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Volumn 12, Issue 13, 2011, Pages 2025-2040

Recent advances in the treatment of chronic hepatitis B

Author keywords

antiviral therapy; chronic hepatitis B; drug resistant hepatitis B virus; nucleos(t)ide analogues; pegylated interferon

Indexed keywords

ADEFOVIR DIPIVOXIL; ALPHA2A INTERFERON; ALPHA2B INTERFERON; CREATININE; EMTRICITABINE; ENTECAVIR; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; TELBIVUDINE; TENOFOVIR DISOPROXIL; VIRUS DNA;

EID: 80051498209     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2011.590474     Document Type: Review
Times cited : (26)

References (131)
  • 1
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
    • DOI 10.1053/j.gastro.2004.09.014, PII S0016508504015938
    • Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology 2004;12(Suppl 1):S35-50 (Pubitemid 39423368)
    • (2004) Gastroenterology , vol.127 , Issue.SUPPL.
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 2
    • 0348047588 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan
    • Kao JH. Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan. Intervirology 2003;46:400-7
    • (2003) Intervirology , vol.46 , pp. 400-407
    • Kao, J.H.1
  • 3
    • 0037198749 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • Lok AS. Chronic hepatitis B. N Engl J Med 2002;346:1682-3
    • (2002) N Engl J Med , vol.346 , pp. 1682-1683
    • Lok, A.S.1
  • 4
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: Update 2009
    • The practice guidelines for treatment of chronic hepatitis B developed by AASLD.
    • Lok AS, McMahon BJ. Chronic hepatitis B: Update 2009. Hepatology 2009;50:661-2 The practice guidelines for treatment of chronic hepatitis B developed by AASLD.
    • (2009) Hepatology , vol.50 , pp. 661-662
    • Lok, A.S.1    McMahon, B.J.2
  • 5
    • 58149296156 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of chronic hepatitis B
    • European Association for the Study of the Liver, The practice guidelines for treatment of chronic hepatitis B developed by EASL.
    • European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of chronic hepatitis B. J Hepatol 2009;50:227-42 The practice guidelines for treatment of chronic hepatitis B developed by EASL.
    • (2009) J Hepatol , vol.50 , pp. 227-242
  • 6
    • 51049107683 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2008 update
    • The practice guidelines for treatment of chronic hepatitis B developed by APASL.
    • Liaw YF, Leung N, Kao JH, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2008 update. Hepatol Int 2008;2:263-83 The practice guidelines for treatment of chronic hepatitis B developed by APASL.
    • (2008) Hepatol Int , vol.2 , pp. 263-283
    • Liaw, Y.F.1    Leung, N.2    Kao, J.H.3
  • 7
    • 0027222630 scopus 로고
    • Biological basis for the clinical use of interferon
    • Dianzani F. Biological basis for the clinical use of interferon. Gut 1993;34(Suppl):S74-6 (Pubitemid 23156092)
    • (1993) Gut , vol.34 , Issue.SUPPL. 2
    • Dianzani, F.1
  • 9
    • 67349168493 scopus 로고    scopus 로고
    • High rates of HBsAg seroconversion in HBeAg-positive chronic hepatitis B patients responding to interferon: A long-term follow-up study
    • Moucari R, Korevaar A, Lada O, et al. High rates of HBsAg seroconversion in HBeAg-positive chronic hepatitis B patients responding to interferon: A long-term follow-up study. J Hepatol 2009;50:1084-92
    • (2009) J Hepatol , vol.50 , pp. 1084-1092
    • Moucari, R.1    Korevaar, A.2    Lada, O.3
  • 10
    • 2942627691 scopus 로고    scopus 로고
    • Treatment with interferons (including pegylated interferons) in patients with hepatitis B
    • DOI 10.1055/s-2004-828678
    • Cooksley WG. Treatment with interferons (including pegylated interferons) in patients with hepatitis B. Semin Liver Dis 2004;24(Suppl 1):45-53 (Pubitemid 38738358)
    • (2004) Seminars in Liver Disease , vol.24 , Issue.SUPPL. 1 , pp. 45-53
    • Cooksley, W.G.1
  • 12
    • 34250011735 scopus 로고    scopus 로고
    • Treatment paradigms on hepatitis B e antigen-negative chronic hepatitis B patients
    • DOI 10.1517/13543784.16.6.777
    • Hadziyannis SJ. Treatment paradigms on hepatitis B e antigen negative chronic hepatitis B patients. Expert Opin Investig Drugs 2007;16:777-86 (Pubitemid 46882353)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.6 , pp. 777-786
    • Hadziyannis, S.J.1
  • 14
    • 0344012054 scopus 로고    scopus 로고
    • Pegylated interferons for chronic hepatitis B
    • DOI 10.1016/j.antiviral.2003.08.015
    • Craxi A, Cooksley WG, Pegylated interferons for chronic hepatitis B. Antiviral Res. 2003;60:87-9 (Pubitemid 37452451)
    • (2003) Antiviral Research , vol.60 , Issue.2 , pp. 87-89
    • Craxi, A.1    Cooksley, W.G.2
  • 19
    • 48549107919 scopus 로고    scopus 로고
    • Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b
    • A long-term follow-up study of the sustainability of HBeAg and HBsAg negativity in HBeAg-positive CHB patients treated with pegylated interferon a-2b.
