메뉴 건너뛰기




Volumn 17, Issue 8, 2011, Pages

Dose-dependent protection on cisplatin-induced ototoxicity - An electrophysiological study on the effect of three antioxidants in the Sprague-Dawley rat animal model

Author keywords

Auditory brainstem responses; Cisplatin ototoxicity; D methionine; Distortion product otoacoustic emissions; Ebselen; N L acetylcysteine

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CISPLATIN; EBSELEN; METHIONINE;

EID: 80051512581     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.881894     Document Type: Article
Times cited : (36)

References (57)
  • 1
    • 0025857621 scopus 로고
    • Cisplatin chemoprotectionand rescue: Pharmacologic modulation of toxicity
    • Gandara DR, Perez EA, Weibe V, DeGregorio MW: Cisplatin chemoprotectionand rescue: Pharmacologic modulation of toxicity. Sem Oncol,1991;18: 49-55
    • (1991) Sem Oncol , vol.18 , pp. 49-55
    • Gandara, D.R.1    Perez, E.A.2    Weibe, V.3    Degregorio, M.W.4
  • 2
    • 0031971967 scopus 로고    scopus 로고
    • Comparative nephrotoxicityof some antitumour active platinum and rutherium complexes in rats
    • Kersten L, Braunlich H, Keppler BK et al: Comparative nephrotoxicityof some antitumour active platinum and rutherium complexes in rats. J Appl Toxicol, 1998; 18: 93-101
    • (1998) J Appl Toxicol , vol.18 , pp. 93-101
    • Kersten, L.1    Braunlich, H.2    Keppler, B.K.3
  • 3
    • 0031912696 scopus 로고    scopus 로고
    • Protection by ebselen against cisplatin-induced nephrotoxicity: Antioxidant system
    • Husain K, Morris C, Whitworth C et al: Protection by ebselen against cisplatin-induced nephrotoxicity: antioxidant system. Mol Cell Biochem,1998; 178: 127-33
    • (1998) Mol Cell Biochem , vol.178 , pp. 127-133
    • Husain, K.1    Morris, C.2    Whitworth, C.3
  • 4
    • 80051506979 scopus 로고    scopus 로고
    • Mechanism of the protectiveeffect of sodium malate on cisplatin-induced toxicity in mice
    • Ueda H, Sugiyama K, Tashiro S, Yokota M: Mechanism of the protectiveeffect of sodium malate on cisplatin-induced toxicity in mice. BiolPharm Bull, 1998; 16: 234-67
    • (1998) BiolPharm Bull , vol.16 , pp. 234-267
    • Ueda, H.1    Sugiyama, K.2    Tashiro, S.3    Yokota, M.4
  • 5
    • 20344367577 scopus 로고    scopus 로고
    • Use of PARP inhibitors to counteract the side effectsof cytotoxic drugs
    • Sumegi B, Deres P: Use of PARP inhibitors to counteract the side effectsof cytotoxic drugs. Med Sci Monit, 2003; 9(Suppl.1): 65
    • (2003) Med Sci Monit , vol.9 , Issue.SUPPL. 1 , pp. 65
    • Sumegi, B.1    Deres, P.2
  • 7
    • 0026948072 scopus 로고
    • Early detection of ototoxicity usinghigh-frequency tone burst-evoked auditory brainstem responses
    • Fausti SA, Frey RH, Henry JA et al: Early detection of ototoxicity usinghigh-frequency tone burst-evoked auditory brainstem responses. J AmAcad Audiol, 1992; 3: 397-404
    • (1992) J AmAcad Audiol , vol.3 , pp. 397-404
    • Fausti, S.A.1    Frey, R.H.2    Henry, J.A.3
  • 8
    • 0023724327 scopus 로고
    • Cisplatin ototoxicity in guinea pigs withspecial reference to toxic effects in the stria vascularis
