Safety and Efficacy of New 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine Analogs as Potential Phosphodiesterase-4 Inhibitors in NIH-3T3 Mouse Fibroblastic Cells

Chemical Biology and Drug Design

Volumn 78, Issue 3, 2011, Pages 438-444

  Baeeri, Maryam ^a,b   Foroumadi, Alireza ^a,c   Motamedi, Maryam ^a   Yahya Meymandi, Azadeh ^c   Firoozpour, Loghman ^c   Ostad, Seyed N ^a   Shafiee, Abbas ^a   Souzangarzadeh, Saeid ^b   Abdollahi, Mohammad ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

CAMP; CGMP; Drug discovery; Phosphodiesterase inhibitor

Indexed keywords

6 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 3 (2 METHOXYPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 3 (3 METHOXYPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 3 (4 TOLYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 3 ARYL 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 6 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 3 PHENYL 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; CYCLIC AMP; CYCLIC GMP; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SAFETY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL SURVIVAL; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; MICE; NIH 3T3 CELLS; PHOSPHODIESTERASE 4 INHIBITORS; ROLIPRAM; THIADIAZINES;

EID: 80051587557     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01167.x     Document Type: Article

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