Autologous mesenchymal stem cells foster revascularization of ischemic limbs in systemic sclerosis: A case report

Annals of Internal Medicine

Volumn 153, Issue 10, 2010, Pages 650-654

  Guiducci, Serena ^a   Porta, Francesco ^a   Saccardi, Riccardo ^a   Guidi, Stefano ^a   Ibba Manneschi, Lidia ^a,b   Manetti, Mirko ^a,b   Mazzanti, Benedetta ^a   Dal Pozzo, Simone ^a   Milia, Anna Franca ^a   Bellando Randone, Silvia ^a   Miniati, Irene ^a   Fiori, Ginevra ^a   Fontana, Rossana ^a   Amanzi, Laura ^a   Braschi, Francesca ^a   Bosi, Alberto ^a   Matucci Cerinic, Marco ^a  

^a CAREGGI UNIVERSITY HOSPITAL   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENOXAPARIN; ILOPROST; METHYLPREDNISOLONE; PREDNISONE;

ADULT; ANGIOGRAPHY; ARTICLE; BLOOD FLOW; CASE REPORT; CORTICOSTEROID THERAPY; FEMALE; GANGRENE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEG REVASCULARIZATION; LIMB ISCHEMIA; MESENCHYMAL STEM CELL TRANSPLANTATION; PLASMAPHERESIS; PRIORITY JOURNAL; SKIN BIOPSY; SKIN NECROSIS; SYSTEMIC SCLEROSIS;

EID: 78751686638     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-153-10-201011160-00007     Document Type: Article

References (15)

1. Guiducci S, Giacomelli R, Cerinic MM. Vascular complications of scleroderma. Autoimmun Rev. 2007;6:520-3. [PMID: 17854742]
2. Oswald J, Boxberger S, Jørgensen B, Feldmann S, Ehninger G, Bornhäuser M, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells. 2004;22:377-84. [PMID: 15153614]
3. Martens TP, See F, Schuster MD, Sondermeijer HP, Hefti MM, Zannettino A, et al. Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium. Nat Clin Pract Cardiovasc Med. 2006;3 Suppl 1:S18-22. [PMID: 16501624]
4. Dash NR, Dash SN, Routray P, Mohapatra S, Mohapatra PC. Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells. Rejuvenation Res. 2009;12:359-66. [PMID: 19929258]
5. Satija NK, Singh VK, Verma YK, Gupta P, Sharma S, Afrin F, et al. Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine. J Cell Mol Med. 2009;13:4385-402. [PMID: 19602034]
6. Urbani S, Caporale R, Lombardini L, Bosi A, Saccardi R. Use of CFDA-SE for evaluating the in vitro proliferation pattern of human mesenchymal stem cells. Cytotherapy. 2006;8:243-53. [PMID: 16793733] (Pubitemid 43947790)
7. Mazzanti B, Aldinucci A, Biagioli T, Barilaro A, Urbani S, Dal Pozzo S, et al. Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment. J Neuroimmunol. 2008;199:142-50. [PMID: 18562015]
8. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007;25: 2648-59. [PMID: 17615264] (Pubitemid 47582758)
9. Passweg J, Tyndall A. Autologous stem cell transplantation in autoimmune diseases. Semin Hematol. 2007;44:278-85. [PMID: 17961728] (Pubitemid 47599541)
10. Tögel F, Weiss K, Yang Y, Hu Z, Zhang P, Westenfelder C. Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol. 2007;292:F1626-35. [PMID: 17213465] (Pubitemid 46701891)
11. Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M, et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol. 2004;287:H2670-6. [PMID: 15284059] (Pubitemid 39557139)
12. Ishigatsubo Y, Ihata A, Kobayashi H, Hama M, Kirino Y, Ueda A, et al. Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells. Mod Rheumatol. 2010;20:263-72. [PMID: 20169390]
13. Nevskaya T, Ananieva L, Bykovskaia S, Eremin I, Karandashov E, Khrennikov J, et al. Autologous progenitor cell implantation as a novel therapeutic intervention for ischaemic digits in systemic sclerosis. Rheumatology (Oxford). 2009;48:61-4. [PMID: 19022831]
14. Liu K, Chi L, Guo L, Liu X, Luo C, Zhang S, et al. The interactions between brain microvascular endothelial cells and mesenchymal stem cells under hypoxic conditions. Microvasc Res. 2008;75:59-67. [PMID: 17662311] (Pubitemid 350266737)
15. Iwase T, Nagaya N, Fujii T, Itoh T, Murakami S, Matsumoto T, et al. Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia. Cardiovasc Res. 2005;66:543-51. [PMID: 15914119]