Detection and genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in India

Journal of Medical Virology

Volumn 83, Issue 10, 2011, Pages 1799-1810

  Banerjee, Sagarika ^a   Sullender, Wayne M ^b,c   Choudekar, Avinash ^a   John, Cherian ^a   Tyagi, Vikas ^a   Fowler, Karen ^b   Lefkowitz, Elliot J ^b   Broor, Shobha ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

Acute respiratory infections; Fusion protein gene; Glycoprotein gene; Human metapneumovirus; Pneumonia

Indexed keywords

ARTICLE; BRONCHIOLITIS; CELL LINEAGE; CHILD; F GENE; FEMALE; G GENE; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HOSPITAL ADMISSION; HUMAN; HUMAN METAPNEUMOVIRUS; INDIA; MAJOR CLINICAL STUDY; MALE; NASOPHARYNGEAL ASPIRATION; NUCLEOTIDE SEQUENCE; PHYLOGENY; PNEUMONIA; RESPIRATORY TRACT INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPRING; VIRUS DETECTION; VIRUS GENE; VIRUS STRAIN; WINTER;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; INDIA; INFANT; MALE; METAPNEUMOVIRUS; NASOPHARYNX; PARAMYXOVIRIDAE INFECTIONS; PHYLOGENY; RESPIRATORY TRACT INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, RNA;

HUMAN METAPNEUMOVIRUS;

EID: 80051593078     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.22176     Document Type: Article

References (56)