    • Kohn SM, Fradis J, Zidan L et al: Cisplatin ototoxicity in guinea pigs withspecial reference to toxic effects in the stria vascularis. Laryngoscope,1988; 98: 871-85
    • (1988) Laryngoscope , vol.98 , pp. 871-885
    • Kohn, S.M.1    Fradis, J.2    Zidan, L.3
  • 10
    • 0028081692 scopus 로고
    • Comparative ototoxicity of cisplatin during acute andchronic treatment
    • Saito T, Aran JM: Comparative ototoxicity of cisplatin during acute andchronic treatment. ORL, 1994; 56: 315-20
    • (1994) ORL , vol.56 , pp. 315-320
    • Saito, T.1    Aran, J.M.2
  • 12
    • 0029875766 scopus 로고    scopus 로고
    • Ototoxicity resulting fromcombined administration of cisplatin and gentamicin
    • Riggs LC, Brummett RE, Guitjens SK, Matz GJ: Ototoxicity resulting fromcombined administration of cisplatin and gentamicin. Laryngoscope,1996; 106: 401-6
    • (1996) Laryngoscope , vol.106 , pp. 401-406
    • Riggs, L.C.1    Brummett, R.E.2    Guitjens, S.K.3    Matz, G.J.4
  • 13
    • 0030561543 scopus 로고    scopus 로고
    • D-methionine providesexcellent protection from cisplatin ototoxicity in the rat
    • Campbell CM, Rybak LP, Meech RP, Hughes L: D-methionine providesexcellent protection from cisplatin ototoxicity in the rat. Hear Res, 1996;102: 90-98
    • (1996) Hear Res , vol.102 , pp. 90-98
    • Campbell, C.M.1    Rybak, L.P.2    Meech, R.P.3    Hughes, L.4
  • 14
    • 0023753915 scopus 로고
    • Ototoxicity of highdosecisplatin by bolus administration in patients with advanced cancersand normal hearing
    • Kopelman J, Budnick AS, Kramer MB, Sessions RB: Ototoxicity of highdosecisplatin by bolus administration in patients with advanced cancersand normal hearing. Laryngoscope, 1988; 98: 858-64
    • (1988) Laryngoscope , vol.98 , pp. 858-864
    • Kopelman, J.1    Budnick, A.S.2    Kramer, M.B.3    Sessions, R.B.4
  • 15
    • 0025336060 scopus 로고
    • High dose cisplatin treatment. Hearing lossand plasma concentrations
    • Laurell G, Jungnelius U: High dose cisplatin treatment. Hearing lossand plasma concentrations. Laryngoscope, 1990; 100: 724-34
    • (1990) Laryngoscope , vol.100 , pp. 724-734
    • Laurell, G.1    Jungnelius, U.2
  • 16
    • 0026091350 scopus 로고
    • Degeneration of the organ of Corti followingintravenous administration of cisplatin
    • Laurell G, Bagger-Sjöbäck D: Degeneration of the organ of Corti followingintravenous administration of cisplatin. Acta Otolaryngol, 1991;111: 891-98
    • (1991) Acta Otolaryngol , vol.111 , pp. 891-898
    • Laurell, G.1    Bagger-Sjöbäck, D.2
  • 17
    • 0024596258 scopus 로고
    • The ototoxic effect of cisplatin on guinea pigsin relation to dosage
    • Laurell G, Engström B: The ototoxic effect of cisplatin on guinea pigsin relation to dosage. Hear Res, 1989; 38: 27-33
    • (1989) Hear Res , vol.38 , pp. 27-33
    • Laurell, G.1    Engström, B.2
  • 18
    • 0026658596 scopus 로고
    • Carboplatin and cisplatin ototoxicityin guinea pigs
    • Taudy M, Syka J, Popelar J, Ulehlova L: Carboplatin and cisplatin ototoxicityin guinea pigs. Audiology, 1992; 31: 293-99
    • (1992) Audiology , vol.31 , pp. 293-299