    • Buster EH, Flink HJ, Cakaloglu Y, et al. Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b. Gastroenterology 2008;135:459-67 A long-term follow-up study of the sustainability of HBeAg and HBsAg negativity in HBeAg-positive CHB patients treated with pegylated interferon a-2b.
    • (2008) Gastroenterology , vol.135 , pp. 459-467
    • Buster, E.H.1    Flink, H.J.2    Cakaloglu, Y.3
  • 21
    • 45549088044 scopus 로고    scopus 로고
    • Virological and biochemical response in patients with HBeAg-negative chronic hepatitis B treated with peginterferon alfa-2a (40KD) with or without lamivudine: Results of 4-year follow-up
    • Marcellin P Piratvisuth T, Brunetto M, et al. Virological and biochemical response in patients with HBeAg-negative chronic hepatitis B treated with peginterferon alfa-2a (40KD) with or without lamivudine: Results of 4-year follow-up. J Hepatol 2008;48(Suppl 2):S46
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Marcellin, P.1    Piratvisuth, T.2    Brunetto, M.3
  • 22
    • 66149168936 scopus 로고    scopus 로고
    • Endpoints of therapy in chronic hepatitis B
    • Feld JJ, Wong DK, Heathcote EJ. Endpoints of therapy in chronic hepatitis B. Hepatology 2009;49:96-102
    • (2009) Hepatology , vol.49 , pp. 96-102
    • Feld, J.J.1    Wong, D.K.2    Heathcote, E.J.3
  • 26
    • 8344277996 scopus 로고    scopus 로고
    • Four years of lamivudine treatment in Chinese patients with chronic hepatitis B
    • Chang TT, Lai CL, Chien RN, et al. Four years of lamivudine treatment in Chinese patients with chronic hepatitis B. J Gastroenterol Hepatol 2004;19:1276-82
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 1276-1282
    • Chang, T.T.1    Lai, C.L.2    Chien, R.N.3
  • 27
    • 0003134396 scopus 로고    scopus 로고
    • Efficacy and safety of 5 years lamivudine treatment of Chinese patients with chronic hepatitis B (abstr)
    • Guan R, Lai CL, Liaw YF, et al. Efficacy and safety of 5 years lamivudine treatment of Chinese patients with chronic hepatitis B (abstr). J Gastroenterol Hepatol 2001;16:A60
    • (2001) J Gastroenterol Hepatol , vol.16
    • Guan, R.1    Lai, C.L.2    Liaw, Y.F.3
  • 29
    • 0033803799 scopus 로고    scopus 로고
    • Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B
    • Hadziyannis SJ, Papatheodoridis GV, Dimou E, et al. Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B. Hepatology 2000;32:847-51
    • (2000) Hepatology , vol.32 , pp. 847-851
    • Hadziyannis, S.J.1    Papatheodoridis, G.V.2    Dimou, E.3
  • 32
    • 65449140873 scopus 로고    scopus 로고
    • A 7-year study of lamivudine therapy for hepatitis B virus e antigen-positive chronic hepatitis B patients in China
    • Yao GB, Zhu M, Cui ZY, et al. A 7-year study of lamivudine therapy for hepatitis B virus e antigen-positive chronic hepatitis B patients in China. J Dig Dis 2009;10:131-7
    • (2009) J Dig Dis , vol.10 , pp. 131-137
    • Yao, G.B.1    Zhu, M.2    Cui, Z.Y.3
  • 33
    • 0034815011 scopus 로고    scopus 로고
    • Impact of YMDD mutations during lamivudine therapy in patients with chronic hepatitis B
    • Liaw YF. Impact of YMDD mutations during lamivudine therapy in patients with chronic hepatitis B. Antivir Chem Chemother 2001;12(Suppl 1):67-71
    • (2001) Antivir Chem Chemother , vol.12 , Issue.SUPPL. 1 , pp. 67-71
    • Liaw, Y.F.1
  • 35
    • 79851513676 scopus 로고    scopus 로고
    • Long-term nucleos(t)ide analogues therapy for adults with chronic hepatitis B reduces the risk of long-term complications: A meta-analysis
    • A meta-analysis showing the reduced risk of complications including decompensated cirrhosis, liver-related death or HCC in CHB patients with long-term nucleos(t)ide analogues therapy.
    • Zhang QQ, An X, Liu YH, et al. Long-term nucleos(t)ide analogues therapy for adults with chronic hepatitis B reduces the risk of long-term complications: A meta-analysis. Virol J 2011;8:72 A meta-analysis showing the reduced risk of complications including decompensated cirrhosis, liver-related death or HCC in CHB patients with long-term nucleos(t)ide analogues therapy.
