Clearance of HCV RNA in peripheral blood mononuclear cell as a predictor of response to antiviral therapy in patients with chronic hepatitis C

Hepatobiliary and Pancreatic Diseases International

Volumn 4, Issue 4, 2005, Pages 550-553

  Xu, Dao Zhen ^a   Xie, Yao ^a   Li, Zheng Qin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Chronic hepatitis C; HCV RNA; Interferon; Peripheral blood mononuclear cell

Indexed keywords

ALPHA2B INTERFERON; ANTIVIRUS AGENT; INTERFERON; RIBAVIRIN; VIRUS RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIVER FUNCTION; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; ANTIVIRAL AGENTS; BIOLOGICAL MARKERS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RNA, VIRAL;

EID: 28444454563     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Forton DM, Karayiannis P, Mahmud N, Taylor-Robinson SD, Thomas HC. Identificdtion of unique hepatitis C virus quasispecies in the central nervous system and comparative arialysis of internal translational efficiency of brain, liver, and serum variants. J Virol 2004;78:5170-5183.
2. Ryan EL, Morgello S, Isaacs K, Naseer M, Gerits P. Neuropsychiatric impact of hepatitis C on advanced HIV. Neurology 2004;62:957-962.
3. Pham TN, MacParland SA, Mulrooney PM, Cooksley H, Naoumov NV, Michalak TI. Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. J Virol 2004;78:5867-5874.
4. Goutagny N, Vieux C, Decullier E, Ligeoix B, Epstein A, Trepo C, et al. Quantification and functional analysis of plasmacytoid dendritic cells in patients with chronic hepatitis C virus infection. J Infect Dis 2004;189:1646-1655.
5. Mochizuki K, Kagawa T, Takashimizu S, Kawazoe K, Kojima S, Nagata N, et al. Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C. World J Gastroenterol 2004; 10:733-736.
6. Gong GZ, Lai LY, Jiang YF, He Y, Su XS. HCV replication in PBMC and its influence on interferon therapy. World J Gastroenterol 2003;9:291-294.
7. Piekarska A, Sidorkiewicz M, Lewandowska U, Kuydowicz J. Evaluation of persistence of IFN-alpha treatment response in chronic hepatitis C patients according with HCV-RNA presence in PBMC. Pol Arch Med Wewn 2001;106:939-944.
8. Chen L, Chen P, Fan G, Li L, Liu C. Localization of hepatitis C virus core protein in the nucleus of peripheral blood mononuclear cells of hepatitis C patients. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2002;16:37-39.
9. Lindsay KL. Introduction to therapy of hepatitis C. Hepatology 2002;36:S114-120.
10. McHutchison JG, Manns MP, Ling M, Koury K, Albrecht JK. Peginterferon alpha-2b plus ribavirin for treatment of chronic hepatitis C: is patient gender a confounding factors for sustained virologic response when ribavirin dose is expressed as mg/kg of body weight? Hepatology 2001;34:329A.
11. Reddy KR, Hoofnagle JH, Tong MJ, Lee WM, Pockros P, Heathcote EJ, et al. Racial differences in responses to therapy with interferon in chronic hepatitis C. Hepatology 1999;30: 779-787.
12. Medina J, Garcia-Buey L, Moreno-Monteagudo JA, Trapero-Marugan M, Moreno-Otero R. Combined antiviral options for the treatment of chronic hepatitis C. Antiviral Res 2003; 60: 135-43.
13. Fukutomi T, Fukutomi M, Iwao M, Watanabe H, Tanabe Y, Hiroshige K, et al. Predictors of the efficacy of intravenous natural interferon-beta treatment in chronic hepatitis C. Med Sci Monit 2000;6:692-698.
14. Saito T, Ito T, Ishiko H, Yonaha M, Morikawa K, Miyokawa A, et al. Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b. Am J Gastroenterol 2003;98:1377-1383.
15. Moatter T, Hussainy AS, Hamid S, Ahmad Z, Siddiqui S. Comparative analysis of viral titers and histologic features of Pakistani patients infected with hepatitis C virus type 3. Int J Infect Dis 2002;6:272-276.
16. Yeh BI, Han KH, Lee HW, Sohn JH, Ryu WS, Yoon DJ, et al. Factors predictive of response to interferon-alpha therapy in hepatitis C virus type 1b infection. J Med Virol 2002;66: 481-487.