    • Taudy, M.1    Syka, J.2    Popelar, J.3    Ulehlova, L.4
  • 19
    • 0031729011 scopus 로고    scopus 로고
    • Protective effcts ofa neurotrophic ACTH(4-9) analog on cisplatin ototoxicity in relationto the cisplatin dose: An electrocochleographic study in albino guineapigs
    • Stengs CH, Klis SF, Huizing EH, Smoorenburg GF: Protective effcts ofa neurotrophic ACTH(4-9) analog on cisplatin ototoxicity in relationto the cisplatin dose: an electrocochleographic study in albino guineapigs. Hear Res, 1998; 124: 108-17
    • (1998) Hear Res , vol.124 , pp. 108-117
    • Stengs, C.H.1    Klis, S.F.2    Huizing, E.H.3    Smoorenburg, G.F.4
  • 20
    • 0021329342 scopus 로고
    • Changes in the stria vascularis of the guinea pigdue to cis-platinum
    • Tange R, Vuzevski VD: Changes in the stria vascularis of the guinea pigdue to cis-platinum. Arch. Otorhinolaryngol, 1982; 239: 41-47
    • (1982) Arch Otorhinolaryngol , vol.239 , pp. 41-47
    • Tange, R.1    Vuzevski, V.D.2
  • 22
    • 0031760577 scopus 로고
    • A SemiquantitativeAnalysis of the Effects of Cisplatin on the Rat Stria Vascularis
    • Meech RP, Campbell KC, Hughes LP, Rybak LP: A SemiquantitativeAnalysis of the Effects of Cisplatin on the Rat Stria Vascularis. Hear Res,1988; 124: 44-59
    • (1988) Hear Res , vol.124 , pp. 44-59
    • Meech, R.P.1    Campbell, K.C.2    Hughes, L.P.3    Rybak, L.P.4
  • 23
    • 0032721363 scopus 로고    scopus 로고
    • D-Methionine protectsagainst cisplatin damage to the stria vascularis
    • Campbell KC, Meech RP, Rybak LP, Hughes LF: D-Methionine protectsagainst cisplatin damage to the stria vascularis. Hear Res, 1999;138: 13-28
    • (1999) Hear Res , vol.138 , pp. 13-28
    • Campbell, K.C.1    Meech, R.P.2    Rybak, L.P.3    Hughes, L.F.4
  • 24
    • 0030998626 scopus 로고    scopus 로고
    • Protection of both auditoryhair cells and auditory neurons from cisplatin-induced damage
    • Gabaizadeh R, Staecker H, Liu W et al: Protection of both auditoryhair cells and auditory neurons from cisplatin-induced damage. Actaotolaryngol, 1997; 117: 232-38
    • (1997) Actaotolaryngol , vol.117 , pp. 232-238
    • Gabaizadeh, R.1    Staecker, H.2    Liu, W.3
  • 25
    • 0141575856 scopus 로고    scopus 로고
    • The effect ofD-methionine on cochlear oxidative state with and without cisplatinadministration: Mechanisms of otoprotection
    • Campbell KC, Meech RP, Rybak LP, Hughes LF: The effect ofD-methionine on cochlear oxidative state with and without cisplatinadministration: Mechanisms of otoprotection. J Am Acad Audiol, 2003;14: 144-56
    • (2003) J Am Acad Audiol , vol.14 , pp. 144-156
    • Campbell, K.C.1    Meech, R.P.2    Rybak, L.P.3    Hughes, L.F.4
  • 26
    • 33947275322 scopus 로고    scopus 로고
    • Prevention of Noise- and Drug-Induced Hearing Loss with D-methionine
    • Campbell KC, Meech RP, Klemens JJ et al: Prevention of Noise- and Drug-Induced Hearing Loss with D-methionine Hearing Res, 2007;226: 92-103
    • (2007) Hearing Res , vol.226 , pp. 92-103
    • Campbell, K.C.1    Meech, R.P.2    Klemens, J.J.3
  • 27
    • 0032733811 scopus 로고    scopus 로고