    • (2011) Virol J , vol.8 , pp. 72
    • Zhang, Q.Q.1    An, X.2    Liu, Y.H.3
  • 37
    • 51349107091 scopus 로고    scopus 로고
    • Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    • Marcellin P, Chang TT, Lim SG, et al. Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. Hepatology 2008;48:750-8
    • (2008) Hepatology , vol.48 , pp. 750-758
    • Marcellin, P.1    Chang, T.T.2    Lim, S.G.3
  • 40
    • 33748557091 scopus 로고    scopus 로고
    • Telbivudine preclinical safety studies suggest minimal risk of chronic toxicity, reproductive toxicity or carcinogenicity
    • Bridges EG. Telbivudine preclinical safety studies suggest minimal risk of chronic toxicity, reproductive toxicity or carcinogenicity. J Hepatol 2006;44(Suppl 2):S147
    • (2006) J Hepatol , vol.44 , Issue.SUPPL. 2
    • Bridges, E.G.1
  • 41
    • 58649096155 scopus 로고    scopus 로고
    • 2-Year GLOBE trial results: Telbivudine is superior to lamivudine in patients with chronic hepatitis B
    • GLOBE Study Group
    • Liaw YF, Gane E, Leung N, et al. GLOBE Study Group. 2-Year GLOBE trial results: Telbivudine is superior to lamivudine in patients with chronic hepatitis B. Gastroenterology 2009;136:486-95
    • (2009) Gastroenterology , vol.136 , pp. 486-495
    • Liaw, Y.F.1    Gane, E.2    Leung, N.3
  • 42
    • 77956592924 scopus 로고    scopus 로고
    • Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients
    • Wursthorn K, Jung M, Riva A, et al. Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients. Hepatology 2010;52:1611-20
    • (2010) Hepatology , vol.52 , pp. 1611-1620
    • Wursthorn, K.1    Jung, M.2    Riva, A.3
  • 43
    • 49849098807 scopus 로고    scopus 로고
    • Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure
    • DOI 10.1007/s12072-008-9048-3
    • Locarnini S. Primary resistance, multidrug resistance and cross-resistance pathways in HBV as a consequence of treatment failure. Hepatol Int 2008;2:147-51 (Pubitemid 351650142)
    • (2008) Hepatology International , vol.2 , Issue.2 , pp. 147-151
    • Locarnini, S.1
  • 44
    • 0036892435 scopus 로고    scopus 로고
    • Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection
    • DOI 10.1053/gast.2002.37058
    • Lai CL, Rosmawati M, Lao J, et al. Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection. Gastroenterology 2002;123:1831-8 (Pubitemid 35408307)
    • (2002) Gastroenterology , vol.123 , Issue.6 , pp. 1831-1838
    • Lai, C.-L.1    Rosmawati, M.2    Lao, J.3    Van Vlierberghe, H.4    Anderson, F.H.5    Thomas, N.6    Dehertogh, D.7
  • 47
    • 75449107726 scopus 로고    scopus 로고
    • Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B
    • Chang TT, Lai CL, Kew Yoon S, et al. Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B. Hepatology 2010;51:422-30
    • (2010) Hepatology , vol.51 , pp. 422-430
    • Chang, T.T.1    Lai, C.L.2    Kew Yoon, S.3
  • 49
    • 72949113706 scopus 로고    scopus 로고
    • Loss of HBsAg antigen during treatment with entecavir or lamivudine in nucleoside-naive HBeAg-positive patients with chronic hepatitis B
    • Gish RG, Chang TT, Lai CL, et al. Loss of HBsAg antigen during treatment with entecavir or lamivudine in nucleoside-naive HBeAg-positive patients with chronic hepatitis B. J Viral Hepat 2010;17:16-22
    • (2010) J Viral Hepat , vol.17 , pp. 16-22
    • Gish, R.G.1    Chang, T.T.2    Lai, C.L.3
  • 50
    • 77956639159 scopus 로고    scopus 로고
    • Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B
    • Chang TT, Liaw YF, Wu SS, et al. Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B. Hepatology 2010;52:886-93
    • (2010) Hepatology , vol.52 , pp. 886-893
    • Chang, T.T.1    Liaw, Y.F.2    Wu, S.S.3
  • 51
    • 77957331059 scopus 로고    scopus 로고
    • Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: A systematic review and Bayesian meta-analyses
    • A meta-analysis of randomized controlled trials evaluating the relative efficacies of 12 months of licensed antiviral therapies for treatment-naïve CHB patients
    • Woo G, Tomlinson G, Nishikawa Y, et al. Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: A systematic review and Bayesian meta-analyses. Gastroenterology 2010;139:1218-29 A meta-analysis of randomized controlled trials evaluating the relative efficacies of 12 months of licensed antiviral therapies for treatment-naïve CHB patients.
    • (2010) Gastroenterology , vol.139 , pp. 1218-1229
    • Woo, G.1    Tomlinson, G.2    Nishikawa, Y.3
  • 52
    • 66149115173 scopus 로고    scopus 로고
    • Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy
    • Tenney DJ, Rose RE, Baldick CJ, et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy. Hepatology 2009;49:1503-14
    • (2009) Hepatology , vol.49 , pp. 1503-1514
    • Tenney, D.J.1    Rose, R.E.2    Baldick, C.J.3
  • 53
    • 57349095400 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B
    • Marcellin P, Heathcote EJ, Buti M, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med 2008;359:2442-55
    • (2008) N Engl J Med , vol.359 , pp. 2442-2455
    • Marcellin, P.1    Heathcote, E.J.2    Buti, M.3
  • 54
    • 79954478573 scopus 로고    scopus 로고
    • Continued efficacy and safety through 4 years of tenofovir disoproxil fumarate (TDF) treatment in HBeAg-negative patients with chronic hepatitis B (Study 102): Preliminary analysis
    • Marcellin P, Buti M, Krastev Z, et al. Continued efficacy and safety through 4 years of tenofovir disoproxil fumarate (TDF) treatment in HBeAg-negative patients with chronic hepatitis B (Study 102): Preliminary analysis. Hepatology 2010;52(Suppl):555A
    • (2010) Hepatology , vol.52 , Issue.SUPPL.
