메뉴 건너뛰기




Volumn 37, Issue 7, 2011, Pages 738-752

Activation of cerebral peroxisome proliferator-activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat

Author keywords

Cerebral ischaemia; Neurodegeneration; Pioglitazone; PPAR ; Rat; Substantia nigra

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; GLUTAMIC ACID; OXIDOPAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE;

EID: 80051513901     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2011.01169.x     Document Type: Article
Times cited : (26)

References (44)
  • 1
    • 0023135167 scopus 로고
    • Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist
    • Saji M, Reis DJ. Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist. Science 1987; 235: 66-9.
    • (1987) Science , vol.235 , pp. 66-69
    • Saji, M.1    Reis, D.J.2
  • 2
    • 0027286473 scopus 로고
    • Delayed histologic damage and neuron death in the substantia nigra reticulata following transient forebrain ischemia depends on the extent of initial striatal injury
    • Saji M, Volpe BT. Delayed histologic damage and neuron death in the substantia nigra reticulata following transient forebrain ischemia depends on the extent of initial striatal injury. Neurosci Lett 1993; 155: 47-50.
    • (1993) Neurosci Lett , vol.155 , pp. 47-50
    • Saji, M.1    Volpe, B.T.2
  • 3
    • 0029279177 scopus 로고
    • Delayed histopathological neuronal damage in the substantia nigra compacta (nucleus A9) after transient forebrain ischaemia
    • Volpe BT, Blau AD, Wessel TC, Saji M. Delayed histopathological neuronal damage in the substantia nigra compacta (nucleus A9) after transient forebrain ischaemia. Neurobiol Dis 1995; 2: 119-27.
    • (1995) Neurobiol Dis , vol.2 , pp. 119-127
    • Volpe, B.T.1    Blau, A.D.2    Wessel, T.C.3    Saji, M.4
  • 4
    • 0030219023 scopus 로고    scopus 로고
    • Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats
    • Yamada K, Goto S, Yoshikawa M, Ushio Y. Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats. Neuroscience 1996; 73: 783-9.
    • (1996) Neuroscience , vol.73 , pp. 783-789
    • Yamada, K.1    Goto, S.2    Yoshikawa, M.3    Ushio, Y.4
  • 5
    • 0030271246 scopus 로고    scopus 로고
    • Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution, and morphology of cell death
    • Stefanis L, Burke RE. Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution, and morphology of cell death. Neuroscience 1996; 74: 997-1008.
    • (1996) Neuroscience , vol.74 , pp. 997-1008
    • Stefanis, L.1    Burke, R.E.2
  • 6
    • 0031461307 scopus 로고    scopus 로고
    • Striatal infarction in the rat causes a transient reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia nigra
    • Soriano MA, Justicia C, Ferrer I, Rodríguez-Farré E, Planas AM. Striatal infarction in the rat causes a transient reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia nigra. Neurobiol Dis 1997; 4: 376-85.
    • (1997) Neurobiol Dis , vol.4 , pp. 376-385
    • Soriano, M.A.1    Justicia, C.2    Ferrer, I.3    Rodríguez-Farré, E.4    Planas, A.M.5
  • 7
    • 0032496756 scopus 로고    scopus 로고
    • Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury
    • DeGiorgio LA, Dibinis C, Milner TA, Saji M, Volpe BT. Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury. Brain Res 1998; 795: 1-9.
    • (1998) Brain Res , vol.795 , pp. 1-9
    • DeGiorgio, L.A.1    Dibinis, C.2    Milner, T.A.3    Saji, M.4    Volpe, B.T.5
  • 8
    • 0030756467 scopus 로고    scopus 로고
    • Degeneration of the ipsilateral substantia nigra after striatal infarction: evaluation with MR imaging
    • Ogawa T, Okudera T, Inugami A, Noguchi K, Kado H, Yoshida Y, Uemura K. Degeneration of the ipsilateral substantia nigra after striatal infarction: evaluation with MR imaging. Radiology 1997; 204: 847-51.
    • (1997) Radiology , vol.204 , pp. 847-851
    • Ogawa, T.1    Okudera, T.2    Inugami, A.3    Noguchi, K.4    Kado, H.5    Yoshida, Y.6    Uemura, K.7
  • 9
    • 74549213830 scopus 로고    scopus 로고
    • Signal change of the substantia nigra on diffusion-weighted imaging following striatal infarction
    • Nakajima M, Hirano T, Terasaki T, Uchino M. Signal change of the substantia nigra on diffusion-weighted imaging following striatal infarction. Intern Med 2010; 49: 65-8.
    • (2010) Intern Med , vol.49 , pp. 65-68
    • Nakajima, M.1    Hirano, T.2    Terasaki, T.3    Uchino, M.4
  • 10
    • 58149299835 scopus 로고    scopus 로고
    • Delayed substantia nigra damage and leukoencephalopathy after hypoxic-ischemic injury