    • L- and D-Methionine Provide Equivalent Long Term Protection Against cisplatin-Induced Ototoxicity In Vivo,With Partial In Vitro and In Vivo Retention of Antineoplastic Activity
    • Reser D, Rho M, Dewan D et al: L- and D-Methionine Provide Equivalent Long Term Protection Against cisplatin-Induced Ototoxicity In Vivo,With Partial In Vitro and In Vivo Retention of Antineoplastic Activity. Neurotoxicology, 1999; 20: 731-48
    • (1999) Neurotoxicology , vol.20 , pp. 731-748
    • Reser, D.1    Rho, M.2    Dewan, D.3
  • 28
    • 0034986032 scopus 로고    scopus 로고
    • Round window membrane deliveryof L-methionine provides protection from cisplatin ototoxicity withoutcompromising chemotherapeutic efficacy
    • Li G, Frenz DA, Brahmblatt S et al: Round window membrane deliveryof L-methionine provides protection from cisplatin ototoxicity withoutcompromising chemotherapeutic efficacy. NeuroToxicol, 2001; 22:163-76
    • (2001) NeuroToxicol , vol.22 , pp. 163-176
    • Li, G.1    Frenz, D.A.2    Brahmblatt, S.3
  • 30
    • 2342441227 scopus 로고    scopus 로고
    • Round Window Application ofD-methionine, sodium thiosulfate, brain-derived neurotrophic factor,and fibroblast growth factor-2 in Cisplatin-induced ototoxicity
    • Wimmer C, Mees, K, Stumpf P et al: Round Window Application ofD-methionine, sodium thiosulfate, brain-derived neurotrophic factor,and fibroblast growth factor-2 in Cisplatin-induced ototoxicity. OtolNeurotol, 2004; 25: 33-40
    • (2004) OtolNeurotol , vol.25 , pp. 33-40
    • Wimmer, C.1    Mees, K.2    Stumpf, P.3
  • 31
    • 0000105880 scopus 로고
    • Reversibility of binding of cisplatin-methioninein proteins by diethyldithiocarbamate or thiourea: A study of model adducts
    • Lempers E, Reedijk J: Reversibility of binding of cisplatin-methioninein proteins by diethyldithiocarbamate or thiourea: a study of model adducts.Inorg Chem, 1990; 29: 217-22
    • (1990) Inorg Chem , vol.29 , pp. 217-222
    • Lempers, E.1    Reedijk, J.2
  • 32
    • 0028852816 scopus 로고
    • Oxidation of methionyl residues in proteins: Tools, targets andreversal
    • Vogt J: Oxidation of methionyl residues in proteins: tools, targets andreversal. Free Radic Biol Med, 1995; 18: 93-105
    • (1995) Free Radic Biol Med , vol.18 , pp. 93-105
    • Vogt, J.1
  • 33
    • 0034482931 scopus 로고    scopus 로고
    • Evaluation of D-Methionine as a cytoprotectantin cisplatin treatment of an animal model for ovarian cancer
    • Cloven NG, Re A, McHale M et al: Evaluation of D-Methionine as a cytoprotectantin cisplatin treatment of an animal model for ovarian cancer.Anti Cancer Research, 2000; 20: 4205-10
    • (2000) Anti Cancer Research , vol.20 , pp. 4205-4210
    • Cloven, N.G.1    Re, A.2    McHale, M.3
  • 34
    • 42249102303 scopus 로고    scopus 로고
    • Evaluation of a D-Methionineas a Novel Oral Radioprotector for Prevention of Mucositis
    • Vuyyuri SB, Hamstra DA, Khanna D et al: Evaluation of a D-Methionineas a Novel Oral Radioprotector for Prevention of Mucositis. ClinicalCancer Research, 2008; 14(7): 2161-70
    • (2008) ClinicalCancer Research , vol.14 , Issue.7 , pp. 2161-2170
    • Vuyyuri, S.B.1    Hamstra, D.A.2    Khanna, D.3
