A comparison of vascular effects from complex and individual air pollutants indicates a role for monoxide gases and volatile hydrocarbons

Environmental Health Perspectives

Volumn 118, Issue 7, 2010, Pages 921-927

  Campen, Matthew J ^a   Lund, Amie K ^a   Doyle Eisele, Melanie L ^a   McDonald, Jacob D ^a   Knuckles, Travis L ^a   Rohr, Annette C ^b   Knipping, Eladio M ^b   Mauderly, Joe L ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b ELECTRIC POWER RESEARCH INSTITUTE   (United States)

Author keywords

Atherosclerosis; Carbon monoxide; Cardiovascular; Lipid peroxidation; Nitric oxide; Particulate matter; Vascular remodeling; Zymography

Indexed keywords

CARBON MONOXIDE; COAL; ENDOTHELIN 1; GASOLINE; GELATINASE; GELATINASE B; HEME OXYGENASE 1; HYDROCARBON; LIPID PEROXIDE; NITRIC OXIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VOLATILE AGENT; AIR POLLUTANT; APOLIPOPROTEIN E; EXHAUST GAS; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AIR POLLUTION; AIR POLLUTION CONTROL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CARDIOVASCULAR EFFECT; COMBUSTION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ZYMOGRAPHY; AIR POLLUTANT; ANALYSIS OF VARIANCE; ANIMAL; BLOOD VESSEL; C57BL MOUSE; DRUG EFFECTS; EXHAUST GAS; GENETIC TRANSCRIPTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; POLYMERASE CHAIN REACTION; TOXICITY;

MURINAE; MUS;

AIR POLLUTANTS; ANALYSIS OF VARIANCE; ANIMALS; APOLIPOPROTEINS E; BLOOD VESSELS; CARBON MONOXIDE; ENDOTHELIN-1; HEME OXYGENASE-1; LIPID PEROXIDATION; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; POLYMERASE CHAIN REACTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSCRIPTION, GENETIC; VEHICLE EMISSIONS;

EID: 77954843129     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0901207     Document Type: Article

References (35)

1. Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, et al. 2008. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res 102:589-596.
2. -/- mice. Toxicol Appl Pharmacol 242:310-317.
3. Cherng TW, Campen MJ, Knuckles TL, Gonzalez-Bosc L, Kanagy NL. 2009. Impairment of coronary endothelial cell ETB receptor function following short-term inhalation exposure to whole diesel emissions. Am J Physiol Regul Integr Comp Physiol 297:R640-R647.
4. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, et al. 2009. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest 119:1335-1349.
5. Chung HT, Choi BM, Kwon YG, Kim YM. 2008. Interactive relations between nitric oxide (NO) and carbon monoxide (CO): heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation. Methods Enzymol 441:329-338.
6. De Fré R, Bruynseraede P, Kretzschmar JG. 1994. Air pollution measurements in traffic tunnels. Environ Health Perspect 102(suppl 4):31-37.
7. Fujita EM, Campbell DE, Zielinska B, Sagebiel JC, Bowen JL, Goliff WS, et al. 2003. Diurnal and weekday variations in the source contributions of ozone precursors in California's South Coast Air Basin. J Air Waste Manag Assoc 53:844-863.
8. Gerlofs-Nijland ME, Dormans JA, Bloemen HJ, Leseman DL, John A, Boere F, et al. 2007. Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles. Inhal Toxicol 19(13):1055-1069.
9. Gough PJ, Gomez IG, Wille PT, Raines EW. 2006. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest 116:59-69.
10. Hlatky MA, Ashley E, Quertermous T, Boothroyd DB, Ridker P, Southwick A, et al. 2007. Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. Atherosclerotic Disease, Vascular Function and Genetic Epidemiology (ADVANCE) Study. Am Heart J 154:1043-1051.
11. Hoffmann B, Moebus S, Möhlenkamp S, Stang A, Lehmann N, Dragano N, et al. 2007. Residential exposure to traffic is associated with coronary atherosclerosis. Circulation 116:489-496.
12. Johnson JL, Baker AH, Oka K, Chan L, Newby AC, Jackson CL, et al. 2006. Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis. Circulation 113:2435-2444.
13. Kamei M, Yanagisawa Y. 1997. Estimation of CO exposure of road construction workers in tunnel. Ind Health 35:119-125.
14. Knuckles TL, Lund AK, Lucas SN, Campen MJ. 2008. Diesel exhaust exposure enhances venoconstriction through uncoupling of eNOS. Toxicol Appl Pharmacol 230:346-351.
15. Lund AK, Knuckles TL, Obot Akata C, Shohet R, McDonald JD, Gigliotti A, et al. 2007. Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol Sci 95:485-494.
16. Lund AK, Lucero JA, Lucas S, Madden MC, McDonald JD, Seagrave JC, et al. 2009. Vehicular emissions induce vascular MMP-9 expression and activity via endothelin-1 mediated pathways. Arterioscler Thromb Vasc Biol 29:511-517.
17. Markhorst DG, Leenhoven T, Uiterwijk JW, Meulenbelt J, van Vught AJ. 1996. Occupational exposure during nitric oxide inhalational therapy in a pediatric intensive care setting. Intensive Care Med 22:954-958.
18. McDonald JD, Barr EB, White RK, Chow JC, Schauer JJ, Zielinska B, et al. 2004. Generation and characterization of four dilutions of diesel engine exhaust for a subchronic inhalation study. Environ Sci Technol 38:2513-2522.
19. McDonald JD, Barr EB, White RK, Kracko D, Chow JC, Zielinska B, et al. 2008. Generation and characterization of gasoline engine exhaust inhalation exposure atmospheres. Inhal Toxicol 20:1157-1168.
20. McDonald JD, Doyle-Eisele M, Campen MJ, Seagrave JC, Holmes TD, Lund A, et al. 2010. Cardiopulmonary response to inhalation of biogenic secondary organic aerosol. Inhal Toxicol 22:253-265.
21. McDonald JD, White RK, Barr EB, Zielinska B, Chow JC, Grosjean E. 2006. Generation and characterization of hardwood smoke inhalation exposure atmospheres. Aerosol Sci Technol 40:573-584.
22. Niza S, Jamal HH. 2007. Carbon monoxide exposure assessment among toll operators in Klang Valley, Kuala Lumpur, Malaysia. Int J Environ Health Res 17:95-103.
23. O'Toole TE, Zheng YT, Hellmann J, Conklin DJ, Barski O, Bhatnagar A. 2009. Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages. Toxicol Appl Pharmacol 236:194-201.
24. Peters A, von Klot S, Heier M, Trentinaglia I, Hörmann A, Wichmann HE, et al. 2004. Exposure to traffic and the onset of myocardial infarction. N Engl J Med 351:1721-1730.
25. 2 during therapeutic use of inhaled nitric oxide in adults with acute respiratory distress syndrome. Am J Crit Care 12:147-153.
26. Ramos C, Cisneros J, Gonzalez-Avila G, Becerril C, Ruiz V, Montaño M. 2009. Increase of matrix metalloproteinases in woodsmoke-induced lung emphysema in guinea pigs. Inhal Toxicol 21:119-132.
27. Restrepo C, Zimmerman R, Thurston G, Clemente J, Gorczynski J, Zhong M, et al. 2004. A comparison of ground-level air quality data with New York State Department of Environmental Conservation monitoring stations data in South Bronx, New York. Atmos Environ 38:5295-5304.
28. Sarnat JA, Marmur A, Klein M, Kim E, Russell AG, Sarnat SE, et al. 2008. Fine particle sources and cardiorespiratory morbidity: an application of chemical mass balance and factor analytical source-apportionment methods. Environ Health Perspect 116:459-466.
29. Seagrave J, Campen MJ, McDonald JD, Mauderly JL, Rohr AC. 2008. Oxidative stress, inflammation, and pulmonary function assessment in rats exposed to laboratory-generated pollutant mixtures. J Toxicol Environ Health A 71:1352-1362.
30. Seagrave J, McDonald JD, Bedrick E, Edgerton ES, Gigliotti AP, Jansen JJ, et al. 2006. Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects. Environ Health Perspect 114:1387-1393.
31. Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, et al. 2008. Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. Environ Health Perspect 116:375-380.
32. Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, et al. 2005. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 21:3003-3010.
33. Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, et al. 2009. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538-546.
34. Sun Q, Yue P, Ying Z, Cardounel AJ, Brook RD, Devlin R, et al. 2008. Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arterioscler Thromb Vasc Biol 28:1760-1766.
35. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258:468-471.