Effect of interferon alfa and ribavirin treatment on hepatitis C virus RNA in serum and peripheral blood mononuclear cells in children with chronic hepatitis C

Acta Gastro-Enterologica Belgica

Volumn 69, Issue 2, 2006, Pages 187-190

  Majda Stanisławska, Ewa ^a   Bednarek, M ^a   Jozwiak B ^a   Sidorkiewicz, M ^a   Piekarska, A ^a   Kuydowicz, J ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

HCV; Hepatitis C; Interferon alfa; Peripheral blood mononuclear cells; Ribavirin; Treatment

Indexed keywords

ALPHA INTERFERON; RIBAVIRIN; VIRUS RNA;

ADOLESCENT; ADULT; AGE; ARTICLE; BLOOD ANALYSIS; CHILD; CLEARANCE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; FEMALE; FIBROSIS; GENDER; HEPATITIS B; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; LIVER BIOPSY; LIVER DISEASE; MALE; MONOTHERAPY; OUTCOME ASSESSMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT REFUSAL; TREATMENT RESPONSE; VIRUS ISOLATION;

ADOLESCENT; ANTIVIRAL AGENTS; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, MULTIPLE, VIRAL; DRUG THERAPY, COMBINATION; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; MALE; POLAND; RIBAVIRIN; RNA, VIRAL; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 33747627627     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. HOOFNAGLE J.H. Course and outcome of hepatitis C. Hepatology, 2002, 36: 21-29.
2. SEEF L.B. Natural history of chronic hepatitis C. Hepatology, 2002, 36: 35-46.
3. MONZÓN C.G., JARA P., BERMEJO M.F., HIERRO L., FRAUCA E., CAMARENA C., DIAZ C., DE LA VEGA A., LARRAURI J., GARCIA-IGLESIAS C., BORQUE MJ., SANZ P., GARCIA-BUEY L., MORENO-MONTEGUDO J.A., MORENO-OTERO R. Chronic hepatitis C in children: a clinical and immunohistochemical comparative study with adult patients. Hepatology, 1998, 28: 1696-1701.
4. TOVO P.A., PEMBREY L.J., NOWELL M.L. Persistence rate and progression of vertically acquired hepatitis C infection. J. Infect. Dis., 2000, 181: 419-424.
5. VOGT M., LANG T., FROSNER G., KLINGLER C., SENDL A., ZELLER A., WIEBECKE B., LANGER B., MEISNER H., HESS J. Prevalence and clinical outcome of hepatitis C infection in children who underwent cardiac surgery before the implementation of blood-donor screening. N. Engl. J. Med., 1999, 341: 866-870.
6. BORTOLOTTI F., VAJRO P., CADROBBI P., LEPORE L., ZANCAN L., BARBERA C., CRIVELLARO C., FONTANELLA A., ALBERTI A., D'ADDEZIO M. Cryptogenic chronic liver disease and hepatitis C virus infection in children. J. Hepatol., 1992, 15: 73-76.
7. CHANG M.H., NI Y.H., HWANG L.H., LIN K.H., LIN H.H., CHEN P.J., LEE C.Y., CHEN D.S. Long term clinical and virologic outcome of primary hepatitis C virus infection in children: a prospective study. Pediatr. Infect. Dis. J., 1994, 13: 769-773.
8. KARIM B., ALEX G., SMITH A.L., HARDIKAR W. Hepatitis C infection in children: a Melbourne perspective. J. Paediatr. Child Health, 2000, 36: 385-388.
9. INUI A., FUJISAWA T., MIYAGAWA Y., SEKINE I., HANADA R., YAMAMOTO K., SHIIHARA H., INUI M. Histologic activity of the liver in children with transfusion-associated chronic hepatitis C. J. Hepatol., 1994, 21: 748-753.
10. BADIZADEGAN K., JONAS M.M., OTT M.J., NELSON S.P., PEREZ-ATAYDE A.R. Histopathology of the liver in children with chronic hepatitis C viral infection. Hepatology, 1998, 28: 1416-1423.
11. SCHEUER P.J., ASHRAFZADEH P., SHERLOCK S., BROWN D., DUSHEIKO G.M. The pathology of hepatitis C. Hepatology. 1992, 15: 567-571.
12. JONAS M.M. Children with hepatitis C. Hepatology, 2002, 36: 173-178.
13. MAJDA-STANISLAWSKA E., OMULECKA A., SZAFLIK I. Clinical picture of chronic hepatitis C in children - Polish experience. Acta Gastroenterol. Belg., 2001, 64: 20-24.
14. GUIDO M., RUGGE M., JARA P., HIERRO L., GIACCHINO R., LARRAURI J., ZANCAN L., LEANDRO G., MARINO C., BALLI F., BAGNI A., TIMITILLI A., BORTOLOTTI F. Chronic hepatitis C in children: the pathological and clinical spectrum. Gastroenterology, 1998, 115: 1525-1529.
15. JONAS M.M. Treatment of chronic hepatitis C in pediatric patients. Clin. Liver Dis., 1999, 3: 855-867.
16. SCHWARZ K.B. Pediatric issues in new therapies for hepatitis B and C. Curr. Gastrenterol. Rep., 2003, 5: 233-239.
