Voltage-gated sodium channel Nav1.7 maintains the membrane potential and regulates the activation and chemokine-induced migration of a monocyte-derived dendritic cell subset

Journal of Immunology

Volumn 187, Issue 3, 2011, Pages 1273-1280

  Kis Toth, Katalin ^a   Hajdu, Peter ^a   Bacskai, Ildiko ^a   Szilagyi, Orsolya ^a   Papp, Ferenc ^a   Szanto, Attila ^a   Posta, Edit ^a   Gogolak, Peter ^a   Panyi, Gyorgy ^a   Rajnavolgyi, Eva ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; SODIUM CHANNEL NAV1.7; T6 ANTIGEN; TETRODOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL MEMBRANE POTENTIAL; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DOWN REGULATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MEMBRANE STEADY POTENTIAL; MONOCYTE; PRIORITY JOURNAL; REGULATORY MECHANISM; SCN9A GENE; SODIUM CURRENT;

CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINES; CYTOKINES; DENDRITIC CELLS; G0 PHASE; HUMANS; MEMBRANE POTENTIALS; MONOCYTES; SODIUM CHANNELS;

EID: 80051621439     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003345     Document Type: Article

References (45)

1. Steinman, R. M., and H. Hemmi. 2006. Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311: 17-58. (Pubitemid 47413194)
2. Shortman, K., and Y. J. Liu. 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2: 151-161. (Pubitemid 37336516)
3. Caux, C., B. Vanbervliet, C. Massacrier, C. Dezutter-Dambuyant, B. de Saint- Vis, C. Jacquet, K. Yoneda, S. Imamura, D. Schmitt, and J. Banchereau. 1996. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J. Exp. Med. 184: 695-706. (Pubitemid 26324123)
4. Brigl, M., and M. B. Brenner. 2004. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22: 817-890. (Pubitemid 38680443)
5. Manolova, V., M. Kistowska, S. Paoletti, G. M. Baltariu, H. Bausinger, D. Hanau, L. Mori, and G. De Libero. 2006. Functional CD1a is stabilized by exogenous lipids. Eur. J. Immunol. 36: 1083-1092.
6. Moody, D. B., and S. A. Porcelli. 2003. Intracellular pathways of CD1 antigen presentation. Nat. Rev. Immunol. 3: 11-22. (Pubitemid 37328696)
7. Caux, C., C. Massacrier, B. Vanbervliet, B. Dubois, I. Durand, M. Cella, A. Lanzavecchia, and J. Banchereau. 1997. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha. II. Functional analysis. Blood 90: 1458-1470. (Pubitemid 27355417)
8. Randolph, G. J., K. Inaba, D. F. Robbiani, R. M. Steinman, and W. A. Muller. 1999. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11: 753-761. (Pubitemid 30030714)
9. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118.
10. Gogolak, P., B. Rethi, I. Szatmari, A. Lanyi, B. Dezso, L. Nagy, and E. Rajnavolgyi. 2007. Differentiation of CD1a2 and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPARgamma. Blood 109: 643-652. (Pubitemid 46105965)
11. Dubsky, P., H. Ueno, B. Piqueras, J. Connolly, J. Banchereau, and A. K. Palucka. 2005. Human dendritic cell subsets for vaccination. J. Clin. Immunol. 25: 551-572. (Pubitemid 43011747)
12. Hodgkin, A. L., and A. F. Huxley. 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117: 500-544.
13. Kim, S. Y., M. R. Silver, and T. E. DeCoursey. 1996. Ion channels in human THP-1 monocytes. J. Membr. Biol. 152: 117-130. (Pubitemid 26266044)
14. Ince, C., B. Van Duijn, D. L. Ypey, E. Van Bavel, F. Weidema, and P. C. Leijh. 1987. Ionic channels and membrane hyperpolarization in human macrophages. J. Membr. Biol. 97: 251-258. (Pubitemid 17112401)
15. Chandy, K. G., T. E. DeCoursey, M. D. Cahalan, C. McLaughlin, and S. Gupta. 1984. Voltage-gated potassium channels are required for human T lymphocyte activation. J. Exp. Med. 160: 369-385. (Pubitemid 14052503)
16. Black, J. A., S. Liu, and S. G. Waxman. 2008. Sodium channel activity modulates multiple functions in microglia. Glia 57: 1072-1081.
17. Craner, M. J., T. G. Damarjian, S. Liu, B. C. Hains, A. C. Lo, J. A. Black, J. Newcombe, M. L. Cuzner, and S. G. Waxman. 2005. Sodium channels contribute to microglia/macrophage activation and function in EAE and MS. Glia 49: 220-229. (Pubitemid 40188501)
18. Roselli, F., P. Livrea, and E. Jirillo. 2006. Voltage-gated sodium channel blockers as immunomodulators. Recent Patents CNS Drug Discov. 1: 83-91.
19. Zsiros, E., K. Kis-Toth, P. Hajdu, R. Gaspar, J. Bielanska, A. Felipe, E. Rajnavolgyi, and G. Panyi. 2009. Developmental switch of the expression of ion channels in human dendritic cells. J. Immunol. 183: 4483-4492.
20. Cummins, T. R., J. R. Howe, and S. G. Waxman. 1998. Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel. J. Neurosci. 18: 9607-9619. (Pubitemid 28543742)
21. Klugbauer, N., L. Lacinova, V. Flockerzi, and F. Hofmann. 1995. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J. 14: 1084-1090.