    • Lou M, Jing CH, Selim MH, Caplan LR, Ding MP. Delayed substantia nigra damage and leukoencephalopathy after hypoxic-ischemic injury. J Neurol Sci 2009; 277: 147-9.
    • (2009) J Neurol Sci , vol.277 , pp. 147-149
    • Lou, M.1    Jing, C.H.2    Selim, M.H.3    Caplan, L.R.4    Ding, M.P.5
  • 11
    • 5444258474 scopus 로고    scopus 로고
    • Innervation of the substantia nigra
    • Misgeld U. Innervation of the substantia nigra. Cell Tissue Res 2004; 318: 107-14.
    • (2004) Cell Tissue Res , vol.318 , pp. 107-114
    • Misgeld, U.1
  • 12
    • 0037311051 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation
    • Kielian T, Drew PD. Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. J Neurosci Res 2003; 71: 315-25.
    • (2003) J Neurosci Res , vol.71 , pp. 315-325
    • Kielian, T.1    Drew, P.D.2
  • 14
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC. Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J Neurochem 2002; 82: 615-24.
    • (2002) J Neurochem , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 15
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation
    • Dehmer T, Heneka MT, Sastre M, Dichgans J, Schulz JB. Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J Neurochem 2004; 88: 494-501.
    • (2004) J Neurochem , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 16
    • 58149347303 scopus 로고    scopus 로고
    • Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease
    • Kumar P, Kaundal RK, More S, Sharma SS. Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease. Behav Brain Res 2009; 197: 398-403.
    • (2009) Behav Brain Res , vol.197 , pp. 398-403
    • Kumar, P.1    Kaundal, R.K.2    More, S.3    Sharma, S.S.4
  • 20
    • 0032704575 scopus 로고    scopus 로고
    • Blockade of central angiotensin AT(1) receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats
    • Dai WJ, Funk A, Herdegen T, Unger T, Culman J. Blockade of central angiotensin AT(1) receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats. Stroke 1999; 30: 2391-8.
    • (1999) Stroke , vol.30 , pp. 2391-2398
    • Dai, W.J.1    Funk, A.2    Herdegen, T.3    Unger, T.4    Culman, J.5
  • 21
    • 0028959038 scopus 로고
    • Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation
    • Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke 1995; 26: 627-34.
    • (1995) Stroke , vol.26 , pp. 627-634
    • Garcia, J.H.1    Wagner, S.2    Liu, K.F.3    Hu, X.J.4
  • 22
    • 13844253258 scopus 로고    scopus 로고
    • Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons
    • Schmued LC, Stowers CC, Scallet AC, Xu L. Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 2005; 1035: 24-31.
    • (2005) Brain Res , vol.1035 , pp. 24-31
    • Schmued, L.C.1    Stowers, C.C.2    Scallet, A.C.3    Xu, L.4
  • 24
    • 33745983234 scopus 로고    scopus 로고
    • Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats
    • Zhao Y, Patzer A, Herdegen T, Gohlke P, Culman J. Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. FASEB J 2006; 20: 1162-75.
    • (2006) FASEB J , vol.20 , pp. 1162-1175
    • Zhao, Y.1    Patzer, A.2    Herdegen, T.3    Gohlke, P.4    Culman, J.5
  • 25
    • 33644934738 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity
    • Zhao X, Ou Z, Grotta JC, Waxham N, Aronowski J. Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity. Brain Res 2006; 1073-1074: 460-9.
    • (2006) Brain Res , vol.1073-1074 , pp. 460-469
    • Zhao, X.1    Ou, Z.2    Grotta, J.C.3    Waxham, N.4    Aronowski, J.5
  • 26
    • 72149120574 scopus 로고    scopus 로고
    • The microtubule network and neuronal morphogenesis: dynamic and coordinated orchestration through multiple players
    • Poulain FE, Sobel A. The microtubule network and neuronal morphogenesis: dynamic and coordinated orchestration through multiple players. Mol Cell Neurosci 2010; 43: 15-32.
    • (2010) Mol Cell Neurosci , vol.43 , pp. 15-32
    • Poulain, F.E.1    Sobel, A.2
  • 27
    • 61649086903 scopus 로고    scopus 로고
    • TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion
    • Liu F, Schafer DP, McCullough LD. TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion. J Neurosci Methods 2009; 179: 1-8.
    • (2009) J Neurosci Methods , vol.179 , pp. 1-8
    • Liu, F.1    Schafer, D.P.2    McCullough, L.D.3
  • 28
    • 13444292185 scopus 로고    scopus 로고
    • Somatotopy in the basal ganglia: experimental and clinical evidence for segregated sensorimotor channels
    • Romanelli P, Esposito V, Schaal DW, Heit G. Somatotopy in the basal ganglia: experimental and clinical evidence for segregated sensorimotor channels. Brain Res Brain Res Rev 2005; 48: 112-28.
