Cellular players in angiogenesis during the course of systemic sclerosis

Autoimmunity Reviews

Volumn 10, Issue 10, 2011, Pages 641-646

  Cipriani, Paola ^a   Marrelli, Alessandra ^a   Liakouli, Vasiliki ^a   Di Benedetto, Paola ^a   Giacomelli, Roberto ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Endothelial progenitor cells; Ischemia; Mesenchymal stem cells; Systemic sclerosis; Vasculogenesis

Indexed keywords

ENDOTHELIAL CELL ANTIBODY; UROKINASE; VASCULOTROPIN;

ANGIOGENESIS; BLOOD VESSEL INJURY; BONE MARROW; CAPILLARY; CELL PROLIFERATION; ENDOTHELIAL PROGENITOR CELL; HUMAN; ISCHEMIA; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; MORPHOGENESIS; REVIEW; SKIN BLOOD FLOW; SYSTEMIC SCLEROSIS;

ANIMALS; ENDOTHELIUM, VASCULAR; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; MESENCHYMAL STEM CELLS; NEOVASCULARIZATION, PATHOLOGIC; SCLERODERMA, SYSTEMIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80051667736     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2011.04.016     Document Type: Review

References (76)

1. Abraham D., Distler O. How does endothelial cell injury start? The role of endothelin in systemic sclerosis. Arthritis Res Ther 2007, 9. Suppl 2: S2.
2. Kahaleh M.B. Vascular involvement in systemic sclerosis. Clin Exp Rheumatol 2004, 22(Suppl 33):S19-S23.
3. Kahaleh B. Vascular disease in scleroderma: mechanisms of vascular injury. Rheum Dis Clin North Am 2008, 34:57-71.
4. Nietert P.J., Silver R.M. Systemic sclerosis: environmental and occupational risk factors. Curr Opin Rheumatol 2000, 12:520-526.
5. Renaudineau Y., Revelen R., Levy Y., Salojin K., Gilburg B., Shoenfeld Y., et al. Anti-endothelial cell antibodies in systemic sclerosis. Clin Diagn Lab Immunol 1999, 6:156-160.
6. Pandey J.P., LeRoy E.C. Human cytomegalovirus and the vasculopathies of autoimmune diseases (especially scleroderma), allograft rejection, and coronary restenosis. Arthritis Rheum 1998, 41:10-15.
7. Sgonc R., Gruschwitz M.S., Boeck G., Sepp N., Gruber J., Wick G. Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95. Arthritis Rheum 2000, 43:2550-2562.
8. Lunardi C., Bason C., Navone R., Millo E., Damonte G., Corrocher R., et al. Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis inhuman endothelial cells. Nat Med 2000, 6:1183-1186.
9. Humbert M., Morrell N.W., Archer S.L., Stenmark K.R., MacLean M.R., Lang I.M., Christman B.W., et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 2004 Jun 16, 43(12 Suppl. S):13S-24S.
10. Distler J.H., Gay S., Distler O., Distler J.H., Gay S., Distler O. Angiogenesis and vasculogenesis in systemic sclerosis. Rheumatology 2006 Oct, 45. Oxford, Suppl 3: iii26-7.
11. Distler O., Distler J.H., Scheid A., Acker T., Hirth A., Rethage J., et al. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res 2004, 95:109-116.
12. Kahaleh B. Progress in research into systemic sclerosis. Lancet 2004, 364:561-562.
13. Distler O., Del Rosso A., Giacomelli R., Cipriani P., Conforti M.L., Guiducci S., et al. Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 2002, 4:R11.
14. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000, 6:389-395.
15. Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., Ferrara N. Science 1989, 246:1306-1309.
16. Gerber H.P., Dixit V., Ferrara N. J Biol Chem 1998, 273:13313-13316.
17. Gerber H.P., McMurtrey A., Kowalski J., Yan M., Keyt B.A., Dixit V., et al. J Biol Chem 1998, 273:30336-30343.
18. Takahashi T., Kalka C., Masuda H., Chen D., Silver M., Kearney M., et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999, 5:434-438.
19. Asahara T., Murohara T., Sullivan A., Silver M., van der Zee R., Li T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-967.
20. Shi Q., Rafii S., Wu M.H., Wijelath E.S., Yu C., Ishida A., et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 1998, 92:362-367.
21. Urbich C., Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 2004, 95:343-353.
22. Grunewald M., Avraham I., Dor Y., Bachar-Lustig E., Itin A., Jung S., et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 2006, 124:175-189.
23. Koch A.E., Distler O. Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis. Arthritis Res Ther 2007, 9(Suppl 2):S3.
24. Nagy J.A., Dvorak A.M., Dvorak H.F. VEGF-A and the induction of pathological angiogenesis. Annu Rev Pathol 2007, 2:251-275.
25. Cutolo M., Grassi W., Matucci-Cerinic M. Raynaud's phenomenon and the role of capillaroscopy. Arthritis Rheum 2003, 48:3023-3030.
