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Volumn 3, Issue , 2010, Pages 147-155

New advancements and developments in treatment of renal cell carcinoma: Focus on pazopanib

Author keywords

Pazopanib; Renal cell carcinoma; Targeted agents; Vascular endothelial growth factor inhibitors

Indexed keywords

AXITINIB; BEVACIZUMAB; EVEROLIMUS; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 3; INTERFERON; PAZOPANIB; PLACEBO; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SORAFENIB; STEM CELL FACTOR RECEPTOR; SUNITINIB; TEMSIROLIMUS; TIVOZANIB; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 80051574572     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S12480     Document Type: Review
Times cited : (14)

References (39)
  • 1
    • 0035048096 scopus 로고    scopus 로고
    • Cytokine therapy for metastatic renal cell carcinoma
    • Bukowski RM. Cytokine therapy for metastatic renal cell carcinoma. Semin Urol Oncol. 2001;19(2):148-154.
    • (2001) Semin Urol Oncol , vol.19 , Issue.2 , pp. 148-154
    • Bukowski, R.M.1
  • 2
    • 0037093238 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factors in human renal cancer: Relationship to angiogenesis and to the von Hippel-Lindau gene mutation
    • Turner KJ, Moore JW, Jones A, et al. Expression of hypoxia-inducible factors in human renal cancer: Relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res. 2002;62(10): 2957-2961.
    • (2002) Cancer Res , vol.62 , Issue.10 , pp. 2957-2961
    • Turner, K.J.1    Moore, J.W.2    Jones, A.3
  • 3
    • 33646764243 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, hypoxia, and tumor angiogenesis
    • Gruber M, Simon MC. Hypoxia-inducible factors, hypoxia, and tumor angiogenesis. Curr Opin Hematol. 2006;13(3):169-174.
    • (2006) Curr Opin Hematol , vol.13 , Issue.3 , pp. 169-174
    • Gruber, M.1    Simon, M.C.2
  • 4
    • 0033693293 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha - hypoxia response element - VEGF cascade differentially regulates vascular response and growth rate in tumors
    • Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha - hypoxia response element - VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res. 2000;60(22):6248-6252.
    • (2000) Cancer Res , vol.60 , Issue.22 , pp. 6248-6252
    • Tsuzuki, Y.1    Fukumura, D.2    Oosthuyse, B.3    Koike, C.4    Carmeliet, P.5    Jain, R.K.6
  • 5
    • 0032544686 scopus 로고    scopus 로고
    • Tumor induction of VEGF promoter activity in stromal cells
    • Fukumura D, Xavier R, Sugiura T, et al. Tumor induction of VEGF promoter activity in stromal cells. Cell. 1998;94(6):715-725.
    • (1998) Cell , vol.94 , Issue.6 , pp. 715-725
    • Fukumura, D.1    Xavier, R.2    Sugiura, T.3
  • 7
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology. 2005;69(Suppl 3):4-10.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 4-10
    • Carmeliet, P.1
  • 8
    • 0032949884 scopus 로고    scopus 로고
    • Serum concentrations of VEGF and b-FGF in renal cell, prostate and urinary bladder carcinomas
    • Edgren M, Lennernas B, Larsson A, Nilsson S. Serum concentrations of VEGF and b-FGF in renal cell, prostate and urinary bladder carcinomas. Anticancer Res. 1999;19(1B):869-873.
    • (1999) Anticancer Res , vol.19 , Issue.1 B , pp. 869-873
    • Edgren, M.1    Lennernas, B.2    Larsson, A.3    Nilsson, S.4
  • 9
    • 0031776704 scopus 로고    scopus 로고
    • Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumorigenesis
    • Clifford SC, Prowse AH, Affara NA, Buys CH, Maher ER. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumorigenesis. Genes Chromosomes Cancer. 1998;22(3):200-209.
    • (1998) Genes Chromosomes Cancer , vol.22 , Issue.3 , pp. 200-209
    • Clifford, S.C.1    Prowse, A.H.2    Affara, N.A.3    Buys, C.H.4    Maher, E.R.5
  • 10
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16(9):4604-4613.
    • (1996) Mol Cell Biol , vol.16 , Issue.9 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 11
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer. J Clin Oncol. 2004;22(24):4991-5004.
    • (2004) J Clin Oncol , vol.22 , Issue.24 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 12
    • 4644231084 scopus 로고    scopus 로고
    • Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: Regulation by hypoxia and participation in angiogenesis