  • 35
    • 0036100452 scopus 로고    scopus 로고
    • D-Methionine and cisplatinototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics
    • Ekborn A, Laurell G, Johnström P et al: D-Methionine and cisplatinototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics.Hear Res, 2002; 165: 53-61
    • (2002) Hear Res , vol.165 , pp. 53-61
    • Ekborn, A.1    Laurell, G.2    Johnström, P.3
  • 36
    • 0028219218 scopus 로고
    • The nephrotoxicity, cytotoxicity andrenal handling of a cisplatin-methionine complex in male Wistar rats
    • Deegan PM, Pratt IS, Ryan MP: The nephrotoxicity, cytotoxicity andrenal handling of a cisplatin-methionine complex in male Wistar rats.Toxicology, 1994; 25: 1-14
    • (1994) Toxicology , vol.25 , pp. 1-14
    • Deegan, P.M.1    Pratt, I.S.2    Ryan, M.P.3
  • 37
    • 73449113303 scopus 로고    scopus 로고
    • Effect ofN-acetylcysteine on microalbuminuria in patients with acute respiratorydistress syndrome
    • Najafi A, Mojtahedzadeh M, Mahmoodpoor A et al: Effect ofN-acetylcysteine on microalbuminuria in patients with acute respiratorydistress syndrome. Arch Med Sci, 2009: 5(3): 408-14
    • (2009) Arch Med Sci , vol.5 , Issue.3 , pp. 408-414
    • Najafi, A.1    Mojtahedzadeh, M.2    Mahmoodpoor, A.3
  • 38
    • 2142788844 scopus 로고    scopus 로고
    • Protection againstcisplatin-induced ototoxicity by N-acetylcysteine in a rat model
    • Dickey DT, Muldoon LL, Kraemer DF, Neuwelt EA: Protection againstcisplatin-induced ototoxicity by N-acetylcysteine in a rat model. HearRes, 2004; 193: 25-30
    • (2004) HearRes , vol.193 , pp. 25-30
    • Dickey, D.T.1    Muldoon, L.L.2    Kraemer, D.F.3    Neuwelt, E.A.4
  • 39
    • 0032804642 scopus 로고    scopus 로고
    • Ototoxicity. Amelioration by protective agents
    • Rybak LP, Somani S: Ototoxicity. Amelioration by protective agents.Ann N Y Acad Sci, 1999; 884: 143-51
    • (1999) Ann N Y Acad Sci , vol.884 , pp. 143-151
    • Rybak, L.P.1    Somani, S.2
  • 40
    • 13844266756 scopus 로고    scopus 로고
    • Reduction of acute cisplatin ototoxicityand nephrotoxicity in rats by oral administration of allopurinol andebselen
    • Lynch ED, Gu R, Pierce C, Kil J: Reduction of acute cisplatin ototoxicityand nephrotoxicity in rats by oral administration of allopurinol andebselen. Hear Res, 2005; 201: 81-89
    • (2005) Hear Res , vol.201 , pp. 81-89
    • Lynch, E.D.1    Gu, R.2    Pierce, C.3    Kil, J.4
  • 41
    • 0038691959 scopus 로고    scopus 로고
    • Ebselen attenuates cochlear damage causedby acoustic trauma
    • Pourbakht A, Yamasoba T: Ebselen attenuates cochlear damage causedby acoustic trauma. Hear Res, 2003; 181: 100-8
    • (2003) Hear Res , vol.181 , pp. 100-108
    • Pourbakht, A.1    Yamasoba, T.2
  • 42
    • 0042466676 scopus 로고    scopus 로고
    • Electrophysiological findingsin the Sprague-Dawley rat induced by moderate-dose carboplatin
    • Hatzopoulos S, Petruccelli J, Laurell G et al: Electrophysiological findingsin the Sprague-Dawley rat induced by moderate-dose carboplatin.Hear Res, 2003; 182: 48-55
    • (2003) Hear Res , vol.182 , pp. 48-55
