Correlation of sex hormone and androgen receptor with diabetes mellitus in elderly men

Aging Male

Volumn 14, Issue 3, 2011, Pages 162-167

  Cao, Jian ^a   Li, Jian ^a   Hao, Weijun ^a   Li, Xiaoying ^a   Wang, Hao ^a   Liu, Lin ^a   Zhu, Bingpo ^a   Guo, Zhiqin ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

androgen; diabetes mellitus; Gonadal; receptors; Steroid Hormones

Indexed keywords

ANDROGEN RECEPTOR; ESTRADIOL; FOLLITROPIN; GLUCOSE; LUTEINIZING HORMONE; PRASTERONE SULFATE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AGED; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; ESTRADIOL BLOOD LEVEL; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; TESTOSTERONE BLOOD LEVEL; WAIST HIP RATIO;

AGE FACTORS; AGED; BLOOD GLUCOSE; DIABETES MELLITUS; FOLLICLE STIMULATING HORMONE; GONADAL STEROID HORMONES; HUMANS; LOGISTIC MODELS; LUTEINIZING HORMONE; MALE; RECEPTORS, ANDROGEN; RISK FACTORS; SEX HORMONE-BINDING GLOBULIN; WAIST-HIP RATIO;

EID: 80051512988     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2011.575479     Document Type: Article

References (24)

1. Haidar A, Yassin A, Saad F, Shabsigh R. Effects of androgen deprivation on glycaemic control and on cardiovascular biochemical risk factors in men with advanced prostate cancer with diabetes. Aging Male 2007;10:189-196. (Pubitemid 350146723)
2. Keating NL, O'Malley AJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol 2006;24:4448-4456. (Pubitemid 46630983)
3. Fukui M, Soh J, Tanaka M, Kitagawa Y, Hasegawa G, Yoshikawa T, Miki T, Nakamura N. Low serum testosterone concentration in middle-aged men with type 2 diabetes. Endocr J 2007;54:871-877. (Pubitemid 351346769)
4. Saad F, Gooren L. The role of testosterone in the metabolic syndrome: A review. J Steroid Biochem Mol Biol 2009;114:40-43.
5. Cao J, Zou H, Zhu BP, Wang H, Li J, Ding Y, Li XY. Sex hormones and androgen receptor: Risk factors of coronary heart disease in elderly men. Chin Med Sci J 2010;25:44-49.
6. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: A systematic review and meta-analysis. JAMA 2006;295:1288-1299.
7. Haffner SM, Shaten J, Stern MP, Smith GD, Kuller L. Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. Mrfit research group. Multiple risk factor intervention trial. Am J Epidemiol 1996;143:889-897. (Pubitemid 26131096)
8. Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: Prospective results from the massachusetts male aging study. Diabetes Care 2000;23:490-494. (Pubitemid 30185792)
9. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in adult men with androgen deficiency syndromes: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2006;91: 1995-2010. (Pubitemid 43854972)
10. Rhoden EL, Ribeiro EP, Teloken C, Souto CA. Diabetes mellitus is associated with subnormal serum levels of free testosterone in men. BJU Int 2005;96:867-870. (Pubitemid 41391398)
11. O' Donnell AB, Araujo AB, McKinlay JB. The health of normally aging men: The massachusetts male aging study (1987-2004). Exp Gerontol 2004;39:975-984. (Pubitemid 38952878)
12. Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004;27:1036-1041. (Pubitemid 38579762)
13. Isidori AM, Caprio M, Strollo F, Moretti C, Frajese G, Isidori A, Fabbri A. Leptin and androgens in male obesity: Evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999;84:3673-3680. (Pubitemid 30645224)
14. Marin P, Oden B, Bjorntorp P. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: Effects of androgens. J Clin Endocrinol Metab 1995;80:239-243.
15. Davani B, Khan A, Hult M, Martensson E, Okret S, Efendic S, Jörnvall H, Oppermann UC. Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. J Biol Chem 2000;275:34841-34844.
16. Dötsch J, Rascher W. The role of 11beta-hydroxysteroid dehydrogenase activity in the metabolic syndrome: Lessons learned from the animal model. Eur J Endocrinol 2002;146:603-605. (Pubitemid 34552491)
17. Boyanov MA, Boneva Z, Christov VG.Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male 2003;6:1-7. (Pubitemid 36606394)
18. Shahani S, Braga-Basaria M, Basaria S. Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosis. J Clin Endocrinol Metab 2008;93:2042-2049. (Pubitemid 351831513)
19. Pitteloud N Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D, Hayes FJ. Increasing insulin resistance is associated with a decrease in leydig cell testosterone secretion in men. J Clin Endocrinol Metab 2005;90:2636-2641. (Pubitemid 40686302)
20. Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF Jr, Hayes FJ. Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: Evidence from the tandem study of normal and gonadotropin-releasing hormonedeficient men. J Clin Endocrinol Metab 2008;93:784-791. (Pubitemid 351398554)
21. Caprio M, Isidori AM, Carta AR, Moretti C, Dufau ML, Fabbri A. Expression of functional leptin receptors in rodent leydig cells. Endocrinology 1999;140:4939-4947.
22. Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH, Lee K. Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol Cell Biol 2004;24:2593-2604. (Pubitemid 38381254)
23. Pitteloud N, Mootha VK, Dwyer AA, HardinM, Lee H, Eriksson KF, Tripathy D, Yialamas M, Groop L, Elahi D, Hayes FJ. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care 2005;28:1636-1642. (Pubitemid 41340902)
24. Fan W, Yanase T, Nomura M, Okabe T, Goto K, Sato T, Kawano H, Kato S, Nawata H. Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion. Diabetes 2005; 54(4):1000-1008. (Pubitemid 40450323)