    • Yamakawa M, Liu LX, Belanger AJ, et al. Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: Regulation by hypoxia and participation in angiogenesis. Am J Physiol Renal Physiol. 2004; 287(4):F649-F657.
    • (2004) Am J Physiol Renal Physiol , vol.287 , Issue.4
    • Yamakawa, M.1    Liu, L.X.2    Belanger, A.J.3
  • 13
    • 65949122058 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma
    • Rini BI. Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma. Cancer. 2009;115(Suppl 10):2306-2312.
    • (2009) Cancer , vol.115 , Issue.SUPPL. 10 , pp. 2306-2312
    • Rini, B.I.1
  • 14
    • 0036789574 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    • Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002;22(20):7004-7014.
    • (2002) Mol Cell Biol , vol.22 , Issue.20 , pp. 7004-7014
    • Hudson, C.C.1    Liu, M.2    Chiang, G.G.3
  • 15
    • 49449117755 scopus 로고    scopus 로고
    • Discovery of 5-[[4-[(2,3- dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-m ethyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor
    • Harris PA, Boloor A, Cheung M, et al. Discovery of 5-[[4-[(2,3- dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-m ethyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008;51(15): 4632-4640.
    • (2008) J Med Chem , vol.51 , Issue.15 , pp. 4632-4640
    • Harris, P.A.1    Boloor, A.2    Cheung, M.3
  • 16
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokineticpharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar R, Knick VB, Rudolph SK, et al. Pharmacokineticpharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther. 2007;6(7):201-221.
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 201-221
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3
  • 17
    • 67449164582 scopus 로고    scopus 로고
    • Phase I trial of pazopanib in patients with advanced cancer
    • Hurwitz HI, Dowlati A, Saini S, et al. Phase I trial of pazopanib in patients with advanced cancer. Clin Cancer Res. 2009;15(12):4220-4227.
    • (2009) Clin Cancer Res , vol.15 , Issue.12 , pp. 4220-4227
    • Hurwitz, H.I.1    Dowlati, A.2    Saini, S.3
  • 18
    • 75749090050 scopus 로고    scopus 로고
    • Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma
    • 20
    • Hutson TE, Davis ID, Machiels JP, et al. Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol. 2010;20;28(3):475-480.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 475-480
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3
  • 19
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized Phase III trial
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized Phase III trial. J Clin Oncol. 2010;28(6):1061-1068.
    • (2010) J Clin Oncol , vol.28 , Issue.6 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 20
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356(2):125-134.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 21
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115-124.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 22
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 2009;27(22): 3584-3590.
    • (2009) J Clin Oncol , vol.27 , Issue.22 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 23
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356(22): 2271-2281.
    • (2007) N Engl J Med , vol.356 , Issue.22 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 24
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 1999;17(8):2530-2540.
    • (1999) J Clin Oncol , vol.17 , Issue.8 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3    Berg, W.4    Amsterdam, A.5    Ferrara, J.6
  • 25
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebocontrolled phase III trial
    • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebocontrolled phase III trial. Lancet. 2008;372(9637):449-456.
    • (2008) Lancet , vol.372 , Issue.9637 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 26
    • 77955625913 scopus 로고    scopus 로고
    • Updated data from a phase III randomized trial of everolimus (RAD001) versus PBO in metastatic renal cell carcinoma (mRCC)
    • Feb 26-28, Orlando, FL
    • Kay A, Motzer R, Figlin R, et al. Updated data from a phase III randomized trial of everolimus (RAD001) versus PBO in metastatic renal cell carcinoma (mRCC). ASCO Genitourinary Cancer Symposium. 2009 Feb 26-28, Orlando, FL.
    • (2009) ASCO Genitourinary Cancer Symposium
    • Kay, A.1    Motzer, R.2    Figlin, R.3
  • 27