    • Marcellin, P.1    Buti, M.2    Krastev, Z.3
  • 55
    • 79953311247 scopus 로고    scopus 로고
    • Long term (4 Year) efficacy and safety of tenofovir disoproxil fumarate (TDF) treatment in HBeAg-positive patients (HBeAg+) with chronic hepatitis B (Study 103): Preliminary analysis
    • Heathcote E, Gane EJ, deMan RA, et al. Long term (4 Year) efficacy and safety of tenofovir disoproxil fumarate (TDF) treatment in HBeAg-positive patients (HBeAg+) with chronic hepatitis B (Study 103): Preliminary analysis. Hepatology 2010;52(Suppl):556A
    • (2010) Hepatology , vol.52 , Issue.SUPPL.
    • Heathcote, E.1    Gane, E.J.2    DeMan, R.A.3
  • 56
    • 78349304725 scopus 로고    scopus 로고
    • Tenofovir nephrotoxicity: Acute tubular necrosis with distinctive clinical, pathological and mitochondrial abnormalities
    • Herlitz LC, Mohan S, Stokes MB, et al. Tenofovir nephrotoxicity: Acute tubular necrosis with distinctive clinical, pathological and mitochondrial abnormalities. Kidney Int 2010;78:1171-7
    • (2010) Kidney Int , vol.78 , pp. 1171-1177
    • Herlitz, L.C.1    Mohan, S.2    Stokes, M.B.3
  • 57
    • 34247194561 scopus 로고    scopus 로고
    • Management of hepatitis B: Summary of a clinical research workshop
    • DOI 10.1002/hep.21627
    • Hoofnagle JH, Doo E, Liang TJ, et al. Management of hepatitis B: Summary of a clinical research workshop. Hepatology 2007;45:1056-75 (Pubitemid 46646501)
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 1056-1075
    • Hoofnagle, J.H.1    Doo, E.2    Liang, T.J.3    Fleischer, R.4    Lok, A.S.F.5
  • 60
    • 73449142131 scopus 로고    scopus 로고
    • A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen-negative chronic hepatitis B
    • Piccolo P, Lenci I, Demelia L, et al. A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen-negative chronic hepatitis B. Antivir Ther 2009;14:1165-74
    • (2009) Antivir Ther , vol.14 , pp. 1165-1174
    • Piccolo, P.1    Lenci, I.2    Demelia, L.3
  • 61
    • 79956278410 scopus 로고    scopus 로고
    • De novo combination of lamivudine and adefovir versus entecavir monotherapy for the treatment of naive HBeAg-negative chronic hepatitis B patients
    • Epub ahead of print
    • Wang LC, Chen EQ, Cao J, et al. De novo combination of lamivudine and adefovir versus entecavir monotherapy for the treatment of naive HBeAg-negative chronic hepatitis B patients. Hepatol Int 2011; Epub ahead of print
    • (2011) Hepatol Int
    • Wang, L.C.1    Chen, E.Q.2    Cao, J.3
  • 62
    • 78751491184 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF and entecavir in patients with decompensated chronic hepatitis B liver disease
    • Liaw YF, Sheen IS, Lee CM, et al. Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF and entecavir in patients with decompensated chronic hepatitis B liver disease. Hepatology 2011;53:62-72
    • (2011) Hepatology , vol.53 , pp. 62-72
    • Liaw, Y.F.1    Sheen, I.S.2    Lee, C.M.3
  • 64
    • 66149164719 scopus 로고    scopus 로고
    • Antiviral resistance and hepatitis B therapy
    • Ghany MG, Doo EC. Antiviral resistance and hepatitis B therapy. Hepatology 2009;49(5 Suppl):S174-84
    • (2009) Hepatology , vol.49 , Issue.5 SUPPL.
    • Ghany, M.G.1    Doo, E.C.2
  • 68
    • 77949874166 scopus 로고    scopus 로고
    • Antiviral effect of entecavir in chronic hepatitis B: Influence of prior exposure to nucleos(t)ide analogues
    • VIRGIL Surveillance Study Group
    • Reijnders JG, Deterding K, Petersen J, et al. VIRGIL Surveillance Study Group. Antiviral effect of entecavir in chronic hepatitis B: Influence of prior exposure to nucleos(t)ide analogues. J Hepatol 2010;52:493-500
    • (2010) J Hepatol , vol.52 , pp. 493-500
    • Reijnders, J.G.1    Deterding, K.2    Petersen, J.3
  • 69
    • 73449121925 scopus 로고    scopus 로고
    • Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues
    • van Bommel F, de Man RA, Wedemeyer H, et al. Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues. Hepatology 2010;51:73-80
    • (2010) Hepatology , vol.51 , pp. 73-80
    • Van Bommel, F.1    De Man, R.A.2    Wedemeyer, H.3
  • 71
    • 41249103028 scopus 로고    scopus 로고
    • Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure
    • Villet S, Pichoud C, Billioud G, et al. Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure. J Hepatol 2008;48:747-55
    • (2008) J Hepatol , vol.48 , pp. 747-755
    • Villet, S.1    Pichoud, C.2    Billioud, G.3
  • 72
    • 77955849324 scopus 로고    scopus 로고
    • Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir
    • Heo NY, Lim YS, Lee HC, et al. Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir. J Hepatol 2010;53:449-54
    • (2010) J Hepatol , vol.53 , pp. 449-454
    • Heo, N.Y.1    Lim, Y.S.2    Lee, H.C.3
  • 74
    • 52749088340 scopus 로고    scopus 로고
    • Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: Successful rescue therapy with tenofovir
    • Leemans WF, Niesters HG, van der Eijk AA, et al. Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: Successful rescue therapy with tenofovir. Eur J Gastroenterol Hepatol 2008;20:773-7
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 773-777
    • Leemans, W.F.1    Niesters, H.G.2    Van Der Eijk, A.A.3
  • 75
    • 65049086668 scopus 로고    scopus 로고
    • Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B
    • Kobashi H, Fujioka S, Kawaguchi M, et al. Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B. Hepatol Int 2009;3:403-10
    • (2009) Hepatol Int , vol.3 , pp. 403-410
    • Kobashi, H.1    Fujioka, S.2    Kawaguchi, M.3
  • 76
    • 50649112802 scopus 로고    scopus 로고
    • Treatment predictors of a sustained virological response in hepatitis B and C
    • A systemic review of the predictors of the response to either interferon-based or nucleos(t)ide analogues therapies for CHB patients
    • Kau A, Vermehren J, Sarrazin C. Treatment predictors of a sustained virological response in hepatitis B and C. J Hepatol 2008;49:634-51 A systemic review of the predictors of the response to either interferon-based or nucleos(t)ide analogues therapies for CHB patients.