26. Maricq H.R. Wide-field capillary microscopy: technique and rating scale for abnormalities seen in scleroderma and related disorders. Arthritis Rheum 1981, 24:1159-1165.
27. van Hinsbergh V.W., Koolwijk P. Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead. Cardiovasc Res 2008, 78:203-212.
28. D'Alessio S., Fibbi G., Cinelli M., Guiducci S., Del Rosso A., Margheri F., et al. Matrix metalloproteinase 12 dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. Arthritis Rheum 2004, 50:3275-3285.
29. Margheri F., Serratì S., Lapucci A., Chillà A., Bazzichi L., Bombardieri S., et al. Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. Arthritis Rheum 2010, 62:2488-2498.
30. Manetti M., Allanore Y., Revillod L., Fatini C., Guiducci S., Cuomo, et al. A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis. Arthritis Rheum 2011, 63:247-256.
31. Petit I., Jin D., Rafii S. The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol 2007, 28:299-307.
32. Yao L., Salvucci O., Cardones A.R., Hwang S.T., Aoki Y., De La Luz Sierra M., et al. Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis. Blood 2003, 102:3900-3905.
33. Salvucci O., Yao L., Villalba S., Sajewicz A., Pittaluga S., Tosato G. Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. Blood 2002, 99:2703-2711.
34. Yamaguchi J., Kusano K.F., Masuo O., Kawamoto A., Silver M., Murasawa S., et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 2003, 107:1322-1328.
35. Cipriani P., Franca Milia A., Liakouli V., Pacini A., Manetti M., Marrelli A., et al. Differential expression of stromal cell-derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: pathogenetic implications. Arthritis Rheum 2006, 54:3022-3033.
36. Fleming J.N., Nash R.A., McLeod D.O., Fiorentino D.F., Shulman H.M., Connolly M.K., et al. Capillary regeneration in scleroderma: stem cell therapy reverses phenotype?. PLoS ONE 2008, (e1452):1-13.
37. Zammaretti P., Zisch A.H. Adult 'endothelial progenitor cells': renewing vasculature. Int J Biochem Cell Biol 2005, 37:493-503.
38. Adams V., Lenk K., Linke A., Lenz D., Erbs S., Sandri M., et al. Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler Thromb Vasc Biol 2004, 24:684-690.
39. Dimmeler S., Aicher A., Vasa M., Mildner-Rihm C., Adler K., Tiemann M., et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001, 108:391-397.
40. Hill J.M., Zalos G., Halcox J.P., Schenke W.H., Waclawiw M.A., Quyyumi A.A., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003, 348:593-600.
41. Smadja D.M., Cornet A., Emmerich J., Aiach M., Gaussem P. Endothelial progenitor cells: characterization, in vitro expansion, and prospects for autologous cell therapy. Cell Biol Toxicol 2007, 23:223-239.
42. Hristov M., Weber C. Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance. J Cell Mol Med 2004, 8:498-508.
43. Zhao Y., Glesne D., Huberman E. A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc Natl Acad Sci USA 2003, 100:2426-2431.
44. Medina R.J., O'Neill C.L., Sweeney M., Guduric-Fuchs J., Gardiner T.A., Simpson D.A., et al. Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities. BMC Med Genomics 2010, 3:18.
45. Sieveking D.P., Buckle A., Celermajer D.S., Ng M.K. Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: insights from a novel human angiogenesis assay. J Am Coll Cardiol 2008, 51:660-668.
46. Mukai N., Akahori T., Komaki M., Li Q., Kanayasu-Toyoda T., Ishii-Watabe A., et al. A comparison of the tube forming potentials of early and late endothelial progenitor cells. Exp Cell Res 2008, 314:430-440.
47. Allanore Y., Batteux F., Avouac J., Assous N., Weill B., Kahan A. Levels of circulating endothelial progenitor cells in systemic sclerosis. Clin Exp Rheumatol 2007, 25:60-66.
48. Avouac J., Juin F., Wipff J., Couraud P., Chiocchia G., Kahan A., et al. Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity. Ann Rheum Dis 2008, 67:1455-1460.
49. Del Papa N., Cortiana M., Vitali C., Silvestris I., Maglione W., Comina D.P., et al. Simvastatin reduces endothelial activation and damage but is partially ineffective in inducing endothelial repair in systemic sclerosis. J Rheumatol 2008, 35:1323-1328.
50. Del Papa N., Quirici N., Soligo D., Scavullo C., Cortiana M., Borsotti C., et al. Bone marrow endothelial progenitors are defective in systemic sclerosis. Arthritis Rheum 2006, 54:2605-2615.