    • (2005) Brain Res Brain Res Rev , vol.48 , pp. 112-128
    • Romanelli, P.1    Esposito, V.2    Schaal, D.W.3    Heit, G.4
  • 29
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999; 22: 391-7.
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 30
    • 0027956162 scopus 로고
    • Apoptosis in substantia nigra following developmental striatal excitotoxic injury
    • Macaya A, Munell F, Gubits RM, Burke RE. Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc Natl Acad Sci U S A 1994; 91: 8117-21.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8117-8121
    • Macaya, A.1    Munell, F.2    Gubits, R.M.3    Burke, R.E.4
  • 31
    • 0142011572 scopus 로고    scopus 로고
    • Microglial activation and tyrosine hydroxylase immunoreactivity in the substantia nigral region following transient focal ischemia in rats
    • Huh Y, Jung JW, Park C, Ryu JR, Shin CY, Kim WK, Ryu JH. Microglial activation and tyrosine hydroxylase immunoreactivity in the substantia nigral region following transient focal ischemia in rats. Neurosci Lett 2003; 349: 63-7.
    • (2003) Neurosci Lett , vol.349 , pp. 63-67
    • Huh, Y.1    Jung, J.W.2    Park, C.3    Ryu, J.R.4    Shin, C.Y.5    Kim, W.K.6    Ryu, J.H.7
  • 32
    • 33745264383 scopus 로고    scopus 로고
    • Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2-mediated protection of brain after experimental cerebral ischemia in rat
    • Ou Z, Zhao X, Labiche LA, Strong R, Grotta JC, Herrmann O, Aronowski J. Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2-mediated protection of brain after experimental cerebral ischemia in rat. Brain Res 2006; 1096: 196-203.
    • (2006) Brain Res , vol.1096 , pp. 196-203
    • Ou, Z.1    Zhao, X.2    Labiche, L.A.3    Strong, R.4    Grotta, J.C.5    Herrmann, O.6    Aronowski, J.7
  • 35
    • 54849409185 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia
    • Patzer A, Zhao Y, Stöck I, Gohlke P, Herdegen T, Culman J. Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. Eur J Neurosci 2008; 28: 1786-94.
    • (2008) Eur J Neurosci , vol.28 , pp. 1786-1794
    • Patzer, A.1    Zhao, Y.2    Stöck, I.3    Gohlke, P.4    Herdegen, T.5    Culman, J.6
  • 36
    • 77954383974 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptors gamma and peroxisome-proliferator-activated receptors beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain
    • Glatz T, Stöck I, Nguyen-Ngoc M, Gohlke P, Herdegen T, Culman J, Zhao Y. Peroxisome-proliferator-activated receptors gamma and peroxisome-proliferator-activated receptors beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain. J Hypertens 2010; 28: 1488-97.
    • (2010) J Hypertens , vol.28 , pp. 1488-1497
    • Glatz, T.1    Stöck, I.2    Nguyen-Ngoc, M.3    Gohlke, P.4    Herdegen, T.5    Culman, J.6    Zhao, Y.7
  • 37
    • 0033913058 scopus 로고    scopus 로고
    • Apoptotic and antiapoptotic mechanisms in stroke
    • Mattson MP, Culmsee C, Yu ZF. Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res 2000; 301: 173-87.
    • (2000) Cell Tissue Res , vol.301 , pp. 173-187
    • Mattson, M.P.1    Culmsee, C.2    Yu, Z.F.3
  • 38
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
    • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001; 65: 135-72.
    • (2001) Prog Neurobiol , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.L.5    Sadoul, R.6    Verna, J.M.7
  • 42
    • 77955899519 scopus 로고    scopus 로고
    • The beta isotypes of tubulin in neuronal differentiation
    • Guo J, Walss-Bass C, Ludueña RF. The beta isotypes of tubulin in neuronal differentiation. Cytoskeleton (Hoboken) 2010; 67: 431-41.
    • (2010) Cytoskeleton (Hoboken) , vol.67 , pp. 431-441
    • Guo, J.1    Walss-Bass, C.2    Ludueña, R.F.3
  • 43
    • 24144475908 scopus 로고    scopus 로고
    • Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation
    • Zhao Y, Foryst-Ludwig A, Bruemmer D, Culman J, Bader M, Unger T, Kintscher U. Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation. J Neurochem 2005; 94: 1395-401.
    • (2005) J Neurochem , vol.94 , pp. 1395-1401
    • Zhao, Y.1    Foryst-Ludwig, A.2    Bruemmer, D.3    Culman, J.4    Bader, M.5    Unger, T.6    Kintscher, U.7
  • 44
    • 38449085356 scopus 로고    scopus 로고
    • Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists
    • Kapadia R, Yi JH, Vemuganti R. Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front Biosci 2008; 13: 1813-26.
    • (2008) Front Biosci , vol.13 , pp. 1813-1826
    • Kapadia, R.1    Yi, J.H.2    Vemuganti, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.