    • (2008) J Hepatol , vol.49 , pp. 634-651
    • Kau, A.1    Vermehren, J.2    Sarrazin, C.3
  • 77
    • 33644858331 scopus 로고    scopus 로고
    • Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    • DOI 10.1053/j.gastro.2005.11.016, PII S0016508505022766
    • Iloeje UH, Yang HI, Su J, et al. Predicting liver cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006;130:678-86 (Pubitemid 43374518)
    • (2006) Gastroenterology , vol.130 , Issue.3 , pp. 678-686
    • Iloeje, U.H.1    Yang, H.-I.2    Su, J.3    Jen, C.-L.4    You, S.-L.5    Chen, C.-J.6
  • 79
    • 39849088923 scopus 로고    scopus 로고
    • Hepatitis B viral factors and clinical outcomes of chronic hepatitis B
    • Lin CL, Kao JH. Hepatitis B viral factors and clinical outcomes of chronic hepatitis B. J Biomed Sci 2008;15:137-45
    • (2008) J Biomed Sci , vol.15 , pp. 137-145
    • Lin, C.L.1    Kao, J.H.2
  • 80
    • 0038276960 scopus 로고    scopus 로고
    • Serum HBV DNA as a marker of efficacy during therapy for chronic HBV infection: Analysis and review of the literature
    • DOI 10.1053/jhep.2003.50208
    • Mommeja-Marin H, Mondou E, Blum MR, Rousseau F. Serum HBV DNA as a marker of efficacy during therapy for chronic HBV infection: Analysis and review of the literature. Hepatology 2003;37:1309-19 (Pubitemid 36667310)
    • (2003) Hepatology , vol.37 , Issue.6 , pp. 1309-1319
    • Mommeja-Marin, H.1    Mondou, E.2    Blum, M.R.3    Rousseau, F.4
  • 82
    • 67349178133 scopus 로고    scopus 로고
    • Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B
    • Zeuzem S, Gane E, Liaw YF, et al. Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B. J Hepatol 2009;51:11-20
    • (2009) J Hepatol , vol.51 , pp. 11-20
    • Zeuzem, S.1    Gane, E.2    Liaw, Y.F.3
  • 85
    • 84983726702 scopus 로고    scopus 로고
    • Impact of host and viral factors on HBeAg-positive chronic hepatitis B patients receiving peginterferon alfa-2a therapy
    • In press
    • Tseng TC, Yu ML, Liu CJ, et al. Impact of host and viral factors on HBeAg-positive chronic hepatitis B patients receiving peginterferon alfa-2a therapy. Antivir Ther 2011 (In press)
    • (2011) Antivir Ther
    • Tseng, T.C.1    Yu, M.L.2    Liu, C.J.3
  • 86
    • 84876033056 scopus 로고    scopus 로고
    • The role of quantitative hepatitis B serology in the natural history and management of chronic hepatitis B
    • Nguyen T, Desmond P, Locarnini S. The role of quantitative hepatitis B serology in the natural history and management of chronic hepatitis B. Hepatol Int 2009;3:S5-15
    • (2009) Hepatol Int , vol.3
    • Nguyen, T.1    Desmond, P.2    Locarnini, S.3
  • 87
    • 77952716572 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen and hepatitis B e antigen titers: Disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers
    • Thompson AJV, Nguyen T, Iser D, et al. Serum hepatitis B surface antigen and hepatitis B e antigen titers: Disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers. Hepatology 2010;51:1933-44
    • (2010) Hepatology , vol.51 , pp. 1933-1944
    • Thompson, A.J.V.1    Nguyen, T.2    Iser, D.3
  • 88
    • 77949656255 scopus 로고    scopus 로고
    • Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: A European perspective
    • Jaroszewicz J, Serrano BC, Wursthorn K, et al. Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: A European perspective. J Hepatol 2010;52:514-22
    • (2010) J Hepatol , vol.52 , pp. 514-522
    • Jaroszewicz, J.1    Serrano, B.C.2    Wursthorn, K.3
  • 89
    • 84984584244 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen concentration correlates with HBV DNA level in patients with chronic hepatitis B
    • Su TH, Hsu CS, Chen CL, et al. Serum hepatitis B surface antigen concentration correlates with HBV DNA level in patients with chronic hepatitis B. Antivir Ther 2010;15:1133-9
    • (2010) Antivir Ther , vol.15 , pp. 1133-1139
    • Su, T.H.1    Hsu, C.S.2    Chen, C.L.3
  • 90
    • 77957958049 scopus 로고    scopus 로고
    • Prediction of sustained response to peginterferon alfa-2b for hepatitis B e antigen-positive chronic hepatitis B using on-treatment hepatitis B surface antigen decline
    • Sonneveld MJ, Rijckborst V, Boucher CA, et al. Prediction of sustained response to peginterferon alfa-2b for hepatitis B e antigen-positive chronic hepatitis B using on-treatment hepatitis B surface antigen decline. Hepatology 2010;52:1251-7
    • (2010) Hepatology , vol.52 , pp. 1251-1257
    • Sonneveld, M.J.1    Rijckborst, V.2    Boucher, C.A.3
  • 91
    • 77955703978 scopus 로고    scopus 로고
    • Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels
