HCV RNA in serum and peripheral blood mononuclear cells after successful interferon therapy

Hepato-Gastroenterology

Volumn 58, Issue 107-108, 2011, Pages 932-936

  Mohamed, Hala Ibrahem ^a   Fath El Bab, Hanaa Kh ^a   Kamal, Amal M ^b  

^a Minia University   (Egypt)

^b El Minia Faculty of Medicine   (Egypt)

Author keywords

Hepatitis C; IFN; Liver; Peripheral blood mononuclear cells; Real time PCR

Indexed keywords

PEGINTERFERON ALPHA2A PLUS RIBAVIRIN; VIRUS RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TREATMENT RESPONSE; VIRAL CLEARANCE; VIREMIA; VIRUS DETECTION; VIRUS LOAD;

ADULT; ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RIBAVIRIN; RNA, VIRAL;

EID: 80051617633     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Alter M: Epidemiology of hepatitis C virus infection. J Gastroenterol 2007; 13:2436-2441.
2. Blackard J, Kemmer N, Sherman K: Extra hepatic replication of HCV: insights into clinical manifestations and biological consequences. Hepatology 2006; 44:15-22.
3. Bouffard P, Hayashi PH, Acevedo R, Levy N, Zeldis JB: Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells-of infected patients. J Infect Dis 1992; 166:1276-1280.
4. Terrault NA, Dailey PJ, Ferrell L, Collins ML, Wilber JC: Hepatitis C virus: Quantitation and distributionln liver. Med Virol 1997; 51:217-224. (Pubitemid 27157804)
5. Laskus T, Operskalski EA, Radkowski M: Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV positive/ HIV-infected women. J Infect Dis 2007; 195:124-133. (Pubitemid 44958234)
6. Hoofnagle JH, Di Bisceglie AM: The treatment of chronic viral hepatitis. N Engl J Med 1997; 336:347-356.
7. Pascale T, Pierre-Henri B, Victor D, Benoit O, Geneieve C, Marie-France S: Quantitation of Hepatitis C Virus RNA in Plasma and Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis Treated with Interferon-a. Dig Dis and Sci 2000; 45(1):175-181.
8. Ansaldi F, Torre F, Bruzzone BM: Evaluation of a new hepatitis C virus sequencing assay as a routine method for genotyping. J Med Virol 2001; 63:17-21.
9. Giachetti C, Limnen I, Kolk D, Dockter J,Gillotte K, Park M: Highly sensitive multiplex assay for detection of human immunodeficiency virus type 1 and hepatitis C virus RNA. J Clin Microbiol 2002; 40:2408-2419. (Pubitemid 34747340)
10. Wittwer C T, Hahn M, Kaul K: Rapid cycle real-time PCR - methodes and applications: quantification.Berlin: Springer, (2004)223 pp.
11. Abdel-Aziz F, Habib M, Mohamed MK: Hepatitis C virus (HCV) infection in a community in the Nile Delta: population description and HCV prevalence. Hepatol 2000; 32:111-115. (Pubitemid 30432374)
12. Nguyen MH, Keeffe EB: Prevalence and treatment of hepatitis C virus genotypes 4, 5 and 6. Clin Gastroenterol Hepatol 2005; 3(10 suppl 2):97-101.
13. Bedossa P, Poynard T: For the METAVIR Cooperative Study Group: An algorithm for the grading of activity in chronic hepatitis C. Hepatol 1996; 24:289-293 (Pubitemid 26260021)
14. An P, Chen L, Tian H, Chen P, Li L, Liu C: The significance of detection of hepatitis C virus RNA in peripheral blood mononuclear cells of patients with chronic hepatitis C [in Chinese]. Zhonghua Nei Ke Za Zhi 1999; 38:737-739.
15. Philippe H, Marc B, Denis O, Damien S, David S, Hac Kh, Guillaume P: Occult Hepatitis C Virus Infection Revisited with Ultrasensitive Real-Time PCR Assay. J of Clin Mic 2008; 46 (6):2106-2108.
16. Norma P , Thelma C, Carlos E ,Suzana R, Evaldo S, Fátima M: Detection of HCV by PCR in Serum and PBMC of Patients with Hepatitis C after Treatment. Braz J Inf Dis 2007; 11(5):471-474.
17. Ping Z , Qing C, You C, Mu S, Jian G, Xiao J: Hepatitis C virus RNA detection in serum and peripheral blood mononuclear cells of patients with hepatitis C. China Nati J New Gastroenterol 1997; 3(2):108-110.
18. Pham TN, Mac Parland SA, Mulrooney PM: Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. J Virol 2004; 78:5867-5874. (Pubitemid 38661674)
19. Majda-Stanislawska E, Bednarek M, Jozwiak B: Effect of interferon alfa and ribavirin treatment on hepatitis C virus RNA in serum and peripheral blood mononuclear cells in children with chronic hepatitis C. Acta Gastroenterol Belg 2006; 69(2): 187-190. (Pubitemid 44265340)
20. Meier V, Mihm S, Braun PW, Ramadori G: HCV-RNA positivity in peripheral blood mononuclear cells of patients with chronic HCV infection: does it reality mean viral replication? World J Gastro 2001; 7(2):228-234.
21. Xu DZ, Xie Y, Li ZQ: Clearance of HCV RNA in peripheral blood mononuclear cell as a predictor of response to antiviral therapy in patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int 2005; 4:550-553. (Pubitemid 41723809)
22. Adinolfi L, Andreana A, Utili R, Zampino R, Ragone E,Ruggiero G: HCV RNA levels in serum, liver, and peripheral blood mononuclear cells of chronic hepatitis C patients and their relationship to liver injury. The Am J Of Gastroenterol 1998; 93(11):2162-2166. (Pubitemid 29076868)
23. Hagiwara H, Hayashi N, Mita M: Quantitation of hepatitis C virus RNA in serum of asymptomatic blood donors and patients with type C chronic liver disease. Hepatol 1993; 17:545-550. (Pubitemid 23115496)
24. Gretch D, Corey L, Wilson J: Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease. J Infect Dis 1994; 169:1219-1225. (Pubitemid 24164583)
25. Kumar U, Thomas HC, Monjardino J: Serum HCV RNA levels in chronic HCV hepatitis measured by quantitative PCR assay: correlation with serum AST.J Vir Methods 1994; 47:95-102.