17. Takenokuchi M, Yasuda C, Nakamachi Y, Mukai M, Yoon S, Kondoh S, et al. Comparative evaluation of serum HCV RNA by Roche Monitor Assay. Versions 1.0 and 2.0; as a predictive marker of subsequent response to IFN therapy. Rinsho Byori 2002;50:392-397.
18. Yamaguchi Y, Hino K, Fujiwara D, Ren F, Katoh Y, Satoh Y, et al. Expression of type I interferon receptor in liver and peripheral blood mononuclear cells in chronic hepatitis C patients. Dig Dis Sci 2002;47:1611-1617.
19. Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J. Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5. J Viral Hepat 2001;8:103-110.
20. Ji X, Cheung R, Cooper S, Li Q, Greenberg HB, He XS. Interferon alfa regulated gene expression in patients initiating interferon treatment for chronic hepatitis C. Hepatology 2003; 37:610-621.
21. An P, Chen L, Tian H, Chen P, Li L, Liu C. The significance of detection of hepatitis C virus RNA in peripheral blood mononuclear cells of patients with chronic hepatitis C. Zhonghua Nei Ke Za Zhi 1999;38:737-739.
22. Chinese Medical Association. Scheme of prevention and cure in viral hepatitis. Chin J Infect Dis 1995;4:241-247.
23. Choo SH, So HS, Cho JM, Ryu WS. Association of hepatitis C virus particles with immunoglobulin: a mechanism for persistent infection. J Gen Virol 1995;76:2337-2341.
24. Meyer-Olson D, Shoukry NH, Brady KW, Kim H, Olson DP, Hartman K, et al. Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. J Exp Med 2004;200:307-319.
25. Kimura Y, Gushima T, Rawale S, Kaumaya P, Walker CM. Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection. J Virol 2005;79:4870-4876.
26. Wang H, Eckels DD. Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may have important consequences for T cell recognition. J Immunol 1999;162:4177-4183.
27. Radkowski M, Wilkinson J, Nowicki M, Adair D, Vargas H, Ingui C, et al. Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. J Virol 2002;76:600-608.
28. Zignego AL, De Carli M, Monti M, Careccia G, La Villa G, Giannini C, et al. Hepatitis C virus infection of mononuclear cells from peripheral blood and liver infiltrates in chronically infected patients. J Med Virol 1995;47:58-64.
29. Chang TT, Young KC, Yang YJ, Lei HY, Wu HL. Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection. Hepatology 1996; 23:977-981.
30. Bouffard P, Hayashi PH, Acevedo R, Levy N, Zeldis JB. Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells of infected patients. J Infect Dis 1992;166:1276-1280.
31. Moldvay J, Deny P, Pol S, Brechot C, Lamas E. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization. Blood 1994;83:269-273.
32. Taliani G, Badolato C, Lecce R, Poliandri G, Bozza A, Duca F, et al. Hepatitis C virus RNA in peripheral blood mononuclear cells: relation with response to interferon treatment. J Med Virol 1995;47:16-22.
33. Lohr HF, Goergen B, Meyer zum Buschenfelde KH, Gerken G. HCV replication in mononuclear cells stimulates anti-HCV-secreting B cells and reflects nonresponsiveness to interferon-alpha. J Med Virol 1995;46:314-320.
34. McHutchison JG, Shad JA, Gordon SC, Morgan TR, Ling MH, Garaud JJ, et al. Predicting response to initial therapy with interferon plus ribavirin in chronic hepatitis C using serum HCV RNA results during therapy. J Viral Hepat 2001;6;414-420.
35. Ballesteros AL, Franco S, Fuster D, Planas R, Martinez MA, Acosta L, et al. Early HCV dynamics on Peg-interferon and ribavirin in HIV/HCV co-infection: indications for the investigation of new treatment approaches. AIDS 2004;18:59-66.
36. Trimoulet P, de Ledinghen V, Foucher J, Castera L, Fleury H, Couzigou P. Predictive value of early HCV RNA quantitation for sustained response in nonresponders receiving daily interferon and ribavirin therapy. J Med Virol 2004;72:46-51.