    • Rijckborst V, Hansen BE, Cakaloglu Y, et al. Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels. Hepatology 2010;52:454-61
    • (2010) Hepatology , vol.52 , pp. 454-461
    • Rijckborst, V.1    Hansen, B.E.2    Cakaloglu, Y.3
  • 92
    • 79955093993 scopus 로고    scopus 로고
    • Quantitative hepatitis B surface antigen and hepatitis B e antigen titers in prediction of treatment response to entecavir
    • Lee JM, Ahn SH, Kim HS, et al. Quantitative hepatitis B surface antigen and hepatitis B e antigen titers in prediction of treatment response to entecavir. Hepatology 2011;53:1486-93
    • (2011) Hepatology , vol.53 , pp. 1486-1493
    • Lee, J.M.1    Ahn, S.H.2    Kim, H.S.3
  • 93
    • 39549114267 scopus 로고    scopus 로고
    • HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B
    • Fried MW, Piratvisuth T, Lau GK, et al. HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B. Hepatology 2008;47:428-34
    • (2008) Hepatology , vol.47 , pp. 428-4234
    • Fried, M.W.1    Piratvisuth, T.2    Lau, G.K.3
  • 94
    • 78650770247 scopus 로고    scopus 로고
    • The clinical implications of hepatitis B virus genotype: Recent advances
    • Lin CL, Kao JH. The clinical implications of hepatitis B virus genotype: Recent advances. J Gastroenterol Hepatol 2011;26(Suppl 1):123-30
    • (2011) J Gastroenterol Hepatol , vol.26 , Issue.SUPPL. 1 , pp. 123-1230
    • Lin, C.L.1    Kao, J.H.2
  • 95
    • 0002885953 scopus 로고    scopus 로고
    • Molecular characteristics of hepatitis B virus genotype A confer a higher response to interferon treatment
    • Hou J, Schilling R, Janssen HLA. Molecular characteristics of hepatitis B virus genotype A confer a higher response to interferon treatment. J Hepatol 2001;34(Suppl 1):15
    • (2001) J Hepatol , vol.34 , Issue.SUPPL. 1 , pp. 15
    • Hou, J.1    Schilling, R.2    Janssen, H.L.A.3
  • 96
    • 0036896130 scopus 로고    scopus 로고
    • HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C
    • DOI 10.1053/jhep.2002.37139
    • Wai CT, Chu CJ, Hussain M, Lok AS. HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C. Hepatology 2002;36:1425-30 (Pubitemid 35403533)
    • (2002) Hepatology , vol.36 , Issue.6 , pp. 1425-1430
    • Wai, C.T.1    Chu, C.-J.2    Hussain, M.3    Lok, A.S.F.4
  • 97
    • 21044453739 scopus 로고    scopus 로고
    • Response to interferon alfa is hepatitis B virus genotype dependent: Genotype A is more sensitive to interferon than genotype D
    • DOI 10.1136/gut.2004.060327
    • Erhardt A, Blondin D, Hauck K, et al. Response to interferon alfa is hepatitis B virus genotype dependent: Genotype A is more sensitive to interferon than genotype D. Gut 2005;54:1009-13 (Pubitemid 40873918)
    • (2005) Gut , vol.54 , Issue.7 , pp. 1009-1013
    • Erhardt, A.1    Blondin, D.2    Hauck, K.3    Sagir, A.4    Kohnle, T.5    Heintges, T.6    Haussinger, D.7
  • 98
    • 66449121130 scopus 로고    scopus 로고
    • Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a
    • Peginterferon alfa-2a in HBeAg-negative Chronic Hepatitis B Study Group
    • Marcellin P, Bonino F, Lau GK, et al. Peginterferon alfa-2a in HBeAg-negative Chronic Hepatitis B Study Group. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology 2009;136:2169-79
    • (2009) Gastroenterology , vol.136 , pp. 2169-2179
    • Marcellin, P.1    Bonino, F.2    Lau, G.K.3
  • 99
    • 42149123445 scopus 로고    scopus 로고
    • Should treatment of hepatitis B depend on hepatitis B virus genotypes? A hypothesis generated from an explorative analysis of published evidence
    • Wiegand J, Hasenclever D, Tillmann HL. Should treatment of hepatitis B depend on hepatitis B virus genotypes? A hypothesis generated from an explorative analysis of published evidence. Antivir Ther 2008;13:211-20 A meta-analysis addressing whether the determination of HBV genotype has a substantial impact on the selection of antiviral treatments. (Pubitemid 351535372)
    • (2008) Antiviral Therapy , vol.13 , Issue.2 , pp. 211-220
    • Wiegand, J.1    Hasenclever, D.2    Tillmann, H.L.3
  • 100
    • 70649104668 scopus 로고    scopus 로고
    • Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa
    • A study using pooled data from two largest global trials of HBeAg-positive patients to determine the predictors of response to pegylated interferon
    • Buster EH, Hansen BE, Lau GK, et al. Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa. Gastroenterology 2009;137:2002-9 A study using pooled data from two largest global trials of HBeAg-positive patients to determine the predictors of response to pegylated interferon.
