Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Chu, Nain Feng ^a,b   Lin, Fu Hung ^b   Chin, Hsien Chuan ^b   Hong, Ye Jen ^c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Atherosclerotic indexes; Interleukin 6 receptor gene; Lipid profiles; Polymorphism

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6 RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; IL6R PROTEIN, HUMAN; LIPID;

ADOLESCENT; ALLELE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; CHILD; CROSS-SECTIONAL STUDY; DYSLIPIDEMIA; GENE LINKAGE DISEQUILIBRIUM; GENETICS; HOSPITALIZATION; RISK FACTOR; SEX DIFFERENCE; TAIWAN;

ADOLESCENT; ATHEROSCLEROSIS; CHILD; CHOLESTEROL; CHOLESTEROL, HDL; CROSS-SECTIONAL STUDIES; DYSLIPIDEMIAS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; LIPIDS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-6; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; TAIWAN; TRIGLYCERIDES;

EID: 80051588928     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-136     Document Type: Article

References (38)

1. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Ishihara K, Hirano T, Cytokine Growth Factor Rev 2002 13 4-5 357 368 10.1016/S1359-6101(02)00027-8 12220549
2. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Boulanger MJ, Chow DC, Brevnova EE, et al. Science 2003 300 5628 2101 2104 10.1126/science.1083901 12829785 (Pubitemid 36760138)
3. Interleukin-6 stimulates lipolysis and fat oxidation in humans. van Hall G, Steensberg A, Sacchetti M, et al. J Clin Endocrinol Metab 2003 88 7 3005 3010 10.1210/jc.2002-021687 12843134 (Pubitemid 36877463)
4. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Yudkin JS, Kumari M, Humphries SE, et al. Atherosclerosis 2000 148 2 209 214 10.1016/S0021-9150(99)00463-3 10657556 (Pubitemid 30064452)
5. The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21. Kluck PM, Wiegant J, Jansen RP, et al. Hum Genet 1993 90 5 542 544 8428753 (Pubitemid 23072844)
6. Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome. Esteve E, Villuendas G, Mallolas J, et al. Clin Endocrinol (Oxf) 2006 65 1 88 91 10.1111/j.1365-2265.2006.02553.x
7. Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. Hamid YH, Urhammer SA, Jensen DP, et al. Diabetes 2004 53 12 3342 3345 10.2337/diabetes.53.12.3342 15561970 (Pubitemid 39564514)
8. Interleukin-6 receptor gene polymorphism modulates interleukin-6 levels and the metabolic syndrome: GBCS-CVD. Jiang CQ, Lam TH, Liu B, et al. Obesity (Silver Spring) 2010 18 10 1969 1974 10.1038/oby.2010.31
9. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. Mullberg J, Oberthur W, Lottspeich F, et al. J Immunol 1994 152 10 4958 4968 8176214 (Pubitemid 24139089)
10. Relationship between anthropometric variables and lipid levels among school children: The Taipei Children Heart Study. Chu NF, Rimm EB, Wang DJ, et al. Int J Obes Relat Metab Disord 1998 22 1 66 72 10.1038/sj.ijo.0800546 9481602 (Pubitemid 28036591)
11. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Richmond W, Clin Chem 1973 19 12 1350 1356 4757363
12. New colorimetric procedure for the determination of serum triglycerides. Stavropoulos WS, Crouch RD, Clini Chem 1974 20 857
13. Multilayer film elements for clinical analysis: applications to representative chemical determinations. Spayd RW, Bruschi B, Burdick BA, et al. Clin Chem 1978 24 8 1343 1350 567106 (Pubitemid 8392014)
14. Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Warnick GR, Benderson J, Albers JJ, Clin Chem 1982 28 6 1379 1388 7074948 (Pubitemid 12125081)
15. Detection of specific polymerase chain reaction product by utilizing the 5' - - 3' exonuclease activity of Thermus aquaticus DNA polymerase. Holland PM, Abramson RD, Watson R, et al. Proc Natl Acad Sci USA 1991 88 16 7276 7280 10.1073/pnas.88.16.7276 1871133 (Pubitemid 21915133)
16. The structure of haplotype blocks in the human genome. Gabriel SB, Schaffner SF, Nguyen H, et al. Science 2002 296 5576 2225 2229 10.1126/science.1069424 12029063 (Pubitemid 34680308)
17. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Heinrich PC, Behrmann I, Haan S, et al. Biochem J 2003 374 Pt 1 1 20 12773095 (Pubitemid 37046923)