17. JACOBSON K.R., MURRAY K., ZELLOS A., SCHWARZ K.B. An analysis of published trials of interferon monotherapy in children with chronic hepatitis C. J. Pediatr. Gastroenterol. Nutr., 2002, 34: 52-58.
18. DESMET V.J., GERBER M., HOOFNAGLE J.H., MANNS M., SCHEUER P.J. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology, 1994, 19: 1513-1520.
19. DESMET V.J., LEUVEN K.U. Histological classification of chronic hepatitis. Acta Gastroenterol. Belg., 1997, 60: 259-267.
20. DULAK J., FUNK H. Quantitaive PCR reaction in the diagnostics of chronic hepatitis C. Hepatol. Pol., 1996, 3: 31-39.
21. MCHUTCHISON J.G., GORDON S.C., SCHIFF E.R., SHIFFMAN M.L., LEE W.M., RUSTIGI V.K., GOODMAN Z.D., LING M.H., CORT S., ALBRECHT J.K. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N. Engl. J. Med., 1998, 339: 1485-1499.
22. EASL INTERNATIONAL CONSENSUS CONFERENCE ON HEPATITIS C. Paris, 26-28 February, 1999. J. Hepatol., 1999, 30: 956-961.
23. FRANCAVILLA R., MIELI-VERGANI G. Treatment of hepatitis C virus infection in children. Can. J. Gastroenterol., 2000, 14 Suppl B: 41B-44B.
24. LACKNER H., MOSER A., DEUTSCH J., KESSLER HH., BENESCH M., KREBL R., SCHWINGER W., DORNBUSCH H.J., PREISEGGER K.H., URBAN C. Interferon-alpha and ribavirin in treating children and young adults with chronic hepatitis C after malignancy. Paediatrics, 2000, 106: 53-58.
25. WIRTH S., LANG T., GEHRING S., GERNER P. Recombinant alfa-interferon plus ribavirin therapy in children and adolescents with chronic hepatitis C. Hepatology, 2002, 36: 1280-1284.
26. KASAN F., ASKER H., SHAMALI M., KALAOUI M., NAKIB B. Interferon-alpha plus ribavirin combination therapy for the treatment of chronic hepatitis C in interferon non-responders. Hepatogastroenterol., 2000, 47: 1642-1644.
27. SIEVERT W., BATEY R., MOLLISON L. Induction interferon and ribavirin for re-treatment of chronic hepatitis C patients unresponsive to interferon alone. Aliment Pharmacol. Ther., 2003, 17: 1197-1204.
28. PORTAL I., BOURLIERE M., HALFON P. Retreatment with interferon and ribavirin vs interferon alone according to viraemia in interferon responder-relapser hepatitis C patients: a prospective multicentre randomized controlled study. J. Viral. Hepatol., 2003, 10: 215-223.
29. MANNS M.P., MCHUTCHISON J.G., GORDON S.C., RUSTGI V.K., SHIFFMAN M., REINDOLLAR R., GOODMAN Z.D., KOURY K., LING M., ALBRECHT J.K. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet, 2002, 358: 258-265.
30. FRIED M.W., SHIFFMAN M.L., REDDY K.R., SMITH C., MARINOS G., GONCALES F.L. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med., 2002, 347: 975-982.
31. VERSLYPE C., MICHIELSEN P., ADLER M., ORLENT H., SPRENGERS D., DELWAIDE J. et al. The management of patients with mild hepatitis C. Acta Gastroenterol. Belg., 2005, 68, 314-318
32. EL-AWADY M.K., ISMAIL S.M., EL-SAGHEER M., SABOUR Y.A., AMR K.S., ZAKI E.A. Assay for hepatitis C virus in peripheral blood mononuclear cells enhances sensitivity of diagnosis and monitoring of HCV-associated hepatitis. Clin. Chim. Acta, 1999, 283: 1-14.
33. CAUDAI C., PADULA M.G., BASTIANONI I., VALENSIN P.E., SHYMALA V., HAN J., BOGGIANO C.A., ALMI P. Antibody-testing and RT-PCR results in hepatitis C virus infection: HCV-RNA detection in PBMC of plasma viraemia-negative HCV-seropositive persons. Infection, 1998, 26: 151-154.
34. ADINOLFI L.E., ANDREANA A., UTILI R., ZAMPINO R., RAGONE E., RUGGIERO G. HCV RNA levels in serum, liver and peripheral blood mononuclear cells of chronic hepatitis C patients and their relationship to liver injury. Am. J. Gastroenterol., 1998, 93: 2162-2166.
35. BOISVERT J., HE X.S., CHEUNG R., KEEFFE E.B., WRIGHT T., GREENBERG H.B. Quantitative analysis of hepatitis C virus in peripheral blood and liver: replication detected only in the liver. J. Infect. Dis., 2001. 184: 827-835.
36. LASKUS T., RADKOWSKI M., WILKINSON J., VARGAS H., RAKELA J. The origin of hepatitis C virus reinfecting transplanted livers: serum-derived versus peripheral blood mononuclear cell-derived virus. J. Infect. Dis., 2002, 15: 417-421.