    • Hatzopoulos, S.1    Petruccelli, J.2    Laurell, G.3
  • 43
    • 35148868235 scopus 로고    scopus 로고
    • Noise-induced hearing loss: Astudy on the pharmacological protection in the Sprague Dawley ratwith N-acetyl-cysteine
    • Lorito G, Giordano P, Prosser S et al: Noise-induced hearing loss: astudy on the pharmacological protection in the Sprague Dawley ratwith N-acetyl-cysteine. Acta Otorhinolaryngol Ital, 2006; 133-39
    • (2006) Acta Otorhinolaryngol Ital , pp. 133-139
    • Lorito, G.1    Giordano, P.2    Prosser, S.3
  • 44
    • 50249182993 scopus 로고    scopus 로고
    • Different strategies in treatingnoiseinduced hearing loss with N-acetylcysteine
    • Lorito G, Giordano P, Petruccelli J et al: Different strategies in treatingnoiseinduced hearing loss with N-acetylcysteine. Med Sci Monit, 2008;14(8): BR159-64
    • (2008) Med Sci Monit , vol.14 , Issue.8
    • Lorito, G.1    Giordano, P.2    Petruccelli, J.3
  • 45
    • 0034751201 scopus 로고    scopus 로고
    • Cisplatin ototoxicityin the Sprague Dawley rat evaluated by distortion product otoacousticemissions
    • Hatzopoulos S, Di Stefano M, Campbell KC et al: Cisplatin ototoxicityin the Sprague Dawley rat evaluated by distortion product otoacousticemissions. Audiology, 2001; 40: 253-64
    • (2001) Audiology , vol.40 , pp. 253-264
    • Hatzopoulos, S.1    Di Stefano, M.2    Campbell, K.C.3
  • 46
    • 0036697188 scopus 로고    scopus 로고
    • Evaluation of anesthesia effectsin a rat animal model using otoacoustic emission protocols
    • Hatzopoulos S, Petruccelli J, Laurell G et al: Evaluation of anesthesia effectsin a rat animal model using otoacoustic emission protocols. HearRes, 2002; 170: 12-21
    • (2002) HearRes , vol.170 , pp. 12-21
    • Hatzopoulos, S.1    Petruccelli, J.2    Laurell, G.3
  • 47
    • 0036696953 scopus 로고    scopus 로고
    • Ototoxic effects of cisplatinin a Sprague Dawley rat animal model as revealed by ABR and transientlyevoked otoacoustic emission measurements
    • Hatzopoulos S, Petruccelli J, Laurell G et al: Ototoxic effects of cisplatinin a Sprague Dawley rat animal model as revealed by ABR and transientlyevoked otoacoustic emission measurements. Hear Res, 2002;170: 70-82
    • (2002) Hear Res , vol.170 , pp. 70-82
    • Hatzopoulos, S.1    Petruccelli, J.2    Laurell, G.3
  • 48
    • 35148895878 scopus 로고    scopus 로고
    • Protection against cisplatin ototoxicityin a Sprague-Dawley rat animal model
    • Giordano P, Lorito G, Ciorba A et al: Protection against cisplatin ototoxicityin a Sprague-Dawley rat animal model, Acta OtorhinolaryngolItal, 2006; 26: 198-207
    • (2006) Acta OtorhinolaryngolItal , vol.26 , pp. 198-207
    • Giordano, P.1    Lorito, G.2    Ciorba, A.3
  • 49
    • 0026497977 scopus 로고
    • Evidence for two discretesources of 2f1-f2 distortion-product otoacoustic emission in rabbit.II: Differential physiological vulnerability
    • Whitehead ML, Lonsbury-Martin BL, Martin GK: Evidence for two discretesources of 2f1-f2 distortion-product otoacoustic emission in rabbit.II: Differential physiological vulnerability. J Acoust Soc Am, 1992;92: 2662-82