    • (2009) Gastroenterology , vol.137 , pp. 2002-2009
    • Buster, E.H.1    Hansen, B.E.2    Lau, G.K.3
  • 101
    • 0142244873 scopus 로고    scopus 로고
    • Determinants for sustained HBeAg response to lamivudine therapy
    • Chien RN, Yeh CT, Tsai SL, et al. Determinants for sustained HBeAg response to lamivudine therapy. Hepatology 2003;38:1267-73
    • (2003) Hepatology , vol.38 , pp. 1267-1273
    • Chien, R.N.1    Yeh, C.T.2    Tsai, S.L.3
  • 104
    • 0036186340 scopus 로고    scopus 로고
    • Is hepatitis B virus subtype testing useful in predicting virological response and resistance to lamivudine? [1]
    • DOI 10.1016/S0168-8278(01)00283-5, PII S0168827801002835
    • Buti M, Cotrina M, Valdes A, et al. Is hepatitis B virus subtype testing useful in predicting virological response and resistance to lamivudine? J Hepatol 2002;36:445-6 (Pubitemid 34194808)
    • (2002) Journal of Hepatology , vol.36 , Issue.3 , pp. 445-446
    • Buti, M.1    Cotrina, M.2    Valdes, A.3    Jardi, R.4    Rodriguez-Frias, F.5    Esteban, R.6
  • 107
    • 84984535933 scopus 로고    scopus 로고
    • Hepatitis B virus genotype B has an earlier emergence of lamivudine resistance than genotype C
    • Hsieh TH, Tseng TC, Liu CJ, et al. Hepatitis B virus genotype B has an earlier emergence of lamivudine resistance than genotype C. Antivir Ther 2009;14:1157-63
    • (2009) Antivir Ther , vol.14 , pp. 1157-1163
    • Hsieh, T.H.1    Tseng, T.C.2    Liu, C.J.3
  • 108
    • 84863115768 scopus 로고    scopus 로고
    • Implications of hepatitis B virus genomic variations on treatment outcomes
    • Tseng TC, Liu CJ, Kao JH. Implications of hepatitis B virus genomic variations on treatment outcomes. Curr Pharmacogenomics Personalized Med 2010;8:280-8
    • (2010) Curr Pharmacogenomics Personalized Med , vol.8 , pp. 280-288
    • Tseng, T.C.1    Liu, C.J.2    Kao, J.H.3
  • 109
    • 67149089048 scopus 로고    scopus 로고
    • Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels
    • Tseng TC, Liu CJ, Wang CC, et al. Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels. Antivir Ther 2009;14:203-10
    • (2009) Antivir Ther , vol.14 , pp. 203-210
    • Tseng, T.C.1    Liu, C.J.2    Wang, C.C.3
  • 110
    • 37749021636 scopus 로고    scopus 로고
    • Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response
    • Yuen MF, Fong DY, Wong DK, et al. Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response. Hepatology 2007;46:1695-703
    • (2007) Hepatology , vol.46 , pp. 1695-1703
    • Yuen, M.F.1    Fong, D.Y.2    Wong, D.K.3
  • 111
    • 67149107750 scopus 로고    scopus 로고
    • Clinical usefulness of sequential hepatitis B virus DNA measurement (the roadmap concept) during adefovir treatment in lamivudine-resistant patients
    • Shin JW, Park NH, Jung SW, et al. Clinical usefulness of sequential hepatitis B virus DNA measurement (the roadmap concept) during adefovir treatment in lamivudine-resistant patients. Antivir Ther 2009;14:181-6
    • (2009) Antivir Ther , vol.14 , pp. 181-186
    • Shin, J.W.1    Park, N.H.2    Jung, S.W.3
  • 112
    • 77950673491 scopus 로고    scopus 로고
    • Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B
    • Lee JM, Park JY, Kim do Y, et al. Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B. Antivir Ther 2010;15:235-41
    • (2010) Antivir Ther , vol.15 , pp. 235-241
    • Lee, J.M.1    Park, J.Y.2    Kim Do, Y.3
  • 113
    • 58949087420 scopus 로고    scopus 로고
    • Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir
    • Leung N, Peng CY, Hann HW, et al. Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir. Hepatology 2009;49:72-9
    • (2009) Hepatology , vol.49 , pp. 72-79
    • Leung, N.1    Peng, C.Y.2    Hann, H.W.3
  • 114
    • 60349129272 scopus 로고    scopus 로고
    • Chronic hepatitis B: Early viral suppression and long-term outcomes of therapy with oral nucleos(t)ides
    • Nguyen MH, Keeffe EB. Chronic hepatitis B: Early viral suppression and long-term outcomes of therapy with oral nucleos(t)ides. J Viral Hepat 2009;16:149-55
    • (2009) J Viral Hepat , vol.16 , pp. 149-155
    • Nguyen, M.H.1    Keeffe, E.B.2
  • 116
    • 65449117946 scopus 로고    scopus 로고
    • Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B
    • Brunetto MR, Moriconi F, Bonino F, et al. Hepatitis B virus surface antigen levels: A guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology 2009;49:1141-50
    • (2009) Hepatology , vol.49 , pp. 1141-1150
    • Brunetto, M.R.1    Moriconi, F.2    Bonino, F.3
  • 117
    • 65449123444 scopus 로고    scopus 로고
