Azithromycin reduces airway inflammation in a murine model of lung ischaemia reperfusion injury

Transplant International

Volumn 21, Issue 7, 2008, Pages 688-695

  Geudens, Nele ^b   Timmermans, Lien ^b   Vanhooren, Hadewijch ^b   Vanaudenaerde, Bart M ^b   Vos, Robin ^b   Van De Wauwer, Caroline ^b   Verleden, Geert M ^b   Verbeken, Erik ^b   Lerut, Toni ^a   Van Raemdonck, Dirk E M ^a,b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Azithromycin; Ischemia reperfusion injury; Lung donor; Lung inflammation; Lung transplantation

Indexed keywords

8 ISOPROSTANE; AZITHROMYCIN; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; INFLAMMATION; ISCHEMIA; LEUKOCYTE COUNT; LUNG GRAFT REJECTION; LUNG ISCHEMIA; LUNG LAVAGE; LUNG TRANSPLANTATION; LYMPHOCYTE COUNT; MOUSE; NEUTROPHIL COUNT; NEUTROPHILIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; AZITHROMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; CYTOKINES; DINOPROST; FEMALE; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LEUKOCYTE COUNT; LUNG; MICE; NEUTROPHILS; OXIDATIVE STRESS; REPERFUSION INJURY;

EID: 45449085893     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2008.00670.x     Document Type: Article

References (26)

1. Trulock EP., Edwards LB, Taylor DO, Boucek MM, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult lung and heart-lung transplantation report-2006. J Heart Lung Transplant 2006 25 : 880.
2. Fiser SM, Tribble CG, Long SM, et al. Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response. J Thorac Cardiovasc Surg 2001 121 : 1069.
3. Eppinger MJ, Deeb GM, Bolling SF, Ward PA. Mediators of ischemia-reperfusion injury of rat lung. Am J Pathol 1997 150 : 1773.
4. Eppinger MJ, Jones ML, Deeb GM, Bolling SF, Ward PA. Pattern of injury and the role of neutrophils in reperfusion injury of rat lung. J Surg Res 1995 58 : 713.
5. Sarahrudi K, Estenne M, Corris P, et al. International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection. J Thorac Cardiovasc Surg 2004 127 : 1126.
6. Verleden GM, Dupont LJ, Van Raemdonck D, Vanhaecke J. Effect of switching from cyclosporine to tacrolimus on exhaled nitric oxide and pulmonary function in patients with chronic rejection after lung transplantation. J Heart Lung Transplant 2003 22 : 908.
7. Gerhardt SG, McDyer JF, Girgis RE, Conte JV, Yang SC, Orens JB. Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study. Am J Respir Crit Care Med 2003 168 : 121.
8. Verleden GM, Dupont LJ. Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation. Transplantation 2004 77 : 1465.
9. Yates B, Murphy DM, Forrest IA, et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2005 172 : 772.
10. Verleden GM, Vanaudenaerde BM, Dupont LJ, Van Raemdonck DE. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2006 174 : 566.
11. Jaffe A, Bush A. Anti-inflammatory effects of macrolides in lung disease. Pediatr Pulmonol 2001 31 : 464.
12. Parnham MJ, Culic O, Erakovic V, et al. Modulation of neutrophil and inflammation markers in chronic obstructive pulmonary disease by short-term azithromycin treatment. Eur J Pharmacol 2005 517 : 132.
13. Equi A, Balfour-Lynn IM, Bush A, Rosenthal M. Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial. Lancet 2002 360 : 978.
14. Vanaudenaerde BM, Wuyts WA, Geudens N, et al. Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. Am J Transplant 2007 7 : 76.
15. Geudens N, Vanaudenaerde BM, Neyrinck AP, et al. Impact of warm ischemia on different leukocytes in bronchoalveolar lavage from mouse lung: possible new targets to condition the pulmonary graft from the non-heart- beating donor. J Heart Lung Transplant 2006 25 : 839.
16. Wildfeuer A, Laufen H, Muller-Wening D, Haferkamp O. Interaction of azithromycin and human phagocytic cells. Uptake of the antibiotic and the effect on the survival of ingested bacteria in phagocytes. Arzneimittelforschung 1989 39 : 755.
17. Carevic O, Djokic S. Comparative studies on the effects of erythromycin A and azithromycin upon extracellular release of lysosomal enzymes in inflammatory processes. Agents Actions 1988 25 : 124.
18. Koch CC, Esteban DJ, Chin AC, et al. Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae. J Antimicrob Chemother 2000 46 : 19.
19. Ianaro A, Ialenti A, Maffia P, et al. Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther 2000 292 : 156.
20. Lalak NJ, Morris DL. Azithromycin clinical pharmacokinetics. Clin Pharmacokinet 1993 25 : 370.
21. Girard D, Regan PA, Milisen WB, Retsema JA, Swindell AC. Influence of immunosuppression on the pharmacokinetics and pharmacodynamics of azithromycin in infected mouse tissues. J Antimicrob Chemother 1996 37 (Suppl. C 21.
22. Al-Mehdi A, Shuman H, Fisher AB. Fluorescence microtopography of oxidative stress in lung ischemia-reperfusion. Lab Invest 1994 70 : 579.
23. Tamaoki J, Kadota J, Takizawa H. Clinical implications of the immunomodulatory effects of macrolides. Am J Med 2004 117 (Suppl. 9A 5S.
24. Tsai WC, Rodriguez ML, Young KS, et al. Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infection. Am J Respir Crit Care Med 2004 170 : 1331.
25. Rios AM, Fonseca-Aten M, Mejias A, et al. Microbiologic and immunologic evaluation of a single high dose of azithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia. Antimicrob Agents Chemother 2005 49 : 3970.
26. Hickey AJ, Lu D, Ashley ED, Stout J. Inhaled azithromycin therapy. J Aerosol Med 2006 19 : 54.