18. Muscle-derived interleukin-6 - a possible link between skeletal muscle, adipose tissue, liver, and brain. Pedersen BK, Febbraio M, Brain Behav Immun 2005 19 5 371 376 10.1016/j.bbi.2005.04.008 15935612 (Pubitemid 41074774)
19. The origins of age-related proinflammatory state. Ferrucci L, Corsi A, Lauretani F, et al. Blood 2005 105 6 2294 2299 10.1182/blood-2004-07-2599 15572589 (Pubitemid 40387022)
20. A gender - dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Bonafe M, Olivieri F, Cavallone L, et al. Eur J Immunol 2001 31 8 2357 2361 10.1002/1521-4141(200108)31:8<2357::AID- IMMU2357>3.0.CO;2-X 11500818 (Pubitemid 32785354)
21. Modest implication of interleukin-6 promoter polymorphisms in longevity. Christiansen L, Bathum L, Andersen-Ranberg K, et al. Mech Ageing Dev 2004 125 5 391 395 10.1016/j.mad.2004.03.004 15130757 (Pubitemid 38595191)
22. Role of interleukin-6 signalling in glucose and lipid metabolism. Glund S, Krook A, Acta Physiol (Oxf) 2008 192 1 37 48 (Pubitemid 350265360)
23. Sex differences in monocyte expression of IL-6: role of autonomic mechanisms. O'Connor MF, Motivala SJ, Valladares EM, et al. Am J Physiol Regul Integr Comp Physiol 2007 293 1 145 151 10.1152/ajpregu.00752.2006 17428894 (Pubitemid 47096572)
24. Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. Kristiansen OP, Nolsoe RL, Larsen L, et al. Hum Mol Genet 2003 12 10 1101 1110 10.1093/hmg/ddg132 12719374 (Pubitemid 36622142)
25. Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women. Bustamante M, Nogues X, Mellibovsky L, et al. Eur J Endocrinol 2007 157 5 677 684 10.1530/EJE-07-0389 17984249 (Pubitemid 350187386)
26. Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S Women. Qi L, Rifai N, Hu FB, Diabetes 2007 56 12 3075 3081 10.2337/db07-0505 17898129 (Pubitemid 350223644)
27. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. Qi L, Rifai N, Hu FB, Diabetes 2009 58 1 275 278 10.2337/db08-0968 18852330
28. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Escobar-Morreale HF, Calvo RM, Villuendas G, et al. Obes Res 2003 11 8 987 996 10.1038/oby.2003.136 12917504 (Pubitemid 41137511)
29. Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women. Menon R, Velez DR, Simhan H, et al. Am J Obstet Gynecol 2006 194 6 1616 1624 10.1016/j.ajog.2006. 03.059 16731080
30. Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth. Velez DR, Fortunato SJ, Williams SM, et al. Hum Mol Genet 2008 17 11 1619 1630 10.1093/hmg/ddn049 18276608 (Pubitemid 351737166)
31. Ethnic differences in interleukin 6 (IL-6) and IL6 receptor genes in spontaneous preterm birth and effects on amniotic fluid protein levels. Velez DR, Menon R, Thorsen P, et al. Ann Hum Genet 2007 71 Pt 5 586 600 17346257 (Pubitemid 47087067)
32. Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Gu F, Qureshi AA, Niu T, et al. Melanoma Res 2008 18 5 330 335 10.1097/CMR.0b013e32830658b2 18781131
33. The interaction between the interleukin 6 receptor gene genotype and dietary energy intake on abdominal obesity in Japanese men. Song Y, Miyaki K, Araki J, et al. Metabolism 2007 56 7 925 930 10.1016/j.metabol.2007.02.006 17570254 (Pubitemid 46890975)
34. The IL6-174G/C polymorphism is associated with celiac disease susceptibility in girls. Dema B, Martinez A, Fernandez-Arquero M, et al. Hum Immunol 2009 70 3 191 194 10.1016/j.humimm.2009.01.010 19280716
35. Effects of interleukin-6 on proliferation and follicle-stimulating hormone-induced estradiol production by bovine granulosa cells in vitro: dependence on size of follicle. Alpizar E, Spicer LJ, Biol Reprod 1994 50 1 38 43 10.1095/biolreprod50.1.38 8312448 (Pubitemid 24006005)
36. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Kristiansen OP, Mandrup-Poulsen T, Diabetes 2005 54 Suppl 2 114 124 16306329
37. Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Wolford JK, Colligan PB, Gruber JD, et al. Mol Genet Metab 2003 80 3 338 343 10.1016/j.ymgme.2003.07.003 14680981 (Pubitemid 37324721)
38. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. You T, Berman DM, Ryan AS, et al. J Clin Endocrinol Metab 2004 89 4 1739 1746 10.1210/jc.2003-031310 15070939 (Pubitemid 38507928)