    • Early serum HBsAg drop: A strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients
    • Moucari R, Mackiewicz V, Lada O, et al. Early serum HBsAg drop: A strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology 2009;49:1151-7
    • (2009) Hepatology , vol.49 , pp. 1151-1157
    • Moucari, R.1    Mackiewicz, V.2    Lada, O.3
  • 119
    • 78650825940 scopus 로고    scopus 로고
    • Quantification of hepatitis B surface antigen: A new concept for the management of chronic hepatitis B
    • Moucari R, Marcellin P. Quantification of hepatitis B surface antigen: A new concept for the management of chronic hepatitis B. Liver Int 2011;31(Suppl 1):122-8
    • (2011) Liver Int , vol.31 , Issue.SUPPL. 1 , pp. 122-128
    • Moucari, R.1    Marcellin, P.2
  • 120
    • 79951669706 scopus 로고    scopus 로고
    • Kinetics of hepatitis B surface antigen differ between treatment with peginterferon and entecavir
    • Reijnders JG, Rijckborst V, Sonneveld MJ, et al. Kinetics of hepatitis B surface antigen differ between treatment with peginterferon and entecavir. J Hepatol 2011;54:449-54
    • (2011) J Hepatol , vol.54 , pp. 449-454
    • Reijnders, J.G.1    Rijckborst, V.2    Sonneveld, M.J.3
  • 121
    • 20544439267 scopus 로고    scopus 로고
    • Host genetics and the outcome of hepatitis B viral infection
    • DOI 10.1016/j.trim.2005.03.006, PII S0966327405000341
    • Frodsham AJ. Host genetics and the outcome of hepatitis B viral infection. Transpl Immunol 2005;14:183-6 (Pubitemid 40848524)
    • (2005) Transplant Immunology , vol.14 , Issue.3-4 SPEC. ISS. , pp. 183-186
    • Frodsham, A.J.1
  • 122
    • 67349160018 scopus 로고    scopus 로고
    • A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
    • Kamatani Y, Wattanapokayakit S, Ochi H, et al. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 2009;41:591-5
    • (2009) Nat Genet , vol.41 , pp. 591-595
    • Kamatani, Y.1    Wattanapokayakit, S.2    Ochi, H.3
  • 123
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009;461:798-801
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3
  • 124
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009;461:399-401
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 125
    • 84984559313 scopus 로고    scopus 로고
    • Hepatitis B viraemia: Its heritability and association with common genetic variation in the interferon gamma signalling pathway
    • Huang HH, Shih WL, Li YH, et al. Hepatitis B viraemia: Its heritability and association with common genetic variation in the interferon gamma signalling pathway. Gut 2011;60:99-107
    • (2011) Gut , vol.60 , pp. 99-107
    • Huang, H.H.1    Shih, W.L.2    Li, Y.H.3
  • 127
    • 84983726619 scopus 로고    scopus 로고
    • Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study
    • DOI 10.1053/jhep.2002.37198
    • King JK, Yeh SH, Lin MW, et al. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. Hepatology 2002;36:1416-24 (Pubitemid 35403532)
    • (2002) Hepatology , vol.36 , Issue.6 , pp. 1416-1424
    • King, J.K.1    Yeh, S.-H.2    Lin, M.-W.3    Liu, C.-J.4    Lai, M.-Y.5    Kao, J.-H.6    Chen, D.-S.7    Chen, P.-J.8
  • 128
    • 68349083480 scopus 로고    scopus 로고
    • A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients
    • Wu X, Zhu X, Zhu S, et al. A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients. Antiviral Res 2009;83:252-6
    • (2009) Antiviral Res , vol.83 , pp. 252-256
    • Wu, X.1    Zhu, X.2    Zhu, S.3
  • 129
    • 34447632856 scopus 로고    scopus 로고
    • Appropriate use of interferon for treatment of chronic hepatitis B
    • Kao JH. Appropriate use of interferon for treatment of chronic hepatitis B. Hepatol Res 2007;37:S47-54
    • (2007) Hepatol Res , vol.37
    • Kao, J.H.1
  • 130
    • 79251496109 scopus 로고    scopus 로고
    • Review article: Chronic hepatitis B - Anti-viral or immunomodulatory therapy?
    • Rijckborst V, Sonneveld MJ, Janssen HL. Review article: Chronic hepatitis B - anti-viral or immunomodulatory therapy? Aliment Pharmacol Ther 2011;33:501-13
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 501-513
    • Rijckborst, V.1    Sonneveld, M.J.2    Janssen, H.L.3
  • 131
    • 79953700839 scopus 로고    scopus 로고
    • Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic hepatitis B infection
    • Shamliyan TA, Johnson JR, Macdonald R, et al. Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic hepatitis B infection. J Gen Intern Med 2011;26:326-39
    • (2011) J Gen Intern Med , vol.26 , pp. 326-339
    • Shamliyan, T.A.1    Johnson, J.R.2    Macdonald, R.3


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