Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation

Apoptosis

Volumn 16, Issue 8, 2011, Pages 856-867

  Gan, Fei Fei ^a   Nagle, Amrita A ^a   Ang, Xiaohui ^a   Ho, Olivia Huixian ^a   Tan, Sock Hoon ^a   Yang, Hong ^a   Chui, Wai Keung ^a   Chew, Eng Hui ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Cell cycle checkpoint proteins; G2 M arrest; Shogaols; Spindle assembly checkpoint proteins; Tubulin

Indexed keywords

10 SHOGAOL 1 (4 HYDROXYL 3 METHOXYPHENYL) 4 TETRADECEN 3 ONE; 4 SHOGAOL 1 (4 HYDROXYL 3 METHOXYPHENYL) 4 OCTEN 3 ONE; 6 GINGEROL; 6 SHOGAOL 1 (4 HYDROXYL 3 METHOXYPHENYL) 4 DECEN 3 ONE; 8 SHOGAOL 1 (4 HYDROXYL 3 METHOXYPHENYL) 4 DODECEN 3 ONE; ANTINEOPLASTIC AGENT; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TUBULIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG ACTIVITY; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE;

CASPASE 3; CATECHOLS; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; INTERPHASE; MITOSIS; POLY(ADP-RIBOSE) POLYMERASES; TUBULIN; TUBULIN MODULATORS;

EID: 80051543743     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0611-3     Document Type: Article

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