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind Phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind Phase III trial. Lancet. 2007;370(9605):2103-2111.
    • (2007) Lancet , vol.370 , Issue.9605 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 28
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol. 2008;26(33):5422-5428.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 29
    • 77952300540 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival
    • Escudier B, Bellmunt J, Negrier S, et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival. J Clin Oncol. 2010;28(13):2144-2150.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2144-2150
    • Escudier, B.1    Bellmunt, J.2    Negrier, S.3
  • 30
    • 0029911657 scopus 로고    scopus 로고
    • Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgery
    • Lerner SE, Hawkins CA, Blute ML, et al. Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgery. J Urol. 1996;155(6):1868-1873.
    • (1996) J Urol , vol.155 , Issue.6 , pp. 1868-1873
    • Lerner, S.E.1    Hawkins, C.A.2    Blute, M.L.3
  • 31
    • 18744385855 scopus 로고    scopus 로고
    • Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort
    • Frank I, Blute ML, Leibovich BC, Cheville JC, Lohse CM, Zincke H. Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort. J Urol. 2005;173(6):1889-1892.
    • (2005) J Urol , vol.173 , Issue.6 , pp. 1889-1892
    • Frank, I.1    Blute, M.L.2    Leibovich, B.C.3    Cheville, J.C.4    Lohse, C.M.5    Zincke, H.6
  • 32
    • 0041411517 scopus 로고    scopus 로고
    • Adjuvant high-dose bolus interleukin- 2 for patients with high-risk renal cell carcinoma: A cytokine working group randomized trial
    • Clark JI, Atkins MB, Urba WJ, et al. Adjuvant high-dose bolus interleukin- 2 for patients with high-risk renal cell carcinoma: A cytokine working group randomized trial. J Clin Oncol. 2003;21(16): 3133-3140.
    • (2003) J Clin Oncol , vol.21 , Issue.16 , pp. 3133-3140
    • Clark, J.I.1    Atkins, M.B.2    Urba, W.J.3
  • 33
    • 0038514165 scopus 로고    scopus 로고
    • Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: An Eastern Cooperative Oncology Group/Intergroup trial
    • Messing EM, Manola J, Wilding G, et al. Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: An Eastern Cooperative Oncology Group/Intergroup trial. J Clin Oncol. 2003;21(7):1214-1222.
    • (2003) J Clin Oncol , vol.21 , Issue.7 , pp. 1214-1222
    • Messing, E.M.1    Manola, J.2    Wilding, G.3
  • 34
    • 67349163859 scopus 로고    scopus 로고
    • Sequential sorafenib and sunitinib for renal cell carcinoma
    • discussion 34
    • Sablin MP, Negrier S, Ravaud A, et al. Sequential sorafenib and sunitinib for renal cell carcinoma. J Urol. 2009;182(1):29-34; discussion 34.
    • (2009) J Urol , vol.182 , Issue.1 , pp. 29-34
    • Sablin, M.P.1    Negrier, S.2    Ravaud, A.3
  • 35
    • 77951666852 scopus 로고    scopus 로고
    • Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism
    • Xu CF, Reck BH, Xue Z, et al. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Br J Cancer. 2010;27;102(9):1371-1377.
    • (2010) Br J Cancer , vol.102 , Issue.9 , pp. 1371-1377
    • Xu, C.F.1    Reck, B.H.2    Xue, Z.3
  • 36
    • 77953387918 scopus 로고    scopus 로고
    • Updated activity and safety results of a phase II randomized discontinuation trial (RDT) of AV-951, a potent and selective VEGFR1, 2, and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC)
    • Abstr 5032
    • Bhargava P, Esteves B, Nosov DA, et al. Updated activity and safety results of a phase II randomized discontinuation trial (RDT) of AV-951, a potent and selective VEGFR1, 2, and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC). J Clin Oncol. 2009;27(15S):Abstr 5032.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Bhargava, P.1    Esteves, B.2    Nosov, D.A.3
  • 37
    • 58149337448 scopus 로고    scopus 로고
    • Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
    • Hu-Lowe DD, Zou HY, Grazzini ML, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008;14(22):7272-7283.
    • (2008) Clin Cancer Res , vol.14 , Issue.22 , pp. 7272-7283
    • Hu-Lowe, D.D.1    Zou, H.Y.2    Grazzini, M.L.3
  • 38
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003;9(1):327-337.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 39
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64(19):7099-7109.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3


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