Are marketed topical metronidazole creams bioequivalent? Evaluation by in vivo microdialysis sampling and tape stripping methodology

Skin Pharmacology and Physiology

Volumn 24, Issue 1, 2010, Pages 44-53

  Garcia Ortiz P ^a,c   Hansen, S H ^a   Shah, V P ^b   Sonne, J ^a   Benfeldt, E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Bioequivalence; Cutaneous penetration; Dermal drug levels; Dermatopharmacokinetic method; Drug delivery, topical; Metronidazole; Microdialysis; Percutaneous permeation; Tape stripping

Indexed keywords

METRONIDAZOLE; ROZEX; UNCLASSIFIED DRUG;

ADHESIVE TAPE STRIPPING; ADULT; ARTICLE; BIOEQUIVALENCE; CLINICAL EVALUATION; DIAGNOSTIC PROCEDURE; DRUG PENETRATION; ERYTHEMA; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SKIN PENETRATION; SKIN WATER LOSS; SKINFOLD THICKNESS; STRATUM CORNEUM;

ADMINISTRATION, CUTANEOUS; ADULT; ANTI-INFECTIVE AGENTS; BIOLOGICAL AVAILABILITY; FEMALE; HUMANS; MALE; METRONIDAZOLE; MICRODIALYSIS; MIDDLE AGED; SKIN; SKIN ABSORPTION; THERAPEUTIC EQUIVALENCY;

EID: 77956607520     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000320151     Document Type: Article

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