    • (1992) J Acoust Soc Am , vol.92 , pp. 2662-2682
    • Whitehead, M.L.1    Lonsbury-Martin, B.L.2    Martin, G.K.3
  • 51
    • 17344385626 scopus 로고    scopus 로고
    • Oxidative Stress-induced Apoptosisof Cochlear Sensory Cells: Otoprotective Strategies
    • Huang T, Cheng A, Stupak H et al: Oxidative Stress-induced Apoptosisof Cochlear Sensory Cells: Otoprotective Strategies. Int J Dev Neurosci,2000; 18: 259-70
    • (2000) Int J Dev Neurosci , vol.18 , pp. 259-270
    • Huang, T.1    Cheng, A.2    Stupak, H.3
  • 52
    • 67650648422 scopus 로고    scopus 로고
    • Effect of noise conditioningon cisplatin-induced ototoxicity: A pilot study
    • Theneshkumar S, Lorito G, Giordano P et al: Effect of noise conditioningon cisplatin-induced ototoxicity: a pilot study. Med Sci Monit, 2009;15(7): BR173-77
    • (2009) Med Sci Monit , vol.15 , Issue.7
    • Theneshkumar, S.1    Lorito, G.2    Giordano, P.3
  • 53
    • 39349110546 scopus 로고    scopus 로고
    • Susceptibility to impulse noise indifferent species: Guinea pig, rat and mouse
    • Duan M, Laurell G, Qui J, Borg E: Susceptibility to impulse noise indifferent species: guinea pig, rat and mouse. Acta Otolaryngol, 2008;128(3): 277-83
    • (2008) Acta Otolaryngol , vol.128 , Issue.3 , pp. 277-283
    • Duan, M.1    Laurell, G.2    Qui, J.3    Borg, E.4
  • 54
    • 0028126998 scopus 로고    scopus 로고
    • Phase I study of highly selectivesupradose cisplatin infusions for advanced head and neck cancer
    • Robbins KT, Storniolo AM, Kerber C et al: Phase I study of highly selectivesupradose cisplatin infusions for advanced head and neck cancer.J Clin Oncol, 2002; 12: 2113-20
    • (2002) J Clin Oncol , vol.12 , pp. 2113-2120
    • Robbins, K.T.1    Storniolo, A.M.2    Kerber, C.3
  • 55
    • 0028959496 scopus 로고
    • Distribution of cisplatinin perilymph and cerebrospinal fluid after intravenous administrationin the guinea pig
    • Laurell G, Andersson A, Engström B, Ehrsson H: Distribution of cisplatinin perilymph and cerebrospinal fluid after intravenous administrationin the guinea pig. Cancer Chemother Pharmacol, 1995; 36: 83-86
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 83-86
    • Laurell, G.1    Andersson, A.2    Engström, B.3    Ehrsson, H.4
  • 56
    • 60549111233 scopus 로고    scopus 로고
    • High concentrations of thiosulfatein scala tympani perilymph after systemic administration in theguinea pig
    • Videhult PP, Engmer C, Wallin I et al: High concentrations of thiosulfatein scala tympani perilymph after systemic administration in theguinea pig. Acta Otolaryngol, 2009; 129(2): 132-37
    • (2009) Acta Otolaryngol , vol.129 , Issue.2 , pp. 132-137
    • Videhult, P.P.1    Engmer, C.2    Wallin, I.3
  • 57
    • 0036836799 scopus 로고    scopus 로고
    • Local administration of antioxidantsto the inner ear. Kinetics and distribution
    • Laurell G, Teixeira M, Sterkers O et al: Local administration of antioxidantsto the inner ear. Kinetics and distribution. Hear Res, 2002; 173:198-209
    • (2002) Hear Res , vol.173 , pp. 198-209
    • Laurell, G.1    Teixeira, M.2    Sterkers, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.