51. Kuwana M., Kaburaki J., Okazaki Y., Yasuoka H., Kawakami Y., Ikeda Y. Increase in circulating endothelial precursors by atorvastatin in patients with systemic sclerosis. Arthritis Rheum 2006, 54:1946-1951.
52. Kuwana M., Okazaki Y., Kodama H., Satoh T., Kawakami Y., Ikeda Y. Endothelial differentiation potential of human monocyte derived multipotential cells. Stem Cells 2006, 24:2733-2743.
53. Kuwana M., Okazaki Y., Yasuoka H., Kawakami Y., Ikeda Y. Defective vasculogenesis in systemic sclerosis. Lancet 2004, 364:603-610.
54. Zhu S., Evans S., Yan B., Povsic T.J., Tapson V., Goldschmidt-Clermont P.J., et al. Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. Circulation 2008, 118:2156-2165.
55. Nevskaya T., Bykovskaia S., Lyssuk E., Shakhov I., Zaprjagaeva M., Mach E., et al. Circulating endothelial progenitor cells in systemic sclerosis: relation to impaired angiogenesis and cardiovascular manifestations. Clin Exp Rheumatol 2008, 26:421-429.
56. Rehman J., Li J., Orschell C.M., March K.L. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003, 107:1164-1169.
57. Urbich C., Heeschen C., Aicher A., Dernbach E., Zeiher A.M., Dimmeler S. Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation 2003, 108:2511-2516.
58. Kuwana M., Okazaki Y., Kodama H., et al. Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 2003, 74:833-845.
59. Kodama H., Inoue T., Watanabe R., Yasuoka H., Kawakami Y., Ogawa S., et al. Cardiomyogenic potential of mesenchymal progenitors derived from human circulating CD14+ monocytes. Stem Cell Dev 2005, 14:676-686.
60. Kodama H., Inoue T., Watanabe R., Yasutomi D., Kawakami Y., Ogawa S., et al. Neurogenic potential of progenitors derived from human circulating CD14+ monocytes. Immunol Cell Biol 2006, 84:209-217.
61. Yamaguchi Y., Okazaki Y., Seta N., Satoh T., Takahashi K., Ikezawa Z., et al. Enhanced angiogenic potency of monocytic endothelial progenitor cells in patients with systemic sclerosis. Arthritis Res Ther 2010, 12:R205.
62. Drake C.J. Embryonic and adult vasculogenesis. Birth Defects Res. C Embryo Today 2003, 69:73-82.
63. Tuan R.S., Boland G., Tuli R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 2003, 5:32-45.
64. Arnhold S.J., Goletz I., Klein H., Stumpf G., Beluche L.A., Rohde C., et al. Isolation and characterization of bone marrow-derived equine mesenchymal stem cells. Am J Vet Res 2007, 68:1095-1105.
65. Reyes M., Lund T., Lenvik T., Aguiar D., Koodie L., Verfaillie C.M. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001, 98:2615-2625.
66. Reyes M., Dudek A., Jahagirdar B., Koodie L., Marker P.H., Verfaillie C.M. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 2002, 109:337-346.
67. Ladage D., Brixius K., Steingen C., Mehlhorn U., Schwinger R.H., Bloch W., et al. Mesenchymal stem cells induce endothelial activation via paracine mechanisms. Endothelium 2007, 14:53-63.
68. Choi S.C., Shim W.J., Lim D.S. Specific monitoring of cardiomyogenic and endothelial differentiation by dual promoter-driven reporter systems in bone marrow mesenchymal stem cells. Biotechnol Lett 2008, 30:835-843.
69. Copland I., Sharma K., Lejeune L., Eliopoulos N., Stewart D., Liu P., et al. CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization. Exp Hematol 2008, 36:93-103.
70. Oswald J., Boxberger S., Jorgensen B., Feldmann S., Ehninger G., Bornhauser M., et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004, 22:377-384.
71. Cipriani P., Guiducci S., Miniati I., Cinelli M., Urbani S., Marrelli A., et al. Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis. Arthritis Rheum 2007, 56:1994-2004.
72. Torensma R., Figdor C.G. Differentiating stem cells mask their origins. Stem Cells 2004, 22:250-252.
73. Martens T.P., See F., Schuster M.D., Sondermeijer H.P., Hefti M.M., Zannettino A., et al. Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium. Nat Clin Pract Cardiovasc Med 2006, 3(Suppl 1):S18-S22.
74. Guiducci S., Porta F., Saccardi R., Guidi S., Ibba-Manneschi L., Manetti M., et al. Autologous mesenchymal stem cells foster revascularization of ischemic limbs in systemic sclerosis: a case report. Ann Intern Med 2010, 153:650.
75. Guiducci S., Giacomelli R., Cerinic M.M. Vascular complications of scleroderma. Autoimmun Rev 2007, 6:520-523.
76. Vadasz Z., Attias D., Kessel A., Toubi E. Neuropilins and semaphorins-from angiogenesis to autoimmunity. Autoimmun Rev 2010, 9:825-829.