-
1
-
-
0035048096
-
Cytokine therapy for metastatic renal cell carcinoma
-
Bukowski RM. Cytokine therapy for metastatic renal cell carcinoma. Semin Urol Oncol. 2001;19(2):148-154.
-
(2001)
Semin Urol Oncol
, vol.19
, Issue.2
, pp. 148-154
-
-
Bukowski, R.M.1
-
2
-
-
0037093238
-
Expression of hypoxia-inducible factors in human renal cancer: Relationship to angiogenesis and to the von Hippel-Lindau gene mutation
-
Turner KJ, Moore JW, Jones A, et al. Expression of hypoxia-inducible factors in human renal cancer: Relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res. 2002;62(10): 2957-2961.
-
(2002)
Cancer Res
, vol.62
, Issue.10
, pp. 2957-2961
-
-
Turner, K.J.1
Moore, J.W.2
Jones, A.3
-
3
-
-
33646764243
-
Hypoxia-inducible factors, hypoxia, and tumor angiogenesis
-
Gruber M, Simon MC. Hypoxia-inducible factors, hypoxia, and tumor angiogenesis. Curr Opin Hematol. 2006;13(3):169-174.
-
(2006)
Curr Opin Hematol
, vol.13
, Issue.3
, pp. 169-174
-
-
Gruber, M.1
Simon, M.C.2
-
4
-
-
0033693293
-
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha - hypoxia response element - VEGF cascade differentially regulates vascular response and growth rate in tumors
-
Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha - hypoxia response element - VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res. 2000;60(22):6248-6252.
-
(2000)
Cancer Res
, vol.60
, Issue.22
, pp. 6248-6252
-
-
Tsuzuki, Y.1
Fukumura, D.2
Oosthuyse, B.3
Koike, C.4
Carmeliet, P.5
Jain, R.K.6
-
5
-
-
0032544686
-
Tumor induction of VEGF promoter activity in stromal cells
-
Fukumura D, Xavier R, Sugiura T, et al. Tumor induction of VEGF promoter activity in stromal cells. Cell. 1998;94(6):715-725.
-
(1998)
Cell
, vol.94
, Issue.6
, pp. 715-725
-
-
Fukumura, D.1
Xavier, R.2
Sugiura, T.3
-
6
-
-
0031836159
-
VEGF induces hyperpermeability by a direct action on endothelial cells
-
Hippenstiel S, Krull M, Ikemann A, Risau W, Clauss M, Suttorp N. VEGF induces hyperpermeability by a direct action on endothelial cells. Am J Physiol. 1998;274(5 Pt 1):L678-L684.
-
(1998)
Am J Physiol
, vol.274
, Issue.5 Pt 1
-
-
Hippenstiel, S.1
Krull, M.2
Ikemann, A.3
Risau, W.4
Clauss, M.5
Suttorp, N.6
-
7
-
-
27944473690
-
VEGF as a key mediator of angiogenesis in cancer
-
Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology. 2005;69(Suppl 3):4-10.
-
(2005)
Oncology
, vol.69
, Issue.SUPPL. 3
, pp. 4-10
-
-
Carmeliet, P.1
-
8
-
-
0032949884
-
Serum concentrations of VEGF and b-FGF in renal cell, prostate and urinary bladder carcinomas
-
Edgren M, Lennernas B, Larsson A, Nilsson S. Serum concentrations of VEGF and b-FGF in renal cell, prostate and urinary bladder carcinomas. Anticancer Res. 1999;19(1B):869-873.
-
(1999)
Anticancer Res
, vol.19
, Issue.1 B
, pp. 869-873
-
-
Edgren, M.1
Lennernas, B.2
Larsson, A.3
Nilsson, S.4
-
9
-
-
0031776704
-
Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumorigenesis
-
Clifford SC, Prowse AH, Affara NA, Buys CH, Maher ER. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumorigenesis. Genes Chromosomes Cancer. 1998;22(3):200-209.
-
(1998)
Genes Chromosomes Cancer
, vol.22
, Issue.3
, pp. 200-209
-
-
Clifford, S.C.1
Prowse, A.H.2
Affara, N.A.3
Buys, C.H.4
Maher, E.R.5
-
10
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16(9):4604-4613.
