64. Stewart G.R., Young D.B. Heat-shock proteins and the host-pathogen interaction during bacterial infection. Curr. Opin. Immunol. 2004, 16:506-510.
65. Stio M., Treves C., Celli A., Tarantino O., d'Albasio G., Bonanomi A.G. Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis. Am. J. Gastroenterol. 2002, 97:679-689.
66. Tamura J., Kubota K., Murakami H., Sawamura M., Matsushima T., Tamura T., Saitoh T., Kurabayshi H., Naruse T. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl- B12 treatment. Clin. Exp. Immunol. 1999, 116:28-32.
67. Wang M.H., Grossmann M.E., Young C.Y. Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth. Br. J. Cancer 2004, 90:926-931.
68. Webb A.R., Pilbeam C., Hanafin N., Holick M.F. An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am. J. Clin. Nutr. 1990, 51:1075-1081.
69. Welch W.J. Heat shock proteins functioning as molecular chaperones: their roles in normal and stressed cells. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 1993, 339:327-333.
70. Westman J., Drieu K., Sharma H.S. Antioxidant compounds EGB-761 and BN-520 21 attenuate heat shock protein (HSP 72kDa) response, edema and cell changes following hyperthermic brain injury. An experimental study using immunohistochemistry in the rat. Amino. Acids. 2000, 19:339-350.
71. Wiseman H. Vitamin D is a membrane antioxidant ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS Lett. 1993, 326:285-328.
72. Yu H., Bao E.D., Zhao R.Q., Lv Q.X. Effect of transportation stress on heat shock protein 70 concentration and mRNA expression in heart and kidney tissues and serum enzyme activities and hormone concentrations of pigs. Am. J. Vet. Res. 2007, 68:1145-1150.
73. Zhang D., Sun M., Samols D., Kushner I. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J. Biol. Chem. 1996, 271:9503-9509.