1. Agapov E, Sumino KC, Gaudreault-Keener M, Storch GA, Holtzman MJ. 2006. Genetic variability of human metapneumovirus infection: Evidence of a shift in viral genotype without a change in illness. J Infect Dis 193: 396-403.
2. Banerjee S, Bharaj P, Sullender W, Kabra SK, Broor S. 2007. Human metapneumovirus infections among children with acute respiratory infections seen in a large referral hospital in India. J Clin Virol 38: 70-72.
3. Bastien N, Liu L, Ward D, Taylor T, Li Y. 2004. Genetic variability of the G glycoprotein gene of human metapneumovirus. J Clin Microbiol 42: 3532-3537.
4. Bharaj P, Sullender WM, Kabra SK, Mani K, Cherian J, Tyagi V, Chahar HS, Kaushik S, Dar L, Broor S. 2009. Respiratory viral infections detected by multiplex PCR among pediatric patients with lower respiratory tract infections seen at an urban hospital in Delhi from 2005 to 2007. Virol J 6: 89.
5. Biacchesi S, Skiadopoulos MH, Boivin G, Hanson CT, Murphy BR, Collins PL, Buchholz UJ. 2003. Genetic diversity between human metapneumovirus subgroups. Virology 315: 1-19.
6. Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Cote S, Peret TC, Erdman DD, Anderson LJ. 2002. Virological features and clinical manifestations associated with human metapneumovirus: A new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 186: 1330-1334.
7. Boivin G, De Serres G, Cote S, Gilca R, Abed Y, Rochette L, Bergeron MG, Dery P. 2003. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis 9: 634-640.
8. Boivin G, Mackay I, Sloots TP, Madhi S, Freymuth F, Wolf D, Shemer-Avni Y, Ludewick H, Gray GC, LeBlanc E. 2004. Global genetic diversity of human metapneumovirus fusion gene. Emerg Infect Dis 10: 1154-1157.
9. Broor S, Parveen S, Bharaj P, Prasad VS, Srinivasulu KN, Sumanth KM, Kapoor SK, Fowler K, Sullender WM. 2007. A prospective three-year cohort study of the epidemiology and virology of acute respiratory infections of children in rural India. PLoS One 2: e491.
10. Craig S, Thu HM, Lowry K, Wang XF, Holmes EC, Aaskov J. 2003. Diverse dengue type 2 virus populations contain recombinant and both parental viruses in a single mosquito host. J Virol 77: 4463-4467.
11. Esper F, Boucher D, Weibel C, Martinello RA, Kahn JS. 2003. Human metapneumovirus infection in the United States: Clinical manifestations associated with a newly emerging respiratory infection in children. Pediatrics 111: 1407-1410.
12. Esper F, Martinello RA, Boucher D, Weibel C, Ferguson D, Landry ML, Kahn JS. 2004. A 1-year experience with human metapneumovirus in children aged <5 years. J Infect Dis 189: 1388-1396.
13. Estrada B, Carter M, Barik S, Vidal R, Herbert D, Ramsey KM. 2007. Severe human metapneumovirus infection in hospitalized children. Clin Pediatr (Phila) 46: 258-262.
14. Freymouth F, Vabret A, Legrand L, Eterradossi N, Lafay-Delaire F, Brouard J, Guillois B. 2003. Presence of the new human metapneumovirus in French children with bronchiolitis. Pediatr Infect Dis J 22: 92-94.
15. Gerna G, Campanini G, Rovida F, Sarasini A, Lilleri D, Paolucci S, Marchi A, Baldanti F, Revello MG. 2005. Changing circulation rate of human metapneumovirus strains and types among hospitalized pediatric patients during three consecutive winter-spring seasons. Brief report. Arch Virol 150: 2365-2375.
16. Hall TA. 1999. BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl Acids Symp Ser 41: 95-98.
17. Heininger U, Kruker AT, Bonhoeffer J, Schaad UB. 2009. Human metapneumovirus infections-biannual epidemics and clinical findings in children in the region of Basel, Switzerland. Eur J Pediatr 168: 1455-1460.
18. Hopkins MJ, Redmond C, Shaw JM, Hart IJ, Hart CA, Smyth RL, Semple MG. 2008. Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK. J Clin Virol 42: 273-279.
19. Huck B, Scharf G, Neumann-Haefelin D, Puppe W, Weigl J, Falcone V. 2006. Novel human metapneumovirus sublineage. Emerg Infect Dis 12: 147-150.
20. IJpma FF, Beekhuis D, Cotton MF, Pieper CH, Kimpen JL, van den Hoogen BG, van Doornum GJ, Osterhaus DM. 2004. Human metapneumovirus infection in hospital referred South African children. J Med Virol 73: 486-493.
21. Ishiguro N, Ebihara T, Endo R, Ma X, Kikuta H, Ishiko H, Kobayashi K. 2004. High genetic diversity of the attachment (G) protein of human metapneumovirus. J Clin Microbiol 42: 3406-3414.
22. Ishiguro N, Ebihara T, Endo R, Ma X, Shirotsuki R, Ochiai S, Ishiko H, Kikuta H. 2005. Immunofluorescence assay for detection of human metapneumovirus-specific antibodies by use of baculovirus-expressed fusion protein. Clin Diagn Lab Immunol 12: 202-205.
23. Jartti T, van den Hoogen B, Garofalo RP, Osterhaus AD, Ruuskanen O. 2002. Metapneumovirus and acute wheezing in children. Lancet 360: 1393-1394.
24. Julenius K, Molgaard A, Gupta R, Brunak S. 2005. Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology 15: 153-164.
25. Kaplan NM, Dove W, Abd-Eldayem SA, Abu-Zeid AF, Shamoon HE, Hart CA. 2008. Molecular epidemiology and disease severity of respiratory syncytial virus in relation to other potential pathogens in children hospitalized with acute respiratory infection in Jordan. J Med Virol 80: 168-174.
26. Loo LH, Tan BH, Ng LM, Tee NW, Lin RT, Sugrue RJ. 2007. Human Metapneumovirus in Children, Singapore. Emerg Infect Dis 13: 1396-1398.
27. Ludewick HP, Abed Y, van Niekerk N, Boivin G, Klugman KP, Madhi SA. 2005. Human metapneumovirus genetic variability, South Africa. Emerg Infect Dis 11: 1074-1078.