-
(1996)
Mol Cell Biol
, vol.16
, Issue.9
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
-
11
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer. J Clin Oncol. 2004;22(24):4991-5004.
-
(2004)
J Clin Oncol
, vol.22
, Issue.24
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
12
-
-
4644231084
-
Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: Regulation by hypoxia and participation in angiogenesis
-
Yamakawa M, Liu LX, Belanger AJ, et al. Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: Regulation by hypoxia and participation in angiogenesis. Am J Physiol Renal Physiol. 2004; 287(4):F649-F657.
-
(2004)
Am J Physiol Renal Physiol
, vol.287
, Issue.4
-
-
Yamakawa, M.1
Liu, L.X.2
Belanger, A.J.3
-
13
-
-
65949122058
-
Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma
-
Rini BI. Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma. Cancer. 2009;115(Suppl 10):2306-2312.
-
(2009)
Cancer
, vol.115
, Issue.SUPPL. 10
, pp. 2306-2312
-
-
Rini, B.I.1
-
14
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002;22(20):7004-7014.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.20
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
-
15
-
-
49449117755
-
Discovery of 5-[[4-[(2,3- dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-m ethyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor
-
Harris PA, Boloor A, Cheung M, et al. Discovery of 5-[[4-[(2,3- dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-m ethyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008;51(15): 4632-4640.
-
(2008)
J Med Chem
, vol.51
, Issue.15
, pp. 4632-4640
-
-
Harris, P.A.1
Boloor, A.2
Cheung, M.3
-
16
-
-
34447322566
-
Pharmacokineticpharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
Kumar R, Knick VB, Rudolph SK, et al. Pharmacokineticpharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther. 2007;6(7):201-221.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.7
, pp. 201-221
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
-
17
-
-
67449164582
-
Phase I trial of pazopanib in patients with advanced cancer
-
Hurwitz HI, Dowlati A, Saini S, et al. Phase I trial of pazopanib in patients with advanced cancer. Clin Cancer Res. 2009;15(12):4220-4227.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.12
, pp. 4220-4227
-
-
Hurwitz, H.I.1
Dowlati, A.2
Saini, S.3
-
18
-
-
75749090050
-
Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma
-
20
-
Hutson TE, Davis ID, Machiels JP, et al. Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol. 2010;20;28(3):475-480.
-
(2010)
J Clin Oncol
, vol.28
, Issue.3
, pp. 475-480
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.P.3
-
19
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized Phase III trial
-
Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized Phase III trial. J Clin Oncol. 2010;28(6):1061-1068.
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
20
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356(2):125-134.
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
21
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115-124.
-
(2007)
N Engl J Med
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
22
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 2009;27(22): 3584-3590.
-
(2009)
J Clin Oncol
, vol.27
, Issue.22
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
23
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356(22): 2271-2281.
-
(2007)
N Engl J Med
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
24
-
-
0032772880
-
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
-
Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 1999;17(8):2530-2540.
-
(1999)
J Clin Oncol
, vol.17
, Issue.8
, pp. 2530-2540
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
Berg, W.4
Amsterdam, A.5
Ferrara, J.6
-
25
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebocontrolled phase III trial
-
Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebocontrolled phase III trial. Lancet. 2008;372(9637):449-456.
-
(2008)
Lancet
, vol.372
, Issue.9637
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
26
-
-
77955625913
-
Updated data from a phase III randomized trial of everolimus (RAD001) versus PBO in metastatic renal cell carcinoma (mRCC)
-
Feb 26-28, Orlando, FL
-
Kay A, Motzer R, Figlin R, et al. Updated data from a phase III randomized trial of everolimus (RAD001) versus PBO in metastatic renal cell carcinoma (mRCC). ASCO Genitourinary Cancer Symposium. 2009 Feb 26-28, Orlando, FL.
-
(2009)
ASCO Genitourinary Cancer Symposium
-
-
Kay, A.1
Motzer, R.2
Figlin, R.3
-
27
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind Phase III trial
-
Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind Phase III trial. Lancet. 2007;370(9605):2103-2111.
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
28
-
-
56749161699
-
Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol. 2008;26(33):5422-5428.