22. Sangameswaran, L., L. M. Fish, B. D. Koch, D. K. Rabert, S. G. Delgado, M. Ilnicka, L. B. Jakeman, S. Novakovic, K. Wong, P. Sze, et al. 1997. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. J. Biol. Chem. 272: 14805-14809. (Pubitemid 27251749)
23. Laniado, M. E., E. N. Lalani, S. P. Fraser, J. A. Grimes, G. Bhangal, M. B. Djamgoz, and P. D. Abel. 1997. Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro. Am. J. Pathol. 150: 1213-1221. (Pubitemid 27152640)
24. Waxman, S. G. 2006. Neurobiology: a channel sets the gain on pain. Nature 444: 831-832. (Pubitemid 46024984)
25. Nassar, M. A., L. C. Stirling, G. Forlani, M. D. Baker, E. A. Matthews, A. H. Dickenson, and J. N. Wood. 2004. Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc. Natl. Acad. Sci. USA 101: 12706-12711. (Pubitemid 39122087)
26. Drenth, J. P., and S. G.Waxman. 2007. Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J. Clin. Invest. 117: 3603-3609. (Pubitemid 350224065)
27. Szatmari, I., P. Gogolak, J. S. Im, B. Dezso, E. Rajnavolgyi, and L. Nagy. 2004. Activation of PPARgamma specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansion. Immunity 21: 95-106. (Pubitemid 38925270)
28. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391: 85-100. (Pubitemid 11012976)
29. Grissmer, S., A. N. Nguyen, and M. D. Cahalan. 1993.Calcium-activated potassium channels in resting and activated human T lymphocytes: expression levels, calcium dependence, ion selectivity, and pharmacology. J. Gen. Physiol. 102: 601-630. (Pubitemid 23328148)
30. Connolly, S. F., and D. J. Kusner. 2007. The regulation of dendritic cell function by calcium-signaling and its inhibition by microbial pathogens. Immunol. Res. 39: 115-127. (Pubitemid 47574879)
31. Koski, G. K., L. A. Lyakh, P. A. Cohen, and N. R. Rice. 2001. CD14+ monocytes as dendritic cell precursors: diverse maturation-inducing pathways lead to common activation of NF-kappab/RelB. Crit. Rev. Immunol. 21: 179-189. (Pubitemid 32959360)
32. Gogolák, P., B. Réthi, G. Hajas, and E. Rajnavölgyi. 2003. Targeting dendritic cells for priming cellular immune responses. J. Mol. Recognit. 16: 299-317. (Pubitemid 37231699)
33. Flores-Romo, L. 2001. In vivo maturation and migration of dendritic cells. Immunology 102: 255-262. (Pubitemid 32284945)
34. Ghanshani, S., H. Wulff, M. J. Miller, H. Rohm, A. Neben, G. A. Gutman, M. D. Cahalan, and K. G. Chandy. 2000. Up-regulation of the IKCa1 potassium channel during T-cell activation: molecular mechanism and functional consequences. J. Biol. Chem. 275: 37137-37149. (Pubitemid 32002132)
35. Zanoni, I., R. Ostuni, G. Capuano,M. Collini, M. Caccia, A. E. Ronchi,M. Rocchetti, F. Mingozzi, M. Foti, G. Chirico, et al. 2009. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature 460: 264-268.
36. Offord, J., and W. A. Catterall. 1989. Electrical activity, cAMP, and cytosolic calcium regulate mRNA encoding sodium channel alpha subunits in rat muscle cells. Neuron 2: 1447-1452.
37. Hirsh, J. K., and F. N. Quandt. 1996. Down-regulation of Na channel expression by A23187 in N1E-115 neuroblastoma cells. Brain Res. 706: 343-346. (Pubitemid 26046735)
38. Shang, L. L., and S. C. Dudley Jr. 2005. Tandem promoters and developmentally regulated 5′- and 3′-mRNA untranslated regions of the mouse Scn5a cardiac sodium channel. J. Biol. Chem. 280: 933-940.
39. Shang, L. L., S. Sanyal, A. E. Pfahnl, Z. Jiao, J. Allen, H. Liu, and S. C. Dudley Jr. 2008. NF-kappaB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II. Am. J. Physiol. Cell Physiol. 294: C372-C379.
40. Sontheimer, H., and S. G. Waxman. 1993. Expression of voltage-activated ion channels by astrocytes and oligodendrocytes in the hippocampal slice. J. Neurophysiol. 70: 1863-1873. (Pubitemid 23351029)
41. Sontheimer, H., E. Fernandez-Marques, N. Ullrich, C. A. Pappas, and S. G. Waxman. 1994. Astrocyte Na+ channels are required for maintenance of Na+/K(+)-ATPase activity. J. Neurosci. 14: 2464-2475. (Pubitemid 24140878)
42. Arcangeli, A., O. Crociani, E. Lastraioli, A. Masi, S. Pillozzi, and A. Becchetti. 2009. Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr. Med. Chem. 16: 66-93.
43. Grimes, J. A., S. P. Fraser, G. J. Stephens, J. E. Downing, M. E. Laniado, C. S. Foster, P. D. Abel, and M. B. Djamgoz. 1995. Differential expression of voltage-activated Na+ currents in two prostatic tumour cell lines: contribution to invasiveness in vitro. FEBS Lett. 369: 290-294.
44. Meguro, K., H. Iida, H. Takano, T. Morita, M. Sata, R. Nagai, and T. Nakajima. 2009. Function and role of voltage-gated sodium channel NaV1.7 expressed in aortic smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 296: H211-H219.
45. Jo, T., T. Nagata, H. Iida, H. Imuta, K. Iwasawa, J. Ma, K. Hara, M. Omata, R. Nagai, H. Takizawa, et al. 2004. Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A. FEBS Lett. 567: 339-343. (Pubitemid 38748417)