28. Mackay IM, Bialasiewicz S, Jacob KC, McQueen E, Arden KE, Nissen MD, Sloots TP. 2006. Genetic diversity of human metapneumovirus over 4 consecutive years in Australia. J Infect Dis 193: 1630-1633.
29. Mao HW, Yang XQ, Zhao XD. 2008. Characterization of human metapneumoviruses isolated in Chongqing, China. Chin Med J (Engl) 121: 2254-2257.
30. Mathisen M, Strand TA, Sharma BN, Chandyo RK, Valentiner-Branth P, Basnet S, Adhikari RK, Hvidsten D, Shrestha PS, Sommerfelt H. 2009. RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study. BMC Med 7: 35.
31. McAdam AJ, Hasenbein ME, Feldman HA, Cole SE, Offermann JT, Riley AM, Lieu TA. 2004. Human metapneumovirus in children tested at a tertiary-care hospital. J Infect Dis 190: 20-26.
32. Mullins JA, Erdman DD, Weinberg GA, Edwards K, Hall CB, Walker FJ, Iwane M, Anderson LJ. 2004. Human metapneumovirus infection among children hospitalized with acute respiratory illness. Emerg Infect Dis 10: 700-705.
33. Nei M, Gojobori T. 1986. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 3: 418-426.
34. Nicholas KB, Nicholas HB Jr. 1997. GeneDoc version 2.6.002: A tool for editing and annotating multiple sequence alignments. Available at: .
35. Nissen MD, Siebert DJ, Mackay IM, Sloots TP, Withers SJ. 2002. Evidence of human metapneumovirus in Australian children. Med J Aust 176: 188.
36. Noyola DE, Alpuche-Solis AG, Herrera-Diaz A, Soria-Guerra RE, Sanchez-Alvarado J, Lopez-Revilla R. 2005. Human metapneumovirus infections in Mexico: Epidemiological and clinical characteristics. J Med Microbiol 54: 969-974.
37. Oliveira DB, Durigon EL, Carvalho AC, Leal AL, Souza TS, Thomazelli LM, Moraes CT, Vieira SE, Gilio AE, Stewien KE. 2009. Epidemiology and genetic variability of human metapneumovirus during a 4-year-long study in Southeastern Brazil. J Med Virol 81: 915-921.
38. Peiris JS, Tang WH, Chan KH, Khong PL, Guan Y, Lau YL, Chiu SS. 2003. Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis 9: 628-633.
39. Pelletier G, Dery P, Abed Y, Boivin G. 2002. Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child. Emerg Infect Dis 8: 976-978.
40. Peret TC, Abed Y, Anderson LJ, Erdman DD, Boivin G. 2004. Sequence polymorphism of the predicted human metapneumovirus G glycoprotein. J Gen Virol 85: 679-686.
41. Peret TC, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus AD, Erdman DD, Anderson LJ. 2002. Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis 185: 1660-1663.
42. Rao BL, Gandhe SS, Pawar SD, Arankalle VA, Shah SC, Kinikar AA. 2004. First detection of human metapneumovirus in children with acute respiratory infection in India: A preliminary report. J Clin Microbiol 42: 5961-5962.
43. Schowalter RM, Smith SE, Dutch RE. 2006. Characterization of human metapneumovirus F protein-promoted membrane fusion: Critical roles for proteolytic processing and low pH. J Virol 80: 10931-10941.
44. Singleton RJ, Bulkow LR, Miernyk K, DeByle C, Pruitt L, Hummel KB, Bruden D, Englund JA, Anderson LJ, Lucher L, Holman RC, Hennessy TW. 2010. Viral respiratory infections in hospitalized and community control children in Alaska. J Med Virol 82: 1282-1290.
45. Skiadopoulos MH, Biacchesi S, Buchholz UJ, Riggs JM, Surman SR, Amaro-Carambot E, McAuliffe JM, Elkins WR, St Claire M, Collins PL, Murphy BR. 2004. The two major human metapneumovirus genetic lineages are highly related antigenic relatedness. J Virol 78: 6927-6937.
46. Spann KM, Collins PL, Teng MN. 2003. Genetic recombination during coinfection of two mutants of human respiratory syncytial virus. J Virol 77: 11201-11211.
47. Tamura K, Dudley J, Nei M, Kumar S. 2007. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 1596-1599.
48. Thanasugarn W, Samransamruajkit R, Vanapongtipagorn P, Prapphal N, Van den Hoogen B, Osterhaus AD, Poovorawan Y. 2003. Human metapneumovirus infection in Thai children. Scand J Infect Dis 35: 754-756.
49. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. 1997. The CLUSTAL-X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25: 4876-4882.
50. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. 2001. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 7: 719-724.
51. van den Hoogen BG, Herfst S, Sprong L, Cane PA, Forleo-Neto E, de Swart RL, Osterhaus AD, Fouchier RA. 2004. Antigenic and genetic variability of human metapneumoviruses. Emerg Infect Dis 10: 658-666.
52. van den Hoogen BG, van Doornum GJ, Fockens JC, Cornelissen JJ, Beyer WE, de Groot R, Osterhaus AD, Fouchier RA. 2003. Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis 188: 1571-1577.
53. Vicente D, Montes M, Cilla G, Perez-Yarza EG, Perez-Trallero E. 2006. Differences in clinical severity between genotype A and genotype B human metapneumovirus infection in children. Clin Infect Dis 42: e111-e113.
54. WHO. 2000. Handbook: Integrated Management of Childhood Illness (IMCI). WHO/FCH/CAH/00.12. Geneva: Division of Child and Adolescent Health and Development, World Health Organization.
55. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, Wright PF, Crowe JE Jr. 2004. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 350: 443-450.
56. Zheng H, Storch GA, Zang C, Peret TC, Park CS, Anderson LJ. 1999. Genetic variability in envelope-associated protein genes of closely related group A strains of respiratory syncytial virus. Virus Res 59: 89-99.