-
(2008)
J Clin Oncol
, vol.26
, Issue.33
, pp. 5422-5428
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
29
-
-
77952300540
-
Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival
-
Escudier B, Bellmunt J, Negrier S, et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival. J Clin Oncol. 2010;28(13):2144-2150.
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2144-2150
-
-
Escudier, B.1
Bellmunt, J.2
Negrier, S.3
-
30
-
-
0029911657
-
Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgery
-
Lerner SE, Hawkins CA, Blute ML, et al. Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgery. J Urol. 1996;155(6):1868-1873.
-
(1996)
J Urol
, vol.155
, Issue.6
, pp. 1868-1873
-
-
Lerner, S.E.1
Hawkins, C.A.2
Blute, M.L.3
-
31
-
-
18744385855
-
Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort
-
Frank I, Blute ML, Leibovich BC, Cheville JC, Lohse CM, Zincke H. Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort. J Urol. 2005;173(6):1889-1892.
-
(2005)
J Urol
, vol.173
, Issue.6
, pp. 1889-1892
-
-
Frank, I.1
Blute, M.L.2
Leibovich, B.C.3
Cheville, J.C.4
Lohse, C.M.5
Zincke, H.6
-
32
-
-
0041411517
-
Adjuvant high-dose bolus interleukin- 2 for patients with high-risk renal cell carcinoma: A cytokine working group randomized trial
-
Clark JI, Atkins MB, Urba WJ, et al. Adjuvant high-dose bolus interleukin- 2 for patients with high-risk renal cell carcinoma: A cytokine working group randomized trial. J Clin Oncol. 2003;21(16): 3133-3140.
-
(2003)
J Clin Oncol
, vol.21
, Issue.16
, pp. 3133-3140
-
-
Clark, J.I.1
Atkins, M.B.2
Urba, W.J.3
-
33
-
-
0038514165
-
Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: An Eastern Cooperative Oncology Group/Intergroup trial
-
Messing EM, Manola J, Wilding G, et al. Phase III study of interferon alfa-NL as adjuvant treatment for resectable renal cell carcinoma: An Eastern Cooperative Oncology Group/Intergroup trial. J Clin Oncol. 2003;21(7):1214-1222.
-
(2003)
J Clin Oncol
, vol.21
, Issue.7
, pp. 1214-1222
-
-
Messing, E.M.1
Manola, J.2
Wilding, G.3
-
34
-
-
67349163859
-
Sequential sorafenib and sunitinib for renal cell carcinoma
-
discussion 34
-
Sablin MP, Negrier S, Ravaud A, et al. Sequential sorafenib and sunitinib for renal cell carcinoma. J Urol. 2009;182(1):29-34; discussion 34.
-
(2009)
J Urol
, vol.182
, Issue.1
, pp. 29-34
-
-
Sablin, M.P.1
Negrier, S.2
Ravaud, A.3
-
35
-
-
77951666852
-
Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism
-
Xu CF, Reck BH, Xue Z, et al. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Br J Cancer. 2010;27;102(9):1371-1377.
-
(2010)
Br J Cancer
, vol.102
, Issue.9
, pp. 1371-1377
-
-
Xu, C.F.1
Reck, B.H.2
Xue, Z.3
-
36
-
-
77953387918
-
Updated activity and safety results of a phase II randomized discontinuation trial (RDT) of AV-951, a potent and selective VEGFR1, 2, and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC)
-
Abstr 5032
-
Bhargava P, Esteves B, Nosov DA, et al. Updated activity and safety results of a phase II randomized discontinuation trial (RDT) of AV-951, a potent and selective VEGFR1, 2, and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC). J Clin Oncol. 2009;27(15S):Abstr 5032.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Bhargava, P.1
Esteves, B.2
Nosov, D.A.3
-
37
-
-
58149337448
-
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
-
Hu-Lowe DD, Zou HY, Grazzini ML, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008;14(22):7272-7283.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.22
, pp. 7272-7283
-
-
Hu-Lowe, D.D.1
Zou, H.Y.2
Grazzini, M.L.3
-
38
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003;9(1):327-337.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.1
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
39
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64(19):7099-7109.
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
|